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  1. Article: Carbapenem-Resistant but Cephalosporin-Susceptible

    Gajdács, Márió

    Antibiotics (Basel, Switzerland)

    2020  Volume 9, Issue 4

    Abstract: This paper briefly reports the occurrence and epidemiology of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) ...

    Abstract This paper briefly reports the occurrence and epidemiology of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S)
    Language English
    Publishing date 2020-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics9040153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Importance of Reporting Clinical and Epidemiological Data in Urology: Local Experiences and Insights from the International Literature.

    Gajdács, Márió

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 11

    Abstract: Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) ... ...

    Abstract Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) in the affected patients. Among these diseases, infections and malignancies in this anatomical region are some of the most important illnesses in human medicine; nevertheless, benign prostate hyperplasia (BPH), erectile dysfunction, hypospadias, urinary incontinence, and vesicoureteral reflux are also relevant disorders affecting millions. The publication of various microbiological and clinical studies in urology from different geographical regions has important ramifications from the standpoint of epidemiology: on one hand, reported data may influence the development of therapeutic guidelines for urinary tract infections (UTIs) (empiric antibiotic-therapy) and malignancies (including classical cytotoxic drug protocols and next-generation anticancer therapies) both locally and internationally; on the other hand, the relevant stakeholders and government representatives often base their decisions on published evidence. Therefore, novel studies in the field of urology are strongly encouraged to maintain and improve the high standard of patient care internationally and to ensure continuous information supply for international datasets on the causative agents of UTIs and cancer registries. The present Editorial aims to highlight some relevant studies published from the field of urology in
    MeSH term(s) Humans ; Male ; Prostatic Hyperplasia ; Quality of Life ; Urinary Incontinence ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology ; Urology
    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56110581
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  3. Article ; Online: Resistance trends and epidemiology of

    Gajdács, Márió

    Infectious diseases (London, England)

    2019  Volume 51, Issue 9, Page(s) 710–713

    MeSH term(s) Adolescent ; Adult ; Aeromonas/drug effects ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial ; Female ; Gram-Negative Bacterial Infections/epidemiology ; Humans ; Hungary/epidemiology ; Male ; Middle Aged ; Plesiomonas/drug effects ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2019-07-12
    Publishing country England
    Document type Letter
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2019.1640389
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Anaerobes and laboratory automation: Like oil and water?

    Gajdács, Márió

    Anaerobe

    2019  Volume 59, Page(s) 112–114

    Abstract: Diagnostic laboratories are urged to take advantage of novel technological advancements to provide standardized and high-throughput information for clinicians; however, total laboratory automation (TLA) has only recently been introduced in clinical ... ...

    Abstract Diagnostic laboratories are urged to take advantage of novel technological advancements to provide standardized and high-throughput information for clinicians; however, total laboratory automation (TLA) has only recently been introduced in clinical microbiology in the last 10-12 years. The introduction of total laboratory automation comes with certain advantages and drawbacks that need to be assessed before the introduction of such systems in the diagnostic workflow that includes the detection of anaerobic bacteria. For several reasons, there is yet to be a manufacturer to fully address the issue of anaerobes in the setting of laboratory automation; the aim of the present paper is to address some of the issues associated with anaerobes in lab automation.
    MeSH term(s) Automation, Laboratory/methods ; Bacteria, Anaerobic/classification ; Bacteria, Anaerobic/isolation & purification ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; Bacteriological Techniques/methods ; Clinical Laboratory Techniques/methods ; Humans
    Language English
    Publishing date 2019-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1237621-8
    ISSN 1095-8274 ; 1075-9964
    ISSN (online) 1095-8274
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2019.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4318: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The Concept of an Ideal Antibiotic: Implications for Drug Design.

    Gajdács, Márió

    Molecules (Basel, Switzerland)

    2019  Volume 24, Issue 5

    Abstract: The emergence and spread of antibiotic-resistant pathogens is a major public health issue, which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens-especially "ESKAPE" bacteria-can withstand lethal doses of antibiotics ...

    Abstract The emergence and spread of antibiotic-resistant pathogens is a major public health issue, which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens-especially "ESKAPE" bacteria-can withstand lethal doses of antibiotics with various chemical structures and mechanisms of action. Pharmaceutical companies are increasingly turning away from participating in the development of new antibiotics, due to the regulatory environment and the financial risks. There is an urgent need for innovation in antibiotic research, as classical discovery platforms (e.g., mining soil
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Biofilms/drug effects ; Biofilms/growth & development ; Drug Design ; Drug Discovery/trends ; Drug Resistance, Multiple, Bacterial ; Humans ; Streptomycetaceae/drug effects ; Streptomycetaceae/pathogenicity
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24050892
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: The Continuing Threat of Methicillin-Resistant

    Gajdács, Márió

    Antibiotics (Basel, Switzerland)

    2019  Volume 8, Issue 2

    Abstract: Staphylococcus aureus has been an exceptionally successful pathogen, which is still relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be a causative agent in a plethora of infections, owing to its abundance (in the ... ...

