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Article ; Online: Epigenetic Control of Infant B Cell Precursor Acute Lymphoblastic Leukemia.

de Barrios, Oriol / Parra, Maribel

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by ...

Abstract	B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by genetic alterations of embryonic origin that involve the deregulation of chromatin remodelers. This review considers in depth how the alteration of epigenetic profiles (at DNA and histone levels) induces an aberrant phenotype in B lymphocyte progenitors by modulating the oncogenic drivers and tumor suppressors involved in key cancer hallmarks. DNA methylation patterns have been widely studied in BCP-ALL and their correlation with survival has been established. However, the effect of methylation on histone residues can be very different. For instance, methyltransferase
MeSH term(s)	DNA Methylation/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Leukemic ; Histones/metabolism ; Humans ; Infant ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Protein Processing, Post-Translational
Chemical Substances	Histones
Language	English
Publishing date	2021-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22063127
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epigenetic Control of Infant B Cell Precursor Acute Lymphoblastic Leukemia

Oriol de Barrios / Maribel Parra

International Journal of Molecular Sciences, Vol 22, Iss 3127, p

2021 Volume 3127

Abstract	B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a highly aggressive malignancy, with poorer prognosis in infants than in adults. A genetic signature has been associated with this outcome but, remarkably, leukemogenesis is commonly triggered by genetic alterations of embryonic origin that involve the deregulation of chromatin remodelers. This review considers in depth how the alteration of epigenetic profiles (at DNA and histone levels) induces an aberrant phenotype in B lymphocyte progenitors by modulating the oncogenic drivers and tumor suppressors involved in key cancer hallmarks. DNA methylation patterns have been widely studied in BCP-ALL and their correlation with survival has been established. However, the effect of methylation on histone residues can be very different. For instance, methyltransferase KMT2A gene participates in chromosomal rearrangements with several partners, imposing an altered pattern of methylated H3K4 and H3K79 residues, enhancing oncogene promoter activation, and conferring a worse outcome on affected infants. In parallel, acetylation processes provide an additional layer of epigenetic regulation and can alter the chromatin conformation, enabling the binding of regulatory factors. Therefore, an integrated knowledge of all epigenetic disorders is essential to understand the molecular basis of BCP-ALL and to identify novel entry points that can be exploited to improve therapeutic options and disease prognosis.
Keywords	Epigenetics ; Acute lymphoblastic leukemia ; B lymphocytes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Class IIa HDACs - new insights into their functions in physiology and pathology.

Parra, Maribel

The FEBS journal

2015 Volume 282, Issue 9, Page(s) 1736–1744

Abstract: HDAC4, 5, 7 and 9 constitute the class IIa histone deacetylases (HDACs) within the large family of protein deacetylases. Class IIa HDACs have unique features that distinguish them from other HDACs. They contain an N-terminal domain that is required for ... ...

Abstract	HDAC4, 5, 7 and 9 constitute the class IIa histone deacetylases (HDACs) within the large family of protein deacetylases. Class IIa HDACs have unique features that distinguish them from other HDACs. They contain an N-terminal domain that is required for their interaction with tissue-specific transcription factors and recruitment to their target genes. The N-terminal domain on class IIa HDACs also bears conserved serine residues that undergo signal-dependent phosphorylation, which brings about nuclear export of the enzymes and de-repression of their targets. One of the most important aspects of class IIa HDACs is their expression in specific tissues and organs within the organism, where they have crucial roles in development and differentiation processes. This review brings up to date our knowledge of the physiological and pathological functions of class IIa HDACs, focusing in particular on the most recent discoveries from in vivo studies of mouse model systems.
MeSH term(s)	Animals ; Energy Metabolism ; Histone Deacetylases/metabolism ; Humans ; Immune System/enzymology ; Mice ; Neurons/enzymology ; Obesity/enzymology
Chemical Substances	Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.13061
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Article: Active Commuting to University Is Positively Associated with Physical Activity and Perceived Fitness.

Palma-Leal, Ximena / Parra-Saldías, Maribel / Aubert, Salomé / Chillón, Palma

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 6

Abstract: Background: Fitness is a powerful marker of health associated with physical activity (PA) in university students. However, insufficient PA is a serious health concern among university students. Active commuting provides an opportunity for increased PA ... ...

