LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 263

Search options

  1. Article ; Online: A Regenerative Perspective on Successful and Failed T-Cell Immunity.

    Reiner, Steven L

    Cold Spring Harbor perspectives in biology

    2021  Volume 13, Issue 7

    Abstract: Heightened immunity after a primary infection, persistent control of low-level infection, or vanquished immunity from chronic-active infection and cancer are interrelated issues concerning the nature of T-cell regeneration during immunity. For many ... ...

    Abstract Heightened immunity after a primary infection, persistent control of low-level infection, or vanquished immunity from chronic-active infection and cancer are interrelated issues concerning the nature of T-cell regeneration during immunity. For many regenerating tissues and cellular systems, such as epithelia and blood, there are at least three distinguishable stages of development and repair, marked by progressive loss of self-renewal and progressive commitment to differentiation. T cells seem to be no different. Quiescent precursors become activated and yield anabolic, proliferative progenitors while self-renewing the quiescent precursor population. Activated progenitors then yield differentiated cellular descendants alongside the self-renewal of progenitors. Nomenclature reflecting the mutually opposing nature of T-cell self-renewal and T-cell differentiation would help synchronize phenomena such as T-cell memory, protective immunity, and T-cell exhaustion with other regenerative paradigms, as well as offer new strategies to influence the intensity and duration of immunity.
    MeSH term(s) Adaptive Immunity ; Cell Differentiation ; Cell Self Renewal ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Models, Immunological ; Regeneration ; T-Lymphocytes/physiology
    Chemical Substances HNF1A protein, human ; Hepatocyte Nuclear Factor 1-alpha
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a037937
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Securing front-line T cell defense.

    Reiner, Steven L

    Immunology and cell biology

    2018  Volume 96, Issue 3, Page(s) 241–242

    MeSH term(s) T-Lymphocytes
    Language English
    Publishing date 2018-02-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells.

    Wang, Peter H / Washburn, Robert S / Mariuzza, Dylan L / Lin, Wen-Hsuan W / Gill, Amanda L / Ahmed, Rafi / Reiner, Steven L

    Cell reports

    2023  Volume 42, Issue 10, Page(s) 113155

    Abstract: The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding to cancer and ... ...

    Abstract The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding to cancer and during treatment with immunotherapy is not clear. The subcellular organization of dividing progenitor CD8
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Phosphatidylinositol 3-Kinases ; Cell Differentiation ; Stem Cells ; Signal Transduction
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113155
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: T-bet transcendent: unmasking the faces of multifarious immunity.

    Reiner, Steven L

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 194, Issue 7, Page(s) 2959–2960

    MeSH term(s) Humans ; Immunity ; T-Box Domain Proteins/immunology
    Chemical Substances T-Box Domain Proteins
    Language English
    Publishing date 2014-10-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1500289
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Gastric Cancer and the Immune System: The Key to Improving Outcomes?

    Keshavjee, Sara H / Moy, Ryan H / Reiner, Steven L / Ryeom, Sandra W / Yoon, Sam S

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Gastric adenocarcinoma is by far the most common form of gastric cancer (GC) and is a highly lethal form of cancer arising from the gastric epithelium. GC is an important area of focus of the medical community, given its often late-stage of diagnosis and ...

    Abstract Gastric adenocarcinoma is by far the most common form of gastric cancer (GC) and is a highly lethal form of cancer arising from the gastric epithelium. GC is an important area of focus of the medical community, given its often late-stage of diagnosis and associated high mortality rate. While surgery and chemotherapy remain the primary treatments, attention has been drawn to the use of immunologic therapies, which have shown promise in the treatment of other malignancies. The role for immune-based therapies has become clearer as we obtain a greater understanding of the role of the immune system in gastric cancer formation and growth. A variety treatment to augment the immune system are under evaluation in clinical trials, and these include immune checkpoint inhibitors, antibody-drug conjugates, and immune cell-based therapies. Here, we review the immune landscape and immune-based therapies for GC.
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235940
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Use of Evidence-Based Interventions to Promote Healthy Weight, Nutrition, and Physical Activity in Community Health Improvement Plans from Large Local Health Departments.

