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  1. Article ; Online: Impact of healthy lifestyles on risk of hypertension in the Chinese population: finding from SHUN-CVD study.

    Zhen, Juanying / Liu, Shuyun / Zhao, Guoru / Peng, Hao / Xu, Aimin / Li, Chao / Wu, Jun / Cheung, Bernard Man Yung

    Family practice

    2023  Volume 40, Issue 5-6, Page(s) 737–741

    Abstract: Introduction: Lifestyle factors are known to play a role in the development of hypertension. We aimed to study the relationship between lifestyle and hypertension in a Chinese population.: Methods: This study involved 3,329 participants (1,463 men ... ...

    Abstract Introduction: Lifestyle factors are known to play a role in the development of hypertension. We aimed to study the relationship between lifestyle and hypertension in a Chinese population.
    Methods: This study involved 3,329 participants (1,463 men and 1,866 women) aged 18-96 years in the Shenzhen-Hong Kong United Network on Cardiovascular Disease. A healthy lifestyle score was derived from 5 factors: no smoking, no alcohol consumption, active physical activity, normal body mass index, and a healthy diet. Multiple logistic regression was used to investigate the relationship between lifestyle score and hypertension. The influence of each lifestyle component on hypertension was also assessed.
    Results: In the overall population, 950 (28.5%) participants had hypertension. The risk of hypertension decreased with increasing healthy lifestyle scores. Compared with participants with the lowest score (score: 0), the multivariable odds ratios (ORs) and corresponding 95% confidence intervals for participants with scores 3, 4, and 5 were 0.65 (0.41-1.01), 0.62 (0.40-0.97), and 0.37 (0.22-0.61), respectively (P for trend <0.001). After adjusting for age, sex, and diabetes, the score was associated with hypertension risk (P for trend = 0.005). Compared with a lifestyle score of 0, the adjusted OR for hypertension for participants with a score of 5 was 0.46 (0.26-0.80).
    Conclusions: The risk of hypertension is inversely related to the healthy lifestyle score. This reinforces the need to address lifestyle to reduce the risk of hypertension.
    MeSH term(s) Male ; Humans ; Female ; Cardiovascular Diseases/epidemiology ; Hypertension/epidemiology ; Healthy Lifestyle ; Smoking/epidemiology ; Life Style ; China/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-05-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605939-9
    ISSN 1460-2229 ; 0263-2136
    ISSN (online) 1460-2229
    ISSN 0263-2136
    DOI 10.1093/fampra/cmad041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2021: Show issues Location:
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  2. Book: Shun pao huan kai che

    Liu, Jinqi / Li, Zhigang

    2011  

    Title variant Shun pao huan kaiche ; Shun-p'ao-huan-k'ai-ch'e / Liu Chin-ch'i, Li Chih-kang p'ien
    Author's details Liu Jinqi, Li Zhigang bian
    Keywords Chinesisches Schach
    Language Chinese
    Size 362 S
    Publisher Jing ji guan li chu ban she
    Publishing place Beijing
    Document type Book
    Note In chines. Schr.
    ISBN 9787509614129 ; 7509614120
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis

    Lei Zhang / Ting Li / Rongrong Wang / Jiaan Xu / Li Zhou / Li Yan / Zhengyan Hu / Hongwen Li / Fucun Liu / Wenxi Du / Peijian Tong / Huiling Wu / Shanxing Zhang / Letian Shan / Thomas Efferth

    Frontiers in Pharmacology, Vol

    2020  Volume 11

    Abstract: ... carmichaeli Debeaux derived Hei-shun-pian (Hsp) has been developed for joint pain treatment ...

