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  1. Article ; Online: Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.

    Xia, Tian-Ji / Jin, Su-Wei / Liu, Yong-Guang / Zhang, Shan-Shan / Wang, Zhi / Liu, Xin-Min / Pan, Rui-Le / Jiang, Ning / Liao, Yong-Hong / Yan, Ming-Zhu / Chang, Qi

    Journal of ethnopharmacology

    2024  Volume 326, Page(s) 117992

    Abstract: ... Traditional Chinese medicine prescriptions composed of Ginseng Radix et Rhizoma and Polygalae Radix (Shen Yuan, SY) are ...

    Abstract Ethnopharmacological relevance: Sleep plays a critical role in several physiologic processes, and sleep disorders increase the risk of depression, dementia, stroke, cancer, and other diseases. Stress is one of the main causes of sleep disorders. Ginseng Radix et Rhizoma and Polygalae Radix have been reported to have effects of calming the mind and intensifying intelligence in Chinese Pharmacopoeia. Traditional Chinese medicine prescriptions composed of Ginseng Radix et Rhizoma and Polygalae Radix (Shen Yuan, SY) are commonly used to treat insomnia, depression, and other psychiatric disorders in clinical practice. Unfortunately, the underlying mechanisms of the SY extract's effect on sleep are still unknown.
    Aim of the study: This study aimed to investigate the hypnotic effect of the SY extract in normal mice and mice with chronic restraint stress (CRS)-induced sleep disorders and elucidate the underlying mechanisms.
    Materials and methods: The SY extract (0.5 and 1.0 g/kg) was intragastrically administered to normal mice for 1, 14, and 28 days and to CRS-treated mice for 28 days. The open field test (OFT) and pentobarbital sodium-induced sleep test (PST) were used to evaluate the hypnotic effect of the SY extract. Liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay were utilized to detect the levels of neurotransmitters and hormones. Molecular changes at the mRNA and protein levels were determined using real-time quantitative polymerase chain reaction and Western blot analysis to identify the mechanisms by which SY improves sleep disorders.
    Results: The SY extract decreased sleep latency and increased sleep duration in normal mice. Similarly, the sleep duration of mice subjected to CRS was increased by administering SY. The SY extract increased the levels of tryptophan (Trp) and 5-hydroxytryptamine (5-HT) and the expression of tryptophan hydroxylase 2 (TPH2) in the cortex of normal mice. The SY extract increased the Trp level, transcription and expression of estrogen receptor beta and TPH2 in the cortex in mice with sleep disorders by decreasing the serum corticosterone level, which promoted the synthesis of 5-HT. Additionally, the SY extract enhanced the expression of arylalkylamine N-acetyltransferase, which increased the melatonin level and upregulated the expressions of melatonin receptor-2 (MT2) and Cryptochrome 1 (Cry1) in the hypothalamus of mice with sleep disorders.
    Conclusions: The SY extract exerted a hypnotic effect via the Trp/5-HT/melatonin pathway, which augmented the synthesis of 5-HT and melatonin and further increased the expressions of MT2 and Cry1.
    MeSH term(s) Humans ; Mice ; Animals ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use ; Tryptophan ; Serotonin/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Melatonin/pharmacology ; Sleep Initiation and Maintenance Disorders/drug therapy
    Chemical Substances Hypnotics and Sedatives ; Tryptophan (8DUH1N11BX) ; Serotonin (333DO1RDJY) ; Drugs, Chinese Herbal ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2024-02-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Molecular Research Progress on Xishuangbanna Cucumber ( Cucumis sativus L. var. Xishuangbannesis Qi et Yuan)

    Hesbon Ochieng Obel / Chunyan Cheng / Zhen Tian / Ji Li / Qunfeng Lou / Xiaqing Yu / Yuhui Wang / Joshua Otieno Ogweno / Jinfeng Chen

    Agronomy, Vol 12, Iss 300, p

    Current Status and Future Prospects

    2022  Volume 300

    Abstract: The Xishuangbanna (XIS) cucumber is an important botanical variety, accumulating high levels of β-carotene (700 μg/100 g) in the endocarp of mature fruit compared with normal green/white flesh types (25–50 μg/100 g, fresh weight). β-carotene is an ... ...