Abstract	Background: Fitness is a powerful marker of health associated with physical activity (PA) in university students. However, insufficient PA is a serious health concern among university students. Active commuting provides an opportunity for increased PA levels. Therefore, the aims of this study were (a) to describe the mode of commuting, PA and fitness in university students; (b) to analyze the associations of mode of commuting with PA and fitness; and c) to analyze the relationship between mode of commuting, PA recommendations and fitness. Methods: This was a cross-sectional study. A total of 1257 university students (52.4% women) participated (22.4 ± 5.6 years old). Results: Public commuting was the main mode to and from university. Active and public commuters were more likely to meet the PA recommendations and reported higher muscular strength than those using private commuting. Active and public commuters who met PA recommendations present the highest fitness in most of its components. Conclusions: Achieving the PA recommendations was more relevant than adopting an active mode of commuting in order to have better fitness. Further research targeting a broader understanding of the mode of commuting, PA levels and fitness in university students is needed.
Language	English
Publishing date	2022-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10060990
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Article ; Online: Active Commuting to University Is Positively Associated with Physical Activity and Perceived Fitness

Ximena Palma-Leal / Maribel Parra-Saldías / Salomé Aubert / Palma Chillón

Healthcare, Vol 10, Iss 990, p

2022 Volume 990

Abstract	Background: Fitness is a powerful marker of health associated with physical activity (PA) in university students. However, insufficient PA is a serious health concern among university students. Active commuting provides an opportunity for increased PA levels. Therefore, the aims of this study were (a) to describe the mode of commuting, PA and fitness in university students; (b) to analyze the associations of mode of commuting with PA and fitness; and c) to analyze the relationship between mode of commuting, PA recommendations and fitness. Methods: This was a cross-sectional study. A total of 1257 university students (52.4% women) participated (22.4 ± 5.6 years old). Results: Public commuting was the main mode to and from university. Active and public commuters were more likely to meet the PA recommendations and reported higher muscular strength than those using private commuting. Active and public commuters who met PA recommendations present the highest fitness in most of its components. Conclusions: Achieving the PA recommendations was more relevant than adopting an active mode of commuting in order to have better fitness. Further research targeting a broader understanding of the mode of commuting, PA levels and fitness in university students is needed.
Keywords	fitness ; physical activity ; active commuting ; university students ; health behaviors ; Medicine ; R
Subject code	796
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MYC's Fine Line Between B Cell Development and Malignancy.

de Barrios, Oriol / Meler, Ainara / Parra, Maribel

Cells

2020 Volume 9, Issue 2

Abstract: The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of ...

Abstract	The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of expression are maintained, and its protein levels are not completely silenced until the B cell becomes fully differentiated into a plasma cell or a memory B cell. MYC has been described as a proto-oncogene that is closely involved in many cancers, including leukemia and lymphoma. Aberrant expression of MYC protein in these hematological malignancies results in an uncontrolled rate of proliferation and, thereby, a blockade of the differentiation process. MYC is not activated by mutations in the coding sequence, and, as reviewed here, its overexpression in leukemia and lymphoma is mainly caused by gene amplification, chromosomal translocations, and aberrant regulation of its transcription. This review provides a thorough overview of the role of MYC in the developmental steps of B cells, and of how it performs its essential function in an oncogenic context, highlighting the importance of appropriate MYC regulation circuitry.
MeSH term(s)	Animals ; B-Lymphocytes/metabolism ; Cell Differentiation/genetics ; Cell Transformation, Neoplastic/genetics ; Child ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia/metabolism ; Leukemia/pathology ; Lymphoma/metabolism ; Lymphoma/pathology ; Mice ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Translocation, Genetic ; Young Adult
Chemical Substances	MAS1 protein, human ; MYC protein, human ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-myc
Language	English
Publishing date	2020-02-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9020523
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Article ; Online: First report of environmental isolation of Cryptococcus and Cryptococcus-like yeasts from Boyacá, Colombia.

Serna-Espinosa, Briggith-Nathalia / Forero-Castro, Maribel / Morales-Puentes, María Eugenia / Parra-Giraldo, Claudia Marcela / Escandón, Patricia / Sánchez-Quitian, Zilpa Adriana

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15755

Abstract: The Cryptococcus genus comprises more than 100 species, of which C. neoformans and C. gattii are the leading cause of cryptococcosis. The distribution of C. gattii and C. neoformans species complexes has been extensively studied and widely reported ... ...

Abstract	The Cryptococcus genus comprises more than 100 species, of which C. neoformans and C. gattii are the leading cause of cryptococcosis. The distribution of C. gattii and C. neoformans species complexes has been extensively studied and widely reported globally. Other species such as Naganishia albida, Papiliotrema laurentii, and Papiliotrema flavescens have been reported as pathogenic yeasts. Since there are no reports of environmental isolation in the Boyacá region (Colombia), this study aimed to isolate and characterize Cryptococcus and Cryptococcus-like yeasts from pigeon feces, Eucalyptus, and olive trees distributed in the municipalities of Tunja and Ricaute Alto. The environmental data was recovered, and the isolations obtained were identified by microscopy, biochemical test, MALDI-TOF MS, URA5-RFLP, and sequencing of the ITS and LSU loci. For the 93 pigeon dropping samples collected in Tunja, 23 yielded to C. neoformans, 3 to N. globosa, 2 N. albida and 1 to P. laurentii. Of the 1188 samples collected from olive trees, 17 (1.43%) positive samples were identified as C. gattii species complex (4), C. neoformans species complex (2), P. laurentii (3), N. albida (2), N. globosa (5) and P. flavescens (1). Likewise, specimens of C. neoformans presented molecular type VNI and molecular type VNII; for C. gattii the molecular types found were VGIII and one VGIV by URA5-RFLP but VGIII by MALDI-TOF and sequencing of the ITS and LSU. Therefore, it can be concluded that the species of Cryptococcus, Naganishia and Papiliotrema genera, are present in the environment of Boyacá, and show a predilection for climate conditions that are typical of this region.
MeSH term(s)	Animals ; Colombia ; Cryptococcus neoformans ; Cryptococcus gattii ; Cryptococcosis ; Climate ; Columbidae ; Olea
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41994-6
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Article ; Online: MYC’s Fine Line Between B Cell Development and Malignancy