    Abstract BackgroundAs a degenerative joint disease with severe cartilage destruction and pain, osteoarthritis (OA) has no satisfactory therapy to date. In traditional Chinese medicine (TCM), Aconitum carmichaeli Debeaux derived Hei-shun-pian (Hsp) has been developed for joint pain treatment. However, it causes adverse events in OA patients. Long-time decoction has been traditionally applied to reduce the aconite toxicity of Hsp and other aconite herbs, but its detoxifying effect is uncertain.MethodsHsp was extracted with dilute decoction times (30, 60, and 120 min) and evaluated by toxicological, chemical, pharmacological assays. Acute toxicity assay and chemical analysis were employed to determine the toxicity and chemoprofile of Hsp extracts, respectively. Since the detoxified Hsp (dHsp) was defined, its therapeutic effect was evaluated by using an OA rat model induced by monosodium iodoacetate. dHsp at 14 g/kg was orally administered for 28 days, and the pain assessments (mechanical withdrawal threshold and thermal withdrawal latency) and histopathological analyses (HE and safranin-O staining) were performed. Real-time PCR (qPCR) was applied to determine the molecular actions of dHsp on cartilage tissue and on chondrocytes. MTT assay was conducted to evaluate the effect of dHsp on the cell viability of chondrocytes. The cellular and molecular assays were also conducted to analyze the functions of chemical components in dHsp.ResultsThe chemoprofile result showed that the contents of toxic alkaloids (aconitine, mesaconitine, and hypaconitine) were decreased but that of non-toxic alkaloids (benzoylaconitine, benzoylmesaconitine, and benzoylhypaconitine) were increased with increasing decoction time. Acute toxicity assay showed that only Hsp extract with 120 min decoction was non-toxic within the therapeutic dose range. Thus, it was defined as dHsp for further experiment. In OA experiment, dHsp significantly attenuated joint pain and prevented articular degeneration from MIA attack. qPCR data showed that dHsp restored the ...
    Keywords Aconitum carmichaeli ; traditional Chinese medicine ; osteoarthritis ; monosodium iodoacetate ; pain behaviour ; analgesia ; Therapeutics. Pharmacology ; RM1-950
    Subject code 616
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae).

    Li, Ling / Sun, Bo / Zhang, Qi / Fang, Junjian / Ma, Kunpeng / Li, Yu / Chen, Hebing / Dong, Fangting / Gao, Yue / Li, Famei / Yan, Xianzhong

    Journal of ethnopharmacology

    2008  Volume 116, Issue 3, Page(s) 561–568

    Abstract: The purpose of this paper was to study the effects of Hei-Shun-Pian, the processed lateral root ... divided into four groups (n=5) and each group were administered orally with the decoction of Hei-Shun-Pian ... observed, suggesting a cumulative effect. These results suggest the toxic effect of Hei-Shun-Pian on rat ...

    Abstract The purpose of this paper was to study the effects of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae), on the metabolic profile of rats, to discuss the mechanism of toxicology and to find out the potential biomarkers of the toxic effects. Twenty male Wistar rats were divided into four groups (n=5) and each group were administered orally with the decoction of Hei-Shun-Pian (88.1g/kg per day, 35.6g/kg per day, 17.6g/kg per day) or equal volume of drinking water respectively for 14 days. Urine of every 24-h and the plasma of the last day were collected for NMR experiments, and then analyzed by multivariate analysis methods. Decreases in urinary excretion of taurine and trimethylamine-N-oxide (TMAO) and increases in urinary levels of citrate, 2-oxoglutarate (2-OG), succinate and hippurate were observed in the high and medium dosed groups at the early stage of the dosing period. Taurine level increased at the later stage of the dosing period to the normal value, and then even to a value higher than that of the control group at the end of the experiment. No metabolic differences were observed between low dosed and control groups until the later stage of the dosing period when a slight increase in urinary taurine level was observed, suggesting a cumulative effect. These results suggest the toxic effect of Hei-Shun-Pian on rat heart in a dose dependent manner.
    MeSH term(s) Aconitum/chemistry ; Alkaloids/analysis ; Animals ; Blood/drug effects ; Blood Chemical Analysis ; Magnetic Resonance Spectroscopy ; Male ; Metabolism ; Naphthalenes/toxicity ; Plant Extracts/toxicity ; Plant Roots/chemistry ; Rats ; Rats, Wistar ; Urine/chemistry
    Chemical Substances Alkaloids ; Hei-Shug-Pian ; Naphthalenes ; Plant Extracts
    Language English
    Publishing date 2008-03-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2008.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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  5. Article: Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)

    Li, Ling / Sun, Bo / Zhang, Qi / Fang, Junjian / Ma, Kunpeng / Li, Yu / Chen, Hebing / Dong, Fangting / Gao, Yue / Li, Famei / Yan, Xianzhong

    Journal of ethnopharmacology. 2008 Mar. 28, v. 116, no. 3

    2008  

    Abstract: The purpose of this paper was to study the effects of Hei-Shun-Pian, the processed lateral root ... divided into four groups (n =5) and each group were administered orally with the decoction of Hei-Shun ... the toxic effect of Hei-Shun-Pian on rat heart in a dose dependent manner. ...

