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Article ; Online: Resistance training and inter-interindividual response differences on cardiorespiratory fitness in older adults: An ancillary meta-analysis of randomized controlled trials.

Kelley, George A / Kelley, Kristi S / Stauffer, Brian L

2024 Volume 107, Issue 1, Page(s) 368504241227088

Abstract: Examine true inter-individual response differences (IIRD) as a result of resistance training on cardiorespiratory fitness in older adults. Data from a recent meta-analysis of 22 randomized controlled trials representing 552 men and women (292 resistance ... ...

Abstract	Examine true inter-individual response differences (IIRD) as a result of resistance training on cardiorespiratory fitness in older adults. Data from a recent meta-analysis of 22 randomized controlled trials representing 552 men and women (292 resistance training, 260 control) ≥ 60 years of age were included. The primary outcome was cardiorespiratory fitness (VO
MeSH term(s)	Aged ; Female ; Humans ; Male ; Cardiorespiratory Fitness ; Physical Fitness ; Randomized Controlled Trials as Topic ; Resistance Training ; Middle Aged
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504241227088
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Article ; Online: Effects of resistance training on body weight and body composition in older adults: An inter-individual response difference meta-analysis of randomized controlled trials.

Kelley, George A / Kelley, Kristi S / Stauffer, Brian L

Science progress

2023 Volume 106, Issue 2, Page(s) 368504231179062

Abstract: Whether true inter-individual response differences (IIRD) occur as a result of resistance training on body weight and body composition in older adults with overweight and obesity is not known. To address this gap, data from a previous meta-analysis ... ...

Abstract	Whether true inter-individual response differences (IIRD) occur as a result of resistance training on body weight and body composition in older adults with overweight and obesity is not known. To address this gap, data from a previous meta-analysis representing 587 men and women (333 resistance training, 254 control) ≥ 60 years of age nested in 15 randomized controlled trials of resistance training ≥ 8 weeks were included. Resistance training and control group change outcome standard deviations treated as point estimates for body weight and body composition (percent body fat, fat mass, body mass index in kg
MeSH term(s)	Aged ; Female ; Humans ; Male ; Body Composition/physiology ; Body Weight ; Obesity/therapy ; Randomized Controlled Trials as Topic ; Resistance Training ; Middle Aged
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504231179062
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Article ; Online: Walking and resting blood pressure: An inter-individual response difference meta-analysis of randomized controlled trials.

Kelley, George A / Kelley, Kristi S / Stauffer, Brian L

Science progress

2022 Volume 105, Issue 2, Page(s) 368504221101636

Abstract: Conclusions: While walking is associated with reductions in resting SBP and DBP, a lack of true IIRD exists, suggesting that factors other than training response variation (random variation, physiological responses associated with behavioral changes ... ...

Abstract	Conclusions: While walking is associated with reductions in resting SBP and DBP, a lack of true IIRD exists, suggesting that factors other than training response variation (random variation, physiological responses associated with behavioral changes that are not the result of walking) are responsible for the observed variation in resting SBP and DBP.
MeSH term(s)	Blood Pressure/physiology ; Humans ; Hypertension ; Randomized Controlled Trials as Topic ; Plastic Surgery Procedures ; Rest ; Walking
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	128412-5
ISSN	2047-7163 ; 0036-8504 ; 0302-1785
ISSN (online)	2047-7163
ISSN	0036-8504 ; 0302-1785
DOI	10.1177/00368504221101636
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Article ; Online: Inter-individual response differences on resting blood pressure as a result of qigong in adults: An ancillary meta-analysis of randomized trials.

Kelley, George A / Kelley, Kristi S / Stauffer, Brian L

Complementary therapies in medicine

2022 Volume 66, Page(s) 102818

Abstract: Objective: Conduct an ancillary meta-analysis to determine whether true inter-individual response differences (IIRD) exist with respect to the effects of qigong on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults.: ... ...

