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  1. Article ; Online: Hemodialysis in non-cooperative patients: a structured approach.

    Bailoor, Kunal / Laventhal, Naomi / Heung, Michael / Wright, Julie

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How current law and policy supports providers of NHS healthcare in England to respond to patient harm: A scoping review protocol.

    Assame, Naomi / Greenhalgh, Susan / Tingle, John / Wright, Julie / Yeowell, Gillian

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299121

    Abstract: Introduction: Harm arising from National Health Service (NHS) healthcare results in significant human cost for the patient, those who care for them, and the medical staff involved. Furthermore, patient harm results in substantial financial costs to the ... ...

    Abstract Introduction: Harm arising from National Health Service (NHS) healthcare results in significant human cost for the patient, those who care for them, and the medical staff involved. Furthermore, patient harm results in substantial financial costs to the public purse. Improving how NHS providers in England respond to patient harm could reduce the number of claims for clinical negligence brought against NHS. Doing so will ensure those affected receive the justice they deserve and protect the public purse. Law and policy are key to supporting providers of NHS healthcare to respond to patient harm but are not necessarily understood and therefore can be challenging to apply to practice. Research exploring how law and policy supports this understanding is limited. The purpose of this scoping review is to address this knowledge gap and improve understanding by critically evaluating how law and policy supports providers of NHS healthcare in England to respond to patient harm.
    Methods and analysis: The review will use the methodological framework proposed by Arskey and O'Malley, Levac et al and the Joanna Briggs Institute. Search strategies will be developed using selected key words and index terms. MEDLINE, CINAHL, and Westlaw and reference lists of relevant publications will be searched to identify relevant grey literature. Two reviewers will independently assess the extracted data against the eligibility criteria. All studies identified will be charted and the results presented as a narrative synthesis.
    MeSH term(s) Humans ; State Medicine ; Patient Harm ; Delivery of Health Care ; Policy ; England ; Research Design ; Review Literature as Topic
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Is Pediatric Intensive Care Trauma-Informed? A Review of Principles and Evidence.

    Demers, Lauren A / Wright, Naomi M / Kopstick, Avi J / Niehaus, Claire E / Hall, Trevor A / Williams, Cydni N / Riley, Andrew R

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 10

    Abstract: Pediatric critical illness and injury, along with the experience of recovering from critical illness are among the most potentially traumatic experiences for children and their families. Additionally, children often come to the Pediatric Intensive Care ... ...

    Abstract Pediatric critical illness and injury, along with the experience of recovering from critical illness are among the most potentially traumatic experiences for children and their families. Additionally, children often come to the Pediatric Intensive Care Unit (PICU) with pre-existing trauma that may sensitize them to PICU-related distress. Trauma-informed care (TIC) in the PICU, while under-examined, has the potential to enhance quality of care, mitigate trauma-related symptoms, encourage positive coping, and provide anticipatory guidance for the recovery process. This narrative review paper first describes the need for TIC in the PICU and then introduces the principles of TIC as outlined by the American Academy of Pediatrics: awareness, readiness, detection and assessment, management, and integration. Current clinical practices within PICU settings are reviewed according to each TIC principle. Discussion about opportunities for further development of TIC programs to improve patient care and advance knowledge is also included.
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9101575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes.

    Wright, David J / Hall, Nicola A L / Irish, Naomi / Man, Angela L / Glynn, Will / Mould, Arne / Angeles, Alejandro De Los / Angiolini, Emily / Swarbreck, David / Gharbi, Karim / Tunbridge, Elizabeth M / Haerty, Wilfried

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 79

    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08318-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global Surgery Symposium.

    Wright, Naomi J / Ade-Ajayi, Niyi / Lakhoo, Kokila

    Journal of pediatric surgery

    2018  Volume 54, Issue 2, Page(s) 234–238

    Abstract: This article describes the Global Surgery Symposium held within the 65th British Association of Paediatric Surgeons (BAPS) Annual Congress in 2018. Global surgery is a rapidly expanding and developing field and is of particular importance in paediatrics ... ...

