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  1. Book: Molecular mechanisms that orchestrate the assembly of antigen receptor loci

    Murre, Cornelis

    (Advances in immunology ; 128)

    2015  

    Author's details ed. by Cornelis Murre
    Series title Advances in immunology ; 128
    Collection
    Keywords Immune response ; Pathogenic microorganisms ; B cells ; T cells
    Subject code 616.079
    Language English
    Size XII, 441 S. : Ill., 23 cm
    Edition 1. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018801577
    ISBN 978-0-12-803296-1 ; 0-12-803296-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 191 -128- verfügbar in Königswinter Königswinter

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  2. Book: Epigenetic regulation of lymphocyte development

    Murre, Cornelis

    (Current topics in microbiology and immunology ; 356)

    2012  

    Author's details Cornelis Murre ed
    Series title Current topics in microbiology and immunology ; 356
    Collection
    Keywords Lymphozyt ; Epigenetik
    Subject Lymphocyt ; Lymphzelle ; Lymphozyten ; Lymphocyten
    Language English
    Size X, 191 S. : Ill.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017134426
    ISBN 978-3-642-24102-4 ; 3-642-24102-6 ; 9783642241031 ; 3642241034
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Ud II Zs 24 -356- verfügbar in Königswinter Königswinter

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  3. Article ; Online: 'Big bang' of B-cell development revealed.

    Murre, Cornelis

    Genes & development

    2018  Volume 32, Issue 2, Page(s) 93–95

    Abstract: Earlier studies have identified transcription factors that specify B-cell fate, but the underlying mechanisms remain to be revealed. Two new studies by Miyai and colleagues (pp. 112-126) and Li and colleagues (pp. 96-111) in this issue ... ...

    Abstract Earlier studies have identified transcription factors that specify B-cell fate, but the underlying mechanisms remain to be revealed. Two new studies by Miyai and colleagues (pp. 112-126) and Li and colleagues (pp. 96-111) in this issue of
    MeSH term(s) B-Lymphocytes/immunology ; Cell Differentiation ; Lymphocyte Activation ; Trans-Activators ; Transcription Factors
    Chemical Substances Trans-Activators ; Transcription Factors
    Language English
    Publishing date 2018-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review ; Comment
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.311357.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

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  4. Article ; Online: Bursty gene expression and mRNA decay pathways orchestrate B cell activation.

    Zhou, Yi / Murre, Cornelis

    Science advances

    2021  Volume 7, Issue 49, Page(s) eabm0819

    Abstract: It is well established that the helix-loop-helix proteins, E2A and E2-2, promote B cell activation. Here, we examined how during the course of B cell ... ...

    Abstract It is well established that the helix-loop-helix proteins, E2A and E2-2, promote B cell activation. Here, we examined how during the course of B cell activation
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abm0819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery.

    Murre, Cornelis

    Genes & development

    2018  Volume 33, Issue 1-2, Page(s) 6–25

    Abstract: Helix-loop-helix (HLH) proteins are dimeric transcription factors that control lineage- and developmental-specific gene programs. Genes encoding for HLH proteins arose in unicellular organisms >600 million years ago and then duplicated and diversified ... ...

    Abstract Helix-loop-helix (HLH) proteins are dimeric transcription factors that control lineage- and developmental-specific gene programs. Genes encoding for HLH proteins arose in unicellular organisms >600 million years ago and then duplicated and diversified from ancestral genes across the metazoan and plant kingdoms to establish multicellularity. Hundreds of HLH proteins have been identified with diverse functions in a wide variety of cell types. HLH proteins orchestrate lineage specification, commitment, self-renewal, proliferation, differentiation, and homing. HLH proteins also regulate circadian clocks, protect against hypoxic stress, promote antigen receptor locus assembly, and program transdifferentiation. HLH proteins deposit or erase epigenetic marks, activate noncoding transcription, and sequester chromatin remodelers across the chromatin landscape to dictate enhancer-promoter communication and somatic recombination. Here the evolution of HLH genes, the structures of HLH domains, and the elaborate activities of HLH proteins in multicellular life are discussed.
    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Lineage/genetics ; Enhancer Elements, Genetic/physiology ; Evolution, Molecular ; Gene Expression Regulation, Developmental ; Helix-Loop-Helix Motifs/physiology ; Promoter Regions, Genetic/physiology
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors
    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.320663.118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 54: Show issues

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  6. Article ; Online: Spatial Organization of Chromatin: Transcriptional Control of Adaptive Immune Cell Development.

    Pongubala, Jagan M R / Murre, Cornelis

    Frontiers in immunology

    2021  Volume 12, Page(s) 633825

    Abstract: Higher-order spatial organization of the genome into chromatin compartments (permissive and repressive), self-associating domains (TADs), and regulatory loops provides structural integrity and offers diverse gene regulatory controls. In particular, ... ...

