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Article ; Online: A balancing act between IFITM3 and IRF3.

McMichael, Temet M / Chemudupati, Mahesh / Yount, Jacob S

2017 Volume 15, Issue 10, Page(s) 873–874

MeSH term(s)	Autophagosomes ; Interferon Type I
Chemical Substances	Interferon Type I
Language	English
Publishing date	2017-04-24
Publishing country	China
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/cmi.2017.18
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Article ; Online: Shigellosis outbreak among persons experiencing homelessness-San Diego County, California, October-December 2021.

Ohlsen, Elizabeth C / Angel, Kristen / Maroufi, Azarnoush / Kao, Annie / Victorio, Maria J / Cua, Lynnie S / Kimura, Akiko / Vanden Esschert, Kayla / Logan, Naeemah / McMichael, Temet M / Beatty, Mark E / Shah, Seema

Epidemiology and infection

2023 Volume 152, Page(s) e61

Abstract: During October 2021, the County of San Diego Health and Human Services Agency identified five cases of shigellosis among persons experiencing homelessness (PEH). We conducted an outbreak investigation and developed interventions to respond to shigellosis ...

Abstract	During October 2021, the County of San Diego Health and Human Services Agency identified five cases of shigellosis among persons experiencing homelessness (PEH). We conducted an outbreak investigation and developed interventions to respond to shigellosis outbreaks among PEH. Confirmed cases occurred among PEH with stool-cultured
MeSH term(s)	Humans ; Dysentery, Bacillary/epidemiology ; Pandemics ; Disease Outbreaks/prevention & control ; Ill-Housed Persons ; California
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268823001681
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Article ; Online: Use of standard, contact, and droplet precautions with eye protection for the prevention of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) transmission among home healthcare personnel in hospice and home healthcare settings-King and Snohomish counties, Washington, February-October 2020.

McMichael, Temet M / Duca, Lindsey M / Lewis, James / Riedo, Francis X / Wilde, Nancy / McDonald, Molly / Spitters, Christopher / Wechkin, Hope A

Infection control and hospital epidemiology

2022 Volume 44, Issue 3, Page(s) 510–513

Abstract: Among EvergreenHealth Home Care Service professionals, no coronavirus disease 2019 (COVID-19) cases were reported when they were instructed to use standard, contact, and droplet precautions with eye protection while providing home health care to patients ...

Abstract	Among EvergreenHealth Home Care Service professionals, no coronavirus disease 2019 (COVID-19) cases were reported when they were instructed to use standard, contact, and droplet precautions with eye protection while providing home health care to patients diagnosed with laboratory-confirmed severe acute respiratory coronavirus virus 2 (SARS-CoV-2). These precautions might provide some level of protection against coronavirus disease 2019 (COVID-19) among home healthcare personnel.
MeSH term(s)	Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; Hospices ; Washington ; Virus Diseases ; Home Care Services ; Delivery of Health Care ; Health Personnel
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2021.499
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Article ; Online: Shelter Characteristics, Infection Prevention Practices, and Universal Testing for SARS-CoV-2 at Homeless Shelters in 7 US Urban Areas.

Self, Julie L / Montgomery, Martha P / Toews, Karrie-Ann / Samuels, Elizabeth A / Imbert, Elizabeth / McMichael, Temet M / Marx, Grace E / Lohff, Cortland / Andrews, Tom / Ghinai, Isaac / Mosites, Emily

American journal of public health

2021 Volume 111, Issue 5, Page(s) 854–859

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	COVID-19/epidemiology ; COVID-19 Testing/statistics & numerical data ; Health Personnel/statistics & numerical data ; Homeless Persons/statistics & numerical data ; Humans ; Prevalence ; United States ; Urban Population
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2021.306198
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Article ; Online: Occupational exposures and mitigation strategies among homeless shelter workers at risk of COVID-19.

Rao, Carol Y / Robinson, Tashina / Huster, Karin / Laws, Rebecca L / Keating, Ryan / Tobolowsky, Farrell A / McMichael, Temet M / Gonzales, Elysia / Mosites, Emily

PloS one

2021 Volume 16, Issue 11, Page(s) e0253108

Abstract: Objective: To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19.: Methods: Between June 9-August 10, 2020, we conducted a self-administered survey among ... ...

