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Article: Regional distribution of

Li, Xiang / Li, Zewen / He, Yan / Li, Pan / Zhou, Hongwei / Zeng, Nianyi

2020 Volume 8, Page(s) e9591

Abstract: The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention. ...

Abstract	The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention.
Language	English
Publishing date	2020-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.9591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice

Jie Gao / Lei Wang / Jing Jiang / Qian Xu / Nianyi Zeng / Bingyun Lu / Peibo Yuan / Kai Sun / Hongwei Zhou / Xiaolong He

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 15

Abstract: Abstract Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established ...

Abstract	Abstract Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established probiotics from Lactobacillus, we identify an uncharacterized secreted protein (named LPH here) that is shared by most of these probiotic strains (8/10) and demonstrate that it protects female mice from colitis in multiple models. Functional studies show that LPH is a bi-functional peptidoglycan hydrolase with both N-Acetyl-β-D-muramidase and DL-endopeptidase activities that can generate muramyl dipeptide (MDP), a NOD2 ligand. Different active site mutants of LPH in combination with Nod2 knockout female mice confirm that LPH exerts anti-colitis effects through MDP-NOD2 signaling. Furthermore, we validate that LPH can also exert protective effects on inflammation-associated colorectal cancer in female mice. Our study reports a probiotic enzyme that enhances NOD2 signaling in vivo in female mice and describes a molecular mechanism that may contribute to the effects of traditional Lactobacillus probiotics.
Keywords	Science ; Q
Subject code	570
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice.

Gao, Jie / Wang, Lei / Jiang, Jing / Xu, Qian / Zeng, Nianyi / Lu, Bingyun / Yuan, Peibo / Sun, Kai / Zhou, Hongwei / He, Xiaolong

Nature communications

2023 Volume 14, Issue 1, Page(s) 3338

Abstract: Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established ... ...

Abstract	Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established probiotics from Lactobacillus, we identify an uncharacterized secreted protein (named LPH here) that is shared by most of these probiotic strains (8/10) and demonstrate that it protects female mice from colitis in multiple models. Functional studies show that LPH is a bi-functional peptidoglycan hydrolase with both N-Acetyl-β-D-muramidase and DL-endopeptidase activities that can generate muramyl dipeptide (MDP), a NOD2 ligand. Different active site mutants of LPH in combination with Nod2 knockout female mice confirm that LPH exerts anti-colitis effects through MDP-NOD2 signaling. Furthermore, we validate that LPH can also exert protective effects on inflammation-associated colorectal cancer in female mice. Our study reports a probiotic enzyme that enhances NOD2 signaling in vivo in female mice and describes a molecular mechanism that may contribute to the effects of traditional Lactobacillus probiotics.
MeSH term(s)	Mice ; Female ; Animals ; Ligands ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Colitis ; Mice, Knockout ; Probiotics ; Nod2 Signaling Adaptor Protein/metabolism ; Peptidoglycan/metabolism
Chemical Substances	Ligands ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28) ; Acetylmuramyl-Alanyl-Isoglutamine (53678-77-6) ; Nod2 Signaling Adaptor Protein ; Peptidoglycan
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38950-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epidemiology reveals mask wearing by the public is crucial for COVID-19 control

Zeng, Nianyi / Li, Zewen / Ng, Sherrianne / Chen, Dingqiang / Zhou, Hongwei

Medicine in Microecology

2020 Volume 4, Page(s) 100015

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2590-0978
DOI	10.1016/j.medmic.2020.100015
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epidemiology reveals mask wearing by the public is crucial for COVID-19 control.

Zeng, Nianyi / Li, Zewen / Ng, Sherrianne / Chen, Dingqiang / Zhou, Hongwei

Medicine in microecology

2020 Volume 4, Page(s) 100015

Abstract: Objective: The pandemic 2019 Coronavirus disease (COVID-19) is the greatest concern globally. Here we analyzed the epidemiological features of China, South Korea, Italy and Spain to find out the relationship of major public health events and ... ...

