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Article: Editorial: Linking nitrogen cycling transformations to microbial diversity in freshwater ecosystems.

Castellano-Hinojosa, Antonio / González-López, Jesús / Cardenas, Laura M / Strauss, Sarah L

2022 Volume 13, Page(s) 1098905

Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1098905
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Article ; Online: Biodistribution of progesterone in the eye after topical ocular administration via drops or inserts.

Alambiaga-Caravaca, Adrián M / González Iglesias, Laura G / Rodilla, Vicent / Kalia, Yogeshvar N / López-Castellano, Alicia

International journal of pharmaceutics

2022 Volume 630, Page(s) 122453

Abstract: Progesterone (PG) has been shown to have a slowing effect on photoreceptor cell death in mouse models of retinitis pigmentosa when administered orally. The aim of this study was to investigate whether ophthalmically administered progesterone was able to ... ...

Abstract	Progesterone (PG) has been shown to have a slowing effect on photoreceptor cell death in mouse models of retinitis pigmentosa when administered orally. The aim of this study was to investigate whether ophthalmically administered progesterone was able to reach neuroretina and thus, the distribution through ocular tissues of different PG formulations was studied. The effect of different initial PG concentration was also investigated. Different formulations with PG in their composition (drops, a corneal/scleral-insert and scleral-inserts) were prepared and assayed. Using whole porcine eyes, the different formulations were topically administered to the ocular surface. Frozen eyes were dissected, the PG in each tissue was extracted in acetonitrile and the amount of PG quantified by UHPLC-MS/MS. Our results show that after topical administration, PG diffuses from the ocular surface and distributes throughout all tissues of the eye. Lower levels of PG were found in sclera, choroid and neuroretina when PG was applied as drops compared to inserts. Our results also show that an increase in the initial PG concentrations applied, resulted in a statistically significant increase in the amounts of PG in aqueous humour, sclera, choroid and neuroretina.
Language	English
Publishing date	2022-11-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2022.122453
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Article ; Online: Co-designing implementation strategies to promote remote physical activity programs in frail older community-dwellers.

Villa-García, Lorena / Davey, Vanessa / Peréz, Laura M / Soto-Bagaria, Luis / Risco, Ester / Díaz, Pako / Kuluski, Kerry / Giné-Garriga, Maria / Castellano-Tejedor, Carmina / Inzitari, Marco

Frontiers in public health

2023 Volume 11, Page(s) 1062843

Abstract: Background: The "AGIL Barcelona (AGILBcn)" community-based integrated care program is a multicomponent healthy aging intervention for frail older adults. In this context, the present study aimed to identify implementation strategies to optimize the ... ...

Abstract	Background: The "AGIL Barcelona (AGILBcn)" community-based integrated care program is a multicomponent healthy aging intervention for frail older adults. In this context, the present study aimed to identify implementation strategies to optimize the accessibility, acceptability, and adaptability of mobile health (mhealth) interventions to enhance physical activity in frail older adults, and to prioritize action points according to their importance and feasibility, through a co-design process. Material and methods: A mixed methods approach was used. In the qualitative phase, a method adapted from the World Café was applied in 6 virtual groups to identify strategies to facilitate the virtual physical activity program. In the quantitative phase, prioritization and feasibility of the strategies was analyzed through surveys. Strategies were ranked based on priority vs. feasibility, revealing if strategies should either be: implemented first; if possible; taken into account for future consideration; or directly disregarded. The convenience sample included older adults ( Results: A total of 27 strategies were identified and grouped into four categories: general strategies for reducing barriers; specific strategies for facilitating the use of a digital application; specific strategies for facilitating participation in virtual exercise groups; and specific strategies for facilitating external support. According to the ranking of strategies, the first ones to be implemented included: digital literacy, digital capability assessment, family technology support, weekly telephone follow-up by professionals, personalizing exercises, and virtual exercises in small groups. Conclusion: The active participation of all stakeholders enabled us to identify potential strategies for implementing person-oriented technology in physical activity programs and for engaging older adults.
MeSH term(s)	Humans ; Aged ; Frail Elderly ; Exercise ; Exercise Therapy
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1062843
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Article ; Online: Tuning Hsp104 specificity to selectively detoxify α-synuclein.

