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Article ; Online: Sperm Ion Transporters and Channels in Human Asthenozoospermia: Genetic Etiology, Lessons from Animal Models, and Clinical Perspectives.

Cavarocchi, Emma / Whitfield, Marjorie / Saez, Fabrice / Touré, Aminata

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle that provides the ... ...

Abstract	In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle that provides the mechanical force for sperm propulsion and motility. Importantly several functional maturation events that occur during the journey of the sperm cells through the genital tracts are necessary for the activation of flagellar beating and the acquisition of fertilization potential. Ion transporters and channels located at the surface of the sperm cells have been demonstrated to be involved in these processes, in particular, through the activation of downstream signaling pathways and the promotion of novel biochemical and electrophysiological properties in the sperm cells. We performed a systematic literature review to describe the currently known genetic alterations in humans that affect sperm ion transporters and channels and result in asthenozoospermia, a pathophysiological condition defined by reduced or absent sperm motility and observed in nearly 80% of infertile men. We also present the physiological relevance and functional mechanisms of additional ion channels identified in the mouse. Finally, considering the state-of-the art, we discuss future perspectives in terms of therapeutics of asthenozoospermia and male contraception.
MeSH term(s)	Animals ; Asthenozoospermia/genetics ; Asthenozoospermia/metabolism ; Female ; Humans ; Ion Channels/metabolism ; Male ; Mammals ; Mice ; Models, Animal ; Sperm Motility/genetics ; Spermatozoa/metabolism
Chemical Substances	Ion Channels
Language	English
Publishing date	2022-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073926
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Article ; Online: Sperm Ion Transporters and Channels in Human Asthenozoospermia

Emma Cavarocchi / Marjorie Whitfield / Fabrice Saez / Aminata Touré

International Journal of Molecular Sciences, Vol 23, Iss 3926, p

Genetic Etiology, Lessons from Animal Models, and Clinical Perspectives

2022 Volume 3926

Abstract	In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle that provides the mechanical force for sperm propulsion and motility. Importantly several functional maturation events that occur during the journey of the sperm cells through the genital tracts are necessary for the activation of flagellar beating and the acquisition of fertilization potential. Ion transporters and channels located at the surface of the sperm cells have been demonstrated to be involved in these processes, in particular, through the activation of downstream signaling pathways and the promotion of novel biochemical and electrophysiological properties in the sperm cells. We performed a systematic literature review to describe the currently known genetic alterations in humans that affect sperm ion transporters and channels and result in asthenozoospermia, a pathophysiological condition defined by reduced or absent sperm motility and observed in nearly 80% of infertile men. We also present the physiological relevance and functional mechanisms of additional ion channels identified in the mouse. Finally, considering the state-of-the art, we discuss future perspectives in terms of therapeutics of asthenozoospermia and male contraception.
Keywords	sperm ; asthenozoospermia ; gene mutation ; ion channel ; mouse ; human ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multifunctional polylactic acid sensing fabric based on biomass flame retardants for intelligent fire early-warning.

Jin, Xu / Zhang, Jing / Wang, Bin / Li, Xiaolu / Zeng, Jing / Ma, Jiayu / Zhao, Ximeng / Wu, Wenqi / Del Río Sáez, José Sánchez / Zhang, Xiuqin / Wang, De-Yi / Wang, Rui

International journal of biological macromolecules

2024 Volume 259, Issue Pt 1, Page(s) 129158

Abstract: ... a novel multifunctional fire early-warning polylactic acid-based fabric (MFR-PBF) by coating MXene ... insights into the preparation and application of intelligent fire early-warning fabrics in the smart ... materials and to realize preventive measures to reduce fires or their damage. In this work, we fabricated ...