    Abstract The Xishuangbanna (XIS) cucumber is an important botanical variety, accumulating high levels of β-carotene (700 μg/100 g) in the endocarp of mature fruit compared with normal green/white flesh types (25–50 μg/100 g, fresh weight). β-carotene is an essential precursor of provitamin A synthesis required for human health, thus XIS cucumber is an appealing germplasm for vitamin A breeding programs. In this review, we highlighted the molecular research progress of XIS cucumber as well as the bottlenecks undermining its utilization in genetic breeding. The XIS cucumber was first reported in 1983; thereafter, the literature on XIS cucumber was sporadic until 2012 and 2013 following QTL mapping of the Ore gene and subsequent cloning of the CsaBCH1 gene, respectively. Whereas QTL mapping studies underlying its flowering time and fruit quality related traits have been reported, fine mapping of their candidate genes remains unknown. Cucumber fruits are mainly consumed at fresh immature stage; however, XIS cucumber accumulates β-carotene at mature fruit state, thus limiting the utilization of β-carotene derived from it. In our opinion, we believe that the production and commercialization of immature orange-fleshed cucumber would gain wider acceptance among consumers. Additionally, we highlighted a comprehensive breeding strategy, precisely for enhanced β-carotene accumulation based on prior studies of XIS cucumber coupled with those from other crops. In MAS, we proposed schematic molecular backcross breeding strategy using lines possessing both ore and fft1.1 loci. This review, therefore, provides insights of XIS cucumber research and opportunities for further genetic breeding.
    Keywords Xishuangbanna cucumber ; molecular breeding ; orange-fleshed ; β-carotene ; Agriculture ; S
    Subject code 590
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Molecular Research Progress on Xishuangbanna Cucumber (Cucumis sativus L. var. Xishuangbannesis Qi et Yuan): Current Status and Future Prospects

    Obel, Hesbon Ochieng / Cheng, Chunyan / Tian, Zhen / Li, Ji / Lou, Qunfeng / Yu, Xiaqing / Wang, Yuhui / Ogweno, Joshua Otieno / Chen, Jinfeng

    Agronomy. 2022 Jan. 25, v. 12, no. 2

    2022  

    Abstract: The Xishuangbanna (XIS) cucumber is an important botanical variety, accumulating high levels of β-carotene (700 μg/100 g) in the endocarp of mature fruit compared with normal green/white flesh types (25–50 μg/100 g, fresh weight). β-carotene is an ... ...

    Abstract The Xishuangbanna (XIS) cucumber is an important botanical variety, accumulating high levels of β-carotene (700 μg/100 g) in the endocarp of mature fruit compared with normal green/white flesh types (25–50 μg/100 g, fresh weight). β-carotene is an essential precursor of provitamin A synthesis required for human health, thus XIS cucumber is an appealing germplasm for vitamin A breeding programs. In this review, we highlighted the molecular research progress of XIS cucumber as well as the bottlenecks undermining its utilization in genetic breeding. The XIS cucumber was first reported in 1983; thereafter, the literature on XIS cucumber was sporadic until 2012 and 2013 following QTL mapping of the Ore gene and subsequent cloning of the CsaBCH1 gene, respectively. Whereas QTL mapping studies underlying its flowering time and fruit quality related traits have been reported, fine mapping of their candidate genes remains unknown. Cucumber fruits are mainly consumed at fresh immature stage; however, XIS cucumber accumulates β-carotene at mature fruit state, thus limiting the utilization of β-carotene derived from it. In our opinion, we believe that the production and commercialization of immature orange-fleshed cucumber would gain wider acceptance among consumers. Additionally, we highlighted a comprehensive breeding strategy, precisely for enhanced β-carotene accumulation based on prior studies of XIS cucumber coupled with those from other crops. In MAS, we proposed schematic molecular backcross breeding strategy using lines possessing both ore and fft1.1 loci. This review, therefore, provides insights of XIS cucumber research and opportunities for further genetic breeding.
    Keywords Cucumis sativus ; agronomy ; backcrossing ; commercialization ; cucumbers ; endocarp ; fruit quality ; genes ; germplasm ; human health ; immatures ; vitamin A
    Language English
    Dates of publication 2022-0125
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy12020300
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Potential of hydrogen production from sugarcane juice by Ethanoligenens harbinense Yuan-3

    Li, Weiming / Cao, Guangli / Cheng, Chi / Ren, Nanqi / Yang, Shang-Tian

    Journal of cleaner production. 2019 Nov. 10, v. 237

    2019  

    Abstract: Inexpensive biomass is an ideal substrate for low-cost production of biohydrogen, but little was known about the biomass utilization performance of the ethanol-type hydrogen-producing bacteria Ethanoligenens harbinense. This study investigated the ... ...