    Abstract This article describes the Global Surgery Symposium held within the 65th British Association of Paediatric Surgeons (BAPS) Annual Congress in 2018. Global surgery is a rapidly expanding and developing field and is of particular importance in paediatrics since children account for up to 50% of the population in low- and middle-income countries (LMICs). It is estimated that up to a third of childhood deaths in LMICs are the result of a surgical condition, and congenital anomalies have risen to become the 5th leading cause of death in children less than 5-years of age globally. Trainees in high-income countries (HICs) are increasingly interested in global surgery engagement through clinical placements, research, or education, or a combination of these. There is considerable controversy regarding the ethics, practicalities, usefulness, safety, and sustainability of these initiatives. In addition, there is debate as to whether such placements should occur within the paediatric surgery training pathway. LEVEL OF EVIDENCE: 5 (Expert Opinion).
    MeSH term(s) Developed Countries ; Developing Countries ; Fellowships and Scholarships/ethics ; Global Health/education ; Global Health/ethics ; Humans ; Pediatrics/education ; Specialties, Surgical/education
    Language English
    Publishing date 2018-11-07
    Publishing country United States
    Document type Congress
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2018.10.076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Care of infants with gastroschisis in low-resource settings.

    Wright, Naomi J / Sekabira, John / Ade-Ajayi, Niyi

    Seminars in pediatric surgery

    2018  Volume 27, Issue 5, Page(s) 321–326

    Abstract: There is great global disparity in the outcome of infants born with gastroschisis. Mortality approaches 100% in many low income countries. Barriers to better outcomes include lack of antenatal diagnosis, deficient pre-hospital care, ineffective neonatal ... ...

    Abstract There is great global disparity in the outcome of infants born with gastroschisis. Mortality approaches 100% in many low income countries. Barriers to better outcomes include lack of antenatal diagnosis, deficient pre-hospital care, ineffective neonatal resuscitation and venous access, limited intensive care facilities, poor access to the operating theatre and safe neonatal anesthesia, and lack of neonatal parenteral nutrition. However, lessons can be learned from the evolution in management of gastroschisis in high-income countries, generic efforts to improve neonatal survival in low- and middle-income countries as well as specific gastroschisis management initiatives in low-resource settings. Micro and meso-level interventions include educational outreach programs, and pre and in hospital management protocols that focus on resuscitation and include the delay or avoidance of early neonatal anesthesia by using a preformed silo or equivalent. Furthermore, multidisciplinary team training, nurse empowerment, and the intentional involvement of mothers in monitoring and care provision may contribute to improving survival. Macro level interventions include the incorporation of ultrasound into World Health Organisation antenatal care guidelines to improve antenatal detection and the establishment of the infrastructure to enable parenteral nutrition provision for neonates in low- and middle-income countries. On a global level, gastroschisis has been suggested as a bellwether condition for evaluating access to and outcomes of neonatal surgical care provision.
    MeSH term(s) Developing Countries ; Gastroschisis/diagnosis ; Gastroschisis/therapy ; Healthcare Disparities ; Humans ; Infant ; Infant, Newborn ; Prognosis ; Quality Improvement
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1133381-9
    ISSN 1532-9453 ; 1055-8586
    ISSN (online) 1532-9453
    ISSN 1055-8586
    DOI 10.1053/j.sempedsurg.2018.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Impact of Race and Ethnicity on Use of Minimally Invasive Surgery for Myomas.

    Schneyer, Rebecca J / Greene, Naomi H / Wright, Kelly N / Truong, Mireille D / Molina, Andrea L / Tran, Kevin / Siedhoff, Matthew T

    Journal of minimally invasive gynecology

    2022  Volume 29, Issue 11, Page(s) 1241–1247

    Abstract: Study objective: To determine whether minimally invasive surgery (MIS) for uterine myomas is used differentially based on race and ethnicity.: Design: Retrospective cohort study.: Setting: Quaternary care academic hospital in the United States.: ...

