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  1. Article ; Online: Early Palliative Care Consultation Before High-risk Surgery.

    Haas, Barbara / Rubenfeld, Gordon D

    JAMA network open

    2023  Volume 6, Issue 5, Page(s) e2314627

    MeSH term(s) Humans ; Palliative Care ; Referral and Consultation
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.14627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: The organization of critical care

    Scales, Damon C. / Rubenfeld, Gordon D.

    an evidence-based approach to improving quality

    (Respiratory medicine)

    2014  

    Author's details Damon C. Scales ; Gordon D. Rubenfeld ed
    Series title Respiratory medicine
    Keywords Intensive care units/Management
    Subject code 362.174068
    Language English
    Size IX, 284 S. : Ill., graph. Darst., 24 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018358239
    ISBN 978-1-4939-0810-3 ; 1-4939-0810-3 ; 9781493908110 ; 1493908111
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 3152 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: To J.R.C. with L.O.V.E.

    Rubenfeld, Gordon D / Halpern, Scott D

    Journal of pain and symptom management

    2022  Volume 63, Issue 6, Page(s) e577–e578

    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2022.04.165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2252: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: What Can Simulations Tell Us About Triage Protocols in a Real Pandemic?

    Sathya, Abhinay / Rubenfeld, Gordon D / Fowler, Rob

    Chest

    2021  Volume 160, Issue 2, Page(s) 398–399

    MeSH term(s) Clinical Protocols ; Humans ; Influenza, Human/epidemiology ; Pandemics ; Triage
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.04.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  5. Article ; Online: Rebuttal From Dr Rubenfeld.

    Rubenfeld, Gordon D

    Chest

    2016  Volume 149, Issue 3, Page(s) 629–630

    MeSH term(s) Certificate of Need ; Critical Care/manpower ; Health Care Rationing ; Humans ; Intensive Care Units ; Medical Staff, Hospital/supply & distribution ; Physicians/supply & distribution ; Regional Health Planning
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2015.11.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: COUNTERPOINT: Does the United States Need More Intensivist Physicians? No.

    Rubenfeld, Gordon D

    Chest

    2016  Volume 149, Issue 3, Page(s) 625–628

    MeSH term(s) Critical Care/manpower ; Health Services Needs and Demand ; Humans ; Intensive Care Units ; Medical Staff, Hospital/supply & distribution ; Personnel Management ; Physicians/supply & distribution ; Population Dynamics ; United States
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2015.11.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Evaluation of Three Cytomegalovirus IgG Lateral Flow Assays for Rapid Determination of CMV Serostatus.

    Joncas-Schronce, Laurel / Ali, Fatima / Pepper, Gregory / Stapleton, Renee D / Rubenfeld, Gordon D / Boeckh, Michael / Limaye, Ajit P

    Open forum infectious diseases

    2024  Volume 11, Issue 3, Page(s) ofae084

    Abstract: Background: Cytomegalovirus (CMV) serostatus is a major determinant of CMV infection, disease risk, and transplant outcomes. Current clinical serology assays are limited by relatively slow turnaround time, design for batched testing, need for trained ... ...

    Abstract Background: Cytomegalovirus (CMV) serostatus is a major determinant of CMV infection, disease risk, and transplant outcomes. Current clinical serology assays are limited by relatively slow turnaround time, design for batched testing, need for trained personnel, and/or specialized equipment. Rapid diagnostic assays in development have a role in emerging settings, such as critically ill patients, but have not been systematically evaluated.
    Methods: We assessed the performance of 3 rapid lateral flow assays (LFAs) for the detection of CMV immunoglobulin (Ig)G antibodies compared with a reference commercially available CMV IgG enzyme-linked immunosorbent assay in residual serum samples from 200 consecutive adults who underwent clinical CMV serology testing. Samples with discrepant results between the LFA and reference assay were tested by a second reference assay. A subset of serum samples was assessed for interoperator variability. Operating characteristics of the QooLabs LFA were separately assessed in plasma samples.
    Results: The sensitivity and specificity of the individual LFA assays using serum varied significantly: 86%/83%, 99/93%, and 57/97%, for Healgen, QNow automated reader, and nanoComposix, respectively, compared with the reference assay. Results for the QNow assay were comparable between automated and manual reads. Among a subset of 10 serum samples assessed by 5 individual operators, 44 of 50 (88%) results were concordant. Among 50 plasma samples assessed by the QooLabs LFA, the sensitivity and specificity were 72% and 96%.
    Conclusions: The ease of performance, rapid turnaround time, and good operating characteristics provide the rationale for further evaluation of the Qoolabs QNow LFA in specialized settings where rapid assessment of CMV serostatus would be advantageous.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae084
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  8. Article ; Online: Keeping Meta-analyses Fresh.

