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  1. Article ; Online: Multianatomical site EBV DNA testing could facilitate the diagnosis of infectious mononucleosis in children-Comment on "Diagnostic value of serological and molecular biological tests for infectious mononucleosis by EBV in different age stages and course of disease".

    Yang, Ying / Hua, Chun-Zhen

    Journal of medical virology

    2021  Volume 93, Issue 11, Page(s) 6077–6078

    MeSH term(s) Antibodies, Viral/blood ; Child ; Child, Preschool ; DNA, Viral/blood ; Female ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/immunology ; Humans ; Infectious Mononucleosis/blood ; Infectious Mononucleosis/diagnosis ; Infectious Mononucleosis/immunology ; Molecular Diagnostic Techniques/standards ; Sensitivity and Specificity ; Serologic Tests/standards
    Chemical Substances Antibodies, Viral ; DNA, Viral
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27148
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  2. Article: Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population.

    Yang, Ying / Wang, Hong-Jiao / Hu, Wei-Lin / Bai, Guan-Nan / Hua, Chun-Zhen

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: Interferon-gamma release assays (IGRAs) are widely used in the diagnosis ... ...

    Abstract Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12020453
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  3. Article ; Online: Evaluation of a Novel Simulation Curriculum With the Segmented Model in Pediatric Cardiovascular Education

    Ying Yang / Lan-Fang Tang / Chun-Zhen Hua / Jian-Hua Mao / Yun-Xia Hong

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: ObjectiveThe need to develop the full range of knowledge, skills, and professionalism poses new challenges for pediatric cardiovascular education. This study aimed to investigate the effectiveness of a novel simulation curriculum with the segmented model ...

    Abstract ObjectiveThe need to develop the full range of knowledge, skills, and professionalism poses new challenges for pediatric cardiovascular education. This study aimed to investigate the effectiveness of a novel simulation curriculum with the segmented model for pediatric cardiovascular residents.Materials and MethodsFirst, the simulation course was designed according to a prior survey and based on a human patient simulator setting. Then, another 55 residents were randomly selected and assigned to participate in a simulation course (about acute fulminant myocarditis in children), either in the experimental group or the control group. Taking full advantage of the simulation education, the simulation case in the experimental group was divided into three segments and included a micro-debriefing at the end of each segment. The three segments were independent but together formed the whole case. It was designed through three cycles of running and debriefing, and more challenging tasks were gradually proposed to residents. The case in the control group was not split and included only one case running and debriefing. The assessments of the residents' knowledge, skills, professionalism performance, and satisfaction feedback from residents were analyzed to evaluate the effectiveness of the course.ResultsIn total, 44 residents completed the whole experimental period, including 23 participants in the experimental group and 21 participants in the control group. The pre-course knowledge assessment scores of the two groups were comparable, while the mean post-course score in the experimental group was 82.61 ± 17.38, which was significantly higher than that in the control group (50.48 ± 18.57, p < 0.01). The mean skills assessment score of residents in the experimental group was 84.17 ± 6.01, which was significantly higher than the control group (54.50 ± 5.72, p < 0.01). In terms of the professionalism assessment, the residents in the experimental group achieved better performance than those in the control group in all ...
    Keywords pediatric cardiovascular specialty ; simulation education ; residency training ; novel model ; teaching effectiveness ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Diagnostic Value of Interferon-Gamma Release Assays for Tuberculosis in the Immunocompromised Population

    Ying Yang / Hong-Jiao Wang / Wei-Lin Hu / Guan-Nan Bai / Chun-Zhen Hua

    Diagnostics, Vol 12, Iss 453, p

    2022  Volume 453

    Abstract: Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of Mycobacterium tuberculosis ( M. tuberculosis ) infection by detecting interferon-γ released by previously sensitized T-cells in-vitro. Currently, there are two assays based on ... ...

    Abstract Interferon-gamma release assays (IGRAs) are widely used in the diagnosis of Mycobacterium tuberculosis ( M. tuberculosis ) infection by detecting interferon-γ released by previously sensitized T-cells in-vitro. Currently, there are two assays based on either enzyme-linked immunosorbent assay (ELISA) or enzyme-linked immunospot (ELISPOT) technology, with several generations of products available. The diagnostic value of IGRAs in the immunocompromised population is significantly different from that in the immunocompetent population because their results are strongly affected by the host immune function. Both physiological and pathological factors can lead to an immunocompromised situation. We summarized the diagnostic value and clinical recommendations of IGRAs for different immunocompromised populations, including peoplewith physiological factors (pregnant and puerperal women, children, and older people), as well as people with pathological factors (solid organ transplantation recipients, combination with human immunodeficiency virus infection, diabetes mellitus, end-stage renal disease, end-stage liver disease, and chronic immune-mediated inflammatory diseases). Though the performance of IGRAs is not perfect and often requires a combination with other diagnostic strategies, it still has some value in the immunocompromised population. Hopefully, the newly developed IGRAs could better target this population.
    Keywords interferon-gamma release assays ; Mycobacterium tuberculosis ; the immunocompromised population ; diagnostic value ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Evaluation of a Novel Simulation Curriculum With the Segmented Model in Pediatric Cardiovascular Education.

