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Article ; Online: Unfinished business.

Crews, David

Journal of experimental zoology. Part A, Ecological and integrative physiology

2021 Volume 337, Issue 1, Page(s) 99–102

Abstract: At the time of my retirement there were two topics that I considered unfinished business. The first is the Evolution of Sex Differences and the second, the she-male controversy in the Canadian red-sided snake (Thamnophis sirtalis parietalis). These ... ...

Abstract	At the time of my retirement there were two topics that I considered unfinished business. The first is the Evolution of Sex Differences and the second, the she-male controversy in the Canadian red-sided snake (Thamnophis sirtalis parietalis). These questions are developed in this perspective.
MeSH term(s)	Animals ; Canada ; Colubridae ; Female ; Male ; Sex Characteristics
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1474896-4
ISSN	2471-5646 ; 1932-5223 ; 2471-5646 ; 1932-5231 ; 1552-499X
ISSN (online)	2471-5646 ; 1932-5223
ISSN	2471-5646 ; 1932-5231 ; 1552-499X
DOI	10.1002/jez.2543
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PROTAC targeted protein degraders: the past is prologue.

Békés, Miklós / Langley, David R / Crews, Craig M

Nature reviews. Drug discovery

2022 Volume 21, Issue 3, Page(s) 181–200

Abstract: Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept of ... ...

Abstract	Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept of a proteolysis-targeting chimera (PROTAC) molecule harnessing the ubiquitin-proteasome system to degrade a target protein was reported, TPD has moved from academia to industry, where numerous companies have disclosed programmes in preclinical and early clinical development. With clinical proof-of-concept for PROTAC molecules against two well-established cancer targets provided in 2020, the field is poised to pursue targets that were previously considered 'undruggable'. In this Review, we summarize the first two decades of PROTAC discovery and assess the current landscape, with a focus on industry activity. We then discuss key areas for the future of TPD, including establishing the target classes for which TPD is most suitable, expanding the use of ubiquitin ligases to enable precision medicine and extending the modality beyond oncology.
MeSH term(s)	Humans ; Proteasome Endopeptidase Complex/metabolism ; Proteins/metabolism ; Proteolysis
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Proteins
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2062954-0
ISSN	1474-1784 ; 1474-1776
ISSN (online)	1474-1784
ISSN	1474-1776
DOI	10.1038/s41573-021-00371-6
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Zs.A 5564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Journal of Experimental Zoology Part A: Ecological Genetics and Physiology. Editorial.

Crews, David

Journal of experimental zoology. Part A, Ecological genetics and physiology

2014 Volume 321, Issue 5, Page(s) 241–242

MeSH term(s)	Ecology ; Genetic Research ; Periodicals as Topic ; Physiology ; Zoology
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Editorial
ZDB-ID	2099021-2
ISSN	1932-5231 ; 1552-499X ; 2471-5638 ; 0022-104X ; 1932-5223 ; 1548-8969
ISSN (online)	1932-5231 ; 1552-499X
ISSN	2471-5638 ; 0022-104X ; 1932-5223 ; 1548-8969
DOI	10.1002/jez.1857
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Article ; Online: Evolutionary insights into sexual behavior from whiptail lizards.

O'Connell, Lauren A / Crews, David

Journal of experimental zoology. Part A, Ecological and integrative physiology

2021 Volume 337, Issue 1, Page(s) 88–98

Abstract: ... In this review, we celebrate the over 40-year career of David Crews, beginning with the story of how ...

Abstract	Is the brain bipotential or is sex-typical behavior determined during development? Thirty years of research in whiptail lizards transformed the field of behavioral neuroscience to show the brain is indeed bipotential, producing behaviors along a spectrum of male-typical and female-typical behavior via a parliamentary system of neural networks and not a predetermined program of constrained behavioral output. The unusual clade of whiptail lizards gave these insights as there are several parthenogenetic all-female species that display both male-typical and female-typical sexual behavior. These descendant species exist alongside their ancestors, allowing a unique perspective into how brain-behavior relationships evolve. In this review, we celebrate the over 40-year career of David Crews, beginning with the story of how he established whiptails as a model system through serendipitous behavioral observations and ending with advice to young scientists formulating their own questions. In between these personal notes, we discuss the discoveries that integrated hormones, neural activity, and gene expression to provide transformative insights into how brains function and reshaped our understanding of sexuality.
MeSH term(s)	Animals ; Biological Evolution ; Brain ; Female ; Lizards ; Male ; Parthenogenesis ; Sexual Behavior, Animal
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1474896-4
ISSN	2471-5646 ; 1932-5223 ; 2471-5646 ; 1932-5231 ; 1552-499X
ISSN (online)	2471-5646 ; 1932-5223
ISSN	2471-5646 ; 1932-5231 ; 1552-499X
DOI	10.1002/jez.2467
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Closing the Water Balance with a Precision Small-Scale Field Lysimeter.

