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Article: Kwon, Jeong-Im: Hegels Bestimmung der Kunst, die Bedeutung der "symbolischen Kunstform" in Hegels Ästhetik : München, Fink, 2001 / [rezensiert von:] Egbert Witte

Witte, Egbert / Kwŏn, Jeong-Im

Hegel-Studien Bd. 37. 2002 ,S. 327-330

2004

Language	German
Publisher	Meiner
Publishing place	Hamburg
Document type	Article
ZDB-ID	2416-8
Database	Former special subject collection: coastal and deep sea fishing

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Article: Role of epithelial splicing regulatory protein 1 in cancer progression.

Kwon, Mi Jeong

Cancer cell international

2023 Volume 23, Issue 1, Page(s) 331

Abstract: As aberrant alternative splicing by either dysregulation or mutations of splicing factors contributes to cancer initiation and progression, splicing factors are emerging as potential therapeutic targets for cancer therapy. Therefore, pharmacological ... ...

Abstract	As aberrant alternative splicing by either dysregulation or mutations of splicing factors contributes to cancer initiation and progression, splicing factors are emerging as potential therapeutic targets for cancer therapy. Therefore, pharmacological modulators targeting splicing factors have been under development. Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific splicing factor, whose downregulation is associated with epithelial-mesenchymal transition (EMT) by regulating alternative splicing of multiple genes, such as CD44, CTNND1, ENAH, and FGFR2. Consistent with the downregulation of ESRP1 during EMT, it has been initially revealed that high ESRP1 expression is associated with favorable prognosis and ESRP1 plays a tumor-suppressive role in cancer progression. However, ESRP1 has been found to promote cancer progression in some cancers, such as breast and ovarian cancers, indicating that it plays a dual role in cancer progression depending on the type of cancer. Furthermore, recent studies have reported that ESRP1 affects tumor growth by regulating the metabolism of tumor cells or immune cell infiltration in the tumor microenvironment, suggesting the novel roles of ESRP1 in addition to EMT. ESRP1 expression was also associated with response to anticancer drugs. This review describes current understanding of the roles and mechanisms of ESRP1 in cancer progression, and further discusses the emerging novel roles of ESRP1 in cancer and recent attempts to target splicing factors for cancer therapy.
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-03180-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Matrix metalloproteinases as therapeutic targets in breast cancer.

Kwon, Mi Jeong

Frontiers in oncology

2023 Volume 12, Page(s) 1108695

Abstract: Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in tumorigenesis. They were initially recognized to promote tumor progression by remodeling the extracellular matrix through their proteolytic activity. However, accumulating ... ...

Abstract	Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in tumorigenesis. They were initially recognized to promote tumor progression by remodeling the extracellular matrix through their proteolytic activity. However, accumulating evidence has revealed that some MMPs have protective roles in cancer progression, and the same MMP can exert opposing roles depending on the cell type in which it is expressed or the stage of cancer. Moreover, studies have shown that MMPs are involved in cancer progression through their roles in other biological processes such as cell signaling and immune regulation, independent of their catalytic activity. Despite the prognostic significance of tumoral or stromal expression of MMPs in breast cancer, their roles and molecular mechanisms in breast cancer progression remain unclear. As the failures of early clinical trials with broad-spectrum MMP inhibitors were mainly due to a lack of drug specificity, substantial efforts have been made to develop highly selective MMP inhibitors. Some recently developed MMP inhibitory monoclonal antibodies demonstrated promising anti-tumor effects in preclinical models of breast cancer. Importantly, anti-tumor effects of these antibodies were associated with the modulation of tumor immune microenvironment, suggesting that the use of MMP inhibitors in combination with immunotherapy can improve the efficacy of immunotherapy in HER2-positive or triple-negative breast cancer. In this review, the current understanding of the roles of tumoral or stromal MMPs in breast cancer is summarized, and recent advances in the development of highly selective MMP inhibitors are discussed.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1108695
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Article ; Online: Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer.

