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  1. Article ; Online: What could re-infection tell us about R

    Feldman, Joshua / Mishra, Sharmistha

    Infectious Disease Modelling

    2019  Volume 4, Page(s) 257–264

    Abstract: ... the prevalence of repeat infection and the basic reproductive number (R ...

    Abstract Many infectious diseases can lead to re-infection. We examined the relationship between the prevalence of repeat infection and the basic reproductive number (R
    Language English
    Publishing date 2019-09-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 3015225-2
    ISSN 2468-0427 ; 2468-2152
    ISSN (online) 2468-0427
    ISSN 2468-2152
    DOI 10.1016/j.idm.2019.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TubAR: an R Package for Quantifying Tuber Shape and Skin Traits from Images

    Miller, Michael D. / Schmitz Carley, Cari A. / Figueroa, Rachel A. / Feldman, Max J. / Haagenson, Darrin / Shannon, Laura M.

    Am. J. Potato Res.. 2023 Feb., v. 100, no. 1 p.52-62

    2023  

    Abstract: ... between evaluators and breeding programs. Here we present TubAR (Tuber Analysis in R), an image analysis ...

    Abstract Potato market value is heavily affected by tuber quality traits such as shape, color, and skinning. Despite this, potato breeders often rely on subjective scales that fail to precisely define phenotypes. Individual human evaluators and the environments in which ratings are taken can bias visual quality ratings. Collecting quality trait data using machine vision allows for precise measurements that will remain reliable between evaluators and breeding programs. Here we present TubAR (Tuber Analysis in R), an image analysis program designed to collect data for multiple tuber quality traits at low cost to breeders. To assess the efficacy of TubAR in comparison to visual scales, red-skinned potatoes were evaluated using both methods. Broad sense heritability was consistently higher for skinning, roundness, and length to width ratio using TubAR. TubAR collects essential data on fresh market potato breeding populations while maintaining efficiency by measuring multiple traits through one phenotyping protocol.
    Keywords color ; computer vision ; fresh market ; heritability ; humans ; image analysis ; market value ; phenotype ; potatoes
    Language English
    Dates of publication 2023-02
    Size p. 52-62.
    Publishing place Springer US
    Document type Article ; Online
    ISSN 1099-209X
    DOI 10.1007/s12230-022-09894-z
    Database NAL-Catalogue (AGRICOLA)

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  3. Book ; Online: Stronger Privacy Amplification by Shuffling for R\'enyi and Approximate Differential Privacy

    Feldman, Vitaly / McMillan, Audra / Talwar, Kunal

    2022  

    Abstract: ... both theoretically and numerically. Our first contribution is the first asymptotically optimal analysis of the R ...

    Abstract The shuffle model of differential privacy has gained significant interest as an intermediate trust model between the standard local and central models [EFMRTT19; CSUZZ19]. A key result in this model is that randomly shuffling locally randomized data amplifies differential privacy guarantees. Such amplification implies substantially stronger privacy guarantees for systems in which data is contributed anonymously [BEMMRLRKTS17]. In this work, we improve the state of the art privacy amplification by shuffling results both theoretically and numerically. Our first contribution is the first asymptotically optimal analysis of the R\'enyi differential privacy parameters for the shuffled outputs of LDP randomizers. Our second contribution is a new analysis of privacy amplification by shuffling. This analysis improves on the techniques of [FMT20] and leads to tighter numerical bounds in all parameter settings.

    Comment: Errata added. 14 pages, 4 figures
    Keywords Computer Science - Cryptography and Security ; Computer Science - Data Structures and Algorithms ; Computer Science - Machine Learning ; Statistics - Machine Learning
    Subject code 303 ; 005
    Publishing date 2022-08-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online ; E-Book: Practical ways to improve patient adherence

    Lewis, Daniel J. / Feldman, Steven R.

    (Series in dermatological treatment)

    2024  

    Author's details Daniel J. Lewis, Steven R. Feldman
    Series title Series in dermatological treatment
    Keywords Medication Adherence ; Quality Improvement ; Patients / psychology ; Skin Diseases / drug therapy ; Patient compliance
    Subject code 610.19
    Language English
    Size 1 Online-Ressource (x, 130 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030058734
    ISBN 978-1-0009-1655-3 ; 978-1-003-36762-8 ; 9781032435022 ; 9781032435015 ; 1-0009-1655-3 ; 1-003-36762-3 ; 103243502X ; 1032435011
    DOI 10.1201/9781003367628
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Post-treatment (not interim) positron emission tomography-computed tomography scan status is highly predictive of outcome in mantle cell lymphoma patients treated with R-HyperCVAD.