    Abstract Staphylococcus aureus has been an exceptionally successful pathogen, which is still relevant in modern age-medicine due to its adaptability and tenacity. This bacterium may be a causative agent in a plethora of infections, owing to its abundance (in the environment and in the normal flora) and the variety of virulence factors that it possesses. Methicillin-resistant S. aureus (MRSA) strains-first described in 1961-are characterized by an altered penicillin-binding protein (PBP2a/c) and resistance to all penicillins, cephalosporins, and carbapenems, which makes the β-lactam armamentarium clinically ineffective. The acquisition of additional resistance determinants further complicates their eradication; therefore, MRSA can be considered as the first representative of multidrug-resistant bacteria. Based on 230 references, the aim of this review is to recap the history, the emergence, and clinical features of various MRSA infections (hospital-, community-, and livestock-associated), and to summarize the current advances regarding MRSA screening, typing, and therapeutic options (including lipoglycopeptides, oxazolidinones, anti-MRSA cephalosporins, novel pleuromutilin-, tetracycline- and quinolone-derivatives, daptomycin, fusidic acid, in addition to drug candidates in the development phase), both for an audience of clinical microbiologists and infectious disease specialists.
    Language English
    Publishing date 2019-05-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics8020052
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  7. Article ; Online: The Importance of Reporting Clinical and Epidemiological Data in Urology

    Márió Gajdács

    Medicina, Vol 56, Iss 581, p

    Local Experiences and Insights from the International Literature

    2020  Volume 581

    Abstract: Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) ... ...

    Abstract Pathologies of the genito-urinary tract are responsible for a considerable disease burden worldwide, leading to significant losses of income, lost working days, increased expenditures for national healthcare systems, and decreased quality of life (QoL) in the affected patients. Among these diseases, infections and malignancies in this anatomical region are some of the most important illnesses in human medicine; nevertheless, benign prostate hyperplasia (BPH), erectile dysfunction, hypospadias, urinary incontinence, and vesicoureteral reflux are also relevant disorders affecting millions. The publication of various microbiological and clinical studies in urology from different geographical regions has important ramifications from the standpoint of epidemiology: on one hand, reported data may influence the development of therapeutic guidelines for urinary tract infections (UTIs) (empiric antibiotic-therapy) and malignancies (including classical cytotoxic drug protocols and next-generation anticancer therapies) both locally and internationally; on the other hand, the relevant stakeholders and government representatives often base their decisions on published evidence. Therefore, novel studies in the field of urology are strongly encouraged to maintain and improve the high standard of patient care internationally and to ensure continuous information supply for international datasets on the causative agents of UTIs and cancer registries. The present Editorial aims to highlight some relevant studies published from the field of urology in Medicina over the last several years.
    Keywords urology ; renal ; epidemiology ; urinary tract infections ; urological cancers ; malignancies ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Correlation between Stenotrophomonas maltophilia incidence and systemic antibiotic use: A 10-year retrospective, observational study in Hungary.

    Gajdács, Márió / Matuz, Mária / Ria, Benkő / Pető, Zoltán / Hajdú, Edit

    European journal of microbiology & immunology

    2024  

    Abstract: Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A ... ...

    Abstract Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A retrospective, observational study was carried out in a tertiary-care hospital in Hungary, between January 1st 2010 and December 31st 2019. Incidence-density for SM and SM resistant to trimethoprim-sulfamethoxazole (SXT) was standardized for 1000 patient-days, while systemic antibiotic use was expressed as defined daily doses (DDDs) per 100 patient-days. Mean incidence density for SM infections was 0.42/1000 patient-days; 11.08% were were resistant to SXT, the mean incidence density for SXT-resistant SM was 0.047/1000 patient-days. Consumption rate for colistin, glycopeptides and carbapenems increased by 258.82, 278.94 and 372.72% from 2010 to 2019, respectively. Strong and significant positive correlations were observed with the consumption of carbapenems (r: 0.8759; P < 0.001 and r: 0.8968; P < 0.001), SXT (r: 0.7552; P = 0.011 and r: 0.7004; P = 0.024), and glycopeptides (r: 0.7542; P = 0.012 and r: 0.8138; P < 0.001) with SM and SXT-resistant SM incidence-density/1000 patient-days, respectively. Implementation of institutional carbapenem-sparing strategies are critical in preserving these life-saving drugs, and may affect the microbial spectrum of infections in clinical settings.
    Language English
    Publishing date 2024-03-05
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2024.00022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Microbiological and Clinical Aspects of

    Urbán, Edit / Gajdács, Márió

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Obligate anaerobic bacteria are important members of the normal human microbiota, present in high numbers on mucosal surfaces (e [ ... ]. ...

    Abstract Obligate anaerobic bacteria are important members of the normal human microbiota, present in high numbers on mucosal surfaces (e [...].
    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10020151
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  10. Article: Anaerobes and laboratory automation: Like oil and water?

    Gajdács, Márió

    Anaerobe. 2019 Oct., v. 59

    2019  

    Abstract: Diagnostic laboratories are urged to take advantage of novel technological advancements to provide standardized and high-throughput information for clinicians; however, total laboratory automation (TLA) has only recently been introduced in clinical ... ...

    Abstract Diagnostic laboratories are urged to take advantage of novel technological advancements to provide standardized and high-throughput information for clinicians; however, total laboratory automation (TLA) has only recently been introduced in clinical microbiology in the last 10–12 years. The introduction of total laboratory automation comes with certain advantages and drawbacks that need to be assessed before the introduction of such systems in the diagnostic workflow that includes the detection of anaerobic bacteria. For several reasons, there is yet to be a manufacturer to fully address the issue of anaerobes in the setting of laboratory automation; the aim of the present paper is to address some of the issues associated with anaerobes in lab automation.
    Keywords anaerobes ; automation ; bacteria ; oils
    Language English
    Dates of publication 2019-10
    Size p. 112-114.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1237621-8
    ISSN 1075-9964
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2019.06.009
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4318: Show issues Location:
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