Kwon, Mi Jeong

Archives of pharmacal research

2022 Volume 45, Issue 9, Page(s) 597–617

Abstract: Globally, breast cancer is the most common malignancy in women. Substantial efforts have been made to develop novel therapies, including targeted therapies and immunotherapies, for patients with breast cancer who do not respond to standard therapies. ... ...

Abstract	Globally, breast cancer is the most common malignancy in women. Substantial efforts have been made to develop novel therapies, including targeted therapies and immunotherapies, for patients with breast cancer who do not respond to standard therapies. Consequently, new targeted therapies, such as cyclin-dependent kinase 4 and 6 inhibitors, poly (ADP-ribose) polymerase inhibitors, phosphoinositide 3-kinase inhibitor, and antibody-drug conjugates targeting human epidermal growth factor receptor 2 or trophoblast cell surface antigen-2, and immune checkpoint inhibitor targeting programmed cell death-1, have been developed and are now in clinical use. However, only some patients have benefited from these novel therapies; therefore, the identification and validation of reliable or more accurate biomarkers for predicting responses to these agents remain a major challenge. This review summarizes the currently available predictive biomarkers for breast cancer and describes recent efforts undertaken to identify potential predictive markers for molecularly targeted therapies and immune checkpoint inhibitors.
MeSH term(s)	Breast Neoplasms/drug therapy ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Female ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunoconjugates/therapeutic use ; Immunotherapy ; Molecular Targeted Therapy ; Phosphatidylinositol 3-Kinases ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use
Chemical Substances	Immune Checkpoint Inhibitors ; Immunoconjugates ; Poly(ADP-ribose) Polymerase Inhibitors ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22)
Language	English
Publishing date	2022-08-18
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-022-01402-5
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Article ; Online: Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer

Kwon, Mi Jeong

Arch. Pharm. Res.. 2022 Sept., v. 45, no. 9 p.597-617

2022

Abstract	Globally, breast cancer is the most common malignancy in women. Substantial efforts have been made to develop novel therapies, including targeted therapies and immunotherapies, for patients with breast cancer who do not respond to standard therapies. Consequently, new targeted therapies, such as cyclin-dependent kinase 4 and 6 inhibitors, poly (ADP-ribose) polymerase inhibitors, phosphoinositide 3-kinase inhibitor, and antibody–drug conjugates targeting human epidermal growth factor receptor 2 or trophoblast cell surface antigen-2, and immune checkpoint inhibitor targeting programmed cell death-1, have been developed and are now in clinical use. However, only some patients have benefited from these novel therapies; therefore, the identification and validation of reliable or more accurate biomarkers for predicting responses to these agents remain a major challenge. This review summarizes the currently available predictive biomarkers for breast cancer and describes recent efforts undertaken to identify potential predictive markers for molecularly targeted therapies and immune checkpoint inhibitors.
Keywords	biomarkers ; breast neoplasms ; cyclin-dependent kinase ; erbB-2 receptor ; phosphatidylinositol 3-kinase ; trophoblast
Language	English
Dates of publication	2022-09
Size	p. 597-617.
Publishing place	Pharmaceutical Society of Korea
Document type	Article ; Online
Note	Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-022-01402-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bifenthrin Diminishes Male Fertility Potential by Inducing Protein Defects in Mouse Sperm.

Bae, Jeong-Won / Hwang, Ju-Mi / Yoon, Minjung / Kwon, Woo-Sung

Toxics

2024 Volume 12, Issue 1

Abstract: A synthetic pyrethroid pesticide, bifenthrin, has been commonly used as an effective exterminator, although the rise in its usage has raised concerns regarding its effects on the environment and public health, including reproduction, globally. The ... ...