    Abstract Inexpensive biomass is an ideal substrate for low-cost production of biohydrogen, but little was known about the biomass utilization performance of the ethanol-type hydrogen-producing bacteria Ethanoligenens harbinense. This study investigated the feasibility and performance of biohydrogen production by Ethanoligenens harbinense from sugarcane juice (SJ). Medium and process were firstly optimized with SJ as carbon source and the highest hydrogen yield was obtained when SJ was hydrolyzed by acid, and the medium contained 10 g/L sugar and 3 g/L yeast extract with pH at 6.0. Compared to batch fermentation, fed-batch fermentation with cell recycle showed significant improvement in hydrogen productivity and yield. The maximum productivity reached 5.22 mmol-H2/L•h, 201.7% higher than that of the single batch (1.73 mmol-H2/L•h). The highest H2 yield was 2.23 mol-H2/mol-hexose, 65.2% higher than that of single batch fermentation. Cell immobilization with the fibrous bed bioreactor (FBB) also improved hydrogen productivity to 2.6 times that of batch fermentation with free cells. This study demonstrated the feasibility of hydrogen production from SJ with Ethanoligens sp., and a great improvement in hydrogen production was obtained by recycling cells and immobilizing cells in a fibrous bed bioreactor.
    Keywords batch fermentation ; biohydrogen ; biomass ; bioreactors ; carbon ; gas production (biological) ; hydrogen production ; hydrolysis ; pH ; sugarcane juice ; sugars ; yeast extract
    Language English
    Dates of publication 2019-1110
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2019.07.027
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Genetic and Transcriptomic Analysis Reveal the Molecular Basis of Photoperiod-Regulated Flowering in Xishuangbanna Cucumber (Cucumis sativus L. var. xishuangbannesis Qi et Yuan)

    Tian, Zhen / Jahn, Molly / Qin, Xiaodong / Obel, Hesbon Ochieng / Yang, Fan / Li, Ji / Chen, Jinfeng

    Genes. 2021 July 13, v. 12, no. 7

    2021  

    Abstract: Xishuangbanna (XIS) cucumber (Cucumis sativus L. var. xishuangbannesis Qi et Yuan), is a botanical ...

    Abstract Xishuangbanna (XIS) cucumber (Cucumis sativus L. var. xishuangbannesis Qi et Yuan), is a botanical variety of cucumber cultivars native to southwest China that possesses excellent agronomic traits for cucumber improvement. However, breeding utilization of XIS cucumber is limited due to the current poor understanding of its photoperiod-sensitive flowering characteristics. In this study, genetic and transcriptomic analysis were conducted to reveal the molecular basis of photoperiod-regulated flowering in XIS cucumber. A major-effect QTL locus DFF1.1 was identified that controls the days to first flowering (DFF) of XIS cucumbers with a span of 1.38 Mb. Whole-genome re-sequencing data of 9 cucumber varieties with different flowering characteristics in response to photoperiod suggested that CsaNFYA1 was the candidate gene of DFF1.1, which harbored a single non-synonymous mutation in its fifth exon. Transcriptomic analysis revealed the positive roles of auxin and ethylene in accelerating flowering under short-day (SD) light-dark cycles when compared with equal-day/night treatment. Carbohydrate storage and high expression levels of related genes were important reasons explaining early flowering of XIS cucumber under SD conditions. By combining with the RNA-Seq data, the co-expression network suggested that CsaNFYA1 integrated multiple types of genes to regulate the flowering of XIS cucumber. Our findings explain the internal regulatory mechanisms of a photoperiodic flowering pathway. These findings may guide the use of photoperiod shifts to promote flowering of photoperiod-sensitive crops.
    Keywords Cucumis sativus ; auxins ; carbohydrates ; cucumbers ; cultivars ; ethylene ; exons ; loci ; mutation ; sequence analysis ; transcriptomics ; China
    Language English
    Dates of publication 2021-0713
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12071064
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Future changes in Yuan River ecohydrology: Individual and cumulative impacts of climates change and cascade hydropower development on runoff and aquatic habitat quality.

    Wen, Xin / Liu, Zhehua / Lei, Xiaohui / Lin, Rongjie / Fang, Guohua / Tan, Qiaofeng / Wang, Chao / Tian, Yu / Quan, Jin

    The Science of the total environment

    2018  Volume 633, Page(s) 1403–1417

    Abstract: ... the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify ...