Oriol de Barrios / Ainara Meler / Maribel Parra

Cells, Vol 9, Iss 2, p

2020 Volume 523

Abstract	The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of expression are maintained, and its protein levels are not completely silenced until the B cell becomes fully differentiated into a plasma cell or a memory B cell. MYC has been described as a proto-oncogene that is closely involved in many cancers, including leukemia and lymphoma. Aberrant expression of MYC protein in these hematological malignancies results in an uncontrolled rate of proliferation and, thereby, a blockade of the differentiation process. MYC is not activated by mutations in the coding sequence, and, as reviewed here, its overexpression in leukemia and lymphoma is mainly caused by gene amplification, chromosomal translocations, and aberrant regulation of its transcription. This review provides a thorough overview of the role of MYC in the developmental steps of B cells, and of how it performs its essential function in an oncogenic context, highlighting the importance of appropriate MYC regulation circuitry.
Keywords	myc ; b cell development ; leukemia ; lymphoma ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epigenetic events during B lymphocyte development.

Parra, Maribel

Epigenetics

2010 Volume 4, Issue 7, Page(s) 462–468

Abstract: The generation of B cells is the result of several cell lineage choices, cell commitment and differentiation. These cellular transitions take place in a stepwise manner and are regulated at the transcriptional level. In recent years, investigators ... ...

Abstract	The generation of B cells is the result of several cell lineage choices, cell commitment and differentiation. These cellular transitions take place in a stepwise manner and are regulated at the transcriptional level. In recent years, investigators working in this field have made significant advances towards understanding the contribution of transcription factors during B lymphopoiesis.They have established the existence of transcription factor networks that are essential for the proper establishment and maintenance of the B cell lineage. As is the case for other developmental processes, emerging evidence demonstrates that B cell development is also regulated at the epigenetic level and that such regulation may act in concert with transcription factors. The aim of this review is to summarize the current knowledge concerning the epigenetic events that contribute toB lymphopoiesis.
MeSH term(s)	Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Lineage ; Epigenesis, Genetic ; Humans ; Lymphopoiesis ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors
Language	English
Publishing date	2010-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.4161/epi.4.7.10052
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence of air pollution exposure on adolescents' objectively-measured physical activity and sedentary behavior.

Viciana, Jesús / Mayorga-Vega, Daniel / Parra-Saldías, Maribel

Ciencia & saude coletiva

2019 Volume 24, Issue 7, Page(s) 2649–2658

Abstract: Although regular physical activity is recommended for health, highly contaminated air exposure acts to the detriment of the benefits produced in individuals. The purpose of the present study was to compare the accelerometer-measured physical activity and ...

Abstract	Although regular physical activity is recommended for health, highly contaminated air exposure acts to the detriment of the benefits produced in individuals. The purpose of the present study was to compare the accelerometer-measured physical activity and sedentary behavior during the whole day, in-school time, out-of-school time, and school breaks between highly contaminated air days and non-highly contaminated air days in Chilean adolescents. Nineteen adolescents from Santiago of Chile were assessed by a GT3X accelerometer. The vertical axis and steps per minute for the whole day, and both of these variables together with the percentage of time of moderate-to-vigorous physical activity level in the out-of-school time period were higher in highly contaminated air days than in non-highly contaminated air days (p < 0.05; with effect sizes from r = 0.36 to r = 0.46). Results for sedentary behavior were similar in both conditions for every period of time analyzed. These results allow us to conclude the lack of awareness of the participants in this research regarding the health repercussions in relation to the physical activity performed during air pollution exposure. Some strategies in order to improve the Chilean adolescents' physical activity and sedentary behavior are suggested and discussed.
MeSH term(s)	Accelerometry ; Adolescent ; Air Pollution/statistics & numerical data ; Child ; Chile ; Exercise/physiology ; Female ; Humans ; Male ; Schools/statistics & numerical data ; Sedentary Behavior ; Time Factors
Language	English
Publishing date	2019-07-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1413-8123
ISSN (online)	1678-4561
ISSN	1413-8123
DOI	10.1590/1413-81232018247.15662017
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