Abstract	Objective: Conduct an ancillary meta-analysis to determine whether true inter-individual response differences (IIRD) exist with respect to the effects of qigong on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Methods: Data from a meta-analysis representing 370 participants (181 qigong, 189 control) from 7 randomized trials on qigong and resting SBP and DBP in men and women were included. Qigong and control group change outcome standard deviations treated as point estimates for both resting SBP and DBP were used to calculate true IIRD from each study. The inverse variance heterogeneity (IVhet) model was used to pool results. Results: For participants with essential hypertension, statistically significant and clinically important reductions in resting SBP (X̅, -18.2 mmHg, 95% CI, -21.3 to -15.2 mmHg) and DBP (X̅, -11.7 mmHg, 95% CI, -17.0 to -6.3 mmHg) were found. However, true IIRD were neither significant nor clinically important for either SBP (X̅, -6.0 mmHg, 95% CI, -9.1 to 3.5 mmHg) or DBP (X̅, 2.8 mmHg, 95% CI, -3.4 to 5.2 mmHg). The 95% prediction interval for true IIRD was - 11.9 to 8.4 mmHg for SBP and - 5.8 to 7.0 mmHg for DBP. Conclusions: While qigong is associated with reductions in resting SBP and DBP in adults with essential hypertension, a lack of true IIRD exists, suggesting that other external factors are responsible for any variation.
MeSH term(s)	Adult ; Blood Pressure ; Female ; Humans ; Hypertension/therapy ; Male ; Qigong ; Randomized Controlled Trials as Topic ; Rest
Language	English
Publishing date	2022-02-22
Publishing country	Scotland
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2022.102818
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Article ; Online: Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers.

Huck, Daniel M / Rosenberg, Michael A / Stauffer, Brian L

Journal of hypertension

2022 Volume 40, Issue 5, Page(s) 1019–1029

Abstract: Objective: Nonvasodilatory beta blockers are associated with inferior cardiovascular event reduction compared with other antihypertensive classes, and there is uncertainty about first-line use of beta blockers for hypertension in guidelines. The third ... ...

Abstract	Objective: Nonvasodilatory beta blockers are associated with inferior cardiovascular event reduction compared with other antihypertensive classes, and there is uncertainty about first-line use of beta blockers for hypertension in guidelines. The third generation vasodilatory beta blocker nebivolol has unique beneficial effects on central and peripheral vasculature. Our objective was to compare longitudinal cardiovascular outcomes of hypertensive patients taking nebivolol with those taking the nonvasodilatory beta blockers metoprolol and atenolol. Methods: We performed a retrospective cohort analysis of hypertensive adults in the University of Colorado health system, without preceding diagnosis of cardiovascular or cerebrovascular disease. The primary outcome was composite incident heart failure, stroke, myocardial infarction, angina, or coronary revascularization. Mahalanobis 1:2 distance matching and Cox proportional hazards regression was used. Matching and regression variables included baseline demographics, socioeconomic factors, medical insurance type, prescribing provider type, cardiovascular risk factors, Charlson comorbidity index, other medications, and follow-up duration. Results: After matching, patients were predominantly women (54%, 3085 of 5705) and non-Hispanic Caucasian (79%, 4534 of 5705), with median age of 58. In matched Cox regression analysis, nebivolol was associated with 17% reduction in incident cardiovascular events compared with all nonvasodilatory beta blockers [hazard ratio 0.83, 95% confidence interval (CI) 0.74-0.94, P = 0.004], and 24% reduction compared with metoprolol (hazard ratio 0.76, CI 0.66-0.87, P = 0.0001). Conclusion: The vasodilatory beta blocker nebivolol was associated with reduced incident cardiovascular events compared with nonvasodilatory beta blockers. Additional study of other beta blockers is necessary to determine if this is a vasodilatory beta blocker class effect or is specific to nebivolol. http://links.lww.com/HJH/B916.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Adult ; Female ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Male ; Metoprolol/therapeutic use ; Nebivolol/therapeutic use ; Retrospective Studies
Chemical Substances	Adrenergic beta-Antagonists ; Nebivolol (030Y90569U) ; Metoprolol (GEB06NHM23)
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003109
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Isometric exercise and inter-individual response differences on resting systolic and diastolic blood pressure in adults: a meta-analysis of randomized controlled trials.

Kelley, George A / Kelley, Kristi S / Stauffer, Brian L

Blood pressure

2021 Volume 30, Issue 5, Page(s) 310–321

Abstract: Purpose: Isometric exercise (IE) has been shown to reduce resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. However, no one to date has determined whether true inter-individual response differences (IIRD) versus random ... ...