Abstract	Objective: The pandemic 2019 Coronavirus disease (COVID-19) is the greatest concern globally. Here we analyzed the epidemiological features of China, South Korea, Italy and Spain to find out the relationship of major public health events and epidemiological curves. Study design: In this study we described and analyzed the epidemiological characteristics of COVID-19 in and outside China. We used GAM to generate the epidemiological curves and simulated infection curves with reported incubation period. Results: The epidemiological curves derived from the GAM suggested that the infection curve can reflect the public health measurements sensitively. Under the massive actions token in China, the infection curve flattened at 23rd of January. While surprisingly, even before Wuhan lockdown and first level response of public emergency in Guangdong and Shanghai, those infection curve came to the reflection point both at 21st of January, which indicated the mask wearing by the public before 21st Jan were the key measure to cut off the transmission. In the countries outside China, infection curves also changed in response to measures, but its rate of decline was much smaller than the curve of China's. Conclusion: The present analysis comparing the epidemiological curves in China, South Korea, Italy and Spain supports the importance of mask wearing by the public. Analysis of the infection curve helped to clarify the impact of important public health events, evaluate the efficiencies of prevention measures, and showed wearing masks in public resulted in significantly reduced daily infected cases.
Language	English
Publishing date	2020-05-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-0978
ISSN (online)	2590-0978
DOI	10.1016/j.medmic.2020.100015
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Article: Urinary peptidome analysis in CKD and IgA nephropathy.

Li, Zewen / Zeng, Nianyi / Zhao, Xin / Chen, Xuedong / Liang, Guangqing / Liu, Haiyue / Lin, Jinyan / Zheng, Peizhuang / Lin, Xingtao / Zhou, Hongwei / Zheng, Daowen

Clinical kidney journal

2023 Volume 16, Issue 11, Page(s) 1965–1973

Abstract: Background: Chronic kidney disease (CKD) has emerged as a significant challenge to human health and economic stability in aging societies worldwide. Current clinical practice strategies remain insufficient for the early identification of kidney ... ...

Abstract	Background: Chronic kidney disease (CKD) has emerged as a significant challenge to human health and economic stability in aging societies worldwide. Current clinical practice strategies remain insufficient for the early identification of kidney dysfunction, and the differential diagnosis of immunoglobulin A nephropathy (IgAN) predominantly relies on invasive kidney biopsy procedures. Methods: First, we assessed a case-control cohort to obtain urine samples from healthy controls and biopsy-confirmed CKD patients. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) was applied to detect urinary peptide and then these urinary peptide profiles were used to construct diagnostic models to distinguish CKD patients from controls and identify IgAN patients from other nephropathy patients. Furthermore, we assessed the robustness of the diagnostic models and their reproducibility by applying different algorithms. Results: A rapid and accurate working platform for detecting CKD and its IgAN subtype based on urinary peptide pattern detected by MALDI-TOF MS was established. Naturally occurring urinary peptide profiles were used to construct a diagnostic model to distinguish CKD patients from controls and identify IgAN patients from other nephropathy patients. The performance of several algorithms was assessed and demonstrated that the robustness of the diagnostic models as well as their reproducibility were satisfactory. Conclusions: The present findings suggest that the CKD-related and IgAN-specific urinary peptides discovered facilitate precise identification of CKD and its IgAN subtype, offering a dependable framework for screening conditions linked to renal dysfunction. This will aid in comprehending the pathogenesis of nephropathy and identifying potential protein targets for the clinical management of nephropathy.
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfad211
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Article ; Online: Ultrasonic effects on the degradation kinetics, structural characteristics and protective effects on hepatocyte lipotoxicity induced by palmitic acid of Pueraria Lobata polysaccharides

Zuman Dou / Yulong Zhang / Waijiao Tang / Qiong Deng / Baishun Hu / Xianwei Chen / Hui Niu / Wenduo Wang / Zhuang Li / Hongwei Zhou / Nianyi Zeng

Ultrasonics Sonochemistry, Vol 101, Iss , Pp 106652- (2023)

2023

Abstract: In this study, a high-molecular-weight Pueraria lobata polysaccharide (PLP) with a molecular weight of 273.54 kDa was degraded by ultrasound, and the ultrasonic degradation kinetics, structural characteristics and hepatoprotective activity of ultrasonic ... ...

