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  1. Article ; Online: Loss of hematopoietic diversity with age.

    Beerman, Isabel

    Blood

    2019  Volume 133, Issue 18, Page(s) 1921–1922

    MeSH term(s) Animals ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Life ; Mice
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2019-03-900902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Set(d1a)-ing novel links between HSC regulators.

    Beerman, Isabel

    Blood

    2018  Volume 131, Issue 12, Page(s) 1267–1269

    Language English
    Publishing date 2018-03-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-02-829077
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  3. Article ; Online: Cell umbrella protects stem cells from DNA damage.

    Beerman, Isabel

    Nature

    2018  Volume 558, Issue 7710, Page(s) 374–375

    MeSH term(s) DNA Damage ; DNA Repair ; Stem Cells ; Ultraviolet Rays
    Language English
    Publishing date 2018-06-15
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-05166-1
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  4. Article ; Online: Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet?

    Hare, Joshua M / Beerman, Isabel

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2022  Volume 77, Issue 7, Page(s) 1292–1294

    Abstract: While there is extensive interest in geroscience approaches to health and disease, few basic science discoveries have made their way into clinical trials. Herein, we comment on cell-based therapies, in which supplementing robust stem cell capacity to ... ...

    Abstract While there is extensive interest in geroscience approaches to health and disease, few basic science discoveries have made their way into clinical trials. Herein, we comment on cell-based therapies, in which supplementing robust stem cell capacity to aged systems theoretically could lead to sustained improvement. This exciting approach has undergone translational development, and we highlight studies targeting a single system and others aimed at treating overall aging frailty by restoring the aged stem cell niches that underly diminished endogenous regenerative capacity.
    MeSH term(s) Stem Cells
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glac003
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  5. Article ; Online: Detection of DNA Damage in Hematopoietic Stem Cells.

    Ayyar, Saipriya / Beerman, Isabel

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2567, Page(s) 11–28

    Abstract: Single-cell gel electrophoresis (SCGE or Comet assay) and the Fast Halo assay, also known as the Halo assay, are powerful tools to generate DNA damage measurements with single-cell resolution. Though these techniques are prone to have variability, they ... ...

    Abstract Single-cell gel electrophoresis (SCGE or Comet assay) and the Fast Halo assay, also known as the Halo assay, are powerful tools to generate DNA damage measurements with single-cell resolution. Though these techniques are prone to have variability, they can be robust tools for quantifying DNA damage when planned and executed carefully. Here, we present both assays and highlight each technique's advantages and challenges in measuring DNA damage in cells with limiting cell number, such as hematopoietic stem cells (HSCs). The Comet assay is highly sensitive at the cost of increased variability. The Halo assay attenuates some of the effects of variability present in the Comet assay but does not eliminate them entirely and is less sensitive. Overall, the Comet and Halo assays are powerful means of directly measuring DNA damage. We recommend the below methods for detecting damage in hematopoietic stem cells, but the methods can easily be adjusted for measuring damage in any type of single cells in suspension.
    MeSH term(s) Comet Assay/methods ; DNA Damage ; Hematopoietic Stem Cells
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2679-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Frontiers in aging special issue: DNA repair and interventions in aging perspective on "loss of epigenetic information as a cause of mammalian aging".

    Schaffer, Ethan D / Beerman, Isabel / de Cabo, Rafael / Brosh, Robert M

    Frontiers in aging

    2023  Volume 4, Page(s) 1199596

    Abstract: The recently published article ... ...

    Abstract The recently published article in
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3076785-4
    ISSN 2673-6217 ; 2673-6217
    ISSN (online) 2673-6217
    ISSN 2673-6217
    DOI 10.3389/fragi.2023.1199596
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  7. Article ; Online: Accumulation of DNA damage in the aged hematopoietic stem cell compartment.

    Beerman, Isabel

    Seminars in hematology

    2016  Volume 54, Issue 1, Page(s) 12–18

    Abstract: Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue-specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging ...

    Abstract Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue-specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue-specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny, as well as propagated within the stem cell compartment through self-renewal divisions. This review will discuss the evidence for DNA damage accumulation in the aged HSC compartment, potential drivers, and finally the consequences of the acquired damage.
    MeSH term(s) Cell Differentiation ; Cellular Senescence/genetics ; DNA Damage/genetics ; Hematopoietic Stem Cells/metabolism ; Humans
    Language English
    Publishing date 2016-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2016.11.001
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  8. Article ; Online: Short-term senolytic treatment: a paradigm to promote fracture repair during aging.

    Beerman, Isabel / Basisty, Nathan / de Cabo, Rafael

    The Journal of clinical investigation

    2022  Volume 132, Issue 8

    Abstract: Increased age is blamed for a wide range of bone physiological changes, and although the underlying mechanisms affecting the decreased capacity for fracture healing are not fully understood, they are clearly linked to changes at the cellular level. ... ...

    Abstract Increased age is blamed for a wide range of bone physiological changes, and although the underlying mechanisms affecting the decreased capacity for fracture healing are not fully understood, they are clearly linked to changes at the cellular level. Recent evidence suggests potential roles of senescent cells in response to most tissue injuries, including bone fractures. In this issue of the JCI, Liu, Zhang, and co-authors showed that a senolytic drug cocktail cleared senescent cells from the callus and improved bone fracture repair in aged mice. Understanding how senescent cells emerge at fracture sites and how their timely removal improves fracture healing should provide insights for effective therapeutic approaches in old age.
    MeSH term(s) Aging ; Animals ; Bony Callus ; Fracture Healing/physiology ; Fractures, Bone/drug therapy ; Mice
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI158871
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  9. Article ; Online: Proliferation: Driver of HSC aging phenotypes?

    Yanai, Hagai / Beerman, Isabel

    Mechanisms of ageing and development

    2020  Volume 191, Page(s) 111331

    Abstract: The decline of stem cell performance with age is a potential paramount mechanism of aging. Hematopoietic stem cells (HSCs) are perhaps the most studied and best characterized tissue-specific somatic stem cells. As such, HSCs offer an excellent research ... ...

    Abstract The decline of stem cell performance with age is a potential paramount mechanism of aging. Hematopoietic stem cells (HSCs) are perhaps the most studied and best characterized tissue-specific somatic stem cells. As such, HSCs offer an excellent research model of how aging affects stem cell performance, and vice versa. Studies from recent years have elucidated major aging phenotypes of HSCs including a decline in reconstitution potential, altered differentiation predisposition, an increase in number, accumulation of DNA damage/mutations and several others. However, what drives these changes, and exactly how they translate to pathology is poorly understood. Recent studies point to proliferative stress of HSCs as a potential driver of their aging and the resulting pathologies. Here we discuss the recent discoveries and suggest the context in which aging phenotypes could be driven, and the relevant mechanisms by which HSCs could be affected.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Proliferation ; Cellular Senescence ; DNA Damage ; Hematopoietic Stem Cells/metabolism ; Humans
    Language English
    Publishing date 2020-08-14
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2020.111331
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  10. Article ; Online: Regenerative Medicine and the Biology of Aging.

    Hare, Joshua M / Beerman, Isabel

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2019  Volume 74, Issue 9, Page(s) 1339–1340

    MeSH term(s) Aging/physiology ; Cell- and Tissue-Based Therapy ; Humans ; MicroRNAs/physiology ; Regenerative Medicine/methods
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glz132
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