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Article ; Online: Lawrence R. Klein y la economía aplicada

A. PULIDO SAN ROMÁN / J. PÉREZ GARCÍA

Estudios de Economía Aplicada, Vol 24, Iss 1, Pp 43-

2006 Volume 94

Abstract: A lo largo del presente artículo hemos intentado recoger las principales aportaciones del profesor ... Klein al amplio campo de la economía aplicada a lo largo de su dilatada carrera como docente e ... en torno a cuatro grandes apartados: pensamiento económico, métodos econométricos, modelos econométricos ...

Abstract	A lo largo del presente artículo hemos intentado recoger las principales aportaciones del profesor Klein al amplio campo de la economía aplicada a lo largo de su dilatada carrera como docente e investigador. Siendo conscientes de las limitaciones que puede suponer la revisión completa de una obra tan vasta como la generada por el citado autor hemos optado por agrupar sus principales aportaciones en torno a cuatro grandes apartados: pensamiento económico, métodos econométricos, modelos econométricos aplicados y otras áreas de Investigación.
Keywords	Economic theory. Demography ; HB1-3840 ; Social Sciences ; H
Language	Spanish
Publishing date	2006-01-01T00:00:00Z
Publisher	Asociación Internacional de Economía Aplicada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Developing a reporting item checklist for studies of HIV drug resistance prevalence or incidence: a mixed methods study.

Garcia, Cristian / Holbrook, Anne / Djiadeu, Pascal / Alvarez, Elizabeth / Matos Silva, Jéssyca / Mbuagbaw, Lawrence

BMJ open

2024 Volume 14, Issue 3, Page(s) e080014

Abstract: Background: Adequate surveillance of HIV drug resistance prevalence is challenged by heterogenous and inadequate data reporting. To address this issue, we recently published reporting guidance documentation for studies of HIV drug resistance prevalence ... ...

Abstract	Background: Adequate surveillance of HIV drug resistance prevalence is challenged by heterogenous and inadequate data reporting. To address this issue, we recently published reporting guidance documentation for studies of HIV drug resistance prevalence and incidence. Objectives: In this study, we describe the methods used to develop this reporting guidance. Design: We used a mixed-methods sequential explanatory design involving authors and users of studies of HIV drug resistance prevalence. In the quantitative phase, we conducted a cross-sectional electronic survey (n=51). Survey participants rated various reporting items on whether they are essential to report. Validity ratios were computed to determine the items to discuss in the qualitative phase. In the qualitative phase, two focus group discussions (n=9 in total) discussed this draft item checklist, providing a justification and examples for each item. We conducted a descriptive qualitative analysis of the group discussions to identify emergent themes regarding the qualities of an essential reporting item. Results: We identified 38 potential reporting items that better characterise the study participants, improve the interpretability of study results and clarify the methods used for HIV resistance testing. These items were synthesised to create the reporting item checklist. Qualitative insights formed the basis of the explanation, elaboration, and rationale components of the guidance document. Conclusions: We generated a list of reporting items for studies on the incidence or prevalence of HIV drug resistance along with an explanation of why researchers believe these items are important. Mixed methods allowed for the simultaneous generation and integration of the item list and qualitative insights. The integrated findings were then further developed to become the subsequently published reporting guidance.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Checklist ; Prevalence ; Research Design ; HIV Infections/drug therapy ; HIV Infections/epidemiology
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-080014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measures of retention in HIV care: A protocol for a mixed methods study.

Rehman, Nadia / Garcia, Michael Cristian / Jones, Aaron / Ma, Jinhui / Mertz, Dominik / Mbuagbaw, Lawrence

PloS one

2024 Volume 19, Issue 2, Page(s) e0294824

Abstract: Introduction: Retention in HIV care is necessary to achieve adherence to antiretroviral therapy, viral load suppression, and optimal health outcomes. There is no standard definition for retention in HIV care, which compromises consistent and reliable ... ...