Abstract	Purpose: Isometric exercise (IE) has been shown to reduce resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. However, no one to date has determined whether true inter-individual response differences (IIRD) versus random variability exist with respect to IE and resting SBP and DBP in adults ≥18 years of age. The purpose of the current study was to address this gap. Methods and materials: Using the meta-analytic approach, randomised controlled trials from a recent meta-analysis that examined the effects of IE on resting SBP and DBP were included. Change outcome standard deviations for SBP and DBP from IE and control groups were used to calculate true IIRD from each study. The inverse variance heterogeneity (IVhet) model was used to pool results. Results: Pooled changes for true IIRD in SBP (16 studies, 411 participants) were 3.3 mmHg (95% confidence interval, -3.1 to 5.6 mmHg) while tau ( Conclusion: While IE reduces resting SBP and DBP in adults, the results of the current study suggest that random variability versus true IIRD account for any potential differences as a result of IE on changes in resting SBP and DBP in adults. Thus, a search for potential moderators and mediators, including potential genetic interactions associated with IE, may not be warranted.
MeSH term(s)	Adult ; Blood Pressure ; Exercise ; Humans ; Hypertension ; Randomized Controlled Trials as Topic ; Rest ; Systole
Language	English
Publishing date	2021-06-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1170048-8
ISSN	1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
ISSN (online)	1651-1999 ; 1651-2480
ISSN	0803-7051 ; 0803-8023
DOI	10.1080/08037051.2021.1940837
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Zs.A 3843: Show issues

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Article ; Online: Inter-individual response differences on resting blood pressure as a result of qigong in adults

George A. Kelley / Kristi S. Kelley / Brian L. Stauffer

Complementary Therapies in Medicine, Vol 66, Iss , Pp 102818- (2022)

An ancillary meta-analysis of randomized trials

2022

Abstract	Objective: Conduct an ancillary meta-analysis to determine whether true inter-individual response differences (IIRD) exist with respect to the effects of qigong on resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Methods: Data from a meta-analysis representing 370 participants (181 qigong, 189 control) from 7 randomized trials on qigong and resting SBP and DBP in men and women were included. Qigong and control group change outcome standard deviations treated as point estimates for both resting SBP and DBP were used to calculate true IIRD from each study. The inverse variance heterogeneity (IVhet) model was used to pool results. Results: For participants with essential hypertension, statistically significant and clinically important reductions in resting SBP (X̅, −18.2 mmHg, 95% CI, −21.3 to −15.2 mmHg) and DBP (X̅, −11.7 mmHg, 95% CI, −17.0 to −6.3 mmHg) were found. However, true IIRD were neither significant nor clinically important for either SBP (X̅, −6.0 mmHg, 95% CI, −9.1 to 3.5 mmHg) or DBP (X̅, 2.8 mmHg, 95% CI, −3.4 to 5.2 mmHg). The 95% prediction interval for true IIRD was − 11.9 to 8.4 mmHg for SBP and − 5.8 to 7.0 mmHg for DBP. Conclusions: While qigong is associated with reductions in resting SBP and DBP in adults with essential hypertension, a lack of true IIRD exists, suggesting that other external factors are responsible for any variation.
Keywords	Qigong ; Blood pressure ; Meta-analysis ; Adults ; Other systems of medicine ; RZ201-999
Subject code	310
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women.

Wenner, Megan M / Welti, Laura M / Dow, Caitlin A / Greiner, Jared J / Stauffer, Brian L / DeSouza, Christopher A

American journal of physiology. Heart and circulatory physiology

2023 Volume 324, Issue 6, Page(s) H732–H738

Abstract: Endothelin-1 (ET-1) contributes to vascular dysfunction in postmenopausal women (PMW). Although aerobic exercise is beneficial in reducing ET-1-mediated vasoconstrictor tone in men, it is unknown whether this favorable vascular effect occurs in women. We ...

Abstract	Endothelin-1 (ET-1) contributes to vascular dysfunction in postmenopausal women (PMW). Although aerobic exercise is beneficial in reducing ET-1-mediated vasoconstrictor tone in men, it is unknown whether this favorable vascular effect occurs in women. We tested the hypothesis that aerobic exercise training reduces ET-1-mediated vasoconstriction in PMW. We further hypothesized that reductions in ET-1 vasoconstrictor tone underly exercise-induced improvements in endothelium-dependent vasodilatation in PMW. Forearm blood flow (FBF) responses to intra-arterial infusion of selective ET
MeSH term(s)	Male ; Humans ; Female ; Vasodilation ; Vasoconstriction ; Endothelin-1/pharmacology ; Acetylcholine/pharmacology ; Postmenopause ; Vasodilator Agents/pharmacology ; Vasoconstrictor Agents/pharmacology ; Endothelium, Vascular ; Exercise/physiology ; Regional Blood Flow
Chemical Substances	Endothelin-1 ; Acetylcholine (N9YNS0M02X) ; Vasodilator Agents ; Vasoconstrictor Agents
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00674.2022
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Article ; Online: Circulating and Cardiac Tissue miRNAs in Children with Dilated Cardiomyopathy.

