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  1. Article ; Online: Radiosynthesis of (R,S)-[

    Qiao, Luxi / Fisher, Emily / McMurray, Lindsay / Milicevic Sephton, Selena / Hird, Matthew / Kuzhuppilly-Ramakrishnan, Nisha / Williamson, David J / Zhou, Xiouyun / Werry, Eryn / Kassiou, Michael / Luthra, Saijinder / Trigg, William / Aigbirhio, Franklin I

    ChemMedChem

    2019  Volume 14, Issue 9, Page(s) 982–993

    Abstract: ... with a low-affinity binder/high-affinity binder (LAB/HAB) ratio similar (1.2 vs. 1.3) to that of (R)-[ ...

    Abstract Translocator protein (TSPO) is a biomarker of neuroinflammation, which is a hallmark of many neurodegenerative diseases and has been exploited as a positron emission tomography (PET) target. Carbon-11-labelled PK11195 remains the most applied agent for imaging TSPO, despite its short-lived isotope and low brain permeability. Second-generation radiotracers show variance in affinity amongst subjects (low-, mixed-, and high-affinity binders) caused by the genetic polymorphism (rs6971) of the TSPO gene. To overcome these limitations, a new structural scaffold was explored based on the TSPO pharmacophore, and the analogue with a low-affinity binder/high-affinity binder (LAB/HAB) ratio similar (1.2 vs. 1.3) to that of (R)-[
    MeSH term(s) Animals ; Fluorine Radioisotopes/chemistry ; Humans ; Polymorphism, Genetic ; Positron-Emission Tomography ; Proof of Concept Study ; Protein Binding ; Radiopharmaceuticals/chemical synthesis ; Rats ; Receptors, GABA/chemistry ; Receptors, GABA/metabolism ; Stereoisomerism
    Chemical Substances Fluorine Radioisotopes ; Radiopharmaceuticals ; Receptors, GABA ; TSPO protein, human
    Language English
    Publishing date 2019-04-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.201900023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet.

    Davis, Rachel A H / Deemer, Sarah E / Bergeron, Jonathan M / Little, Jason T / Warren, Jonathan L / Fisher, Gordon / Smith, Daniel L / Fontaine, Kevin R / Dickinson, Stephanie L / Allison, David B / Plaisance, Eric P

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2018  Volume 33, Issue 2, Page(s) 2409–2421

    Abstract: ... of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc ... The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure ...

    Abstract The dietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure (REE) and markers of brown and white adipose thermogenesis in lean mice. The purpose of this investigation was to determine whether the ketone ester, R, S-1,3-butanediol diacetoacetate (BD-AcAc
    MeSH term(s) Acetoacetates/administration & dosage ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, White/drug effects ; Adiposity/drug effects ; Animals ; Body Composition ; Body Weight/drug effects ; Butylene Glycols/administration & dosage ; Diet, High-Fat/adverse effects ; Energy Intake ; Energy Metabolism/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/physiopathology ; Obesity/prevention & control
    Chemical Substances 1,3-butanediol diacetoacetate ; Acetoacetates ; Butylene Glycols
    Language English
    Publishing date 2018-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201800821RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Search for heavy neutrinos and W(R) bosons with right-handed couplings in a left-right symmetric model in pp collisions at sqrt[s]=7  TeV.