    Abstract Study objective: To determine whether minimally invasive surgery (MIS) for uterine myomas is used differentially based on race and ethnicity.
    Design: Retrospective cohort study.
    Setting: Quaternary care academic hospital in the United States.
    Patients: Patients undergoing hysterectomy or myomectomy for uterine myomas between March 15, 2015, and March 14, 2020 (N = 1311). Cases involving correction of pelvic organ prolapse, malignancy, peripartum hysterectomy, or combined procedures with nongynecologic specialties were excluded. Racial/ethnic composition of the study population was 40.0% non-Hispanic white (white), 27.9% non-Hispanic black (black), 14.0% Hispanic, 13.7% non-Hispanic Asian (Asian), and 4.3% non-Hispanic American Indian/Alaska Native/Pacific Islander/Other.
    Interventions: Hysterectomy, myomectomy.
    Measurements and main results: Of the 1311 cases, 35.9% were minimally invasive hysterectomy, 16.4% abdominal hysterectomy, 35.6% minimally invasive myomectomy, and 12.1% abdominal myomectomy. MIS rates were 94.7% among fellowship-trained minimally invasive gynecologic surgery subspecialists, 44.2% among obstetrics and gynecology specialists, and 46.8% among gynecologic oncologists. There were disparities in surgeon type based on race/ethnicity, with 59.8% of white patients having undergone surgery with a minimally invasive gynecologic surgery subspecialist vs 44.0% of black patients and 45.7% of Hispanic patients. Black and Hispanic patients were less likely to undergo MIS overall vs white patients (adjusted odds ratio [aOR] 0.33, 95% confidence interval [CI] 0.22-0.48 and aOR 0.44, 95% CI 0.28-0.72, respectively). Black and Hispanic patients undergoing hysterectomy were less likely than white patients to undergo MIS (aOR 0.33, 95% CI 0.21-0.51 and aOR 0.35, 95% CI 0.20-0.60, respectively). There were no significant differences in rates of MIS based on race/ethnicity for myomectomies nor differences in major or minor complications by race/ethnicity overall.
    Conclusion: At a quaternary care institution, black and Hispanic patients were significantly less likely than white patients to undergo MIS for uterine myomas, particularly for hysterectomy.
    MeSH term(s) Pregnancy ; Humans ; United States ; Female ; Ethnicity ; Retrospective Studies ; Hysterectomy/methods ; Leiomyoma/surgery ; Minimally Invasive Surgical Procedures ; Myoma/surgery
    Language English
    Publishing date 2022-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2022.06.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Addressing paediatric surgical care on World Birth Defects Day.

    Wright, Naomi J / Anderson, Jamie E / Ozgediz, Doruk / Farmer, Diana L / Banu, Tahmina

    Lancet (London, England)

    2018  Volume 391, Issue 10125, Page(s) 1019

    MeSH term(s) Child ; Child, Preschool ; Congenital Abnormalities/mortality ; Congenital Abnormalities/surgery ; Humans ; Infant ; Infant, Newborn
    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(18)30501-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells.

    de Lucia, Chiara / Murphy, Tytus / Maruszak, Aleksandra / Wright, Paul / Powell, Timothy R / Hartopp, Naomi / de Jong, Simone / O'Sullivan, Michael J / Breen, Gerome / Price, Jack / Lovestone, Simon / Thuret, Sandrine

    Aging and disease

    2021  Volume 12, Issue 8, Page(s) 2151–2172

    Abstract: Age-related alteration in neural stem cell function is linked to neurodegenerative conditions and cognitive decline. In rodents, this can be reversed by exposure to a young systemic milieu and conversely, the old milieu can inhibit stem cell function in ... ...

    Abstract Age-related alteration in neural stem cell function is linked to neurodegenerative conditions and cognitive decline. In rodents, this can be reversed by exposure to a young systemic milieu and conversely, the old milieu can inhibit stem cell function in young rodents. In this study, we investigated the
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2021.0409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes.

    Wright, David J / Hall, Nicola A L / Irish, Naomi / Man, Angela L / Glynn, Will / Mould, Arne / Angeles, Alejandro De Los / Angiolini, Emily / Swarbreck, David / Gharbi, Karim / Tunbridge, Elizabeth M / Haerty, Wilfried

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 42

    Abstract: Background: Alternative splicing is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and how this affects cellular ...

    Abstract Background: Alternative splicing is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and how this affects cellular differentiation remains unclear. Long read sequencing allows full-length transcript recovery and quantification, enabling transcript-level analysis of alternative splicing processes and how these change with cell state. Here, we utilise Oxford Nanopore Technologies sequencing to produce a custom annotation of a well-studied human neuroblastoma cell line SH-SY5Y, and to characterise isoform expression and usage across differentiation.
    Results: We identify many previously unannotated features, including a novel transcript of the voltage-gated calcium channel subunit gene, CACNA2D2. We show differential expression and usage of transcripts during differentiation identifying candidates for future research into state change regulation.
    Conclusions: Our work highlights the potential of long read sequencing to uncover previously unknown transcript diversity and mechanisms influencing alternative splicing.
    MeSH term(s) Alternative Splicing ; Animals ; High-Throughput Nucleotide Sequencing ; Humans ; Nanopores ; Protein Isoforms/genetics ; RNA Splicing
    Chemical Substances Protein Isoforms
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-021-08261-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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