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Article ; Online: Response to the letter "Red blood cell distribution width as a biomarker: the importance of age-dependent changes and other variables".

Jiang, Ziying / Wang, Yongxiang / Du, Yifeng / Qiu, Chengxuan

Aging clinical and experimental research

2023 Volume 35, Issue 4, Page(s) 899–900

MeSH term(s)	Humans ; Erythrocyte Indices ; Biomarkers ; Erythrocytes
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-20
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-022-02339-x
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Article: Associations of Vascular Risk Factors,

Gui, Wenjun / Qiu, Chengxuan / Shao, Qi / Li, Juan

Frontiers in psychiatry

2021 Volume 12, Page(s) 617773

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.617773
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Article ; Online: Change in cardiovascular health and rate of cognitive decline in older adults: a 15-year population-based study.

Speh, Andreja / Kramberger, Milica G / Winblad, Bengt / Bäckman, Lars / Qiu, Chengxuan / Laukka, Erika J

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 263

Abstract: Background: Previous research on associations between cardiovascular health, measured at a single timepoint, and rate of age-related cognitive decline shows divergent findings dependent on the participants' age and the health metric studied. The aim of ... ...

Abstract	Background: Previous research on associations between cardiovascular health, measured at a single timepoint, and rate of age-related cognitive decline shows divergent findings dependent on the participants' age and the health metric studied. The aim of this study was to add to the knowledge in this field by investigating whether change in cardiovascular health, assessed with Life's Simple 7 (LS7) score, is associated with rate of cognitive change in young-old and old-old adults. Methods: The study included 1022 participants aged ≥ 60 years from the Swedish National Study on Aging and Care-Kungsholmen (SNAC-K), who underwent repeated neuropsychological testing (episodic memory, semantic memory, verbal fluency, and perceptual speed) across up to 15 years. LS7, composed of seven cardiovascular health metrics (smoking, diet, physical activity, body mass index, plasma glucose, total serum cholesterol, and blood pressure), was assessed at baseline and at the 6-year follow-up. Change in LS7 was calculated as the difference between baseline and 6 years (range - 5 to 8 points) and categorised into worse (-5 to -2 points), stable (-1 to 1 points), and improved (2 to 8 points). Change in cognitive performance as a function of LS7 change categories was estimated using linear mixed-effects models. Results: Participants were classified as stable (67.1%), improved (21.0%), or worse (11.8%) according to changes in LS7 score. Both the worse and improved categories were associated with faster cognitive decline. Age-stratified analyses revealed that worsening of LS7 was clearly associated with faster cognitive decline in the old-old (≥ 78 years), whereas improvement tended be associated with faster cognitive decline in the young-old (< 78 years) group. Conclusions: Change in cardiovascular health in old age may lead to accelerated cognitive decline, particularly in late senescence. These results suggest that it is important to monitor and maintain cardiovascular health status in very old adults.
MeSH term(s)	Humans ; Aged ; Cholesterol ; Smoking ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Diet ; Blood Pressure ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Risk Factors
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04856-y
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Article ; Online: Association of Metabolic Syndrome with Macular Thickness and Volume in Older Adults: A Population-Based Optical Coherence Tomography Study.

Zhang, Cong / Zhang, Qinghua / Wang, Yongxiang / Liu, Rui / Dong, Yi / Shi, Zhuoyu / Sun, Ying / Ge, Zhengwei / Liang, Yajun / Zhang, Jiayi / Du, Yifeng / Qiu, Chengxuan

Metabolic syndrome and related disorders

2024 Volume 22, Issue 2, Page(s) 141–150

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Male ; Humans ; Female ; Aged ; Middle Aged ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Tomography, Optical Coherence ; Cross-Sectional Studies ; Obesity/complications ; Prevalence ; Diabetes Mellitus ; Risk Factors
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2151220-6
ISSN	1557-8518 ; 1540-4196
ISSN (online)	1557-8518
ISSN	1540-4196
DOI	10.1089/met.2023.0098
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Article ; Online: Comparing glycemic traits in defining diabetes among rural Chinese older adults.

Wang, Pin / Li, Yuanjing / Wang, Mingqi / Song, Lin / Dong, Yi / Han, Xiaolei / Tuomilehto, Jaakko / Wang, Yongxiang / Du, Yifeng / Qiu, Chengxuan

PloS one

2024 Volume 19, Issue 1, Page(s) e0296694

Abstract: Background: We sought to identify the optimal cut-off of glycated hemoglobin (HbA1c) for defining diabetes and to assess the agreements of fasting plasma glucose (FPG), fasting serum glucose (FSG), and HbA1c in defining diabetes among rural older adults ...