Abstract	Objective: To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19. Methods: Between June 9-August 10, 2020, we conducted a self-administered survey among homeless shelter workers in Washington, Massachusetts, Utah, Maryland, and Georgia. We calculated frequencies for work environment, personal protective equipment use, and SARS-CoV-2 testing history. We used generalized linear models to produce unadjusted prevalence ratios (PR) to assess risk factors for SARS-CoV-2 infection. Results: Of the 106 respondents, 43.4% reported frequent close contact with clients; 75% were worried about work-related SARS-CoV-2 infections; 15% reported testing positive. Close contact with clients was associated with testing positive for SARS-CoV-2 (PR 3.97, 95%CI 1.06, 14.93). Conclusions: Homeless shelter workers may be at risk of being exposed to individuals with COVID-19 during the course of their work. Frequent close contact with clients was associated with SARS-CoV-2 infection. Protecting these critical essential workers by implementing mitigation measures and prioritizing for COVID-19 vaccination is imperative during the pandemic.
MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; COVID-19 Vaccines/therapeutic use ; Cell Movement/physiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Occupational Exposure/adverse effects ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Young Adult
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0253108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

Matthew Sermersheim / Adam D. Kenney / Pei-Hui Lin / Temet M. McMichael / Chuanxi Cai / Kristyn Gumpper / T. M. Ayodele Adesanya / Haichang Li / Xinyu Zhou / Ki-Ho Park / Jacob S. Yount / Jianjie Ma

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 12

Abstract: TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction. ...

Abstract	TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Keywords	Science ; Q
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occupational exposures and mitigation strategies among homeless shelter workers at risk of COVID-19

Carol Y. Rao / Tashina Robinson / Karin Huster / Rebecca L. Laws / Ryan Keating / Farrell A. Tobolowsky / Temet M. McMichael / Elysia Gonzales / Emily Mosites

PLoS ONE, Vol 16, Iss

2021 Volume 11

Abstract: Objective To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19. Methods Between June 9-August 10, 2020, we conducted a self-administered survey among homeless ... ...

Abstract	Objective To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19. Methods Between June 9-August 10, 2020, we conducted a self-administered survey among homeless shelter workers in Washington, Massachusetts, Utah, Maryland, and Georgia. We calculated frequencies for work environment, personal protective equipment use, and SARS-CoV-2 testing history. We used generalized linear models to produce unadjusted prevalence ratios (PR) to assess risk factors for SARS-CoV-2 infection. Results Of the 106 respondents, 43.4% reported frequent close contact with clients; 75% were worried about work-related SARS-CoV-2 infections; 15% reported testing positive. Close contact with clients was associated with testing positive for SARS-CoV-2 (PR 3.97, 95%CI 1.06, 14.93). Conclusions Homeless shelter workers may be at risk of being exposed to individuals with COVID-19 during the course of their work. Frequent close contact with clients was associated with SARS-CoV-2 infection. Protecting these critical essential workers by implementing mitigation measures and prioritizing for COVID-19 vaccination is imperative during the pandemic.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occupational exposures and mitigation strategies among homeless shelter workers at risk of COVID-19.

Carol Y Rao / Tashina Robinson / Karin Huster / Rebecca L Laws / Ryan Keating / Farrell A Tobolowsky / Temet M McMichael / Elysia Gonzales / Emily Mosites

PLoS ONE, Vol 16, Iss 11, p e

2021 Volume 0253108

Abstract	Objective To describe the work environment and COVID-19 mitigation measures for homeless shelter workers and assess occupational risk factors for COVID-19. Methods Between June 9-August 10, 2020, we conducted a self-administered survey among homeless shelter workers in Washington, Massachusetts, Utah, Maryland, and Georgia. We calculated frequencies for work environment, personal protective equipment use, and SARS-CoV-2 testing history. We used generalized linear models to produce unadjusted prevalence ratios (PR) to assess risk factors for SARS-CoV-2 infection. Results Of the 106 respondents, 43.4% reported frequent close contact with clients; 75% were worried about work-related SARS-CoV-2 infections; 15% reported testing positive. Close contact with clients was associated with testing positive for SARS-CoV-2 (PR 3.97, 95%CI 1.06, 14.93). Conclusions Homeless shelter workers may be at risk of being exposed to individuals with COVID-19 during the course of their work. Frequent close contact with clients was associated with SARS-CoV-2 infection. Protecting these critical essential workers by implementing mitigation measures and prioritizing for COVID-19 vaccination is imperative during the pandemic.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins.