    Yang, Ying / Tang, Lan-Fang / Hua, Chun-Zhen / Mao, Jian-Hua / Hong, Yun-Xia

    Frontiers in public health

    2022  Volume 10, Page(s) 887405

    Abstract: Objective: The need to develop the full range of knowledge, skills, and professionalism poses new challenges for pediatric cardiovascular education. This study aimed to investigate the effectiveness of a novel simulation curriculum with the segmented ... ...

    Abstract Objective: The need to develop the full range of knowledge, skills, and professionalism poses new challenges for pediatric cardiovascular education. This study aimed to investigate the effectiveness of a novel simulation curriculum with the segmented model for pediatric cardiovascular residents.
    Materials and methods: First, the simulation course was designed according to a prior survey and based on a human patient simulator setting. Then, another 55 residents were randomly selected and assigned to participate in a simulation course (about acute fulminant myocarditis in children), either in the experimental group or the control group. Taking full advantage of the simulation education, the simulation case in the experimental group was divided into three segments and included a micro-debriefing at the end of each segment. The three segments were independent but together formed the whole case. It was designed through three cycles of running and debriefing, and more challenging tasks were gradually proposed to residents. The case in the control group was not split and included only one case running and debriefing. The assessments of the residents' knowledge, skills, professionalism performance, and satisfaction feedback from residents were analyzed to evaluate the effectiveness of the course.
    Results: In total, 44 residents completed the whole experimental period, including 23 participants in the experimental group and 21 participants in the control group. The pre-course knowledge assessment scores of the two groups were comparable, while the mean post-course score in the experimental group was 82.61 ± 17.38, which was significantly higher than that in the control group (50.48 ± 18.57,
    Conclusions: The novel simulation curriculum with the segmented model helps residents achieve better performance in terms of knowledge, skills, and professionalism while improving self-confidence. It has some value in pediatric cardiovascular education and is worthy of further promotion.
    MeSH term(s) Child ; Clinical Competence ; Computer Simulation ; Curriculum ; Educational Measurement ; Humans ; Internship and Residency
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.887405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Histiocytic Necrotizing Lymphadenitis Mimicking Acute Appendicitis in a Child: A Case Report.

    Hua, Chun-Zhen / Chen, Yu-Kai / Chen, Shun-Zhi / Gu, Wei-Zhong / Shu, Qiang

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 682738

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.682738
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  7. Article ; Online: Microbiological Findings of Symptomatic Vulvovaginitis in Chinese Prepubertal Girls.

    Hu, Bo-Fei / Hua, Chun-Zhen / Sun, Li-Ying / Chao-Fang / Zhou, Ming-Ming

    Journal of pediatric and adolescent gynecology

    2021  Volume 34, Issue 6, Page(s) 799–804

    Abstract: Study objective: To study the bacteria and fungi causing vulvovaginitis in prepubertal girls.: Design: Swabs from vaginal introitus were collected from patients with vulvovaginitis in 2018, and cultured for the identification of microorganisms with ... ...

    Abstract Study objective: To study the bacteria and fungi causing vulvovaginitis in prepubertal girls.
    Design: Swabs from vaginal introitus were collected from patients with vulvovaginitis in 2018, and cultured for the identification of microorganisms with standard microbiological techniques.
    Setting: A children's hospital in Hangzhou, East China.
    Participants: A total of 1235 Chinese prepubertal girls diagnosed with vulvovaginitis.
    Main outcome measure: Bacteria or fungi in pure cultures or as the predominant organism were defined as pathogens.
    Results: A total of 1235 cases were diagnosed as vulvovaginitis, and 515 isolates were identified from 494 patients (40%, 494/1235). The most common pathogen was Streptococcus pyogenes (27.6%,142/515), followed by Haemophilus influenzae (27.2%,140/515), Candida albicans (22.3%,115/515), Staphylococcus aureus (5.8%, 30/515) and Escherichia coli (4.7%,24/515). All S pyogenes isolates were sensitive to penicillin, whereas 53.7% (73/136) of H influenzae isolates were sensitive to ampicillin, and 70.4% (19/27) of S aureus isolates were sensitive to oxacillin.
    Conclusion: S pyogenes and H influenzae were the 2 most commonly identified pathogenic bacteria found in prepubertal girls with vulvovaginitis. Vulvovaginitis in prepubertal girls caused by C albicans may be more common in older children.
    MeSH term(s) Child ; China/epidemiology ; Female ; Haemophilus influenzae ; Humans ; Streptococcus pyogenes ; Vulvovaginitis
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2021.05.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Epidemiological and clinical characteristics of pertussis in children and their close contacts in households: A cross-sectional survey in Zhejiang Province, China.