Mack, Korrie L / Kim, Hanna / Barbieri, Edward M / Lin, JiaBei / Braganza, Sylvanne / Jackrel, Meredith E / DeNizio, Jamie E / Yan, Xiaohui / Chuang, Edward / Tariq, Amber / Cupo, Ryan R / Castellano, Laura M / Caldwell, Kim A / Caldwell, Guy A / Shorter, James

Molecular cell

2023 Volume 83, Issue 18, Page(s) 3314–3332.e9

Abstract: Hsp104 is an AAA+ protein disaggregase that solubilizes and reactivates proteins trapped in aggregated states. We have engineered potentiated Hsp104 variants to mitigate toxic misfolding of α-synuclein, TDP-43, and FUS implicated in fatal ... ...

Abstract	Hsp104 is an AAA+ protein disaggregase that solubilizes and reactivates proteins trapped in aggregated states. We have engineered potentiated Hsp104 variants to mitigate toxic misfolding of α-synuclein, TDP-43, and FUS implicated in fatal neurodegenerative disorders. Though potent disaggregases, these enhanced Hsp104 variants lack substrate specificity and can have unfavorable off-target effects. Here, to lessen off-target effects, we engineer substrate-specific Hsp104 variants. By altering Hsp104 pore loops that engage substrate, we disambiguate Hsp104 variants that selectively suppress α-synuclein toxicity but not TDP-43 or FUS toxicity. Remarkably, α-synuclein-specific Hsp104 variants emerge that mitigate α-synuclein toxicity via distinct ATPase-dependent mechanisms involving α-synuclein disaggregation or detoxification of soluble α-synuclein conformers. Importantly, both types of α-synuclein-specific Hsp104 variant reduce dopaminergic neurodegeneration in a C. elegans model of Parkinson's disease more effectively than non-specific variants. We suggest that increasing the substrate specificity of enhanced disaggregases could be applied broadly to tailor therapeutics for neurodegenerative disease.
MeSH term(s)	Animals ; Humans ; alpha-Synuclein/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Neurodegenerative Diseases ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism
Chemical Substances	alpha-Synuclein ; Saccharomyces cerevisiae Proteins ; Heat-Shock Proteins
Language	English
Publishing date	2023-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.07.029
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Article ; Online: Importance of Soft Skills in Health Sciences Students and Their Repercussion after the COVID-19 Epidemic: Scoping Review.

Sancho-Cantus, David / Cubero-Plazas, Laura / Botella Navas, Marta / Castellano-Rioja, Elena / Cañabate Ros, Montserrat

International journal of environmental research and public health

2023 Volume 20, Issue 6

Abstract: Soft skills (SKs) are skills related to the interaction among people and their way of dealing with tasks. Increasingly valued in the workplace, they are especially relevant in health professionals due to the importance of the relationship among them and ... ...

Abstract	Soft skills (SKs) are skills related to the interaction among people and their way of dealing with tasks. Increasingly valued in the workplace, they are especially relevant in health professionals due to the importance of the relationship among them and their patients and families. Given their importance, the university training of healthcare professionals must promote the development of SKs. The COVID-19 pandemic has been a turning point in many areas, changing the learning process and, even more, the use of these soft skills as a fundamental ingredient in human relationships. The aim of this study was to analyse the available evidence regarding SKs in health science students, specifically nursing students, and to describe whether there is a worsening in the development of such skills after the COVID-19 pandemic. According to the PRISMA-ScR methodology for systematic reviews, this study included articles on social skills and possible changes in these skills as a consequence of the pandemic in health sciences students The results highlight the importance of these emotional competences for future nurses, being particularly relevant for communication and emotional self-awareness and showing their influence on academic aspects, such as academic performance or mental health and coping skills. A major limitation of the present study was not considering aspects such as compassion or empathy. However, the novelty provided by this work is the analysis of the changes in SKs produced as a consequence of the pandemic. It is definitely clear that there is a need to enhance emotional intelligence, and thus soft skills, in future health professionals.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Emotional Intelligence ; Empathy ; Pandemics ; Students, Nursing/psychology
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20064901
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Article ; Online: Co-designing implementation strategies to promote remote physical activity programs in frail older community-dwellers