    Chatrchyan, S / Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Aguilo, E / Bergauer, T / Dragicevic, M / Erö, J / Fabjan, C / Friedl, M / Frühwirth, R / Ghete, V M / Hammer, J / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V /
    Krammer, M / Krätschmer, I / Liko, D / Mikulec, I / Pernicka, M / Rahbaran, B / Rohringer, C / Rohringer, H / Schöfbeck, R / Strauss, J / Taurok, A / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Bansal, M / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Luyckx, S / Mucibello, L / Ochesanu, S / Roland, B / Rougny, R / Selvaggi, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Gonzalez Suarez, R / Kalogeropoulos, A / Maes, M / Olbrechts, A / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Clerbaux, B / De Lentdecker, G / Dero, V / Gay, A P R / Hreus, T / Léonard, A / Marage, P E / Mohammadi, A / Reis, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Adler, V / Beernaert, K / Cimmino, A / Costantini, S / Garcia, G / Grunewald, M / Klein, B / Lellouch, J / Marinov, A / Mccartin, J / Ocampo Rios, A A / Ryckbosch, D / Strobbe, N / Thyssen, F / Tytgat, M / Walsh, S / Yazgan, E / Zaganidis, N / Basegmez, S / Bruno, G / Castello, R / Ceard, L / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Lemaitre, V / Liao, J / Militaru, O / Nuttens, C / Pagano, D / Pin, A / Piotrzkowski, K / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Alves, G A / Correa Martins Junior, M / Martins, T / Pol, M E / Souza, M H G / Aldá Júnior, W L / Carvalho, W / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Malek, M / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santoro, A / Soares Jorge, L / Sznajder, A / Vilela Pereira, A / Anjos, T S / Bernardes, C A / Dias, F A / Fernandez Perez Tomei, T R / Gregores, E M / Lagana, C / Marinho, F / Mercadante, P G / Novaes, S F / Padula, Sandra S / Genchev, V / Iaydjiev, P / Piperov, S / Rodozov, M / Stoykova, S / Sultanov, G / Tcholakov, V / Trayanov, R / Vutova, M / Dimitrov, A / Hadjiiska, R / Kozhuharov, V / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Jiang, C H / Liang, D / Liang, S / Meng, X / Tao, J / Wang, X / Wang, Z / Xiao, H / Xu, M / Zang, J / Zhang, Z / Asawatangtrakuldee, C / Ban, Y / Guo, Y / Li, W / Liu, S / Mao, Y / Qian, S J / Teng, H / Wang, D / Zhang, L / Zou, W / Avila, C / Gomez, J P / Gomez Moreno, B / Osorio Oliveros, A F / Sanabria, J C / Godinovic, N / Lelas, D / Plestina, R / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Duric, S / Kadija, K / Luetic, J / Mekterovic, D / Morovic, S / Attikis, A / Galanti, M / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Finger, M / Assran, Y / Elgammal, S / Ellithi Kamel, A / Khalil, S / Mahmoud, M A / Radi, A / Kadastik, M / Müntel, M / Raidal, M / Rebane, L / Tiko, A / Eerola, P / Fedi, G / Voutilainen, M / Härkönen, J / Heikkinen, A / Karimäki, V / Kinnunen, R / Kortelainen, M J / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Mäenpää, T / Peltola, T / Tuominen, E / Tuominiemi, J / Tuovinen, E / Ungaro, D / Wendland, L / Banzuzi, K / Karjalainen, A / Korpela, A / Tuuva, T / Besancon, M / Choudhury, S / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Ferri, F / Ganjour, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Locci, E / Malcles, J / Millischer, L / Nayak, A / Rander, J / Rosowsky, A / Titov, M / Baffioni, S / Beaudette, F / Benhabib, L / Bianchini, L / Bluj, M / Broutin, C / Busson, P / Charlot, C / Daci, N / Dahms, T / Dalchenko, M / Dobrzynski, L / Florent, A / Granier de Cassagnac, R / Haguenauer, M / Miné, P / Mironov, C / Naranjo, I N / Nguyen, M / Ochando, C / Paganini, P / Sabes, D / Salerno, R / Sirois, Y / Veelken, C / Zabi, A / Agram, J-L / Andrea, J / Bloch, D / Bodin, D / Brom, J-M / Cardaci, M / Chabert, E C / Collard, C / Conte, E / Drouhin, F / Fontaine, J-C / Gelé, D / Goerlach, U / Juillot, P / Le Bihan, A-C / Van Hove, P / Fassi, F / Mercier, D / Beauceron, S / Beaupere, N / Bondu, O / Boudoul, G / Chasserat, J / Chierici, R / Contardo, D / Depasse, P / El Mamouni, H / Fay, J / Gascon, S / Gouzevitch, M / Ille, B / Kurca, T / Lethuillier, M / Mirabito, L / Perries, S / Sgandurra, L / Sordini, V / Tschudi, Y / Verdier, P / Viret, S / Tsamalaidze, Z / Autermann, C / Beranek, S / Calpas, B / Edelhoff, M / Feld, L / Heracleous, N / Hindrichs, O / Jussen, R / Klein, K / Merz, J / Ostapchuk, A / Perieanu, A / Raupach, F / Sammet, J / Schael, S / Sprenger, D / Weber, H / Wittmer, B / Zhukov, V / Ata, M / Caudron, J / Dietz-Laursonn, E / Duchardt, D / Erdmann, M / Fischer, R / Güth, A / Hebbeker, T / Heidemann, C / Hoepfner, K / Klingebiel, D / Kreuzer, P / Merschmeyer, M / Meyer, A / Olschewski, M / Papacz, P / Pieta, H / Reithler, H / Schmitz, S A / Sonnenschein, L / Steggemann, J / Teyssier, D / Thüer, S / Weber, M / Bontenackels, M / Cherepanov, V / Erdogan, Y / Flügge, G / Geenen, H / Geisler, M / Haj Ahmad, W / Hoehle, F / Kargoll, B / Kress, T / Kuessel, Y / Lingemann, J / Nowack, A / Perchalla, L / Pooth, O / Sauerland, P / Stahl, A / Aldaya Martin, M / Behr, J / Behrenhoff, W / Behrens, U / Bergholz, M / Bethani, A / Borras, K / Burgmeier, A / Cakir, A / Calligaris, L / Campbell, A / Castro, E / Costanza, F / Dammann, D / Diez Pardos, C / Eckerlin, G / Eckstein, D / Flucke, G / Geiser, A / Glushkov, I / Gunnellini, P / Habib, S / Hauk, J / Hellwig, G / Jung, H / Kasemann, M / Katsas, P / Kleinwort, C / Kluge, H / Knutsson, A / Krämer, M / Krücker, D / Kuznetsova, E / Lange, W / Leonard, J / Lohmann, W / Lutz, B / Mankel, R / Marfin, I / Marienfeld, M / Melzer-Pellmann, I-A / Meyer, A B / Mnich, J / Mussgiller, A / Naumann-Emme, S / Novgorodova, O / Olzem, J / Perrey, H / Petrukhin, A / Pitzl, D / Raspereza, A / Ribeiro Cipriano, P M / Riedl, C / Ron, E / Rosin, M / Salfeld-Nebgen, J / Schmidt, R / Schoerner-Sadenius, T / Sen, N / Spiridonov, A / Stein, M / Walsh, R / Wissing, C / Blobel, V / Enderle, H / Erfle, J / Gebbert, U / Görner, M / Gosselink, M / Haller, J / Hermanns, T / Höing, R S / Kaschube, K / Kaussen, G / Kirschenmann, H / Klanner, R / Lange, J / Nowak, F / Peiffer, T / Pietsch, N / Rathjens, D / Sander, C / Schettler, H / Schleper, P / Schlieckau, E / Schmidt, A / Schröder, M / Schum, T / Seidel, M / Sibille, J / Sola, V / Stadie, H / Steinbrück, G / Thomsen, J / Vanelderen, L / Barth, C / Berger, J / Böser, C / Chwalek, T / De Boer, W / Descroix, A / Dierlamm, A / Feindt, M / Guthoff, M / Hackstein, C / Hartmann, F / Hauth, T / Heinrich, M / Held, H / Hoffmann, K H / Husemann, U / Katkov, I / Komaragiri, J R / Lobelle Pardo, P / Martschei, D / Mueller, S / Müller, Th / Niegel, M / Nürnberg, A / Oberst, O / Oehler, A / Ott, J / Quast, G / Rabbertz, K / Ratnikov, F / Ratnikova, N / Röcker, S / Schilling, F-P / Schott, G / Simonis, H J / Stober, F M / Troendle, D / Ulrich, R / Wagner-Kuhr, J / Wayand, S / Weiler, T / Zeise, M / Anagnostou, G / Daskalakis, G / Geralis, T / Kesisoglou, S / Kyriakis, A / Loukas, D / Manolakos, I / Markou, A / Markou, C / Mavrommatis, C / Ntomari, E / Gouskos, L / Mertzimekis, T J / Panagiotou, A / Saoulidou, N / Evangelou, I / Foudas, C / Kokkas, P / Manthos, N / Papadopoulos, I / Patras, V / Bencze, G / Hajdu, C / Hidas, P / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Beni, N / Czellar, S / Molnar, J / Palinkas, J / Szillasi, Z / Karancsi, J / Raics, P / Trocsanyi, Z L / Ujvari, B / Beri, S B / Bhatnagar, V / Dhingra, N / Gupta, R / Kaur, M / Mehta, M Z / Nishu, N / Saini, L K / Sharma, A / Singh, J B / Kumar, Ashok / Kumar, Arun / Ahuja, S / Bhardwaj, A / Choudhary, B C / Malhotra, S / Naimuddin, M / Ranjan, K / Sharma, V / Shivpuri, R K / Banerjee, S / Bhattacharya, S / Dutta, S / Gomber, B / Jain, Sa / Jain, Sh / Khurana, R / Sarkar, S / Sharan, M / Abdulsalam, A / Dutta, D / Kailas, S / Kumar, V / Mohanty, A K / Pant, L M / Shukla, P / Aziz, T / Ganguly, S / Guchait, M / Gurtu, A / Maity, M / Majumder, G / Mazumdar, K / Mohanty, G B / Parida, B / Sudhakar, K / Wickramage, N / Dugad, S / Arfaei, H / Bakhshiansohi, H / Etesami, S M / Fahim, A / Hashemi, M / Hesari, H / Jafari, A / Khakzad, M / Mohammadi Najafabadi, M / Paktinat Mehdiabadi, S / Safarzadeh, B / Zeinali, M / Abbrescia, M / Barbone, L / Calabria, C / Chhibra, S S / Colaleo, A / Creanza, D / De Filippis, N / De Palma, M / Fiore, L / Iaselli, G / Maggi, G / Maggi, M / Marangelli, B / My, S / Nuzzo, S / Pacifico, N / Pompili, A / Pugliese, G / Selvaggi, G / Silvestris, L / Singh, G / Venditti, R / Verwilligen, P / Zito, G / Abbiendi, G / Benvenuti, A C / Bonacorsi, D / Braibant-Giacomelli, S / Brigliadori, L / Capiluppi, P / Castro, A / Cavallo, F R / Cuffiani, M / Dallavalle, G M / Fabbri, F / Fanfani, A / Fasanella, D / Giacomelli, P / Grandi, C / Guiducci, L / Marcellini, S / Masetti, G / Meneghelli, M / Montanari, A / Navarria, F L / Odorici, F / Perrotta, A / Primavera, F / Rossi, A M / Rovelli, T / Siroli, G P / Tosi, N / Travaglini, R / Albergo, S / Cappello, G / Chiorboli, M / Costa, S / Potenza, R / Tricomi, A / Tuve, C / Barbagli, G / Ciulli, V / Civinini, C / D'Alessandro, R / Focardi, E / Frosali, S / Gallo, E / Gonzi, S / Meschini, M / Paoletti, S / Sguazzoni, G / Tropiano, A / Benussi, L / Bianco, S / Colafranceschi, S / Piccolo, D / Fabbricatore, P / Musenich, R / Tosi, S / Benaglia, A / De Guio, F / Di Matteo, L / Fiorendi, S / Gennai, S / Ghezzi, A / Malvezzi, S / Manzoni, R A / Martelli, A / Massironi, A / Menasce, D / Moroni, L / Paganoni, M / Pedrini, D / Ragazzi, S / Redaelli, N / Sala, S / Tabarelli de Fatis, T / Buontempo, S / Carrillo Montoya, C A / Cavallo, N / De Cosa, A / Dogangun, O / Fabozzi, F / Iorio, A O M / Lista, L / Meola, S / Merola, M / Paolucci, P / Azzi, P / Bacchetta, N / Bellan, P / Bisello, D / Branca, A / Carlin, R / Checchia, P / Dorigo, T / Dosselli, U / Gasparini, F / Gasparini, U / Gozzelino, A / Kanishchev, K / Lacaprara, S / Lazzizzera, I / Margoni, M / Meneguzzo, A T / Nespolo, M / Pazzini, J / Ronchese, P / Simonetto, F / Torassa, E / Vanini, S / Zotto, P / Zumerle, G / Gabusi, M / Ratti, S P / Riccardi, C / Torre, P / Vitulo, P / Biasini, M / Bilei, G M / Fanò, L / Lariccia, P / Mantovani, G / Menichelli, M / Nappi, A / Romeo, F / Saha, A / Santocchia, A / Spiezia, A / Taroni, S / Azzurri, P / Bagliesi, G / Boccali, T / Broccolo, G / Castaldi, R / D'Agnolo, R T / Dell'Orso, R / Fiori, F / Foà, L / Giassi, A / Kraan, A / Ligabue, F / Lomtadze, T / Martini, L / Messineo, A / Palla, F / Rizzi, A / Serban, A T / Spagnolo, P / Squillacioti, P / Tenchini, R / Tonelli, G / Venturi, A / Verdini, P G / Barone, L / Cavallari, F / Del Re, D / Diemoz, M / Fanelli, C / Grassi, M / Longo, E / Meridiani, P / Micheli, F / Nourbakhsh, S / Organtini, G / Paramatti, R / Rahatlou, S / Sigamani, M / Soffi, L / Amapane, N / Arcidiacono, R / Argiro, S / Arneodo, M / Biino, C / Cartiglia, N / Casasso, S / Costa, M / Demaria, N / Mariotti, C / Maselli, S / Migliore, E / Monaco, V / Musich, M / Obertino, M M / Pastrone, N / Pelliccioni, M / Potenza, A / Romero, A / Ruspa, M / Sacchi, R / Solano, A / Staiano, A / Belforte, S / Candelise, V / Casarsa, M / Cossutti, F / Della Ricca, G / Gobbo, B / Marone, M / Montanino, D / Penzo, A / Schizzi, A / Kim, T Y / Nam, S K / Chang, S / Kim, D H / Kim, G N / Kong, D J / Park, H / Son, D C / Son, T / Kim, J Y / Kim, Zero J / Song, S / Choi, S / Gyun, D / Hong, B / Jo, M / Kim, H / Kim, T J / Lee, K S / Moon, D H / Park, S K / Choi, M / Kim, J H / Park, C / Park, I C / Park, S / Ryu, G / Choi, Y / Choi, Y K / Goh, J / Kim, M S / Kwon, E / Lee, B / Lee, J / Lee, S / Seo, H / Yu, I / Bilinskas, M J / Grigelionis, I / Janulis, M / Juodagalvis, A / Castilla-Valdez, H / De La Cruz-Burelo, E / Heredia-de La Cruz, I / Lopez-Fernandez, R / Martínez-Ortega, J / Sánchez-Hernández, A / Villasenor-Cendejas, L M / Carrillo Moreno, S / Vazquez Valencia, F / Salazar Ibarguen, H A / Casimiro Linares, E / Morelos Pineda, A / Reyes-Santos, M A / Krofcheck, D / Bell, A J / Butler, P H / Doesburg, R / Reucroft, S / Silverwood, H / Ahmad, M / Asghar, M I / Butt, J / Hoorani, H R / Khalid, S / Khan, W A / Khurshid, T / Qazi, S / Shah, M A / Shoaib, M / Bialkowska, H / Boimska, B / Frueboes, T / Górski, M / Kazana, M / Nawrocki, K / Romanowska-Rybinska, K / Szleper, M / Wrochna, G / Zalewski, P / Brona, G / Bunkowski, K / Cwiok, M / Dominik, W / Doroba, K / Kalinowski, A / Konecki, M / Krolikowski, J / Misiura, M / Almeida, N / Bargassa, P / David, A / Faccioli, P / Ferreira Parracho, P G / Gallinaro, M / Seixas, J / Varela, J / Vischia, P / Belotelov, I / Bunin, P / Gavrilenko, M / Golutvin, I / Gorbunov, I / Kamenev, A / Karjavin, V / Kozlov, G / Lanev, A / Malakhov, A / Moisenz, P / Palichik, V / Perelygin, V / Shmatov, S / Smirnov, V / Volodko, A / Zarubin, A / Evstyukhin, S / Golovtsov, V / Ivanov, Y / Kim, V / Levchenko, P / Murzin, V / Oreshkin, V / Smirnov, I / Sulimov, V / Uvarov, L / Vavilov, S / Vorobyev, A / Vorobyev, An / Andreev, Yu / Dermenev, A / Gninenko, S / Golubev, N / Kirsanov, M / Krasnikov, N / Matveev, V / Pashenkov, A / Tlisov, D / Toropin, A / Epshteyn, V / Erofeeva, M / Gavrilov, V / Kossov, M / Lychkovskaya, N / Popov, V / Safronov, G / Semenov, S / Shreyber, I / Stolin, V / Vlasov, E / Zhokin, A / Belyaev, A / Boos, E / Dubinin, M / Dudko, L / Ershov, A / Gribushin, A / Klyukhin, V / Kodolova, O / Lokhtin, I / Markina, A / Obraztsov, S / Perfilov, M / Petrushanko, S / Popov, A / Sarycheva, L / Savrin, V / Snigirev, A / Andreev, V / Azarkin, M / Dremin, I / Kirakosyan, M / Leonidov, A / Mesyats, G / Rusakov, S V / Vinogradov, A / Azhgirey, I / Bayshev, I / Bitioukov, S / Grishin, V / Kachanov, V / Konstantinov, D / Krychkine, V / Petrov, V / Ryutin, R / Sobol, A / Tourtchanovitch, L / Troshin, S / Tyurin, N / Uzunian, A / Volkov, A / Adzic, P / Djordjevic, M / Ekmedzic, M / Krpic, D / Milosevic, J / Aguilar-Benitez, M / Alcaraz Maestre, J / Arce, P / Battilana, C / Calvo, E / Cerrada, M / Chamizo Llatas, M / Colino, N / De La Cruz, B / Delgado Peris, A / Domínguez Vázquez, D / Fernandez Bedoya, C / Fernández Ramos, J P / Ferrando, A / Flix, J / Fouz, M C / Garcia-Abia, P / Gonzalez Lopez, O / Goy Lopez, S / Hernandez, J M / Josa, M I / Merino, G / Puerta Pelayo, J / Quintario Olmeda, A / Redondo, I / Romero, L / Santaolalla, J / Soares, M S / Willmott, C / Albajar, C / Codispoti, G / de Trocóniz, J F / Brun, H / Cuevas, J / Fernandez Menendez, J / Folgueras, S / Gonzalez Caballero, I / Lloret Iglesias, L / Piedra Gomez, J / Brochero Cifuentes, J A / Cabrillo, I J / Calderon, A / Chuang, S H / Duarte Campderros, J / Felcini, M / Fernandez, M / Gomez, G / Gonzalez Sanchez, J / Graziano, A / Jorda, C / Lopez Virto, A / Marco, J / Marco, R / Martinez Rivero, C / Matorras, F / Munoz Sanchez, F J / Rodrigo, T / Rodríguez-Marrero, A Y / Ruiz-Jimeno, A / Scodellaro, L / Vila, I / Vilar Cortabitarte, R / Abbaneo, D / Auffray, E / 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    Physical review letters