Zani, Ashley / Zhang, Lizhi / McMichael, Temet M / Kenney, Adam D / Chemudupati, Mahesh / Kwiek, Jesse J / Liu, Shan-Lu / Yount, Jacob S

The Journal of biological chemistry

2019 Volume 294, Issue 52, Page(s) 19844–19851

Abstract: Type I interferon (IFN) induced by virus infections during pregnancy can cause placental damage, but the mechanisms and identities of IFN-stimulated genes that are involved in this damage remain under investigation. The IFN-induced transmembrane proteins ...

Abstract	Type I interferon (IFN) induced by virus infections during pregnancy can cause placental damage, but the mechanisms and identities of IFN-stimulated genes that are involved in this damage remain under investigation. The IFN-induced transmembrane proteins (IFITMs) inhibit virus infections by preventing virus membrane fusion with cells and by inhibiting fusion of infected cells (syncytialization). Fusion of placental trophoblasts via expression of endogenous retroviral fusogens known as syncytins forms the syncytiotrophoblast, a multinucleated cell structure essential for fetal development. We found here that IFN blocks fusion of BeWo human placental trophoblasts. Stably expressed IFITM1, -2, and -3 also blocked fusion of these trophoblasts while making them more resistant to virus infections. Conversely, stable IFITM knockdowns in BeWo trophoblasts increased their spontaneous fusion and allowed fusion in the presence of IFN while also making the cells more susceptible to virus infection. We additionally found that exogenous expression of IFITMs in HEK293T cells blocked fusion with cells expressing syncytin-1 or syncytin-2, confirming the ability of IFITMs to block individual syncytin-mediated fusion. Overall, our data indicate that IFITMs inhibit trophoblast fusion and suggest that there may be a critical balance between these antifusogenic effects and the beneficial antiviral effects of IFITMs in virus infections during pregnancy.
MeSH term(s)	Antigens, Differentiation/chemistry ; Antigens, Differentiation/genetics ; Antigens, Differentiation/metabolism ; Antiviral Agents/pharmacology ; Cell Fusion ; Female ; Gene Products, env/metabolism ; HEK293 Cells ; Humans ; Interferon Type I/pharmacology ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Placenta/cytology ; Pregnancy ; Pregnancy Proteins/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Trophoblasts/cytology ; Trophoblasts/metabolism ; Virus Internalization/drug effects ; Zika Virus/physiology
Chemical Substances	Antigens, Differentiation ; Antiviral Agents ; ERVFRD-1 protein, human ; Gene Products, env ; IFITM2 protein, human ; IFITM3 protein, human ; Interferon Type I ; Membrane Proteins ; Pregnancy Proteins ; RNA, Small Interfering ; RNA-Binding Proteins ; leu-13 antigen ; syncytin
Language	English
Publishing date	2019-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.AC119.010611
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Article ; Online: E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.

Nicholas M Chesarino / Temet M McMichael / Jacob S Yount

PLoS Pathogens, Vol 11, Iss 8, p e

2015 Volume 1005095

Abstract: Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase responsible for this ...

Abstract	Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections. We previously showed that IFITM3 degradation is increased by its ubiquitination, though the ubiquitin ligase responsible for this modification remained elusive. Here, we demonstrate that the E3 ubiquitin ligase NEDD4 ubiquitinates IFITM3 in cells and in vitro. This IFITM3 ubiquitination is dependent upon the presence of a PPxY motif within IFITM3 and the WW domain-containing region of NEDD4. In NEDD4 knockout mouse embryonic fibroblasts, we observed defective IFITM3 ubiquitination and accumulation of high levels of basal IFITM3 as compared to wild type cells. Heightened IFITM3 levels significantly protected NEDD4 knockout cells from infection by influenza A and B viruses. Similarly, knockdown of NEDD4 in human lung cells resulted in an increase in steady state IFITM3 and a decrease in influenza virus infection, demonstrating a conservation of this NEDD4-dependent IFITM3 regulatory mechanism in mouse and human cells. Consistent with the known association of NEDD4 with lysosomes, we demonstrate for the first time that steady state turnover of IFITM3 occurs through the lysosomal degradation pathway. Overall, this work identifies the enzyme NEDD4 as a new therapeutic target for the prevention of influenza virus infections, and introduces a new paradigm for up-regulating cellular levels of IFITM3 independently of IFN or infection.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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