Lorena Villa-García / Vanessa Davey / Laura M. Peréz / Luis Soto-Bagaria / Ester Risco / Pako Díaz / Kerry Kuluski / Maria Giné-Garriga / Carmina Castellano-Tejedor / Marco Inzitari

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: BackgroundThe “AGIL Barcelona (AGILBcn)” community-based integrated care program is a multicomponent healthy aging intervention for frail older adults. In this context, the present study aimed to identify implementation strategies to optimize the ... ...

Abstract	BackgroundThe “AGIL Barcelona (AGILBcn)” community-based integrated care program is a multicomponent healthy aging intervention for frail older adults. In this context, the present study aimed to identify implementation strategies to optimize the accessibility, acceptability, and adaptability of mobile health (mhealth) interventions to enhance physical activity in frail older adults, and to prioritize action points according to their importance and feasibility, through a co-design process.Material and methodsA mixed methods approach was used. In the qualitative phase, a method adapted from the World Café was applied in 6 virtual groups to identify strategies to facilitate the virtual physical activity program. In the quantitative phase, prioritization and feasibility of the strategies was analyzed through surveys. Strategies were ranked based on priority vs. feasibility, revealing if strategies should either be: implemented first; if possible; taken into account for future consideration; or directly disregarded. The convenience sample included older adults (n = 7), community professionals (n = 9) and health professionals (n = 13). Qualitative data were analyzed by summative content analysis and quantitative data by nonparametric descriptive analyses.ResultsA total of 27 strategies were identified and grouped into four categories: general strategies for reducing barriers; specific strategies for facilitating the use of a digital application; specific strategies for facilitating participation in virtual exercise groups; and specific strategies for facilitating external support. According to the ranking of strategies, the first ones to be implemented included: digital literacy, digital capability assessment, family technology support, weekly telephone follow-up by professionals, personalizing exercises, and virtual exercises in small groups.ConclusionThe active participation of all stakeholders enabled us to identify potential strategies for implementing person-oriented technology in physical activity programs and ...
Keywords	older adults ; frailty ; aging ; mhealth ; World Café ; integrated care ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlates to psychological distress in frail older community-dwellers undergoing lockdown during the COVID-19 pandemic.

Castellano-Tejedor, Carmina / Pérez, Laura M / Soto-Bagaria, Luis / Risco, Ester / Mazo, Maria Victoria / Gómez, Ana / Salvador, Daniel / Yanguas, Javier / Enfedaque, María B / Morandi, Alessandro / Font, Mariona / Davey, Vanessa / Inzitari, Marco

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 516

Abstract: Background: This study identifies correlates of the lockdown's psychological distress in frail older community-dwellers (Catalonia, Spain).: Methods: Participants from a community frailty intervention program, with a comprehensive geriatric ... ...

Abstract	Background: This study identifies correlates of the lockdown's psychological distress in frail older community-dwellers (Catalonia, Spain). Methods: Participants from a community frailty intervention program, with a comprehensive geriatric assessment within the 12-months pre-lockdown and COVID-19 free during the first pandemic wave (March-May 2020), underwent a phone assessment past the lockdown to assess COVID-19-related emotional distress (DME) as well as other sociodemograhic, clinical and psychosocial factors. Results: Of the 94 frail older adults (age = 82,34 ± 6,12 years; 68,1% women; 38,3% living alone), 84,9% were at risk of experiencing moderate-to-high psychological distress, according to the backward stepwise logistic regression model obtained (χ2 = 47,007, p < 0,001, Nagelkerke R Discussion: These findings suggest that it is necessary to favour a prior overall health status and to empower frail older community-dwellers in the use of a broad repertoire of coping strategies in the face of adversity to foster mental health and keep at bay the potential emotional impact of the situation generated by the COVID pandemic.
MeSH term(s)	Aged ; COVID-19/epidemiology ; Communicable Disease Control ; Female ; Frail Elderly ; Humans ; Male ; Pandemics ; Psychological Distress
Language	English
Publishing date	2022-06-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03072-w
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Article ; Online: Storia di un botanico napoletano. Gaetano Nicodemi tra scienza e rivoluzione.

