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Article ; Online: Epigenetic-related Effects of COVID-19 on Human Cells.

Faramarzi, Arezoo / Safaralizadeh, Reza / Dastmalchi, Narges / Teimourian, Shahram

2022 Volume 22, Issue 7, Page(s) 21–26

Abstract: Epigenetics is related to the various pathways that show long-term impacts on the gene expression patterns without alterations in nucleotide sequences. Over the last decade, epigenetics advanced significantly in the science of biology, oncology, innate ... ...

Abstract	Epigenetics is related to the various pathways that show long-term impacts on the gene expression patterns without alterations in nucleotide sequences. Over the last decade, epigenetics advanced significantly in the science of biology, oncology, innate immunity as well as pathogens and infectious diseases. In the present paper, we aimed to review the relationships between COVID-19 and epigenetic alterations of the infected cells. Coronavirus is one of the known infectious diseases that causes respiratory infection, such as pneumonia and coughing, while in animals, it causes diarrhea and upper respiratory disorders. This virus could be transmitted human to human or human to an animal through droplets. It translocates via membrane ACE-2 exopeptidase into the host cells. In conclusion, hypomethylation of angiotensin II converting enzyme (ACE II) possibly upregulates its expression, enhancing the possibility of SARS-CoV-2 infection.
Language	English
Publishing date	2022-04-22
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526522666220420093029
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Article ; Online: Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study.

Sanaie, Sarvin / Dolati, Sanam / Montazer, Majid / Ranjbari, Sarina / Fathalizadeh, Arezoo / Shadvar, Kamran / Faramarzi, Elnaz / Mahmoodpoor, Ata

Iranian journal of medical sciences

2023 Volume 48, Issue 5, Page(s) 465–473

Abstract: Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to ...

Abstract	Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to investigate the role of lipid profiles in determining the probability of organ dysfunction after surgery. Methods: This cross-sectional study included patients who underwent thoracoabdominal surgery and were admitted to the intensive care unit of Imam Reza Hospital in Tabriz, Iran, between October 2016 and September 2018. During the first two days of admission, blood samples were taken, and serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and albumin were measured. The relation between the changes in these laboratory markers and six organ functions including cardiovascular, respiratory, renal, central nervous system, hepatic, and hematologic, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use were investigated. The independent Results: The serum TC increased the risk of mortality (OR=1.09, 95%CI=1.06-1.11, P<0.001), renal dysfunction (OR=1.09, 95%CI=1.06-1.12; P<0.001), liver dysfunction (OR=1.07, 95%CI=1.03-1.10; P<0.001), respiratory dysfunction (OR=1.08, 95%CI=1.05-1.13; P<0.001). Moreover, LDL, HDL, and TG were found to be inversely related to mortality, organ dysfunction, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use. Conclusion: TC could be considered a risk factor for mortality, organ dysfunction, and clinical outcomes. On the other hand, LDL, HDL, and TG played a protective role in the patients' mortality, organ dysfunction, and clinical outcomes.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Multiple Organ Failure/epidemiology ; Multiple Organ Failure/etiology ; Triglycerides ; Cholesterol, HDL ; Cholesterol, LDL
Chemical Substances	Triglycerides ; Cholesterol, HDL ; Cholesterol, LDL
Language	English
Publishing date	2023-10-03
Publishing country	Iran
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603872-4
ISSN	1735-3688 ; 0253-0716
ISSN (online)	1735-3688
ISSN	0253-0716
DOI	10.30476/IJMS.2022.95364.2672
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Article: Leptin levels in patients with Parkinson's disease: A systematic review and meta-analysis

Rahnemayan, Sama / Mirghafourvand, Mojgan / Fathalizadeh, Arezoo / Faramarzi, Elnaz / Reyhanifard, Anita / Mahmoodpoor, Ata / Sanaie, Sarvin

European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2021 Feb., v. 41

2021

Abstract: The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this ... ...

Abstract	The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this mechanism; since it is not only causing inflammation, but it can also play other roles in the body that may contribute to the symptoms described for PD. Regarding the contradictions in the association of serum leptin levels with Parkinson's disease, a systematic review and meta-analysis was performed to have a more accurate estimation of this relationship.Published literature was obtained by searching PubMed, Embase, Cochrane Library, Scopus, Ovid, ProQuest and Google Scholar. Random-effect model analysis was used to calculate pooled standard mean difference (SMD) with 95% confidence interval (CI). Heterogeneity was tested with the heterogeneity statistic Q and quantified using I². Newcastle-Ottawa scale was used to assess the study quality.Six studies including a total number of 198 PD patients and 182 controls were finally included in the meta-analysis. Serum leptin levels in PD patients were non-significantly lower than those in control group (SMD = −0.40 ng/ml, 95% CI -2.33–1.53). Subgroup analyses revealed that serum leptin levels of PD patients and controls in either females or males didn't show any significant difference.This meta-analysis revealed that leptin level doesn't show any significant difference between PD patients and healthy controls, even when taking the participants' gender into consideration.
Keywords	Parkinson disease ; blood serum ; clinical nutrition ; confidence interval ; estimation ; females ; inflammation ; leptin ; literature ; males ; meta-analysis ; models ; patients ; systematic review
Language	English
Dates of publication	2021-02
Size	p. 104-109.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2405-4577
DOI	10.1016/j.clnesp.2020.11.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Leptin levels in patients with Parkinson's disease: A systematic review and meta-analysis.