Abstract	Today, building materials emit many hazardous gases in the event of a fire, causing great harm to human health and the environment. Therefore, it is of great significance to develop bio-based flame retardant materials and to realize preventive measures to reduce fires or their damage. In this work, we fabricated a novel multifunctional fire early-warning polylactic acid-based fabric (MFR-PBF) by coating MXene nanosheet, phytic acid @ furfurylamine (PA@FA) and ammonium polyphosphate (APP) via an eco-friendly layer-by-layer assembly method. MFR-PBF showed outstanding flame retardancy including a limiting oxygen index value of 35 % and better char formation capacity. More importantly, MFR-PBF exhibited sensitive fire early-warning capability (∼1 s) and excellent cyclic alarm stability (>15 cycles) due to the excellent semiconductor responsiveness (light and heat) and the significant catalytic char formation effect. Moreover, MFR-PBF is comfortable, flexible and strong enough to sew onto firefighter uniform to detect a variety of human motions, which can be monitored in the internet by using a LoRa emitter and a gateway. In addition, the controllable heating performance rendered MFR-PBF as a potential portable heater. This work provides new insights into the preparation and application of intelligent fire early-warning fabrics in the smart fire protection and Internet of Things.
MeSH term(s)	Humans ; Biomass ; Flame Retardants ; Catalysis ; Gases ; Polyesters
Chemical Substances	poly(lactide) (459TN2L5F5) ; Flame Retardants ; Gases ; Polyesters
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.129158
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Article ; Online: Dietary Cholesterol and Lipid Overload: Impact on Male Fertility.

Saez, Fabrice / Drevet, Joël R

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 4521786

Abstract: Lipid metabolic disorders due to poor eating habits are on the rise in both developed and developing countries, with a negative impact of the "Western diet" on sperm count and quality. Dietary lipid imbalance can involve cholesterol, fatty acids, or both, ...

Abstract	Lipid metabolic disorders due to poor eating habits are on the rise in both developed and developing countries, with a negative impact of the "Western diet" on sperm count and quality. Dietary lipid imbalance can involve cholesterol, fatty acids, or both, under different pathophysiological conditions grouped under the term dyslipidemia. The general feature of dyslipidemia is the development of systemic oxidative stress, a well-known deleterious factor for the quality of male gametes and associated with infertility. Sperm are particularly rich in polyunsaturated fatty acids (PUFA), an important characteristic associated with normal sperm physiology and reproductive outcomes, but also targets of choice for oxidative thrust. This review focuses on the effects of dietary cholesterol or different fatty acid overload on sperm composition and function in both animals and humans. The links between oxidative stress induced by dyslipidemia and sperm dysfunction are then discussed, including possible preventive or therapeutic strategies to preserve gamete quality, longevity when stored in cryobanking, and male fertility.
MeSH term(s)	Animals ; Cholesterol, Dietary/metabolism ; Disease Models, Animal ; Fertility/physiology ; Humans ; Lipids/physiology ; Male ; Oxidative Stress/physiology
Chemical Substances	Cholesterol, Dietary ; Lipids
Language	English
Publishing date	2019-12-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2019/4521786
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Article: 45S rDNA Diversity

Delorme-Hinoux, Valérie / Mbodj, Assane / Brando, Sophie / De Bures, Anne / Llauro, Christel / Covato, Fabrice / Garrigue, Joseph / Guisset, Claude / Borrut, Jacques / Mirouze, Marie / Reichheld, Jean-Philippe / Sáez-Vásquez, Julio

Plants (Basel, Switzerland)

2023 Volume 12, Issue 14

Abstract: The keystone of ribosome biogenesis is the transcription of 45S rDNA. ... ...

Abstract	The keystone of ribosome biogenesis is the transcription of 45S rDNA. The
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12142722
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Article ; Online: Spermatozoa isolation with Felix™ outperforms conventional density gradient centrifugation preparation in selecting cells with low DNA damage.

Villeneuve, Pauline / Saez, Fabrice / Hug, Elisa / Chorfa, Areski / Guiton, Rachel / Schubert, Benoit / Force, André / Drevet, Joël R

Andrology

2023 Volume 11, Issue 8, Page(s) 1593–1604

Abstract: Background: The optimization of spermatozoa preparation techniques in order to obtain cell fractions enriched with structurally and functionally "superior" spermatozoa is a key objective of the assisted reproduction industry.: Objectives: The purpose ...