Abstract	In this study, a high-molecular-weight Pueraria lobata polysaccharide (PLP) with a molecular weight of 273.54 kDa was degraded by ultrasound, and the ultrasonic degradation kinetics, structural characteristics and hepatoprotective activity of ultrasonic degraded PLP fractions (PLPs) were evaluated. The results showed that the ultrasonic treatment significantly reduced the Mw and particle size of PLP, and the kinetic equation of ultrasonic degradation of PLP followed to the midpoint fracture model (the fist-order model). The monosaccharide composition analysis, FT-IR, triple helix structure and XRD analysis all indicated that the ultrasound degradation did not destroy the primary structure of PLP, but the thermal stability of degraded fractions improved. Additionally, the scanning electron microscopy analysis demonstrated that the surface morphology of PLP was altered from smooth, flat, compact large flaky structure to a sparse rod-like structure with sparse crosslinking (PLP-7). The degraded PLP fractions (0.5 mg/mL) with lower Mw exhibited better antioxidant activities and protective effects against palmitic acid-induced hepatic lipotoxicity, which may be due to the increased exposure of active groups such as hydroxyl groups of PLP after ultrasound. Further investigation showed that PLPs not only increased Nrf2 phosphorylation and its nuclear translocation, thereby activating Nrf2/Keap1 signaling pathway, but also enhanced HO-1, NQO-1, γ-GCL gene expressions and promoted superoxide dismutase and catalase activities, which protected hepatocytes against PA-induced oxidative stress and lipotoxicity. Overall, our research might provide an in-depth insight into P. Lobata polysaccharide in ameliorating lipid metabolic disorders, and the results revealed that ultrasonic irradiation could be a promising degradation method to produce value-added polysaccharide for use in functional food.
Keywords	Ultrasound degradation ; Pueraria lobata polysaccharide ; Palmitic acid ; Oxidative stress ; Hepatoprotective activity ; Nrf2/Keap1 signaling pathway ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
Subject code	500
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasonic effects on the degradation kinetics, structural characteristics and protective effects on hepatocyte lipotoxicity induced by palmitic acid of Pueraria Lobata polysaccharides.

Dou, Zuman / Zhang, Yulong / Tang, Waijiao / Deng, Qiong / Hu, Baishun / Chen, Xianwei / Niu, Hui / Wang, Wenduo / Li, Zhuang / Zhou, Hongwei / Zeng, Nianyi

Ultrasonics sonochemistry

2023 Volume 101, Page(s) 106652

Abstract	In this study, a high-molecular-weight Pueraria lobata polysaccharide (PLP) with a molecular weight of 273.54 kDa was degraded by ultrasound, and the ultrasonic degradation kinetics, structural characteristics and hepatoprotective activity of ultrasonic degraded PLP fractions (PLPs) were evaluated. The results showed that the ultrasonic treatment significantly reduced the Mw and particle size of PLP, and the kinetic equation of ultrasonic degradation of PLP followed to the midpoint fracture model (the fist-order model). The monosaccharide composition analysis, FT-IR, triple helix structure and XRD analysis all indicated that the ultrasound degradation did not destroy the primary structure of PLP, but the thermal stability of degraded fractions improved. Additionally, the scanning electron microscopy analysis demonstrated that the surface morphology of PLP was altered from smooth, flat, compact large flaky structure to a sparse rod-like structure with sparse crosslinking (PLP-7). The degraded PLP fractions (0.5 mg/mL) with lower Mw exhibited better antioxidant activities and protective effects against palmitic acid-induced hepatic lipotoxicity, which may be due to the increased exposure of active groups such as hydroxyl groups of PLP after ultrasound. Further investigation showed that PLPs not only increased Nrf2 phosphorylation and its nuclear translocation, thereby activating Nrf2/Keap1 signaling pathway, but also enhanced HO-1, NQO-1, γ-GCL gene expressions and promoted superoxide dismutase and catalase activities, which protected hepatocytes against PA-induced oxidative stress and lipotoxicity. Overall, our research might provide an in-depth insight into P. Lobata polysaccharide in ameliorating lipid metabolic disorders, and the results revealed that ultrasonic irradiation could be a promising degradation method to produce value-added polysaccharide for use in functional food.
MeSH term(s)	Palmitic Acid/metabolism ; Palmitic Acid/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Pueraria/chemistry ; Ultrasonics ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/pharmacology ; Spectroscopy, Fourier Transform Infrared ; Polysaccharides/chemistry ; Hepatocytes/metabolism ; Antioxidants/chemistry
Chemical Substances	Palmitic Acid (2V16EO95H1) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Polysaccharides ; Antioxidants
Language	English
Publishing date	2023-10-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2023.106652
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Article ; Online: Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis

Xiang Li / Zewen Li / Yan He / Pan Li / Hongwei Zhou / Nianyi Zeng

PeerJ, Vol 8, p e

2020 Volume 9591

Abstract: The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention. Christensenellaceae was recently described as an important player in human health, while its distribution and relationship with MetS in Chinese ... ...

Abstract	The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention. Christensenellaceae was recently described as an important player in human health, while its distribution and relationship with MetS in Chinese population is still unknown. This study sought to observe the association between Christensenellaceae and metabolic indexes in a large sample of residents in South China. A total of 4,781 people from the GGMP project were included, and the fecal microbiota composition of these individuals was characterized by 16S rRNA sequencing and analyzed the relation between Christensenellaceae and metabolism using QIIME (Quantitative Insight Into Microbial Ecology, Version 1.9.1). The results demonstrated that microbial richness and diversity were increased in the group with a high abundance of Christensenellaceae, who showed a greater complexity of the co-occurrence network with other bacteria than residents who lacked Christensenellaceae. The enriched bacterial taxa were predominantly represented by Oscillospira, Ruminococcaceae, RF39, Rikenellaceae and Akkermansia as the Christensenellaceae abundance increased, while the abundances of Veillonella, Fusobacterium and Klebsiella were significantly reduced. Furthermore, Christensenellaceae was negatively correlated with the pathological features of MetS, such as obesity, hypertriglyceridemia and body mass index (BMI). We found reduced levels of lipid biosynthesis and energy metabolism pathways in people with a high abundance of Christensenellaceae, which may explain the negative relationship between body weight and Christensenellaceae. In conclusion, we found a negative correlation between Christensenellaceae and MetS in a large Chinese population and reported the geographical distribution of Christensenellaceae in the GGMP study. The association data from this population-level research support the investigation of strains within Christensenellaceae as potentially beneficial gut microbes.
Keywords	Christensenellaceae ; 16S rRNA sequencing ; Metabolic syndrome ; Human gut microbiota ; Bioinformatic analysis ; Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Epidemiology reveals mask wearing by the public is crucial for COVID-19 control

Zeng, Nianyi / Li, Zewen / Ng, Sherrianne / Chen, Dingqiang / Zhou, Hongwei

Medicine in Microecology

Abstract: Objective The pandemic 2019 Coronavirus disease (COVID-19) is the greatest concern globally Here we analyzed the epidemiological features of China, South Korea, Italy and Spain to find out the relationship of major public health events and ... ...

Abstract	Objective The pandemic 2019 Coronavirus disease (COVID-19) is the greatest concern globally Here we analyzed the epidemiological features of China, South Korea, Italy and Spain to find out the relationship of major public health events and epidemiological curves Study design In this study we describe and analyze the epidemiological characteristics of COVID-19 in and outside China We use GAM to generate the epidemiological curves and simulate infection curves with reported incubation period Results The epidemiological curved derived from the GAM suggested that the infection curve can reflect the public health measurements sensitively Under the massive actions token in China, the infection curve flattened at 23rd of January While surprisingly, even before Wuhan lockdown and first level response of public emergency in Guangdong and Shanghai, those infection curve came to the reflection point both at 21st of January, which indicated the mask wearing by the public before 21st Jan were the key measure to cut off the transmission In the countries outside China, infection curve also changed in response to measures, but its rate of decline was much smaller than the curve of China's Conclusion The present analysis comparing the epidemiological curves in China, South Korea, Italy and Spain supports the importance of mask wearing by the public Analysis of the infection curve helped to clarify the impact of important public health events, evaluate the efficiencies of prevention measures, and showed wearing masks in public resulted in significantly reduced daily infected cases
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #245722
Database	COVID19

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