Abstract	Background: We sought to identify the optimal cut-off of glycated hemoglobin (HbA1c) for defining diabetes and to assess the agreements of fasting plasma glucose (FPG), fasting serum glucose (FSG), and HbA1c in defining diabetes among rural older adults in China. Methods: This population-based cross-sectional study included 3547 participants (age ≥61 years, 57.8% women) from the Multidomain Interventions to Delay Dementia and Disability in Rural China from 2018-2019; of these, 3122 had no previously diagnosed diabetes. We identified the optimal cut-off of HbA1c against FPG ≥7.0 mmol/L for defining diabetes by using receiver operating characteristic curve and Youden index. The agreements of FPG, FSG, and HbA1c in defining diabetes were assessed using kappa statistics. Results: Among participants without previously diagnosed diabetes (n = 3122), the optimal HbA1c cut-off for defining diabetes was 6.5% (48 mmol/mol), with the sensitivity of 88.9%, specificity of 93.7%, and Youden index of 0.825. The correlation coefficients were 0.845 between FPG and FSG, 0.574 between FPG and HbA1c, and 0.529 between FSG and HbA1c in the total sample (n = 3547). The kappa statistic for defining diabetes was 0.962 between FSG and FPG, and 0.812 between HbA1c and FPG. Conclusions: The optimal cut-off of HbA1c for diagnosing diabetes against FPG >7.0 mmol/L is ≥6.5% in Chinese rural-dwelling older adults. The agreement in defining diabetes using FPG, FSG, and HbA1c is nearly perfect. These results have relevant implications for diabetes research and clinical practice among older adults in China. Clinical trial registration: The protocol of MIND-China was registered in the Chinese Clinical Trial Registry (ChiCTR, www.chictr.org.cn; registration no.: ChiCTR1800017758).
MeSH term(s)	Humans ; Female ; Aged ; Middle Aged ; Male ; Glycated Hemoglobin ; Blood Glucose ; Cross-Sectional Studies ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Fasting ; China/epidemiology
Chemical Substances	Glycated Hemoglobin ; Blood Glucose
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296694
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Article ; Online: Cardiovascular health and rate of cognitive decline in preclinical dementia: A 12-year population-based study.

Speh, Andreja / Payton, Nicola Maria / Kramberger, Milica G / Grande, Giulia / Qiu, Chengxuan / Winblad, Bengt / Fratiglioni, Laura / Bäckman, Lars / Laukka, Erika J

Neuropsychology

2024 Volume 38, Issue 3, Page(s) 211–222

Abstract: Objective: We investigated whether vascular risk factors (VRFs), assessed with Life's Simple 7 (LS7), are associated with the rate of cognitive decline in the years preceding a dementia diagnosis.: Method: This study included 1,449 stroke-free ... ...

Abstract	Objective: We investigated whether vascular risk factors (VRFs), assessed with Life's Simple 7 (LS7), are associated with the rate of cognitive decline in the years preceding a dementia diagnosis. Method: This study included 1,449 stroke-free participants aged ≥60 years from the Swedish National Study on Aging and Care in Kungsholmen, who underwent repeated neuropsychological testing (episodic memory, semantic memory, verbal fluency, perceptual speed) across 12 years. The LS7 score, assessed at baseline, included smoking, diet, physical activity, body mass index, plasma glucose, total cholesterol, and blood pressure. Preclinical dementia was defined as being dementia-free at baseline and diagnosed with dementia during follow-up. Level and change in cognitive performance as a function of LS7 category (poor vs. intermediate to optimal) and future dementia status were estimated using linear mixed-effect models. Results: Participants who later developed dementia had, on average, a poorer LS7 score compared to those who remained dementia-free. For individuals aged 60-72 years, poor diet was associated with accelerated decline in perceptual speed (β = -0.05, 95% CI [-0.08, -0.02]), and a poor glucose score was associated with faster rates of verbal fluency (β = -0.019, 95% CI [-0.09, -0.01]) and global cognitive (β = -0.028, 95% CI [-0.06, 0.00]) decline in the preclinical dementia group. Conclusions: VRFs exacerbate rate of cognitive decline in the years preceding a dementia diagnosis. This effect was most pronounced in young-old age and primarily driven by diet and glucose. The effect of VRFs may be especially detrimental for cognitive decline trajectories of individuals with impending dementia. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Cognitive Dysfunction/epidemiology ; Memory ; Risk Factors ; Dementia/diagnosis ; Dementia/epidemiology ; Glucose
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000925
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Article ; Online: Associations of Orthostatic Hypotension and Frailty With Dementia and Mortality in Older Adults: A Population-Based Cohort Study.