Rahnemayan, Sama / Mirghafourvand, Mojgan / Fathalizadeh, Arezoo / Faramarzi, Elnaz / Reyhanifard, Anita / Mahmoodpoor, Ata / Sanaie, Sarvin

Clinical nutrition ESPEN

2020 Volume 41, Page(s) 104–109

Abstract: Background and aims: The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a ... ...

Abstract	Background and aims: The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this mechanism; since it is not only causing inflammation, but it can also play other roles in the body that may contribute to the symptoms described for PD. Regarding the contradictions in the association of serum leptin levels with Parkinson's disease, a systematic review and meta-analysis was performed to have a more accurate estimation of this relationship. Methods: Published literature was obtained by searching PubMed, Embase, Cochrane Library, Scopus, Ovid, ProQuest and Google Scholar. Random-effect model analysis was used to calculate pooled standard mean difference (SMD) with 95% confidence interval (CI). Heterogeneity was tested with the heterogeneity statistic Q and quantified using I Results: Six studies including a total number of 198 PD patients and 182 controls were finally included in the meta-analysis. Serum leptin levels in PD patients were non-significantly lower than those in control group (SMD = -0.40 ng/ml, 95% CI -2.33-1.53). Subgroup analyses revealed that serum leptin levels of PD patients and controls in either females or males didn't show any significant difference. Conclusions: This meta-analysis revealed that leptin level doesn't show any significant difference between PD patients and healthy controls, even when taking the participants' gender into consideration.
MeSH term(s)	Female ; Humans ; Inflammation ; Leptin ; Male ; Parkinson Disease
Chemical Substances	Leptin
Language	English
Publishing date	2020-11-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2020.11.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity.

Moghadam, Ebrahim S / Tehrani, Maryam H / Csuk, René / Fischer, Lucie / Faramarzi, Mohammad Ali / Rashidi, Arezoo / Javadi, Iraj / Amini, Mohsen

Anti-cancer agents in medicinal chemistry

2019 Volume 19, Issue 8, Page(s) 1048–1057

Abstract: Background: During last recent years number of anti-tubulin agents were introduced for treatment of diverse kind of cancer. Despite of their potential in treatment of cancer, drug resistance and adverse toxicity such as peripheral neuropathy are some of ...

Abstract	Background: During last recent years number of anti-tubulin agents were introduced for treatment of diverse kind of cancer. Despite of their potential in treatment of cancer, drug resistance and adverse toxicity such as peripheral neuropathy are some of the negative criteria of anti-tubulin agents. Methods: Twenty seven quinazoline derivatives were synthesized using a multicomponent reaction. The cytotoxicity of compounds 1-27 was tested in SRB assays employing five different human tumor cell lines. Effect of two of active compounds on tubulin polymerization was also checked using a commercially available assay kit. Molecular modelling studies were also performed using autodock tools software. Results: SRB assays showed that compounds 2, 9, 16 and 26, being highly cytotoxic with IC50 values ranging between 2.1 and 14.3µM. The possible mode of action of compounds, 2, 9, 16 and 26, and the taxol binding site of the protein tubulin, an important goal for antimitotic drugs, was also studied by molecular docking, which showed reasonable interactions with tubulin active site, followed by investigation of the effects of compounds 9 and 16 on the polymerization of tubulin. The results showed the tested compounds to be highly active as inducers of tubulin polymerization. Conclusion: Altogether, with respect to obtained results, it is attractive and beneficial to further investigation on quinazoline scaffold as antimitotic agents.
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Binding Sites/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; NIH 3T3 Cells ; Paclitaxel/chemistry ; Paclitaxel/pharmacology ; Polymerization/drug effects ; Quinazolines/chemical synthesis ; Quinazolines/chemistry ; Quinazolines/pharmacology ; Structure-Activity Relationship ; Tubulin/metabolism
Chemical Substances	Antineoplastic Agents ; Quinazolines ; Tubulin ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-03-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520619666190314125254
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Article ; Online: Cumulus co-culture system does not improve the in-vitro maturation (IVM) of oocytes in mice

Tahereh Rahiminia / Azita Faramarzi / Arezoo Khoradmehr / Mohammad Ali Khalili

Middle East Fertility Society Journal, Vol 21, Iss 2, Pp 109-

2016 Volume 113

Abstract: Objective: To examine the effect of co-culture system with CCs on the in vitro maturation (IVM) of immature oocytes retrieved from mice. Design: This is an experimental study. Setting: Research and Clinical Center for Infertility of Yazd. Sample: A total ...