    Dupuis, Roxanne / Reiner, Jennifer F / Silver, Santana / Barrett, Jessica L / Daly, James G / Lee, Rebekka M / Gortmaker, Steven L / Cradock, Angie L

    Journal of public health management and practice : JPHMP

    2023  Volume 29, Issue 5, Page(s) 640–645

    Abstract: We sought to identify evidence-based healthy weight, nutrition, and physical activity strategies related to obesity prevention in large local health department (LHD) Community Health Improvement Plans (CHIPs). We analyzed the content of the most recent, ... ...

    Abstract We sought to identify evidence-based healthy weight, nutrition, and physical activity strategies related to obesity prevention in large local health department (LHD) Community Health Improvement Plans (CHIPs). We analyzed the content of the most recent, publicly available plans from 72 accredited LHDs serving a population of at least 500 000 people. We matched CHIP strategies to the County Health Rankings and Roadmaps' What Works for Health (WWFH) database of interventions. We identified 739 strategies across 55 plans, 62.5% of which matched a "WWFH intervention" rated for effectiveness on diet and exercise outcomes. Among the 20 most commonly identified WWFH interventions in CHIPs, 10 had the highest evidence for effectiveness while 4 were rated as likely to decrease health disparities according to WWFH. Future prioritization of strategies by health agencies could focus on strategies with the strongest evidence for promoting healthy weight, nutrition, and physical activity outcomes and reducing health disparities.
    MeSH term(s) Humans ; Public Health ; Exercise ; Obesity/epidemiology ; Obesity/prevention & control ; Nutritional Status ; Evidence-Based Medicine ; Local Government
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2027860-3
    ISSN 1550-5022 ; 1078-4659
    ISSN (online) 1550-5022
    ISSN 1078-4659
    DOI 10.1097/PHH.0000000000001778
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5302: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Cutting Edge: Promoting T Cell Factor 1

    Wang, Peter H / Washburn, Robert / Maniar, Rohan / Mu, Michael / Ringham, Olivia / Kratchmarov, Radomir / Henick, Brian S / Reiner, Steven L

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 4, Page(s) 660–664

    Abstract: Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor ... ...

    Abstract Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor 1
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Cell Death ; Immunotherapy ; Mice ; Neoplasms ; Phosphatidylinositol 3-Kinases ; T Cell Transcription Factor 1
    Chemical Substances T Cell Transcription Factor 1
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200317
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: TCF1 expression marks self-renewing human CD8

    Kratchmarov, Radomir / Magun, Arthur M / Reiner, Steven L

    Blood advances

    2018  Volume 2, Issue 14, Page(s) 1685–1690

    Abstract: Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced murine ... ...

    Abstract Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced murine CD8
    MeSH term(s) CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Gene Expression Regulation ; Hepatocyte Nuclear Factor 1-alpha/biosynthesis ; Hepatocyte Nuclear Factor 1-alpha/immunology ; Humans ; Immunologic Memory ; Male
    Chemical Substances HNF1A protein, human ; Hepatocyte Nuclear Factor 1-alpha
    Language English
    Publishing date 2018-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2876449-3
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2018016279
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors.

    Gill, Amanda L / Wang, Peter H / Lee, Judong / Hudson, William H / Ando, Satomi / Araki, Koichi / Hu, Yinghong / Wieland, Andreas / Im, Sejin / Gavora, Autumn / Medina, Christopher B / Freeman, Gordon J / Hashimoto, Masao / Reiner, Steven L / Ahmed, Rafi

    Science immunology

    2023  Volume 8, Issue 86, Page(s) eadg0539

    Abstract: ... PD- ... ...

    Abstract PD-1
    MeSH term(s) Humans ; Animals ; Mice ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes ; Antibodies ; Cell Differentiation ; Disease Models, Animal
    Chemical Substances Programmed Cell Death 1 Receptor ; Antibodies
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adg0539
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Decision making during the conception and career of CD4+ T cells.

    Reiner, Steven L

    Nature reviews. Immunology

    2009  Volume 9, Issue 2, Page(s) 81–82

    Abstract: The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both ...

    Abstract The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both immune reaction against various challenges and the suppression of undesirable responses is also revealing new therapeutic options.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Division ; Cell Lineage/immunology ; Cell Proliferation ; Humans ; Lymphopoiesis ; Signal Transduction ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Thymus Gland/immunology
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Comment ; Introductory Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri2490
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top