Castellano, Maria Laura / Ricciardi, Massimo

Laboratorio dell'ISPF, Vol XVI, Iss

2019 Volume 10

Abstract: The story of a Napolitan botanist. Gaetano Nicodemi between science and revolution]. Gaetano Nicodemi, student of the Neapolitan scientist Domenico Cirillo, spent most of his life collecting natural history specimens and taking care of his master’s ... ...

Abstract	[The story of a Napolitan botanist. Gaetano Nicodemi between science and revolution]. Gaetano Nicodemi, student of the Neapolitan scientist Domenico Cirillo, spent most of his life collecting natural history specimens and taking care of his master’s famous collections. After taking part, with Cirillo, at the Neapolitan Republic of 1799, Nicodemi was exiled in France and became director of the Jardin des Plantes in Lyon, founded by the physician-botanist Emmanuel Gilibert, greatly contributing to its growth. He died in 1804 in unclear circumstance, and authorities later attributed his death to suicide by drowning. New documented attestations, together with the recognition of his distinctive handwriting in the labeling of Cirillo’s Herbarium conserved in the Museum of Agrarian Science at the University of Naples Federico II, allow a reconstruction of his life and probable death different from what is still officially claimed today.
Keywords	g. nicodemi ; d. cirillo ; botany ; neapolitan exiles ; History of scholarship and learning. The humanities ; AZ20-999 ; Philosophy (General) ; B1-5802
Subject code	900
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Consiglio Nazionale delle Ricerche (CNR)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Surprising Role of Amyloid Fibrils in HIV Infection.

Castellano, Laura M / Shorter, James

Biology

2012 Volume 1, Issue 1, Page(s) 58–80

Abstract: Despite its discovery over 30 years ago, human immunodeficiency virus (HIV) continues to threaten public health worldwide. Semen is the principal vehicle for the transmission of this retrovirus and several endogenous peptides in semen, including ... ...

Abstract	Despite its discovery over 30 years ago, human immunodeficiency virus (HIV) continues to threaten public health worldwide. Semen is the principal vehicle for the transmission of this retrovirus and several endogenous peptides in semen, including fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2), assemble into amyloid fibrils that promote HIV infection. For example, PAP248-286 fibrils, termed SEVI (Semen derived Enhancer of Viral Infection), potentiate HIV infection by up to 105-fold. Fibrils enhance infectivity by facilitating virion attachment and fusion to target cells, whereas soluble peptides have no effect. Importantly, the stimulatory effect is greatest at low viral titers, which mimics mucosal transmission of HIV, where relatively few virions traverse the mucosal barrier. Devising a method to rapidly reverse fibril formation (rather than simply inhibit it) would provide an innovative and urgently needed preventative strategy for reducing HIV infection via the sexual route. Targeting a host-encoded protein conformer represents a departure from traditional microbicidal approaches that target the viral machinery, and could synergize with direct antiviral approaches. Here, we review the identification of these amyloidogenic peptides, their mechanism of action, and various strategies for inhibiting their HIV-enhancing effects.
Language	English
Publishing date	2012-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology1010058
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Article ; Online: Phosphorylation disrupts long-distance electron transport in cytochrome c.

Gomila, Alexandre M J / Pérez-Mejías, Gonzalo / Nin-Hill, Alba / Guerra-Castellano, Alejandra / Casas-Ferrer, Laura / Ortiz-Tescari, Sthefany / Díaz-Quintana, Antonio / Samitier, Josep / Rovira, Carme / De la Rosa, Miguel A / Díaz-Moreno, Irene / Gorostiza, Pau / Giannotti, Marina I / Lagunas, Anna

Nature communications

2022 Volume 13, Issue 1, Page(s) 7100

Abstract: It has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome ... ...

Abstract	It has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c
MeSH term(s)	Electron Transport ; Cytochromes c ; Phosphorylation ; Oxidation-Reduction ; Cell Respiration
Chemical Substances	Cytochromes c (9007-43-6)
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-34809-1
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