Abstract	Background: The optimization of spermatozoa preparation techniques in order to obtain cell fractions enriched with structurally and functionally "superior" spermatozoa is a key objective of the assisted reproduction industry. Objectives: The purpose of this study was to evaluate a recent development of an electrophoretic spermatozoa separation device (Felix™, Memphasys Ltd, Sydney, Australia) and to compare its performance with conventional spermatozoa preparation by density gradient centrifugation (DGC). Particular attention was paid to the evaluation of sperm DNA/nuclear integrity. Materials & methods: A cohort of 29 human semen samples was studied. Semen samples were analyzed fresh and after DGC or Felix™ preparation. Semen parameters monitored included sample volume, sperm count, total motility, progressive motility, sperm DNA fragmentation using the Sperm Chromatin Structure Assay and sperm DNA oxidation. Results: Spermatozoa preparation with Felix™ resulted in significantly improved spermatozoa fractions with higher progressive motility, lower sperm DNA fragmentation, and lower sperm DNA oxidation compared with raw semen and DGC-prepared spermatozoa. Discussion & conclusion: The data collected in this study support the preparation of spermatozoa by the Felix™ system as it allows selection of spermatozoa with the highest progressive motility as well as the lowest nuclear/DNA damage. These improved sperm parameters, along with the fact that the Felix™ separation process is very fast and highly standardized, should be of great interest to the assisted reproduction technologies industry.
MeSH term(s)	Humans ; Male ; Semen/physiology ; Cell Separation/methods ; Centrifugation, Density Gradient ; Spermatozoa/physiology ; DNA Damage ; DNA ; Sperm Motility/physiology
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13384
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Article ; Online: Identification of

Chorfa, Areski / Goubely, Chantal / Henry-Berger, Joelle / Guiton, Rachel / Drevet, Joël R / Saez, Fabrice

International journal of molecular sciences

2021 Volume 22, Issue 18

Abstract: The cyclical proliferation of the wild fossorial ... ...

Abstract	The cyclical proliferation of the wild fossorial rodent
MeSH term(s)	Animals ; Antibodies/blood ; Antigens/metabolism ; Arvicolinae/immunology ; Contraceptive Agents ; Female ; Gene Ontology ; Immunity ; Immunization ; Male ; Membrane Proteins/metabolism ; Peptides/metabolism ; Proteomics ; Species Specificity ; Spermatozoa/immunology
Chemical Substances	Antibodies ; Antigens ; Contraceptive Agents ; Membrane Proteins ; Peptides
Language	English
Publishing date	2021-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22189965
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Article ; Online: All-Fabric Triboelectric Nanogenerator (AF-TENG) Smart Face Mask: Remote Long-Rate Breathing Monitoring and Apnea Alarm.

Vázquez-López, Antonio / Del Río Saez, José Sánchez / de la Vega, Jimena / Ao, Xiang / Wang, De-Yi

ACS sensors

2023 Volume 8, Issue 4, Page(s) 1684–1692

Abstract: ... we propose the use of an all-fabric TENG (AF-TENG) with the use of high molecular weight polyethylene (UHMWPE ... and cotton fabric as negative and positive triboelectric layers, respectively. With these materials ...

Abstract	Since the beginning of the COVID-19 pandemic, the use of face masks has become not only mandatory in several countries but also an acceptable approach for combating the pandemic. In the quest for designing an effective and useful face mask, triboelectric nanogenerators (TENGs) have been recently proposed. Novel functionalities are provided with the use of TENGs in face masks due to the induced triboelectrification generated by the exhaled and inhaled breath, allowing their use as an energy sensor. Nonetheless, within the face mask, the presence of nontextile plastics or other common triboelectric (TE) materials can be undesired. Herein, we propose the use of an all-fabric TENG (AF-TENG) with the use of high molecular weight polyethylene (UHMWPE) and cotton fabric as negative and positive triboelectric layers, respectively. With these materials, it is possible to detect the breathing of the patient, which in the case of not detecting a signal over a few minutes can trigger an alarm locally, providing valuable time. Also, in this article, we have sent breathing signals locally and remotely to distances up to 20 km via Wi-Fi and LoRa, the same as warning signals in the case of detecting anomalies. This work reveals the use of TENGs in smart face masks as an important tool to be used in difficult epidemiological periods to the general public, bringing much more comfort and relaxation to patients and elderly in today's society, and based on pristine eco-friendly materials.
MeSH term(s)	Aged ; Humans ; Masks ; Apnea ; Pandemics/prevention & control ; COVID-19/prevention & control ; Polyethylene
Chemical Substances	Polyethylene (9002-88-4)
Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.2c02825
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Article ; Online: Prostasomes, post-testicular sperm maturation and fertility.