    Lin, Luo-Na / Zhou, Jin-Si / Hua, Chun-Zhen / Bai, Guan-Nan / Mi, Yu-Mei / Zhou, Ming-Ming

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 976796

    Abstract: Background: Despite the expanded immunization programs, the "re-emergence of pertussis" has become a global concern in recent years. At present, the prevalence of pertussis in China is seriously underestimated, and the role of close contact on the ... ...

    Abstract Background: Despite the expanded immunization programs, the "re-emergence of pertussis" has become a global concern in recent years. At present, the prevalence of pertussis in China is seriously underestimated, and the role of close contact on the disease spreading in children remains unclear.
    Objectives: Our study aimed to investigate pertussis's epidemiological and clinical characteristics in children and their close contacts in households, as well as the antimicrobial resistance of
    Methods: We have collected the retrospective and prospective data of children who were suspected of pertussis and their close contacts in households from January 1, 2018, to December 31, 2020, in the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Nasopharyngeal swabs were collected and cultured for
    Results: A total of 350 index patients and their 946 family members (close contacts in households) from 350 families were recruited.
    Conclusion: Infants under 6 months of age are at high risk of pertussis, and close contacts in households are prone to cluster infection. Culture for
    Language English
    Publishing date 2022-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.976796
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  9. Article: Etiological Analysis of Viral Encephalitis in Children in Zhejiang Province from 2018 to 2019.

    Liu, Juan-Juan / Teng, Li-Ping / Hua, Chun-Zhen / Xie, Yong-Ping / Pan, Yan-Xiang / Hu, Bo-Fei / Hu, Wei-Lin / Wang, Wei-Jian

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 8

    Abstract: Objective: To investigate the common pathogens of viral encephalitis (VE) in children, and to provide guidance for the empirical diagnosis and treatment of patients with VE.: Methods: A total of 227 cerebrospinal fluid (CSF) samples were collected ... ...

    Abstract Objective: To investigate the common pathogens of viral encephalitis (VE) in children, and to provide guidance for the empirical diagnosis and treatment of patients with VE.
    Methods: A total of 227 cerebrospinal fluid (CSF) samples were collected from pediatric patients with VE in Zhejiang province from January 2018 to December 2019. The samples were tested using multiplex and singleplex Reverse Transcription-Polymerase Chain Reaction (RT-PCR) with primers specific to enterovirus (EV), varicella-zoster virus (VZV), mumps virus (MuV), cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1)/type 2 (HSV-2), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6). The data of the two analyses were compared and then verified using Sanger sequencing.
    Results: Of the 227 CSF samples, 90 were shown to be positive for multiplex RT-PCR with a positivity rate of 39.65% and a 95% confidence interval (33.2%, 46.1%). EV was the most common cause of VE, followed by EBV, HHV-6, MuV, CMV, VZV, and HSV-1. Most included cases occurred in summer, accounting for 49.78% of all cases. For EV, EBV, and HSV-2, multiplex RT-PCR showed a positivity rate of 34.36%, which was not statistically different from that of 30.4% shown by singleplex RT-PCR. The sequences of EV, EBV, VZV, MuV, CMV, HSV-1, HHV-6, and HSV-2 were confirmed by sequencing the PCR products obtained from multiplex and singleplex PCR.
    Conclusions: In children, VE is more prevalent in the summer than in other seasons in Zhejiang province, and EV may be the most common causative pathogen.
    Language English
    Publishing date 2022-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12081964
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  10. Article ; Online: Properties of Mucoid Serotype 3

    Yang, Ying / Hua, Chun-Zhen / Fang, Chao / Xie, Yong-Ping / Li, Wei / Fu, Yong / Gao, Feng / Yao, Kai-Hu

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 648040

    Abstract: Objective: To investigate the characteristics of hosts, antimicrobial susceptibility, and molecular epidemiology of mucoid serotype 3 : Method: S. pneumoniae: Results: Twenty (3.04%) isolates of mucoid serotype 3 : Conclusions: Mucoid serotype ... ...

    Abstract Objective: To investigate the characteristics of hosts, antimicrobial susceptibility, and molecular epidemiology of mucoid serotype 3
    Method: S. pneumoniae
    Results: Twenty (3.04%) isolates of mucoid serotype 3
    Conclusions: Mucoid serotype 3
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; China ; Female ; Humans ; Microbial Sensitivity Tests ; Pneumococcal Infections/drug therapy ; Serogroup ; Streptococcus pneumoniae
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.648040
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