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  1. Book ; Online ; E-Book: Encyclopedia of reproduction

    Skinner, Michael K.

    2018  

    Author's details Michael K. Skinner
    Keywords Reproduction
    Language English
    Size 1 Online-Ressource (3911 Seiten, 6 Bände)
    Edition Second edition
    Publisher Elsevier Science & Technology
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019768839
    ISBN 978-0-12-815145-7 ; 9780128118993 ; 0-12-815145-5 ; 0128118997
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Environmental Epigenetics

    Skinner, Michael K

    Environmental epigenetics

    2024  Volume 10, Issue 1, Page(s) dvae004

    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvae004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetic biomarkers for disease susceptibility and preventative medicine.

    Skinner, Michael K

    Cell metabolism

    2024  Volume 36, Issue 2, Page(s) 263–277

    Abstract: The development of molecular biomarkers for disease makes it possible for preventative medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical management can be used to delay or prevent disease development. The problem with ...

    Abstract The development of molecular biomarkers for disease makes it possible for preventative medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical management can be used to delay or prevent disease development. The problem with genetic mutations as biomarkers is the low frequency with genome-wide association studies (GWASs), generally at best a 1% association of the patients with the disease. In contrast, epigenetic alterations have a high-frequency association of greater than 90%-95% of individuals with pathology in epigenome-wide association studies (EWASs). A wide variety of human diseases have been shown to have epigenetic biomarkers that are disease specific and that detect pathology susceptibility. This review is focused on the epigenetic biomarkers for disease susceptibility, and it distinct from the large literature on epigenetics of disease etiology or progression. The development of efficient epigenetic biomarkers for disease susceptibility will facilitate a paradigm shift from reactionary medicine to preventative medicine.
    MeSH term(s) Humans ; DNA Methylation ; Genome-Wide Association Study ; Disease Susceptibility ; Epigenesis, Genetic ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Environmental Epigenetics 2023 update.

    Skinner, Michael K

    Environmental epigenetics

    2023  Volume 9, Issue 1, Page(s) dvad004

    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvad004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Environmental Epigenetics 2022 update.

    Skinner, Michael K

    Environmental epigenetics

    2022  Volume 8, Issue 1, Page(s) dvac008

    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvac008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Environmental epigenetics and climate change.

    Skinner, Michael K

    Environmental epigenetics

    2022  Volume 9, Issue 1, Page(s) dvac028

    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvac028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Environmental Epigenetics

    Skinner, Michael K

    Environmental epigenetics

    2021  Volume 7, Issue 1, Page(s) dvab001

    Language English
    Publishing date 2021-04-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvab001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man?

    Caroppo, Ettore / Skinner, Michael K

    Human reproduction (Oxford, England)

    2023  Volume 39, Issue 3, Page(s) 478–485

    Abstract: Although male infertility is currently diagnosed when abnormal sperm parameters are found, the poor predictive ability of sperm parameters on natural fecundity and medically assisted reproduction outcome poses the need for improved diagnostic techniques ... ...

    Abstract Although male infertility is currently diagnosed when abnormal sperm parameters are found, the poor predictive ability of sperm parameters on natural fecundity and medically assisted reproduction outcome poses the need for improved diagnostic techniques for male infertility. The accumulating evidence about the role played by the sperm epigenome in modulation of the early phases of embryonic development has led researchers to focus on the epigenetic mechanisms within the sperm epigenome to find new molecular markers of male infertility. Indeed, sperm epigenome abnormalities could explain some cases of unexplained male infertility in men showing normal sperm parameters and were found to be associated with poor embryo development in IVF cycles. The present mini-review summarizes the current knowledge about this interesting topic, starting from a description of the epigenetic mechanisms of gene expression regulation (i.e. DNA methylation, histone modifications, and non-coding RNAs' activity). We also discuss possible mechanisms by which environmental factors might cause epigenetic changes in the human germline and affect embryonic development, as well as subsequent generations' phenotypes. Studies demonstrating sperm epigenome abnormalities in men with male infertility are reviewed, with particular emphasis on those with the more severe form of spermatogenic dysfunction. Observations demonstrate that the diagnostic and prognostic efficacy of sperm epigenome evaluation will help facilitate the management of men with male factor infertility.
    MeSH term(s) Humans ; Male ; Epigenesis, Genetic ; Epigenome ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Semen ; Spermatozoa
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dead266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2892: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  9. Article ; Online: Environmental Epigenetics Update and Boards.

    Skinner, Michael K

    Environmental epigenetics

    2019  Volume 5, Issue 1, Page(s) dvz006

    Language English
    Publishing date 2019-05-14
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvz006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Environmental Epigenetics

    Skinner, Michael K

    Environmental epigenetics

    2018  Volume 4, Issue 1, Page(s) dvy009

    Language English
    Publishing date 2018-04-19
    Publishing country England
    Document type Editorial
    ZDB-ID 2831217-X
    ISSN 2058-5888 ; 2058-5888
    ISSN (online) 2058-5888
    ISSN 2058-5888
    DOI 10.1093/eep/dvy009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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