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  1. Book: Infections in transplant an oncology patients

    Marr, Kieren A.

    (Infectious disease clinics of North America ; 24,2)

    2010  

    Author's details guest ed. Kieren A. Marr
    Series title Infectious disease clinics of North America ; 24,2
    Collection
    Language English
    Size XV S., S. 257 - 540
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT016424841
    ISBN 978-1-4377-1831-7 ; 1-4377-1831-0
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The ownership paradox: nurturing continuity and change for the future ASCI.

    Marr, Kieren A

    The Journal of clinical investigation

    2019  Volume 129, Issue 12, Page(s) 5055–5061

    MeSH term(s) African Americans ; Biomedical Research/organization & administration ; Cultural Diversity ; Female ; Humans ; Leadership ; Male ; Models, Organizational ; Motivation ; Physicians ; Societies, Medical/organization & administration ; United States
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI134851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic dilemma in COVID-19-associated pulmonary aspergillosis.

    Permpalung, Nitipong / Maertens, Johan / Marr, Kieren A

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 6, Page(s) 766–767

    MeSH term(s) COVID-19 ; Consensus ; Humans ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/drug therapy ; Pulmonary Aspergillosis/diagnosis ; Pulmonary Aspergillosis/drug therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00060-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aspergillus lentulus:

    Nematollahi, Saman / Permpalung, Nitipong / Zhang, Sean X / Morales, Megan / Marr, Kieren A

    Open forum infectious diseases

    2021  Volume 8, Issue 8, Page(s) ofab392

    Abstract: Aspergillus ... ...

    Abstract Aspergillus lentulus
    Language English
    Publishing date 2021-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Statistical inference on shape and size indexes for counting processes.

    Sun, Yifei / Chiou, Sy Han / Marr, Kieren A / Huang, Chiung-Yu

    Biometrika

    2021  Volume 109, Issue 1, Page(s) 195–208

    Abstract: Single-index models have gained increased popularity in time-to-event analysis owing to their model flexibility and advantage in dimension reduction. We propose a semiparametric framework for the rate function of a recurrent event counting process by ... ...

    Abstract Single-index models have gained increased popularity in time-to-event analysis owing to their model flexibility and advantage in dimension reduction. We propose a semiparametric framework for the rate function of a recurrent event counting process by modelling its size and shape components with single-index models. With additional monotone constraints on the two link functions for the size and shape components, the proposed model possesses the desired directional interpretability of covariate effects and encompasses many commonly used models as special cases. To tackle the analytical challenges arising from leaving the two link functions unspecified, we develop a two-step rank-based estimation procedure to estimate the regression parameters with or without informative censoring. The proposed estimators are asymptotically normal, with a root-
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119-8
    ISSN 1464-3510 ; 0006-3444
    ISSN (online) 1464-3510
    ISSN 0006-3444
    DOI 10.1093/biomet/asab008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fatal invasive pulmonary and cerebral aspergillosis due to triazole-resistant Aspergillus fumigatus with multiple CYP51A mutations.

    Atamna, Alaa / Yeshurun, Moshe / Shargian, Liat / Raanani, Pia / Kramer, Mordechai / Ben Zvi, Haim / Ben Ami, Ronen / Marr, Kieren A / Bishara, Jihad

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 5, Page(s) 1191–1192

    MeSH term(s) Humans ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/drug effects ; Aspergillus fumigatus/isolation & purification ; Drug Resistance, Fungal/genetics ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Fatal Outcome ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Mutation ; Cytochrome P-450 Enzyme System/genetics ; Fungal Proteins/genetics ; Neuroaspergillosis/genetics ; Neuroaspergillosis/microbiology ; Neuroaspergillosis/drug therapy ; Male ; Invasive Pulmonary Aspergillosis/drug therapy ; Invasive Pulmonary Aspergillosis/microbiology ; Microbial Sensitivity Tests ; Middle Aged
    Chemical Substances Antifungal Agents ; Triazoles ; Cytochrome P-450 Enzyme System (9035-51-2) ; Fungal Proteins ; cytochrome P-450 CYP51A, Aspergillus (EC 1.14.14.-)
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply to Pan et al.

    Marr, Kieren A / Anjum, Seher / Hammoud, Dima A / Williamson, Peter R

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 11, Page(s) 3015

    MeSH term(s) Cohort Studies ; Cryptococcosis ; HIV ; Humans ; Longitudinal Studies ; United States
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neuroimaging of Cryptococcal Meningitis in Patients without Human Immunodeficiency Virus: Data from a Multi-Center Cohort Study.

    Anjum, Seher H / Bennett, John E / Dean, Owen / Marr, Kieren A / Hammoud, Dima A / Williamson, Peter R

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 5

    Abstract: Background: A clearer understanding is needed about the use of brain MRI in non-HIV patients with cryptococcal meningitis.: Methods: Cerebral CT and MRI were studied in 62 patients in a multicenter study of cryptococcal meningitis in non-HIV patients. ...