Xia, Xin / Jönsson, Linus / Tazzeo, Clare / Qiu, Chengxuan / Rizzuto, Debora / Laukka, Erika J / Grande, Giulia / Fratiglioni, Laura / Vetrano, Davide Liborio

The journals of gerontology. Series A, Biological sciences and medical sciences

2024 Volume 79, Issue 4

Abstract: Background: This study aimed to assess the associations of orthostatic hypotension (OH), in the presence or absence of frailty, with dementia and mortality in older adults.: Methods: We conducted a 15-year population-based cohort study including 2 ... ...

Abstract	Background: This study aimed to assess the associations of orthostatic hypotension (OH), in the presence or absence of frailty, with dementia and mortality in older adults. Methods: We conducted a 15-year population-based cohort study including 2 703 baseline dementia-free individuals from the Swedish National Study on Aging and Care in Kungsholmen. At baseline, OH was defined as a decline in systolic/diastolic blood pressure ≥20/10 mm Hg 1 minute after standing up from a supine position. Frailty status was defined following Fried's frailty phenotype. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders-fourth edition criteria. Multistate flexible parametric survival models were used to estimate associations of OH and frailty with dementia and mortality. Results: Robust people with OH (adjusted hazard ratio [HR] = 2.28; 95% confidence interval [CI] = 1.47-3.54) and frail people without OH (HR = 1.98; 95% CI = 1.40-2.82) or with OH (HR = 2.73; 95% CI = 1.82-4.10) had a higher dementia risk than OH-free and robust people. Moreover, frail people, independently of the presence of OH, had higher mortality rate than OH-free and robust people. In individuals who developed dementia during the follow-up period, neither OH nor frailty was significantly associated with mortality. Conclusions: Older adults with OH, whether robust or frail, may have a higher dementia risk than those without OH. Older adults with OH, when having frailty, may have a higher mortality rate than those without OH. The concurrent assessments of OH and frailty may provide prognostic values in terms of dementia and mortality risk in older adults.
MeSH term(s)	Humans ; Aged ; Frailty/complications ; Hypotension, Orthostatic/complications ; Hypotension, Orthostatic/epidemiology ; Cohort Studies ; Frail Elderly ; Dementia/epidemiology
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glae010
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Article ; Online: Association of white matter hyperintensity accumulation with domain-specific cognitive decline: a population-based cohort study.

Li, Yuanjing / Kalpouzos, Grégoria / Bäckman, Lars / Qiu, Chengxuan / Laukka, Erika J

Neurobiology of aging

2023 Volume 132, Page(s) 100–108

Abstract: We investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and ... ...

Abstract	We investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2004 to 2016-2019). We found that greater baseline loads of global and regional WMHs were associated with faster decline in letter fluency, perceptual speed, and global cognition. Furthermore, faster accumulation of global, deep, and periventricular WMHs was related to accelerated cognitive decline, primarily in perceptual speed. These data show that WMHs are associated with decline in perceptual speed rather than episodic or semantic memory and that cognitive change is more vulnerable to WMH accumulations in deep and periventricular regions.
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; Cohort Studies ; Magnetic Resonance Imaging ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/psychology ; Cognition
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.08.011
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Erratum: Associations of Microvascular Dysfunction with Mild Cognitive Impairment and Cognitive Function Among Rural-Dwelling Older Adults in China.

Jiang, Chunyan / Wang, Yongxiang / Dong, Yi / Song, Lin / Wang, Shanshan / Xu, Zhe / Ren, Yifei / Han, Xiaodong / Zhao, Mingqing / Wang, Jiafeng / Cong, Lin / Hou, Tingting / Zhang, Qinghua / Du, Yifeng / Qiu, Chengxuan

Journal of Alzheimer's disease : JAD

2023 Volume 94, Issue 2, Page(s) 857

Language	English
Publishing date	2023-07-09
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-239004
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Article: Prevention of cognitive decline in old age-varying effects of interventions in different populations.

Qiu, Chengxuan / Johansson, Gunilla / Zhu, Feiqi / Kivipelto, Miia / Winblad, Bengt

Annals of translational medicine

2019 Volume 7, Issue Suppl 3, Page(s) S142

Language	English
Publishing date	2019-09-25
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2019.06.19
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