Abstract	Introduction: Retention in HIV care is necessary to achieve adherence to antiretroviral therapy, viral load suppression, and optimal health outcomes. There is no standard definition for retention in HIV care, which compromises consistent and reliable reporting and comparison of retention across facilities, jurisdictions, and studies. Objective: The objective of this study is to explore how stakeholders involved in HIV care define retention in HIV care and their preferences on measuring retention. Methods: We will use an exploratory sequential mixed methods design involving HIV stakeholder groups such as people living with HIV, people involved in providing care for PLHIV, and people involved in decision-making about PLHIV. In the qualitative phase of the study, we will conduct 20-25 in-depth interviews to collect the perspectives of HIV stakeholders on using their preferred retention measures. The findings from the qualitative phase will inform the development of survey items for the quantitative phase. Survey participants (n = 385) will be invited to rate the importance of each approach to measuring retention on a seven-point Likert scale. We will merge the qualitative and quantitative findings phase findings to inform a consensus-building framework for a standard definition of retention in care. Ethical issues and dissemination: This study has received ethics approval from the Hamilton Integrated Research Ethics Board. The findings will be disseminated through peer-reviewed publications, conference presentations, and among stakeholder groups. Limitations: This study has limitations; we won't be able to arrive at a standard definition; a Delphi technique amongst the stakeholders will be utilized using the framework to reach a consensus globally accepted definition.
MeSH term(s)	Humans ; Research Design ; Surveys and Questionnaires ; Consensus ; HIV Infections/drug therapy ; Viral Load
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294824
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Article ; Online: Probing the Rotary Cycle of Amine-Substituted Molecular Motors.

van Venrooy, Alexis / Wyderka, Aaron M / García-López, Víctor / Alemany, Lawrence B / Martí, Angel A / Tour, James M

The Journal of organic chemistry

2023 Volume 88, Issue 2, Page(s) 762–770

Abstract: An understanding of the rotary cycle of molecular motors (MMs), a key component of an approach to opening cells using mechanical motion, is important in furthering the research. Nuclear magnetic resonance (NMR) spectroscopy was used ... ...

Abstract	An understanding of the rotary cycle of molecular motors (MMs), a key component of an approach to opening cells using mechanical motion, is important in furthering the research. Nuclear magnetic resonance (NMR) spectroscopy was used for
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.2c01457
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Article ; Online: Impact of medical technologies may be predicted using constructed graph bibliometrics.

Jiang, Lawrence / Raza, Ashir / El Ariss, Abdel-Badih / Chen, David / Danaher-Garcia, Nicole / Lee, Jarone / He, Shuhan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2419

Abstract: Scientific research is driven by allocation of funding to different research projects based in part on the predicted scientific impact of the work. Data-driven algorithms can inform decision-making of scarce funding resources by identifying likely high- ... ...

Abstract	Scientific research is driven by allocation of funding to different research projects based in part on the predicted scientific impact of the work. Data-driven algorithms can inform decision-making of scarce funding resources by identifying likely high-impact studies using bibliometrics. Compared to standardized citation-based metrics alone, we utilize a machine learning pipeline that analyzes high-dimensional relationships among a range of bibliometric features to improve the accuracy of predicting high-impact research. Random forest classification models were trained using 28 bibliometric features calculated from a dataset of 1,485,958 publications in medicine to retrospectively predict whether a publication would become high-impact. For each random forest model, the balanced accuracy score was above 0.95 and the area under the receiver operating characteristic curve was above 0.99. The high performance of high impact research prediction using our proposed models show that machine learning technologies are promising algorithms that can support funding decision-making for medical research.
MeSH term(s)	Retrospective Studies ; Bibliometrics ; Algorithms ; Machine Learning ; Medicine
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52233-x
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Article ; Online: Theileriosis in naturally infected roan antelope (

Clift, Sarah J / Martí-Garcia, Bernat / Lawrence, John A / Mitchell, Emily P / Fehrsen, Jeanni / Martínez, Jorge / Williams, June H / Steyl, Johan C A

Veterinary pathology

2022 Volume 59, Issue 6, Page(s) 1031–1046

Abstract: ... Cases ... ...

Abstract	Cases of
MeSH term(s)	Animals ; Antelopes ; Artiodactyla ; Cattle ; Cattle Diseases ; Retrospective Studies ; Theileria ; Theileriasis/parasitology
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858221120011
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Article ; Online: Endovascular Therapy for Femoropopliteal Disease: Drug-Eluting Stents Are Not the Default Therapy.

Garcia, Lawrence A

Circulation

2016 Volume 133, Issue 3, Page(s) 330–6; discussion 336

MeSH term(s)	Animals ; Drug-Eluting Stents ; Endovascular Procedures/instrumentation ; Endovascular Procedures/methods ; Femoral Artery/pathology ; Femoral Artery/surgery ; Humans ; Popliteal Artery/pathology ; Popliteal Artery/surgery ; Prosthesis Failure/adverse effects ; Randomized Controlled Trials as Topic/methods
Language	English
Publishing date	2016-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.115.018035
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Article ; Online: Associations Among PTSD, Cognitive Functioning, and Health-Promoting Behavior in Post-9/11 Veterans.