    Mato, Anthony R / Svoboda, Jakub / Feldman, Tatyana / Zielonka, Tania / Agress, Harry / Panush, David / Miller, Mitchell / Toth, Patrick / Lizotte, Paul M / Nasta, Sunita / Goldberg, Stuart / Chong, Emeline / Schuster, Steven / Pecora, Andrew L / Goy, Andre

    Cancer

    2012  Volume 118, Issue 14, Page(s) 3565–3570

    Abstract: ... imaging in a uniform MCL patient cohort undergoing dose-intensive chemotherapy (R-HyCVAD) in the frontline ...

    Abstract Background: Although convincing data exist regarding the prognostic utility of positron emission tomographic (PET)-computed tomographic (CT) imaging in Hodgkin lymphoma and diffuse large B-cell lymphoma, its prognostic utility both during treatment and immediately after treatment have not been systematically evaluated in a large mantle cell lymphoma (MCL) patient cohort to support its use in clinical practice.
    Methods: The authors conducted a retrospective cohort study to examine the prognostic utility of PET-CT imaging in a uniform MCL patient cohort undergoing dose-intensive chemotherapy (R-HyCVAD) in the frontline setting. The primary study endpoints were progression-free survival (PFS) and overall survival (OS). PET-CT images were centrally reviewed for the purposes of this study using standardized response criteria.
    Results: Fifty-three patients with advanced stage MCL with PET-CT data were identified. With median follow-up of 32 months, 3-year PFS and OS estimates were 76% (95% confidence interval [CI], 64%-84%) and 84% (95% CI, 72%-90%), respectively. Interim PET-CT status was not associated with PFS (hazard ratio [HR], 0.9; 95% CI, 0.3-2.7; P = .8) or OS (HR, 0.6; 95% CI, 0.1-2.9; P = .5). Post-treatment PET-CT status was statistically significantly associated with PFS (HR, 5.2; 95% CI, 2.0-13.6; P = .001) and trended toward significant for OS (HR, 2.8; 95% CI, 0.8-9.6; P = .07).
    Conclusions: These data do not support the prognostic utility of PET-CT in pretreatment and interim treatment settings. A positive PET-CT after the completion of therapy identifies a patient subset with an inferior PFS and a trend toward inferior OS.
    MeSH term(s) Adult ; Aged ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Dexamethasone/therapeutic use ; Disease-Free Survival ; Doxorubicin/therapeutic use ; Female ; Humans ; Lymphoma, Mantle-Cell/diagnosis ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/mortality ; Male ; Middle Aged ; Multimodal Imaging ; Positron-Emission Tomography ; Rituximab ; Tomography, X-Ray Computed ; Treatment Outcome ; Vincristine/therapeutic use
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Dexamethasone (7S5I7G3JQL) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2012-07-15
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Multicenter Study
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.26731
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.146: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: R&D spillovers and recipient firm size

    Acs, Zoltan J / Audretsch, David B / Feldman, Maryann P

    Innovation and entrepreneurship , p. 413-417

    2009  , Page(s) 413–417

    Author's details Zoltan J. Acs, David B. Audretsch, and Maryann P. Feldman
    Keywords Innovation ; Industrieforschung ; Betriebsgröße ; USA
    Language English
    Publisher Elgar
    Publishing place Cheltenham [u.a.]
    Document type Article
    Database ECONomics Information System

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  7. Article ; Online: Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells.

    Feldman, Douglas Edmund / Chen, Chialin / Punj, Vasu / Tsukamoto, Hidekazu / Machida, Keigo

    Proceedings of the National Academy of Sciences of the United States of America

    2011  Volume 109, Issue 3, Page(s) 829–834

    Abstract: ... derived peptide hormone leptin (OB-R) is a characteristic feature of TISCs and of a broad array ...