    Abstract Background: A clearer understanding is needed about the use of brain MRI in non-HIV patients with cryptococcal meningitis.
    Methods: Cerebral CT and MRI were studied in 62 patients in a multicenter study of cryptococcal meningitis in non-HIV patients. CT was performed in 51 and MRI in 44. MRI results are reported for the images read at NIH for 29 of the 44 patients. CT reports obtained from the original REDCap database were added to calculate the incidence of normal findings.
    Results: CTs were read as normal in 24 of 51 (47%), MRIs were normal in 10% (three of 29). The most characteristic lesions of cryptococcal meningitis on MRI were small basal ganglia lesions representing dilated perivascular spaces in 24% and basal ganglia lesions with restricted diffusion (infarcts) in 38%. In the 18 patients who received contrast, contrast-enhancing lesions, likely representing masses of cryptococci and inflammatory cells, were found in the basal ganglia in 22% and elsewhere in the brain in 22%. Meningeal enhancement was seen in 56%, ependymal enhancement in 24%, and choroid plexus enhancement in 11%. Hydrocephalus was found in five (18%), though increased intacranial pressure was not detected. Suboptimal imaging (n = 6), lack of contrast administration (
    Conclusion: MRI characteristics of non-HIV cryptococcal meningitis include hydrocephalus, meningeal and ependymal enhancement and basal ganglia lesions. Optimal imaging is, however, necessary to maximize the diagnostic and prognostic usefulness of MRI.
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9050594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Teaching Everyone Everywhere All at Once: Leveraging Social Media to Implement a Multisite Fungal Diagnostics Curriculum.

    Nematollahi, Saman / Tackett, Sean / Grieb, Suzanne / Laracy, Justin C / Belcher, Anne / Marr, Kieren A / Shoham, Shmuel / Avery, Robin K / Melia, Michael T

    Open forum infectious diseases

    2023  Volume 10, Issue 12, Page(s) ofad594

    Abstract: Background: Environmental fungi are threats to personal and public health. Fungal in vitro diagnostics help diagnose invasive fungal infections (IFIs), but clinicians remain underinformed about their use and interpretation. Given the increasing use of ... ...

    Abstract Background: Environmental fungi are threats to personal and public health. Fungal in vitro diagnostics help diagnose invasive fungal infections (IFIs), but clinicians remain underinformed about their use and interpretation. Given the increasing use of social media to share infectious diseases-related content, we designed and implemented a multisite Twitter-based curriculum focused on IFIs and related diagnostics.
    Methods: Questions were posted through a dedicated Twitter account twice weekly over 8 weeks. We surveyed clinicians at 3 US academic centers before and after completion of the curriculum and interviewed a subset of participants. We undertook quantitative and qualitative evaluations and reviewed Twitter analytics.
    Results: We surveyed 450 participants. One hundred twenty-one participants (27%) completed the knowledge assessment precurriculum, 68 (15%) postcurriculum, and 53 (12%) pre- and postcurriculum. We found a significant increase (72% vs 80%,
    Conclusions: Educators can leverage social media to share content with a large audience and improve knowledge while being mindful of the barriers associated with implementing a curriculum on social media.
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Invasive Fungal Infections in Inpatient Solid Organ Transplant Recipients With COVID-19: A Multicenter Retrospective Cohort.

    Permpalung, Nitipong / Chiang, Teresa Po-Yu / Manothummetha, Kasama / Ostrander, Darin / Datta, Kausik / Segev, Dorry L / Durand, Christine M / Mostafa, Heba H / Zhang, Sean X / Massie, Allan B / Marr, Kieren A / Avery, Robin K

    Transplantation

    2024  

    Abstract: Background: The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood.: Methods: A retrospective cohort study of SOTRs with COVID-19 admitted to 5 ... ...

    Abstract Background: The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood.
    Methods: A retrospective cohort study of SOTRs with COVID-19 admitted to 5 hospitals within Johns Hopkins Medicine was performed between March 2020 and March 2022. Cox regression multilevel mixed-effects ordinal logistic regression was used.
    Results: In the cohort of 276 SOTRs, 22 (8%) developed IFIs. The prevalence of CAIFIs was highest in lung transplant recipients (20%), followed by recipients of heart (2/28; 7.1%), liver (3/46; 6.5%), and kidney (7/149; 4.7%) transplants. In the overall cohort, only 42 of 276 SOTRs (15.2%) required mechanical ventilation; these included 11 of 22 SOTRs (50%) of the CAIFI group and 31 of 254 SOTRs (12.2%) of the no-CAIFI group. Compared with those without IFIs, SOTs with IFIs had worse outcomes and required more advanced life support (high-flow oxygen, vasopressor, and dialysis). SOTRs with CAIFIs had higher 1-y death-censored allograft failure (hazard ratio 1.65.116.4, P = 0.006) and 1-y mortality adjusting for oxygen requirement (adjusted hazard ratio 1.12.45.1, P < 0.001), compared with SOTRs without CAIFIs.
    Conclusions: The prevalence of CAIFIs in inpatient SOTRs with COVID-19 is substantial. Clinicians should be alert to the possibility of CAIFIs in SOTRs with COVID-19, particularly those requiring supplemental oxygen, regardless of their intubation status.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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