    Abstract The purpose of this paper was to study the effects of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae), on the metabolic profile of rats, to discuss the mechanism of toxicology and to find out the potential biomarkers of the toxic effects. Twenty male Wistar rats were divided into four groups (n =5) and each group were administered orally with the decoction of Hei-Shun-Pian (88.1g/kg per day, 35.6g/kg per day, 17.6g/kg per day) or equal volume of drinking water respectively for 14 days. Urine of every 24-h and the plasma of the last day were collected for NMR experiments, and then analyzed by multivariate analysis methods. Decreases in urinary excretion of taurine and trimethylamine-N-oxide (TMAO) and increases in urinary levels of citrate, 2-oxoglutarate (2-OG), succinate and hippurate were observed in the high and medium dosed groups at the early stage of the dosing period. Taurine level increased at the later stage of the dosing period to the normal value, and then even to a value higher than that of the control group at the end of the experiment. No metabolic differences were observed between low dosed and control groups until the later stage of the dosing period when a slight increase in urinary taurine level was observed, suggesting a cumulative effect. These results suggest the toxic effect of Hei-Shun-Pian on rat heart in a dose dependent manner.
    Keywords Aconitum carmichaelii ; medicinal plants ; medicinal properties ; metabolomics ; roots ; herbal medicines ; Oriental traditional medicine ; rats ; animal models ; toxicity ; biomarkers ; oral administration ; dosage ; urine ; blood chemistry ; metabolome ; metabolites ; excretion ; taurine ; temporal variation ; heart ; subacute toxicity
    Language English
    Dates of publication 2008-0328
    Size p. 561-568.
    Publishing place Amsterdam; New York: Elsevier
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2008.01.014
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  6. Book: Tao hong jing, zhi yi, ji zang, du shun

    Shen, Qian / Li, Shijie / Huiyue

    (Zhong guo li dai si xiang jia ; 7 ; 中國歷代思想家 ; 7)

    1999  

    Author's details shen qian, hui yue, li shi jie zhu
    Series title Zhong guo li dai si xiang jia ; 7
    中國歷代思想家 ; 7
    Language Chinese
    Size 330 p, ill, 21 cm
    Edition Geng xin ban
    Publisher Tai wan shang wu yin shu guan
    Publishing place Tai bei
    Document type Book
    ISBN 9570515732 ; 9789570515732
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article ; Online: The potentiality of bacteria to drive SARS-CoV-2 mutation.

    Zhang, Xiangyu / Li, Shun / Xue, Mengzhou

    mBio

    2024  , Page(s) e0053924

    Abstract: A recent study published ... ...

    Abstract A recent study published in
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00539-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comment on:

    Yang, Jian-Wei / Wan, Shun / Yang, Li

    Journal of endourology

    2023  Volume 37, Issue 10, Page(s) 1113–1114

    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356931-7
    ISSN 1557-900X ; 0892-7790
    ISSN (online) 1557-900X
    ISSN 0892-7790
    DOI 10.1089/end.2023.0271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2628: Show issues Location:
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    Zs.MO 208: Show issues

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  9. Article ; Online: Who Should Receive the Chemotherapy-Free Combination of Nivolumab Plus Ipilimumab as the First-Line Treatment of Advanced Non-Small-Cell Lung Cancer?

    Li, Ziming / Lu, Shun

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 6, Page(s) 1172–1175

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Nivolumab/therapeutic use ; Ipilimumab/therapeutic use ; Lung Neoplasms/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Nivolumab (31YO63LBSN) ; Ipilimumab ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  10. Article: Lignin-Based Mesoporous Hollow Carbon

    Li, Shun / Huang, Jianguo / He, Guijin

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 23

    Abstract: The lignin-based mesoporous hollow ... ...

    Abstract The lignin-based mesoporous hollow carbon
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16237283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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