    Abstract Misregulation of a pluripotency-associated transcription factor network in adult tissues is associated with the expansion of rare, highly malignant tumor-initiating stem cells (TISCs) through poorly understood mechanisms. We demonstrate that robust and selective expression of the receptor for the adipocyte-derived peptide hormone leptin (OB-R) is a characteristic feature of TISCs and of a broad array of embryonic and induced pluripotent stem cells and is mediated directly by the core pluripotency-associated transcription factors OCT4 and SOX2. TISCs exhibit sensitized responses to leptin, including the phosphorylation and activation of the pluripotency-associated oncogene STAT3 and induction of Oct4 and Sox2, thereby establishing a self-reinforcing signaling module. Exposure of cultured mouse embryonic stem cells to leptin sustains pluripotency in the absence of leukemia inhibitory factor. By implanting TISCs into leptin-deficient ob/ob mice or into comparably overweight Lepr(db/db) mice that produce leptin, we provide evidence of a central role for the leptin-TISC-signaling axis in promoting obesity-induced tumor growth. Differential responses to extrinsic, adipocyte-derived cues may promote the expansion of tumor cell subpopulations and contribute to oncogenesis.
    MeSH term(s) AC133 Antigen ; Animals ; Antigens, CD/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/pathology ; Glycoproteins/metabolism ; Humans ; Leptin/pharmacology ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Obesity/metabolism ; Obesity/pathology ; Octamer Transcription Factor-3/metabolism ; Peptides/metabolism ; Pluripotent Stem Cells/drug effects ; Pluripotent Stem Cells/metabolism ; Receptors, Leptin/metabolism ; SOXB1 Transcription Factors/metabolism
    Chemical Substances AC133 Antigen ; Antigens, CD ; Glycoproteins ; Leptin ; Octamer Transcription Factor-3 ; Peptides ; Receptors, Leptin ; SOXB1 Transcription Factors
    Language English
    Publishing date 2011-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1114438109
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: R&D spillovers and the geography of innovation and production

    Audretsch, David B / Feldman, Maryann P

    Innovation and entrepreneurship , p. 440-450

    2009  , Page(s) 440–450

    Author's details by David B. Audretsch and Maryann P. Feldman
    Keywords Innovationsdiffusion ; Produktionsstandort ; Agglomerationseffekt ; USA
    Language English
    Size graph. Darst.
    Publisher Elgar
    Publishing place Cheltenham [u.a.]
    Document type Article
    Database ECONomics Information System

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  9. Book: Rosacea

    Feldman, Steven R.

    (Dermatologic clinics ; volume 36, number 2 (April 2018))

    2018  

    Author's details editors Steven R. Feldman, Leah A. Cardwell, Sarah L. Taylor
    Series title Dermatologic clinics ; volume 36, number 2 (April 2018)
    Collection
    Language English
    Size xi Seiten, Seite 82-174, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019687496
    ISBN 978-0-323-58304-6 ; 0-323-58304-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 851 -36,2- verfügbar in Königswinter Königswinter

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  10. Article: Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells

    Feldman, Douglas Edmund / Chen, Chialin / Punj, Vasu / Tsukamoto, Hidekazu / Machida, Keigo

    Proceedings of the National Academy of Sciences of the United States of America. 2012 Jan. 17, v. 109, no. 3

    2012  

    Abstract: ... derived peptide hormone leptin (OB-R) is a characteristic feature of TISCs and of a broad array ...

    Abstract Misregulation of a pluripotency-associated transcription factor network in adult tissues is associated with the expansion of rare, highly malignant tumor-initiating stem cells (TISCs) through poorly understood mechanisms. We demonstrate that robust and selective expression of the receptor for the adipocyte-derived peptide hormone leptin (OB-R) is a characteristic feature of TISCs and of a broad array of embryonic and induced pluripotent stem cells and is mediated directly by the core pluripotency-associated transcription factors OCT4 and SOX2. TISCs exhibit sensitized responses to leptin, including the phosphorylation and activation of the pluripotency-associated oncogene STAT3 and induction of Oct4 and Sox2, thereby establishing a self-reinforcing signaling module. Exposure of cultured mouse embryonic stem cells to leptin sustains pluripotency in the absence of leukemia inhibitory factor. By implanting TISCs into leptin-deficient ob/ob mice or into comparably overweight Leprdb/db mice that produce leptin, we provide evidence of a central role for the leptin-TISC–signaling axis in promoting obesity-induced tumor growth. Differential responses to extrinsic, adipocyte-derived cues may promote the expansion of tumor cell subpopulations and contribute to oncogenesis.
    Keywords adults ; carcinogenesis ; embryonic stem cells ; leptin ; leukemia ; mice ; obesity ; oncogenes ; phosphorylation ; transcription factors
    Language English
    Dates of publication 2012-0117
    Size p. 829-834.
    Publishing place National Academy of Sciences
    Document type Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 63/44: Show issues
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