Saez, Fabrice / Sullivan, Robert

Frontiers in bioscience (Landmark edition)

2016 Volume 21, Issue 7, Page(s) 1464–1473

Abstract: Prostasomes are known as extracellular organelles originating from the epithelial cells of the prostate and detected in its secretions where they are mixed with sperm cells after ejaculation. They were first described in men but are also present in the ... ...

Abstract	Prostasomes are known as extracellular organelles originating from the epithelial cells of the prostate and detected in its secretions where they are mixed with sperm cells after ejaculation. They were first described in men but are also present in the semen of all mammals studied. Since their characterization by Gunnar Ronquist in the late 1970's studies have focused on different aspects which primarily include their molecular composition and structure, and secondly their ability to interact or even fuse with cells, particularly spermatozoa. They have the ability to bring molecules such as lipids or proteins to spermatozoa during their journey to the oocyte, and their role thus seem to be a sort of a "reservoir" that sperm may use depending on the surrounding conditions. Other properties have been suggested but this review will focus on the properties, acquired by sperm cells via prostasomes, that may influence fertility outcome.
MeSH term(s)	Animals ; Epithelial Cells/physiology ; Epithelial Cells/ultrastructure ; Extracellular Vesicles/immunology ; Extracellular Vesicles/physiology ; Extracellular Vesicles/ultrastructure ; Female ; Fertility/immunology ; Fertility/physiology ; Fertilization/physiology ; Humans ; Male ; Prostate/physiology ; Prostate/ultrastructure ; Sperm Maturation/physiology ; Sperm Motility/physiology ; Spermatozoa/physiology
Language	English
Publishing date	2016-06-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2704569-9
ISSN	2768-6698 ; 1093-9946
ISSN (online)	2768-6698
ISSN	1093-9946
DOI	10.2741/4466
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Article ; Online: A comprehensive bibliometric study of the balanced scorecard.

Suárez-Gargallo, Carlos / Zaragoza-Sáez, Patrocinio

Evaluation and program planning

2023 Volume 97, Page(s) 102256

Abstract: ... and structural indicators. Web of Science Core Collection was used as the source of information ...

Abstract	This research provides a deeper knowledge in the Balanced Scorecard (BSC) insight by using the bibliometric technique. The existing gap between the traditional literatura reviews and previous bibliometric studies, is covered as it is the first comprehensive analysis carried out in applying quantity, quality, and structural indicators. Web of Science Core Collection was used as the source of information, considering it the most accurate and suitable data base for these studies. This research covers the wider period-of-time possible, from 1992 to 2020, with a final sample of 771 articles in 466 reviews. Quantity indicators show the high interest that the BSC still has in the scholar's community, pointing out Kaplan and Norton as the most productive authors,and confirming that 'management', 'business' and 'accountability' are its most common field of activity, although others as 'systems' and sustainability' are coming to prominence; 'Balanced Scorecard' appears as the most remarkable keyword. Quality indicators found 32,706 citations, with Kaplan and Norton occupying again top positions as well as 'Harvard Business Review' as the most impacting review both in cited articles and in average. Co-citation analysis reveals the existence of a triple corecluster for articles, based on the theory, literature reviews, and case-studies.
MeSH term(s)	Humans ; Program Evaluation ; Bibliometrics ; Databases, Factual
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2013444-7
ISSN	1873-7870 ; 0149-7189
ISSN (online)	1873-7870
ISSN	0149-7189
DOI	10.1016/j.evalprogplan.2023.102256
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