    Berlin, Jesse A / Rubenfeld, Gordon D / O'Cearbhaill, Roisin E / Shah, Amy Sanghavi / Fihn, Stephan D

    JAMA network open

    2022  Volume 5, Issue 8, Page(s) e2228541

    MeSH term(s) Humans ; Meta-Analysis as Topic
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.28541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Confronting the frustrations of negative clinical trials in acute respiratory distress syndrome.

    Rubenfeld, Gordon D

    Annals of the American Thoracic Society

    2015  Volume 12 Suppl 1, Page(s) S58–63

    Abstract: Despite robust successes in trials of mechanical ventilation, pharmacologic interventions in acute respiratory distress syndrome have been disappointing. Although ineffective therapy remains the compelling explanation for these negative trials, other ... ...

    Abstract Despite robust successes in trials of mechanical ventilation, pharmacologic interventions in acute respiratory distress syndrome have been disappointing. Although ineffective therapy remains the compelling explanation for these negative trials, other possible explanations exist. These negative trials, better termed "statistically negative trials" or "indeterminate trials," cannot prove that a therapy is ineffective. It is important for clinicians and investigators to appreciate the alternative explanations for negative trials of potentially effective therapies because these indicate options for improving clinical trials in acute respiratory distress syndrome. These options can be organized into strategies that increase sample size, increase the signal from the therapy, and reduce the noise or variation in the study. Each of the strategies to improve the likelihood of a positive clinical trial poses a potential tradeoff in generalizability, cost, sample size, signal, or noise.
    MeSH term(s) Clinical Trials as Topic ; Humans ; Research Design ; Respiratory Distress Syndrome, Adult/therapy
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201409-414MG
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Who cares about preventing acute respiratory distress syndrome?

    Rubenfeld, Gordon D

    American journal of respiratory and critical care medicine

    2015  Volume 191, Issue 3, Page(s) 255–260

    Abstract: Acute respiratory distress syndrome (ARDS) is a common, lethal, and morbid respiratory complication primarily seen in the setting of major trauma and infection. Despite advances in mechanical ventilation for ARDS, many interventions have not been ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is a common, lethal, and morbid respiratory complication primarily seen in the setting of major trauma and infection. Despite advances in mechanical ventilation for ARDS, many interventions have not been successful in reducing mortality. Recent grant announcements and ongoing clinical trials indicate an interest in preventing ARDS. This Perspective challenges some of the basic assumptions of ARDS prevention and preventive care in the intensive care unit. ARDS is an organ function surrogate outcome. Studies of surrogate outcomes in medicine have repeatedly failed to show an association with patient-centered outcomes that might include mortality, quality of life, patient satisfaction, and cost. Organ failure surrogate outcomes in critical care, including oxygenation, cardiac output, and blood pressure, have similarly failed to show a consistent association with patient-centered benefit. Trials designed to demonstrate an effect on surrogate outcomes will rarely be able to demonstrate small, but important, harms so that the net benefit of prevention can be calculated. This will leave clinicians with insufficient information to balance the unknown benefits of ARDS prevention with imprecisely estimated costs or risks of prevention. Because ARDS diagnosis relies on oxygenation and the chest radiograph that might be directly influenced by the prophylactic intervention, studies must be designed to insure that the prevention is not merely cosmetic. Strategies that prevent ARDS need to be tested in trials sufficiently powered to demonstrate their patient-centered costs, benefits and harms before widespread adoption.
    MeSH term(s) Critical Care/standards ; Evidence-Based Medicine ; Hospital Mortality ; Humans ; Physician's Role ; Quality of Life ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult/diagnosis ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/prevention & control ; Risk Factors ; United States
    Language English
    Publishing date 2015-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201408-1574CP
    Database MEDical Literature Analysis and Retrieval System OnLINE

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