    Abstract The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and nonadditive ways, the purpose of this study is to predict the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify the individual and cumulative effect of cascade damming and climate change. The bias corrected and spatial downscaled Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Model (GCM) projections are employed to drive the Soil and Water Assessment Tool (SWAT) hydrological model and to simulate and predict runoff responses under diverse scenarios. Physical habitat simulation model is established to quantify the relationship between river hydrology and fish habitat, and the relative change rate is used to assess the individual and combined effects of cascade damming and climate change. Mean annual temperature, precipitation and runoff in 2015-2100 show an increasing trend compared with that in 1951-2010, with a particularly pronounced difference between dry and wet years. The ecological habitat quality is improved under cascade hydropower development since that ecological requirement has been incorporated in the reservoir operation policy. As for middle reach, the runoff change from January to August is determined mainly by damming, and climate change influence becomes more pronounced in dry seasons from September to December. Cascade development has an effect on runoff of lower reach only in dry seasons due to the limited regulation capacity of reservoirs, and climate changes have an effect on runoff in wet seasons. Climate changes have a less significant effect on fish habitat quality in middle reach than damming, but a more significant effect in lower reach. In addition, the effect of climate changes on fish habitat quality in lower reach is high in dry seasons but low in flood seasons.
    Language English
    Publishing date 2018-08-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2018.03.309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.

    Tian, Y E / Teng, Li-Rong / Wang, Zhen-Zuo / Zhao, Min / Meng, Qing-Fan / Lu, Jia-Hui / Tian, Jian-Ming / Zhang, Wei-Wei / Zheng, Xiaoyi / Wang, D I / Teng, LE-Sheng

    Experimental and therapeutic medicine

    2015  Volume 9, Issue 6, Page(s) 2349–2355

    Abstract: Jia-Yuan-Qing pill (JYQP) composed of ...

    Abstract Jia-Yuan-Qing pill (JYQP) composed of
    Language English
    Publishing date 2015-04-15
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2015.2426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice.

    Tian, Ye / Teng, Li-rong / Song, Jing-jing / Meng, Qing-fan / Lu, Jia-hui / Zhang, Wei-wei / Wei, Kang / Wang, Ning / Wang, Di / Teng, Le-sheng

    Protoplasma

    2014  Volume 251, Issue 5, Page(s) 1245–1253

    Abstract: ... Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is ...

    Abstract The analgesic activity of Porcellio laevis Latreille, Rhizoma Corydalis, and Radix Cynanchi Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is therefore created by combining the three herbs at 9:7:7 ratio according to traditional Chinese theories. The present study aims to evaluate the effect of JYQP as a novel painkiller in various models. Acute toxicity test was applied to evaluate the safety of JYQP. Acetic-acid-induced writhing, hot plate test, formalin test, and naloxone-pretreated writhing test were employed to elaborate the analgesic activity of JYQP and its possible mechanism. A bone cancer pain mouse model was performed to further assess the effect of JYQP in relieving cancer pain. Test on naloxone-precipitated withdrawal symptoms was conduct to examine the physical dependence of mice on JYQP. Data revealed that JYQP reduced writhing and stretching induced by acetic acid; however, this effect could not be blocked by naloxone. JYQP specifically suppressed the phase II reaction time in formalin-treated mice; meanwhile, no analgesic effect of JYQP in hot plate test was observed, indicating that JYQP exerts analgesic activity against inflammatory pain rather than neurogenic pain. Furthermore, JYQP could successfully relieve bone cancer pain in mice. No physical dependence could be observed upon long-term administration in mice. Collectively, our present results provide experimental evidence in supporting clinical use of JYQP as an effective and safe agent for pain treatment.
    MeSH term(s) Analgesics/adverse effects ; Analgesics/pharmacology ; Animals ; Bone Neoplasms/pathology ; Corydalis/metabolism ; Cynanchum/metabolism ; Female ; Inflammation/pathology ; Isopoda/metabolism ; Male ; Medicine, Chinese Traditional/adverse effects ; Mice ; Mice, Inbred C57BL ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Pain/drug therapy ; Phytotherapy ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology
    Chemical Substances Analgesics ; Narcotic Antagonists ; Plant Extracts ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2014-03-28
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123809-7
    ISSN 1615-6102 ; 0033-183X
    ISSN (online) 1615-6102
    ISSN 0033-183X
    DOI 10.1007/s00709-014-0637-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Future changes in Yuan River ecohydrology: Individual and cumulative impacts of climates change and cascade hydropower development on runoff and aquatic habitat quality

    Wen, Xin / Chao Wang / Guohua Fang / Jin Quan / Qiaofeng Tan / Rongjie Lin / Xiaohui Lei / Yu Tian / Zhehua Liu

    Science of the total environment. 2018 Aug. 15, v. 633

    2018  

    Abstract: ... the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify ...