Lyles, Brad F / Sion, Brad D / Page, David / Crews, Jackson B / McDonald, Eric V / Hausner, Mark B

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 7

Abstract: We developed a set of two precision, small-scale, water balance lysimeters to provide accurate measurements of bare soil evaporation. Each lysimeter comprises a soil tank, a balance assembly with load cell, a wicking drainage system, and a stilling well ... ...

Abstract	We developed a set of two precision, small-scale, water balance lysimeters to provide accurate measurements of bare soil evaporation. Each lysimeter comprises a soil tank, a balance assembly with load cell, a wicking drainage system, and a stilling well to measure drained water. Fiberglass wicks installed at the bottom of the soil tanks provide -60 cm of tension to the base of the soil column, and soil water drainage is quantified to close the water balance within the lysimeter. The calibrated lysimeters return mass changes with uncertainties ranging from 3 to 8 g, corresponding to uncertainties of 0.02-0.05 mm of water. Installed at a semi-arid site in northern Nevada, the two lysimeters are filled with uniform construction sand and silt loam. Over a six-month pilot observation period, bare soil evaporation rates of 0.19 and 0.40 mm/day were measured for the construction sand and silt loam, respectively, which is consistent with meteorological data and models of potential evapotranspiration at the site. The design of the lysimeter can be adapted to specific research goals or site restrictions, and these instruments can contribute significantly to our ability to close the soil water balance.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24072039
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Article ; Online: Binary outputs from unitary networks.

Crews, David

Integrative and comparative biology

2013 Volume 53, Issue 6, Page(s) 888–894

Abstract: When considering sex ratios, we have to first define the nature of the question. Are we referring to the gonads, secondary and accessory sex structures, physiology, brain, behavior, or to all of the above elements. If these elements are not concordant, ... ...

Abstract	When considering sex ratios, we have to first define the nature of the question. Are we referring to the gonads, secondary and accessory sex structures, physiology, brain, behavior, or to all of the above elements. If these elements are not concordant, the exceptions can prove illustrative of underlying processes at both the proximate and ultimate levels. At each of these levels, "sex" is the binary outcome resulting from the modulation of conserved networks of genes, proteins, cells, organs, and, in the case of the brain, discrete nuclei. These networks operate at multiple and sequential levels that usually are linear during the lifespan, but in some instances reversals are possible. For example, the gonads arise from a single "anlagen" and, in most instances, ovaries or testes result, although ovotestes are the norm in some species and gonadal reversal a property of other species. Other sexually dimorphic structures differentiate from multiple "anlaga" by reciprocal and sex-specific atrophy/hypertrophy, typically in an exaggerated manner, although the capacity to develop structures characteristic of the opposite gonadal sex remains inherent and intact. A perspective that integrates these different properties are presented here.
MeSH term(s)	Animals ; Biological Evolution ; Brain/growth & development ; Female ; Gonads/growth & development ; Male ; Models, Biological ; Nerve Net ; Sex Characteristics ; Sex Determination Processes/genetics ; Sex Determination Processes/physiology ; Sex Ratio ; Sexual Behavior, Animal/physiology
Language	English
Publishing date	2013-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2159110-6
ISSN	1557-7023 ; 1540-7063
ISSN (online)	1557-7023
ISSN	1540-7063
DOI	10.1093/icb/ict010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The (bi)sexual brain. Science & Society Series on Sex and Science.

Crews, David

EMBO reports

2012 Volume 13, Issue 9, Page(s) 779–784

MeSH term(s)	Animals ; Biological Evolution ; Brain/physiology ; Humans ; Sex ; Sexual Behavior ; Sexual Behavior, Animal ; Sexual Development
Language	English
Publishing date	2012-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.1038/embor.2012.107
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 41: Show issues

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Book: Psychobiology of reproductive behavior

Crews, David

an evolutionary perspective

1987

Author's details	David Crews, ed
Keywords	Sex Behavior ; Sex Behavior, Animal ; Reproduction ; Wirbeltiere ; Fortpflanzungsverhalten ; Evolution ; Sexualverhalten ; Tiere ; Psychobiologie
Subject	Biologische Psychologie ; Fauna ; Tier ; Tierwelt ; Animals ; Sexualität ; Paarungsvorspiel ; Paarungsverhalten ; Abstammung ; Vertebrata ; Vertebraten
Size	XII, 350 S. : Ill., graph. Darst.
Edition	2. [Dr.]
Publisher	Prentice-Hall
Publishing place	Englewood Cliffs, NJ
Publishing country	United States
Document type	Book
HBZ-ID	HT003345702
ISBN	0-13-732090-6 ; 978-0-13-732090-5
Database	Catalogue ZB MED Medicine, Health

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1989 A 3488	order for loan	Magazin

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Article ; Online: Males With Traumatic Lower Limb Loss Differ in Body Fat Distribution Compared to Those Without Limb Loss.