Abstract	A synthetic pyrethroid pesticide, bifenthrin, has been commonly used as an effective exterminator, although the rise in its usage has raised concerns regarding its effects on the environment and public health, including reproduction, globally. The current study investigated the function-related molecular disparities and mechanisms in bifenthrin-exposed sperm cells and the underlying mechanism. Therefore, epididymal spermatozoa were released, and various concentrations of bifenthrin were treated (0.1, 1, 10, and 100 μM) to evaluate their effects on sperm. The findings showed that although bifenthrin had no effect on sperm viability, various other sperm functions (e.g., motility, spontaneous acrosome reaction, and capacitation) related to male fertility were decreased, commencing at a 1 µM treatment. Molecular studies revealed nine differentially expressed sperm proteins that were implicated in motile cilium assembly, sperm structure, and metabolic processes. Furthermore, bifenthrin affected sperm functions through abnormal diminution of the expression of specific sperm proteins. Collectively, these findings provide greater insights into how bifenthrin affects male fertility at the molecular level.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12010053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation.

Hwang, Ju-Mi / Bae, Jeong-Won / Lee, Woo-Jin / Kwon, Woo-Sung

Reproductive toxicology (Elmsford, N.Y.)

2024 Volume 124, Page(s) 108545

Abstract: 4-Nonylphenol (4-NP) is an endocrine-disrupting chemical that impairs animal and human reproduction. However, the mechanisms underlying male reproductive dysfunction by 4-NP have not been fully understood. Herein, we demonstrated the effects of 4-NP on ... ...

Abstract	4-Nonylphenol (4-NP) is an endocrine-disrupting chemical that impairs animal and human reproduction. However, the mechanisms underlying male reproductive dysfunction by 4-NP have not been fully understood. Herein, we demonstrated the effects of 4-NP on boar sperm functions and molecular mechanisms. Spermatozoa were treated with various concentrations of 4-NP (0, 10, 25, 50, 75, and 100 μM) during capacitation. Then, we evaluated sperm motility, capacitation status, intracellular ATP level, and cell viability. Finally, we measured the expression of phosphorylated protein kinase A (PKA), tyrosine phosphorylation, and proteins related to the phosphatidylinositol 3 kinase (PI3K)/phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (AKT) signaling pathways following exposure to 4-NP. Sperm motility and motion kinematics were reduced by 4-NP, whereas intracellular ATP levels were increased significantly in a dose-dependent manner. Furthermore, the expression levels of p-PI3K, PTEN, p-PDK1, AKT, and p-AKT exhibited a significant dose-dependent increase. Moreover, abnormal activation of PKA and tyrosine phosphorylation were observed. Specifically, the ∼24 kDa p-PKA substrate demonstrated a significant reduction following exposure to 4-Np. In addition, the ∼18 kDa p-PKA substrate and tyrosine-phosphorylated proteins displayed a significant dose-dependent increase after exposure to 4-NP. Our results suggest that 4-NP may induce detrimental effects on sperm functions through abnormal changes in PKA activity and tyrosine phosphorylation during capacitation, possibly through unusual alteration of the PI3K/PDK1/AKT signaling pathway. Therefore, 4-NP must be cautiously used considering its reproductive toxicity.
MeSH term(s)	Male ; Humans ; Swine ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinase/pharmacology ; Semen/metabolism ; Sperm Motility ; Signal Transduction ; Spermatozoa ; Phosphorylation ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Tyrosine/metabolism ; Adenosine Triphosphate/metabolism ; Sperm Capacitation ; Phenols
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; 4-nonylphenol (I03GBV4WEL) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Tyrosine (42HK56048U) ; Adenosine Triphosphate (8L70Q75FXE) ; Phenols
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2024.108545
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Article: Emerging immune gene signatures as prognostic or predictive biomarkers in breast cancer.

Kwon, Mi Jeong

Archives of pharmacal research

2019 Volume 42, Issue 11, Page(s) 947–961

Abstract: Several multigene assays have been developed to predict the risk of distant recurrence and response to adjuvant therapy in early breast cancer. However, the prognostic or predictive value of current proliferation gene signature-based assays are limited ... ...