    2012  Volume 109, Issue 26, Page(s) 261802

    Abstract: ... W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis ... neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W(R) mass, dependent ... on the value of M(W(R)). The excluded region in the two-dimensional (M(W(R)), M(N(μ)) mass plane extends to M(W ...

    Abstract Results are presented from a search for heavy, right-handed muon neutrinos, N(μ), and right-handed W(R) bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0  fb(-1) sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W(R) mass, dependent on the value of M(W(R)). The excluded region in the two-dimensional (M(W(R)), M(N(μ)) mass plane extends to M(W(R))=2.5  TeV.
    Language English
    Publishing date 2012-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.109.261802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: THE COMMUTATIVE NEUTRIX PRODUCT OF B (r) (x, ṅ) AND δ (s) (x)

    ADEM KILIÇMAN,BRIAN FISHER, JOEL D. NICHOLAS

    Proceedings of Indian National Science Academy, Vol 29, Iss

    2015  Volume 4

    Abstract: THE COMMUTATIVE NEUTRIX PRODUCT OF B (r) (x, ṅ) AND δ (s) (x) ...

    Abstract THE COMMUTATIVE NEUTRIX PRODUCT OF B (r) (x, ṅ) AND δ (s) (x)
    Keywords Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Simultaneous measurement of the ratio R=B(t --> Wb)/B(t --> Wq) and the top-quark pair production cross section with the D0 detector at sqrt(s) = 1.96 TeV.

    Abazov, V M / Abbott, B / Abolins, M / Acharya, B S / Adams, M / Adams, T / Aguilo, E / Ahn, S H / Ahsan, M / Alexeev, G D / Alkhazov, G / Alton, A / Alverson, G / Alves, G A / Anastasoaie, M / Ancu, L S / Andeen, T / Anderson, S / Andrieu, B /
    Anzelc, M S / Arnoud, Y / Arov, M / Arthaud, M / Askew, A / Asman, B / Assis Jesus, A C S / Atramentov, O / Autermann, C / Avila, C / Ay, C / Badaud, F / Baden, A / Bagby, L / Baldin, B / Bandurin, D V / Banerjee, S / Banerjee, P / Barberis, E / Barfuss, A-F / Bargassa, P / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bauer, D / Beale, S / Bean, A / Begalli, M / Begel, M / Belanger-Champagne, C / Bellantoni, L / Bellavance, A / Benitez, J A / Beri, S B / Bernardi, G / Bernhard, R / Bertram, I / Besançon, M / Beuselinck, R / Bezzubov, V A / Bhat, P C / Bhatnagar, V / Biscarat, C / Blazey, G / Blekman, F / Blessing, S / Bloch, D / Bloom, K / Boehnlein, A / Boline, D / Bolton, T A / Borissov, G / Bose, T / Brandt, A / Brock, R / Brooijmans, G / Bross, A / Brown, D / Buchanan, N J / Buchholz, D / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Burke, S / Burnett, T H / Buszello, C P / Butler, J M / Calfayan, P / Calvet, S / Cammin, J / Carvalho, W / Casey, B C K / Cason, N M / Castilla-Valdez, H / Chakrabarti, S / Chakraborty, D / Chan, K M / Chan, K / Chandra, A / Charles, F / Cheu, E / Chevallier, F / Cho, D K / Choi, S / Choudhary, B / Christofek, L / Christoudias, T / Cihangir, S / Claes, D / Coadou, Y / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Crépé-Renaudin, S / Cutts, D / Cwiok, M / da Motta, H / Das, A / Davies, G / De, K / de Jong, S J / De La Cruz-Burelo, E / De Oliveira Martins, C / Degenhardt, J D / Déliot, F / Demarteau, M / Demina, R / Denisov, D / Denisov, S P / Desai, S / Diehl, H T / Diesburg, M / Dominguez, A / Dong, H / Dudko, L V / Duflot, L / Dugad, S R / Duggan, D / Duperrin, A / Dyer, J / Dyshkant, A / Eads, M / Edmunds, D / Ellison, J / Elvira, V D / Enari, Y / Eno, S / Ermolov, P / Evans, H / Evdokimov, A / Evdokimov, V N / Ferapontov, A V / Ferbel, T / Fiedler, F / Filthaut, F / Fisher, W / Fisk, H E / Ford, M / Fortner, M / Fox, H / Fu, S / Fuess, S / Gadfort, T / Galea, C F / Gallas, E / Galyaev, E / Garcia, C / Garcia-Bellido, A / Gavrilov, V / Gay, P / Geist, W / Gelé, D / Gerber, C E / Gershtein, Y / Gillberg, D / Ginther, G / Gollub, N / Gómez, B / Goussiou, A / Grannis, P D / Greenlee, H / Greenwood, Z D / Gregores, E M / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Guo, J / Guo, F / Gutierrez, P / Gutierrez, G / Haas, A / Hadley, N J / Haefner, P / Hagopian, S / Haley, J / Hall, I / Hall, R E / Han, L / Hansson, P / Harder, K / Harel, A / Harrington, R / Hauptman, J M / Hauser, R / Hays, J / Hebbeker, T / Hedin, D / Hegeman, J G / Heinmiller, J M / Heinson, A P / Heintz, U / Hensel, C / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hobbs, J D / Hoeneisen, B / Hoeth, H / Hohlfeld, M / Hong, S J / Hossain, S / Houben, P / Hu, Y / Hubacek, Z / Hynek, V / Iashvili, I / Illingworth, R / Ito, A S / Jabeen, S / Jaffré, M / Jain, S / Jakobs, K / Jarvis, C / Jesik, R / Johns, K / Johnson, C / Johnson, M / Jonckheere, A / Jonsson, P / Juste, A / Kajfasz, E / Kalinin, A M / Kalk, J R / Kalk, J M / Kappler, S / Karmanov, D / Kasper, P A / Katsanos, I / Kau, D / Kaur, R / Kaushik, V / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y M / Khatidze, D / Kim, T J / Kirby, M H / Kirsch, M / Klima, B / Kohli, J M / Konrath, J-P / Korablev, V M / Kozelov, A V / Krop, D / Kuhl, T / Kumar, A / Kunori, S / Kupco, A / Kurca, T / Kvita, J / Lacroix, F / Lam, D / Lammers, S / Landsberg, G / Lebrun, P / Lee, W M / Leflat, A / Lehner, F / Lellouch, J / Leveque, J / Li, J / Li, Q Z / Li, L / Lietti, S M / Lima, J G R / Lincoln, D / Linnemann, J / Lipaev, V V / Lipton, R / Liu, Y / Liu, Z / Lobodenko, A / Lokajicek, M / Love, P / Lubatti, H J / Luna, R / Lyon, A L / Maciel, A K A / Mackin, D / Madaras, R J / Mättig, P / Magass, C / Magerkurth, A / Mal, P K / Malbouisson, H B / Malik, S / Malyshev, V L / Mao, H S / Maravin, Y / Martin, B / McCarthy, R / Melnitchouk, A / Mendoza, L / 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N / Renkel, P / Reucroft, S / Rich, P / Rieger, J / Rijssenbeek, M / Ripp-Baudot, I / Rizatdinova, F / Robinson, S / Rodrigues, R F / Rominsky, M / Royon, C / Rubinov, P / Ruchti, R / Safronov, G / Sajot, G / Sánchez-Hernández, A / Sanders, M P / Santoro, A / Savage, G / Sawyer, L / Scanlon, T / Schaile, D / Schamberger, R D / Scheglov, Y / Schellman, H / Schliephake, T / Schwanenberger, C / Schwartzman, A / Schwienhorst, R / Sekaric, J / Severini, H / Shabalina, E / Shamim, M / Shary, V / Shchukin, A A / Shivpuri, R K / Siccardi, V / Simak, V / Sirotenko, V / Skubic, P / Slattery, P / Smirnov, D / Snow, J / Snow, G R / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Sopczak, A / Sosebee, M / Soustruznik, K / Spurlock, B / Stark, J / Steele, J / Stolin, V / Stoyanova, D A / Strandberg, J / Strandberg, S / Strang, M A / Strauss, M / Strauss, E / Ströhmer, R / Strom, D / Stutte, L / Sumowidagdo, S / Svoisky, P / Sznajder, A / Talby, M / Tamburello, P / Tanasijczuk, A / Taylor, W / Temple, J / Tiller, B / Tissandier, F / Titov, M / Tokmenin, V V / Toole, T / Torchiani, I / Trefzger, T / Tsybychev, D / Tuchming, B / Tully, C / Tuts, P M / Unalan, R / Uvarov, S / Uvarov, L / Uzunyan, S / Vachon, B / van den Berg, P J / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Vaupel, M / Verdier, P / Vertogradov, L S / Verzocchi, M / Villeneuve-Seguier, F / Vint, P / Vokac, P / Von Toerne, E / Voutilainen, M / Wagner, R / Wahl, H D / Wang, L / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weber, M / Weber, G / Welty-Rieger, L / Wenger, A / Wermes, N / Wetstein, M / White, A / Wicke, D / Wilson, G W / Wimpenny, S J / Wobisch, M / Wood, D R / Wyatt, T R / Xie, Y / Yacoob, S / Yamada, R / Yan, M / Yasuda, T / Yatsunenko, Y A / Yip, K / Yoo, H D / Youn, S W / Yu, J / Zatserklyaniy, A / Zeitnitz, C / Zhao, T / Zhou, B / Zhu, J / Zielinski, M / Zieminska, D / Zieminski, A / Zivkovic, L / Zutshi, V / Zverev, E G