Hailu, Frehiwet T / Karimpour-Fard, Anis / Neltner, Bonnie / Stauffer, Brian L / Lipshultz, Steven / Miyamoto, Shelley D / Sucharov, Carmen C

Journal of cardiovascular development and disease

2023 Volume 10, Issue 9

Abstract: microRNAs (miRs) are small non-coding single-stranded RNAs that regulate gene expression. We previously evaluated expression of miRs in the cardiac tissue of children with dilated cardiomyopathy (DCM) using miRNA-seq. However, a comparative analysis of ... ...

Abstract	microRNAs (miRs) are small non-coding single-stranded RNAs that regulate gene expression. We previously evaluated expression of miRs in the cardiac tissue of children with dilated cardiomyopathy (DCM) using miRNA-seq. However, a comparative analysis of serum and cardiac miRs has not been performed in this population. The current study aimed to evaluate miR levels in the serum of pediatric DCM patients compared to healthy non-failing (NF) donor controls and investigate the association between miR levels in tissue and sera from the same pediatric DCM patients. Defining the relationship between serum and tissue miRs may allow the use of circulating miRs as surrogate markers of cardiac miRs. miR levels were investigated through miR-array in sera [n = 10 NF, n = 12 DCM] and miR-seq in tissue (n = 10 NF, n = 12 DCM). Pathway analysis was investigated using the miR enrichment analysis and annotation tool (miEAA) for the five miRs commonly dysregulated in the sera and tissue of pediatric DCM patients. Functional analysis of miRs commonly dysregulated in the sera and tissue of pediatric DCM patients suggests altered pathways related to cell growth, differentiation and proliferation, inflammation, mitochondrial function, and metabolism. These findings suggest that circulating miRs could reflect altered levels of cardiac tissue miRs.
Language	English
Publishing date	2023-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10090391
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Article ; Online: Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes.

Fandl, Hannah K / Garcia, Vinicius P / Treuth, John W / Brewster, Lillian M / Greiner, Jared J / Davy, Kevin P / Stauffer, Brian L / Desouza, Christopher A

American journal of physiology. Heart and circulatory physiology

2023 Volume 324, Issue 5, Page(s) H675–H685

Abstract: Obesity and hypertension, independently and combined, are associated with increased risk of heart failure and heart failure-related morbidity and mortality. Interest in circulating endothelial cell-derived microvesicles (EMVs) has intensified because of ... ...

Abstract	Obesity and hypertension, independently and combined, are associated with increased risk of heart failure and heart failure-related morbidity and mortality. Interest in circulating endothelial cell-derived microvesicles (EMVs) has intensified because of their involvement in the development and progression of endothelial dysfunction, atherosclerosis, and cardiomyopathy. The experimental aim of this study was to determine, in vitro, the effects of EMVs isolated from obese/hypertensive adults on key proteins regulating cardiomyocyte hypertrophy [cardiac troponin T (cTnT), α-actinin, nuclear factor-kB (NF-kB)] and fibrosis [transforming growth factor (TGF)-β, collagen1-α1], as well as endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production. EMVs (CD144
MeSH term(s)	Male ; Female ; Humans ; Adult ; Middle Aged ; Myocytes, Cardiac/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Troponin T/metabolism ; Nitric Oxide/metabolism ; Actinin/metabolism ; Actinin/pharmacology ; NF-kappa B/metabolism ; Hypertension/metabolism ; Hypertrophy/metabolism ; Hypertrophy/pathology ; Cell-Derived Microparticles/metabolism ; Obesity/metabolism ; Heart Failure/metabolism ; Transforming Growth Factor beta/metabolism ; Fibrosis
Chemical Substances	Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Troponin T ; Nitric Oxide (31C4KY9ESH) ; Actinin (11003-00-2) ; NF-kappa B ; Transforming Growth Factor beta
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00035.2023
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