    Abstract The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and nonadditive ways, the purpose of this study is to predict the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify the individual and cumulative effect of cascade damming and climate change. The bias corrected and spatial downscaled Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Model (GCM) projections are employed to drive the Soil and Water Assessment Tool (SWAT) hydrological model and to simulate and predict runoff responses under diverse scenarios. Physical habitat simulation model is established to quantify the relationship between river hydrology and fish habitat, and the relative change rate is used to assess the individual and combined effects of cascade damming and climate change. Mean annual temperature, precipitation and runoff in 2015–2100 show an increasing trend compared with that in 1951–2010, with a particularly pronounced difference between dry and wet years. The ecological habitat quality is improved under cascade hydropower development since that ecological requirement has been incorporated in the reservoir operation policy. As for middle reach, the runoff change from January to August is determined mainly by damming, and climate change influence becomes more pronounced in dry seasons from September to December. Cascade development has an effect on runoff of lower reach only in dry seasons due to the limited regulation capacity of reservoirs, and climate changes have an effect on runoff in wet seasons. Climate changes have a less significant effect on fish habitat quality in middle reach than damming, but a more significant effect in lower reach. In addition, the effect of climate changes on fish habitat quality in lower reach is high in dry seasons but low in flood seasons.
    Keywords aquatic habitat ; climate change ; dams (hydrology) ; dry season ; fish ; General Circulation Models ; issues and policy ; rivers ; runoff ; simulation models ; Soil and Water Assessment Tool model ; stream flow ; temperature ; water power ; wet season ; China
    Language English
    Dates of publication 2018-0815
    Size p. 1403-1417.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2018.03.309
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice

    Tian, Ye / Teng, Li-rong / Song, Jing-jing / Meng, Qing-fan / Lu, Jia-hui / Zhang, Wei-wei / Wei, Kang / Wang, Ning / Wang, Di / Teng, Le-sheng

    Protoplasma. 2014 Sept., v. 251, no. 5

    2014  

    Abstract: ... Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is ...

    Abstract The analgesic activity of Porcellio laevis Latreille, Rhizoma Corydalis, and Radix Cynanchi Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is therefore created by combining the three herbs at 9:7:7 ratio according to traditional Chinese theories. The present study aims to evaluate the effect of JYQP as a novel painkiller in various models. Acute toxicity test was applied to evaluate the safety of JYQP. Acetic-acid-induced writhing, hot plate test, formalin test, and naloxone-pretreated writhing test were employed to elaborate the analgesic activity of JYQP and its possible mechanism. A bone cancer pain mouse model was performed to further assess the effect of JYQP in relieving cancer pain. Test on naloxone-precipitated withdrawal symptoms was conduct to examine the physical dependence of mice on JYQP. Data revealed that JYQP reduced writhing and stretching induced by acetic acid; however, this effect could not be blocked by naloxone. JYQP specifically suppressed the phase II reaction time in formalin-treated mice; meanwhile, no analgesic effect of JYQP in hot plate test was observed, indicating that JYQP exerts analgesic activity against inflammatory pain rather than neurogenic pain. Furthermore, JYQP could successfully relieve bone cancer pain in mice. No physical dependence could be observed upon long-term administration in mice. Collectively, our present results provide experimental evidence in supporting clinical use of JYQP as an effective and safe agent for pain treatment.
    Keywords Corydalis ; Porcellio ; acetic acid ; acute toxicity ; analgesic effect ; analgesics ; animal models ; formalin ; herbs ; mice ; naloxone ; pain ; toxicity testing
    Language English
    Dates of publication 2014-09
    Size p. 1245-1253.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 123809-7
    ISSN 1615-6102 ; 0033-183X
    ISSN (online) 1615-6102
    ISSN 0033-183X
    DOI 10.1007/s00709-014-0637-9
    Database NAL-Catalogue (AGRICOLA)

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