    Physical review letters

    2008  Volume 100, Issue 19, Page(s) 192003

    Abstract: We present the first simultaneous measurement of the ratio of branching fractions, R=B(t --> Wb)/B ... t --> Wq), with q being a d, s, or b quark, and the top-quark pair production cross section sigma(tt ... over]) in the lepton plus jets channel using 0.9 fb(-1) of pp[over] collision data at sqrt(s)=1.96 TeV ...

    Abstract We present the first simultaneous measurement of the ratio of branching fractions, R=B(t --> Wb)/B(t --> Wq), with q being a d, s, or b quark, and the top-quark pair production cross section sigma(tt[over]) in the lepton plus jets channel using 0.9 fb(-1) of pp[over] collision data at sqrt(s)=1.96 TeV collected with the D0 detector. We extract R and sigma(tt[over]) by analyzing samples of events with 0, 1, and > or =2 identified b jets. We measure R=0.97(+0.09)/(-0.08)(stat+syst) and sigma(tt[over])=8.18(+0.09)(-0.84)(stat+syst) +/- 0.50(lumi) pb, in agreement with the standard model prediction.
    Language English
    Publishing date 2008-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.100.192003
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  6. Article: A.R.D.S. means emergency.

    Cline, B A / Fisher, M L

    Nursing

    1982  Volume 12, Issue 2, Page(s) 62–67

    MeSH term(s) Critical Care ; Emergencies ; Humans ; Hypoxia/nursing ; Intermittent Positive-Pressure Ventilation ; Male ; Middle Aged ; Oxygen Inhalation Therapy ; Respiratory Distress Syndrome, Adult/diagnosis ; Respiratory Distress Syndrome, Adult/nursing ; Shock/nursing
    Language English
    Publishing date 1982-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197895-0
    ISSN 0360-4039
    ISSN 0360-4039
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  7. Article: Estimated variance components in the S-R inventory of anxiousness.

    Silverstein, A B / Fisher, G

    Perceptual and motor skills

    1968  Volume 27, Issue 3, Page(s) 740–742

    MeSH term(s) Adolescent ; Adult ; Analysis of Variance ; Anxiety ; Humans ; Male ; Middle Aged ; Psychological Tests
    Language English
    Publishing date 1968-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204507-2
    ISSN 0031-5125
    ISSN 0031-5125
    DOI 10.2466/pms.1968.27.3.140
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  8. Article ; Online: Using a community engaged research approach to develop the social skills training program for adults with Williams syndrome.

    Fisher, Marisa H / Black, Rhonda S / Kammes, Rebecca R

    Journal of intellectual disabilities : JOID

    2024  , Page(s) 17446295241245783

    Abstract: This article describes the development of a distance-delivered social skills training program for adults with Williams syndrome (SSTP-WS) through a community engaged approach. Throughout six phases of development, the research team received input from ... ...

    Abstract This article describes the development of a distance-delivered social skills training program for adults with Williams syndrome (SSTP-WS) through a community engaged approach. Throughout six phases of development, the research team received input from adults with Williams syndrome, caregivers, service providers, educators, and researchers on (a) the need for a training program and topics to be addressed (Phase 1), (b) an initial draft of the SSTP-WS (Phase 3), (c) the intervention pilot study (Phase 5), and (d) feedback to provide context for the results of the study (Phase 6). The development of the SSTP-WS resulted in an intervention aligned with the Williams syndrome community's values and needs that supports the unique cognitive and behavioral phenotypes and social characteristics of this low incidence disability population.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071898-6
    ISSN 1744-6309 ; 1469-0047 ; 1744-6295
    ISSN (online) 1744-6309
    ISSN 1469-0047 ; 1744-6295
    DOI 10.1177/17446295241245783
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  9. Article ; Online: Prior Treatment with AICAR Causes the Selective Phosphorylation of mTOR Substrates in C2C12 Cells.

    Dedert, Cass J / Bagdady, Kazimir R / Fisher, Jonathan S

    Current issues in molecular biology

    2023  Volume 45, Issue 10, Page(s) 8040–8052

    Abstract: Metabolic stress in skeletal muscle cells causes sustained metabolic changes, but the mechanisms of the prolonged effects are not fully known. In this study, we tested C2C12 cells with the AMP-activated protein kinase (AMPK) stimulator AICAR and measured ...

    Abstract Metabolic stress in skeletal muscle cells causes sustained metabolic changes, but the mechanisms of the prolonged effects are not fully known. In this study, we tested C2C12 cells with the AMP-activated protein kinase (AMPK) stimulator AICAR and measured the changes in the metabolic pathways and signaling kinases. AICAR caused an acute increase in the phosphorylation of the AMPK target ULK1, the mTORC1 substrate S6K, and the mTORC2 target Akt. Intriguingly, prior exposure to AICAR only decreased glucose-6 phosphate dehydrogenase activity when it underwent three-hour recovery after exposure to AICAR in a bicarbonate buffer containing glucose (KHB) instead of Dulbecco's Minimum Essential Medium (DMEM). The phosphorylation of the mTORC1 target S6K was increased after recovery in DMEM but not KHB, although this appeared to be specific to S6K, as the phosphorylation of the mTORC1 target site on ULK1 was not altered when the cells recovered in DMEM. The phosphorylation of mTORC2 target sites was also heterogenous under these conditions, with Akt increasing at serine 473 while other targets (SGK1 and PKCα) were unaffected. The exposure of cells to rapamycin (an mTORC1 inhibitor) and PP242 (an inhibitor of both mTOR complexes) revealed the differential phosphorylation of mTORC2 substrates. Taken together, the data suggest that prior exposure to AICAR causes the selective phosphorylation of mTOR substrates, even after prolonged recovery in a nutrient-replete medium.
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45100508
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  10. Article ; Online: Role of integrated care in optimizing perinatal care delivery and virologic control in pregnant people with HIV during the COVID-19 pandemic.

    Chhabria, Karisma R / Miller, Emily S / Yee, Lynn M / Garcia, Patricia M / Fisher, Stephanie A

    American journal of obstetrics & gynecology MFM

    2024  Volume 6, Issue 4, Page(s) 101344

    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Letter
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2024.101344
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