Abstract	Several multigene assays have been developed to predict the risk of distant recurrence and response to adjuvant therapy in early breast cancer. However, the prognostic or predictive value of current proliferation gene signature-based assays are limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer. Considerable discordance between the different assays in classifying patients into risk groups has also been reported, thus raising questions about the clinical utility of these assays for individual patients. Therefore, there still remains a need for better prognostic or predictive biomarkers for breast cancer. The role of immune cells comprising tumor microenvironment in tumor progression has been recognized. Accumulating evidences have shown that immune gene signatures and tumor-infiltrating lymphocytes (TILs) can be prognostic or predictive factors in breast cancer, particularly with regard to HER2+ and triple-negative breast cancer. In this review, I summarize current multigene assays for breast cancer and discuss recent progress in identifying novel breast cancer biomarkers, focusing on the emerging importance of immune gene signatures and TILs as prognostic or predictive biomarkers.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/mortality ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant/methods ; Disease-Free Survival ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/immunology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Neoadjuvant Therapy/methods ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/immunology ; Prognosis ; Transcriptome/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2019-11-09
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/s12272-019-01189-y
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Article ; Online: Flavivirga spongiicola sp. nov. and Flavivirga abyssicola sp. nov., Isolated from Marine Environments.

Yang, Sung-Hyun / Park, Mi-Jeong / Oh, Hyun-Myung / Park, Yeong-Jun / Kwon, Kae Kyoung

Journal of microbiology (Seoul, Korea)

2024 Volume 62, Issue 1, Page(s) 11–19

Abstract: Two novel Gram-stain-negative, strictly-aerobic, rod-shaped (1.2 ± 3.4 μm × 0.3 ± 0.7 μm), and non-motile marine bacterial species, designated ... ...

Abstract	Two novel Gram-stain-negative, strictly-aerobic, rod-shaped (1.2 ± 3.4 μm × 0.3 ± 0.7 μm), and non-motile marine bacterial species, designated MEBiC05379
MeSH term(s)	RNA, Ribosomal, 16S/genetics ; DNA, Bacterial/genetics ; DNA, Bacterial/chemistry ; Sequence Analysis, DNA ; Flavobacteriaceae ; Fatty Acids/analysis ; Phylogeny ; Bacterial Typing Techniques ; Vitamin K 2/analysis
Chemical Substances	RNA, Ribosomal, 16S ; DNA, Bacterial ; Fatty Acids ; Vitamin K 2 (11032-49-8)
Language	English
Publishing date	2024-02-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-023-00102-z
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Article ; Online: Description of Fervidibacillus gen. nov. with Two Species, Fervidibacillus albus sp. nov., and Fervidibacillus halotolerans sp. nov., Isolated from Tidal Flat Sediments and Emendation of Misclassificed Taxa in the Genus Caldibacillus.

Yang, Sung-Hyun / Park, Mi-Jeong / Oh, Hyun-Myung / Kwon, Kae Kyoung

Journal of microbiology (Seoul, Korea)

2023 Volume 61, Issue 2, Page(s) 175–187

Abstract: Two Gram-stain-positive, motile, endospore-forming, facultatively anaerobic strains, designated ... ...

Abstract	Two Gram-stain-positive, motile, endospore-forming, facultatively anaerobic strains, designated MEBiC13591
MeSH term(s)	Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; DNA, Bacterial/chemistry ; Fatty Acids/analysis ; Bacterial Typing Techniques ; Vitamin K 2/analysis ; Phospholipids/analysis
Chemical Substances	RNA, Ribosomal, 16S ; DNA, Bacterial ; Fatty Acids ; Vitamin K 2 (11032-49-8) ; Phospholipids
Language	English
Publishing date	2023-02-17
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-023-00022-y
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