    Abstract Higher-order spatial organization of the genome into chromatin compartments (permissive and repressive), self-associating domains (TADs), and regulatory loops provides structural integrity and offers diverse gene regulatory controls. In particular, chromatin regulatory loops, which bring enhancer and associated transcription factors in close spatial proximity to target gene promoters, play essential roles in regulating gene expression. The establishment and maintenance of such chromatin loops are predominantly mediated involving CTCF and the cohesin machinery. In recent years, significant progress has been made in revealing how loops are assembled and how they modulate patterns of gene expression. Here we will discuss the mechanistic principles that underpin the establishment of three-dimensional (3D) chromatin structure and how changes in chromatin structure relate to alterations in gene programs that establish immune cell fate.
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.633825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Preface.

    Murre, Cornelis

    Advances in immunology

    2015  Volume 128, Page(s) xi–xii

    MeSH term(s) Animals ; Immunoglobulins/genetics ; Lymphocytes/metabolism ; Nuclear Proteins/metabolism ; Receptors, Antigen/genetics ; V(D)J Recombination
    Chemical Substances Immunoglobulins ; Nuclear Proteins ; Receptors, Antigen
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 80226-8
    ISSN 1557-8445 ; 0065-2776
    ISSN (online) 1557-8445
    ISSN 0065-2776
    DOI 10.1016/S0065-2776(15)00069-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.191: Show issues Location:
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  8. Article ; Online: Ensuring an equal playing field for antigen receptor loci variable regions.

    Murre, Cornelis

    The Journal of experimental medicine

    2015  Volume 212, Issue 1, Page(s) 2

    MeSH term(s) Animals ; Chromatin/genetics ; Precursor Cells, B-Lymphoid/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Thymocytes/metabolism
    Chemical Substances Chromatin ; Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2015-01-12
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2121insight1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Ua VI Zs.107: Show issues Location:
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  9. Article ; Online: Helix-Loop-Helix Proteins in Adaptive Immune Development.

    Aubrey, Megan / Warburg, Zachary J / Murre, Cornelis

    Frontiers in immunology

    2022  Volume 13, Page(s) 881656

    Abstract: The E/ID protein axis is instrumental for defining the developmental progression and functions of hematopoietic cells. The E proteins are dimeric transcription factors that activate gene expression programs and coordinate changes in chromatin ... ...

    Abstract The E/ID protein axis is instrumental for defining the developmental progression and functions of hematopoietic cells. The E proteins are dimeric transcription factors that activate gene expression programs and coordinate changes in chromatin organization. Id proteins are antagonists of E protein activity. Relative levels of E/Id proteins are modulated throughout hematopoietic development to enable the progression of hematopoietic stem cells into multiple adaptive and innate immune lineages including natural killer cells, B cells and T cells. In early progenitors, the E proteins promote commitment to the T and B cell lineages by orchestrating lineage specific programs of gene expression and regulating VDJ recombination of antigen receptor loci. In mature B cells, the E/Id protein axis functions to promote class switch recombination and somatic hypermutation. E protein activity further regulates differentiation into distinct CD4+ and CD8+ T cells subsets and instructs mature T cell immune responses. In this review, we discuss how the E/Id proteins define the adaptive immune system lineages, focusing on their role in directing developmental gene programs.
    MeSH term(s) B-Lymphocytes/metabolism ; Cell Differentiation ; Cell Lineage/genetics ; Hematopoietic Stem Cells/metabolism ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.881656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Common Mechanism that Underpins Antibody Diversification.

    Murre, Cornelis

    Cell

    2015  Volume 163, Issue 5, Page(s) 1055–1056

    Abstract: Targeting of AID to antibody variable (V) regions results in somatic hypermutation, whereas its recruitment to switch (S) regions leads to class-switch recombination. Yeap et al. find that the mechanism by which variable and switch regions recruit AID ... ...

    Abstract Targeting of AID to antibody variable (V) regions results in somatic hypermutation, whereas its recruitment to switch (S) regions leads to class-switch recombination. Yeap et al. find that the mechanism by which variable and switch regions recruit AID essentially is the same but that the two regions differ in the density of double-stranded DNA breaks that are generated. These lead to either point mutations in V exons in somatic hypermutation or deletion of intervening DNA sequences during class switch recombination.
    MeSH term(s) Animals ; B-Lymphocytes/metabolism ; Cytidine Deaminase/genetics ; Humans ; Immunoglobulin Class Switching ; Somatic Hypermutation, Immunoglobulin ; V(D)J Recombination
    Chemical Substances Cytidine Deaminase (EC 3.5.4.5)
    Language English
    Publishing date 2015-11-19
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2015.10.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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