Spain, David R / Andrews, Anne M / Crews, Sara A / Khan, Joetta M

Military medicine

2021 Volume 188, Issue 1-2, Page(s) e140–e144

Abstract: Objectives: The primary objective was to examine body fat composition in males with traumatic lower limb loss and a comparison group without limb loss. A secondary objective was to determine if there are differences in body fat composition by traumatic ... ...

Abstract	Objectives: The primary objective was to examine body fat composition in males with traumatic lower limb loss and a comparison group without limb loss. A secondary objective was to determine if there are differences in body fat composition by traumatic limb loss level. Research methods and procedures: Cross-sectional analyses of baseline in-person intake data was completed at a large military medical center. Data were collected from 2011 to 2020, and analysis was conducted in 2020. Participants (n = 89) included males who sustained traumatic lower limb loss (n = 50) and an age-matched comparison group without limb loss (n = 39). Mean age of participants was 36.0 ± 13.2 years. Main outcomes measured included age, height, body mass index, weight, body fat mass and percent, android fat mass and percent, gynoid fat mass and percent, and android/gynoid percent fat ratio. Differences between groups were assessed using t-tests or Mann-Whitney U tests. Differences between limb loss levels were assessed using one-way ANOVA or Wilcoxon signed-rank test. Results: Body fat percent (P = .001), gynoid fat percent (P = .010), android fat mass (P = .01), and percent (P = .02) were higher in the group with limb loss. There were no differences in body fat composition between limb loss levels (P > .05). Conclusion: Males with traumatic lower limb loss had a higher body fat percent compared to those without limb loss. Given higher body fat composition in individuals with limb loss and the relationship between body fat composition and cardiovascular disease risk, including body composition analysis with clinical screening could identify changes and allow for early intervention.
MeSH term(s)	Male ; Humans ; Young Adult ; Adult ; Middle Aged ; Cross-Sectional Studies ; Absorptiometry, Photon ; Body Fat Distribution ; Body Composition ; Body Mass Index ; Lower Extremity
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usab237
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Article ; Online: Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update).

Bus, Sicco A / Armstrong, David G / Crews, Ryan T / Gooday, Catherine / Jarl, Gustav / Kirketerp-Moller, Klaus / Viswanathan, Vijay / Lazzarini, Peter A

Diabetes/metabolism research and reviews

2023 Volume 40, Issue 3, Page(s) e3647

Abstract: Aims: Offloading mechanical tissue stress is arguably the most important of multiple interventions needed to heal diabetes-related foot ulcers. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline on ... ...

Abstract	Aims: Offloading mechanical tissue stress is arguably the most important of multiple interventions needed to heal diabetes-related foot ulcers. This is the 2023 International Working Group on the Diabetic Foot (IWGDF) evidence-based guideline on offloading interventions to promote healing of foot ulcers in persons with diabetes. It serves as an update of the 2019 IWGDF guideline. Materials and methods: We followed the GRADE approach by devising clinical questions and important outcomes in the PICO (Patient-Intervention-Control-Outcome) format, undertaking a systematic review and meta-analyses, developing summary of judgement tables and writing recommendations and rationales for each question. Each recommendation is based on the evidence found in the systematic review, expert opinion where evidence was not available, and a careful weighing of GRADE summary of judgement items including desirable and undesirable effects, certainty of evidence, patient values, resources required, cost effectiveness, equity, feasibility, and acceptability. Results: For healing a neuropathic plantar forefoot or midfoot ulcer in a person with diabetes, use a non-removable knee-high offloading device as the first-choice offloading intervention. If contraindications or patient intolerance to non-removable offloading exist, consider using a removable knee-high or ankle-high offloading device as the second-choice offloading intervention. If no offloading devices are available, consider using appropriately fitting footwear combined with felted foam as the third-choice offloading intervention. If such a non-surgical offloading treatment fails to heal a plantar forefoot ulcer, consider an Achilles tendon lengthening, metatarsal head resection, joint arthroplasty, or metatarsal osteotomy. For healing a neuropathic plantar or apex lesser digit ulcer secondary to flexibile toe deformity, use digital flexor tendon tenotomy. For healing rearfoot, non-plantar or ulcers complicated with infection or ischaemia, further recommendations have been outlined. All recommendations have been summarised in an offloading clinical pathway to help facilitate the implementation of this guideline into clinical practice. Conclusion: These offloading guideline recommendations should help healthcare professionals provide the best care and outcomes for persons with diabetes-related foot ulcers and reduce the person's risk of infection, hospitalisation and amputation.
MeSH term(s)	Humans ; Diabetic Foot/etiology ; Diabetic Foot/therapy ; Ulcer ; Foot Ulcer/therapy ; Foot ; Wound Healing ; Diabetes Mellitus
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3647
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