Abstract	Objective: To examine the effect of co-culture system with CCs on the in vitro maturation (IVM) of immature oocytes retrieved from mice. Design: This is an experimental study. Setting: Research and Clinical Center for Infertility of Yazd. Sample: A total of 144 oocytes from 5 to 6 weeks mice. Material: After dissecting ovaries, denuded GVs (DGVs) were considered as control group and put in IVM medium. In cumulus oocyte complexes (COCs) as exp I, intact COCs were put in IVM medium and observed for maturation after 24 h and 48 h. In exp II, GVs were co-cultured with mature CCs. For exp II, COCs were incubated for 30 min before removing oocytes. Then, denuded mature oocytes were removed and the remaining CCs were used to culture denuded GVs recovered from ovaries. Main outcome measures: Maturation rates of oocytes after 24 h and 48 h. Results: The rate of oocyte maturation was 77.36 ± 14.4 in control group. In exp I and exp II, the rates of maturation were 91.32 ± 22.5 and 63.33 ± 7.4, respectively (P = 0.04). However, maturation rate did not increase after 24 h. The maturation rate in metaphase I (MI) oocytes was as low as 15% in different groups at 24 h and did not increase by 48 h. Degeneration rate was increased from time 0 to 48 h, but not significant in different times. Conclusion: Presence of intact COCs significantly improved the oocyte maturation rates in animal model. However, co-culture of GVs with mature CCs did not improve IVM program in mice.
Keywords	In vitro maturation ; Cumulus cells ; Mice ; Medicine (General) ; R5-920 ; Reproduction ; QH471-489
Subject code	570
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vitrification of mouse MII oocytes: Developmental competency using paclitaxel.

Fesahat, Farzaneh / Faramarzi, Azita / Khoradmehr, Arezoo / Omidi, Marjan / Anbari, Fatemeh / Khalili, Mohammad Ali

Taiwanese journal of obstetrics & gynecology

2016 Volume 55, Issue 6, Page(s) 796–800

Abstract: Objective: Oocyte cryopreservation provides an important alternative for fertility preservation for women who will be treated with cytotoxic drugs. However, it can cause spindle disorganization of microtubules, putting the zygote at risk for aneuploidy. ...

Abstract	Objective: Oocyte cryopreservation provides an important alternative for fertility preservation for women who will be treated with cytotoxic drugs. However, it can cause spindle disorganization of microtubules, putting the zygote at risk for aneuploidy. Paclitaxel is known to stabilize the microtubules that constitute the spindle. The aim of this study was to investigate the suitable concentration of paclitaxel for adding to the vitrification media to improve the developmental potential of post-thawed mature oocytes to blastocyst formation in mice. Materials and methods: A total of 300 MII oocytes were retrieved from superovulated mice, and were divided into three groups of control, Experimental I, and Experimental II. Oocytes in Experimental I and Experimental II were cryopreserved in the presence of 0.5μM or 1μM of paclitaxel in vitrification media, respectively. After thawing, all oocytes were incubated in G-IVF medium for 1 hour. From each group,12 oocytes were selected for viability evaluation by Hoechst/propidium iodide nuclear staining. Standard in vitro fertilization was performed on the rest of the oocytes and embryo development was followed to the blastocyst stage. Results: Fertilization rate was not significantly different between the three groups. However, the cleavage rate (55%) in Experimental II group was significantly lower compared to Experimental I (88%) and control groups (83%). There was a detectable difference between the three groups at the blastocyst rate (Experimental I and control groups, p = 0.004; Experimental II vs. control and Experimental I, p < 0.001). The highest rates of parthenogenesis and arrest were in Experimental II (16% and 21%, respectively) compared with control (6% and 5%, respectively) and Experimental I (5% and 3%, respectively). There was also a significant decrease in viability rate of oocytes in Experimental II compared to the other groups. Conclusion: A high concentration of paclitaxel, an anticancer drug, interrupted the mouse oocyte competency when supplemented to vitrification media. Consequently, the optimal concentration of this cytoskeleton stabilizer may improve the post-thawed developmental abilities of oocytes.
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/pharmacology ; Blastocyst/drug effects ; Cell Survival/drug effects ; Chi-Square Distribution ; Cryopreservation ; Embryonic Development/drug effects ; Female ; Fertilization in Vitro ; Humans ; Male ; Mice ; Oocyte Retrieval ; Oocytes/drug effects ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacology ; Random Allocation
Chemical Substances	Antineoplastic Agents, Phytogenic ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2016-12
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ISSN	1875-6263
ISSN (online)	1875-6263
DOI	10.1016/j.tjog.2016.05.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epigenetic-related Effects of COVID-19 on Human Cells.

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Article ; Online: Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study.

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Article: Leptin levels in patients with Parkinson's disease: A systematic review and meta-analysis

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Article ; Online: Leptin levels in patients with Parkinson's disease: A systematic review and meta-analysis.

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Article ; Online: 2,4-Disubstituted Quinazoline Derivatives Act as Inducers of Tubulin Polymerization: Synthesis and Cytotoxicity.

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Article ; Online: Cumulus co-culture system does not improve the in-vitro maturation (IVM) of oocytes in mice

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Article ; Online: Vitrification of mouse MII oocytes: Developmental competency using paclitaxel.

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