Lawrence, Karen A / Garcia-Willingham, Natasha E / Slade, Emily / DeBeer, Bryann B / Meyer, Eric C / Morissette, Sandra B

Military medicine

2023

Abstract: Introduction: PTSD is associated with negative health behaviors that increase chronic disease risk, yet health behaviors and their determinants are not well investigated in this context. One understudied mechanism of health behaviors is cognitive ... ...

Abstract	Introduction: PTSD is associated with negative health behaviors that increase chronic disease risk, yet health behaviors and their determinants are not well investigated in this context. One understudied mechanism of health behaviors is cognitive functioning. Deficits in cognitive functioning may undermine engagement in health-promoting behavior, thereby increasing the negative impact of PTSD. We tested three hypotheses: (1) Greater PTSD symptom severity is associated with less health-promoting behavior; (2) greater PTSD symptom severity is associated with poorer cognitive functioning across verbal memory, processing speed, attention, and executive functioning domains; and (3) verbal memory and executive functioning exhibit indirect effects on the relationship between PTSD and health-promoting behavior. Materials and methods: We examined associations between PTSD symptom severity (Clinician-Administered PTSD Scale for DSM-IV), cognitive functioning, and health-promoting behavior (Health-Promoting Lifestyle Profile II) in 124 post-9/11 veterans (average age = 37.82; 85.5% male; 63.7% White; 18.5% Black; 26.6% Hispanic). Cognitive domains examined included verbal memory (California Verbal Learning Test), processing speed (Digit Symbol Coding), attention and working memory (Digit Span), and executive functions (Trail Making Test and Stroop Interference). Results: Regression analyses indicated that greater PTSD symptom severity was associated with less health-promoting behavior (B = -.0101, SE = 0.0016, P < .0001; R2 = 0.3052). Path analyses revealed that verbal learning and memory partially accounted for this relationship (R2 = 0.037- 0.043; P < .05). Conclusions: Therapeutic targeting of these relationships may have implications for the prevention of long-term disease impact in veterans; longitudinal research is needed to elucidate the potential impact on chronic disease.
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad035
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Article ; Online: Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta-analysis.

Nham, Tina / Garcia, Michael Cristian / Tsang, Kai La Jennifer / Silva, Jessyca Matos / Schneider, Tyler / Deng, Jiawen / Lohit, Simran / Mbuagbaw, Lawrence / Holbrook, Anne

Journal of the American Geriatrics Society

2024

Abstract: Background: Cholinesterase inhibitors (ChEIs) are regularly used in Alzheimer's disease. Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million prescriptions in 2020; however, it ...

Abstract	Background: Cholinesterase inhibitors (ChEIs) are regularly used in Alzheimer's disease. Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million prescriptions in 2020; however, it is classified as a "known risk" QT interval-prolonging medication (QTPmed). Given this claim is derived from observational data including single case reports, we aimed to evaluate high-quality literature on the frequency and nature of proarrhythmic major adverse cardiac events (MACE) associated with donepezil. Methods: We searched Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Central from 1996 onwards for randomized controlled trials (RCTs) involving patients age ≥18 years comparing donepezil to placebo. The MACE composite included mortality, sudden cardiac death, non-fatal cardiac arrest, Torsades de pointes, ventricular tachyarrhythmia, seizure or syncope. Random-effects meta-analyses were performed with a treatment-arm continuity correction for single and double zero event studies. Results: Sixty RCTs (n = 12,463) were included. Twenty-five of 60 trials (n = 5886) investigated participants with Alzheimer's disease and 33 trials monitored electrocardiogram data. The mean follow-up duration was 31 weeks (SD = 36). Mortality was the most commonly reported MACE (252/331, 75.8% events), the remainder were syncope or seizures, with no arrhythmia events. There was no increased risk of MACE with exposure to donepezil compared to placebo (risk ratio [RR] 1.08, 95% CI 0.88-1.33, I Conclusions: This systematic review with meta-analysis found donepezil may not be arrhythmogenic. Donepezil was not associated with mortality, ventricular arrhythmias, seizure or syncope, although longer durations of therapy need more study. Further research to clarify actual clinical outcomes related to QTPmed is important to inform prescribing practices.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18909
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Article ; Online: Governance of health emergencies.

Stocking, Barbara / Gostin, Lawrence / Halton, Jane / Saavedra, Jorge / Garcia, Patricia / Baptiste Leite, Ricardo / Mahmood, Jemilah / Mpanju, Winnie / Gurria, Angel / Renganathan, Elil

Lancet (London, England)

2023 Volume 401, Issue 10393, Page(s) 2035

MeSH term(s)	Humans ; Emergencies ; Public Health
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)01065-6
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