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  1. Article ; Online: Nicole Wolf.

    Wolf, Nicole

    The Lancet. Neurology

    2014  Volume 13, Issue 7, Page(s) 653

    MeSH term(s) Female ; Humans ; Nervous System Diseases/diagnosis ; Nervous System Diseases/therapy ; Physicians
    Language English
    Publishing date 2014-07-25
    Publishing country England
    Document type Interview
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/s1474-4422(14)70134-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Wolf Reik: Inheritance beyond DNA. Interview by Nicole Lebrasseur.

    Reik, Wolf

    The Journal of cell biology

    2010  Volume 188, Issue 3, Page(s) 302–303

    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; Genetic Diseases, Inborn ; Genomic Imprinting ; Humans ; RNA, Untranslated
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2010-02-08
    Publishing country United States
    Document type Interview ; Portrait
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.1883pi
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  3. Article: Case report: Minimally invasive primary debulking surgery for advanced stage epithelial ovarian cancer.

    Wolf, Jennifer / Goncalves, Nicole / Alagkiozidis, Ioannis

    Frontiers in oncology

    2024  Volume 14, Page(s) 1302724

    Abstract: The surgical management of advanced ovarian cancer has historically emphasized an open technique, but advances in minimally invasive surgery (MIS) have led to its increasing use in ovarian cancer. Most research has focused on the utility of MIS in the ... ...

    Abstract The surgical management of advanced ovarian cancer has historically emphasized an open technique, but advances in minimally invasive surgery (MIS) have led to its increasing use in ovarian cancer. Most research has focused on the utility of MIS in the interval debulking setting. Here, we present a case of a 38-year-old patient with incidentally diagnosed advanced stage ovarian cancer. We describe the robotic surgery techniques used to achieve complete primary cytoreduction, including resection of disease on the diaphragm. The patient has completed standard adjuvant chemotherapy and maintenance treatment and remains without evidence of disease for more than 2 years. This case details the techniques utilized to achieve complete cytoreduction including trocar placement, robotic instrument preference, and rotation of the robotic boom. This patient has had successful perioperative and oncologic outcomes, and her case highlights the role for minimally invasive primary debulking surgery for select patients with advanced ovarian cancer.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1302724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: OTC-Spezial Beratungswissen Allergien

    Wolf, Elke / Schuster, Nicole

    (Pharmazeutische Zeitung ; [166.] Jg., 9. Ausg., Supplement (4.3.2021))

    2021  

    Title variant Beratungswissen Allergien
    Author's details Elke Wolf, Nicole Schuster
    Series title Pharmazeutische Zeitung ; [166.] Jg., 9. Ausg., Supplement (4.3.2021)
    Collection
    Language German
    Size 22 Seiten, Illustrationen
    Publisher Pharmazeutische Zeitung
    Publishing place Eschborn
    Publishing country Germany
    Document type Book
    HBZ-ID HT020942187
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uf I Zs 10 -166,9,Suppl.- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Rapidly progressive dementias - leukodystrophies as a potentially treatable cause.

    Wolf, Nicole I / Pijnenburg, Yolande A L / van der Knaap, Marjo S

    Nature reviews. Neurology

    2022  Volume 18, Issue 12, Page(s) 758

    MeSH term(s) Humans ; Dementia/etiology ; Neurodegenerative Diseases
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00740-8
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  6. Article ; Online: Basal nuclei are not involved in early metachromatic leukodystrophy.

    Beerepoot, Shanice / Schoenmakers, Daphne H / van der Knaap, Marjo S / Wolf, Nicole I

    Clinical neurology and neurosurgery

    2023  Volume 228, Page(s) 107696

    MeSH term(s) Humans ; Leukodystrophy, Metachromatic/diagnosis ; Basal Ganglia
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2023.107696
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  7. Article ; Online: The effect of intrathecal recombinant arylsulfatase A therapy on structural brain magnetic resonance imaging in children with metachromatic leukodystrophy.

    Groeschel, Samuel / Beerepoot, Shanice / Amedick, Lucas Bastian / Krӓgeloh-Mann, Ingeborg / Li, Jing / Whiteman, David A H / Wolf, Nicole I / Port, John D

    Journal of inherited metabolic disease

    2024  

    Abstract: This study aimed to evaluate the effect of intrathecal (IT) recombinant human arylsulfatase A (rhASA) on magnetic resonance imaging (MRI)-assessed brain tissue changes in children with metachromatic leukodystrophy (MLD). In total, 510 MRI scans were ... ...

    Abstract This study aimed to evaluate the effect of intrathecal (IT) recombinant human arylsulfatase A (rhASA) on magnetic resonance imaging (MRI)-assessed brain tissue changes in children with metachromatic leukodystrophy (MLD). In total, 510 MRI scans were collected from 12 intravenous (IV) rhASA-treated children with MLD, 24 IT rhASA-treated children with MLD, 32 children with untreated MLD, and 156 normally developing children. Linear mixed models were fitted to analyze the time courses of gray matter (GM) volume and fractional anisotropy (FA) in the posterior limb of the internal capsule. Time courses for demyelination load and FA in the centrum semiovale were visualized using locally estimated scatterplot smoothing regression curves. All assessed imaging parameters demonstrated structural evidence of neurological deterioration in children with MLD. GM volume was significantly lower at follow-up (median duration, 104 weeks) in IV rhASA-treated versus IT rhASA-treated children. GM volume decline over time was steeper in children receiving low-dose (10 or 30 mg) versus high-dose (100 mg) IT rhASA. Similar effects were observed for demyelination. FA in the posterior limb of the internal capsule showed a higher trend over time in IT rhASA-treated versus children with untreated MLD, but FA parameters were not different between children receiving the low doses versus those receiving the high dose. GM volume in IT rhASA-treated children showed a strong positive correlation with 88-item Gross Motor Function Measure score over time. In some children with MLD, IT administration of high-dose rhASA may delay neurological deterioration (assessed using MRI), offering potential therapeutic benefit.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438341-2
    ISSN 1573-2665 ; 0141-8955
    ISSN (online) 1573-2665
    ISSN 0141-8955
    DOI 10.1002/jimd.12706
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  8. Article ; Online: To the Reviewers of Neuropediatrics in 2019.

    Plecko, Barbara / Wolf, Nicole I / Neubauer, Bernd A

    Neuropediatrics

    2020  Volume 51, Issue 4, Page(s) 237–240

    Language English
    Publishing date 2020-07-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0040-1713930
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  9. Article ; Online: Wirksamkeit und Sicherheit von Home-Treatment in der Kinder- und Jugendpsychiatrie: Eine systematische Literaturübersicht.

    Zechmeister-Koss, Ingrid / Grössmann, Nicole / Wolf, Sarah

    Psychiatrische Praxis

    2021  Volume 49, Issue 1, Page(s) 11–21

    Abstract: Objective: In child and adolescent psychiatry, home treatment is becoming increasingly important due to limited inpatient care capacities and changing treatment philosophies. This paper examines its effectiveness and safety.: Methods: We did a ... ...

    Title translation Effectiveness and Safety of Home Treatment in Child and Adolescent Mental Health Care: A Systematic Literature Review.
    Abstract Objective: In child and adolescent psychiatry, home treatment is becoming increasingly important due to limited inpatient care capacities and changing treatment philosophies. This paper examines its effectiveness and safety.
    Methods: We did a systematic literature search and summarized the home treatment model characteristics as well as the evidence on its benefits and harms narratively.
    Results: In the six identified studies, improvements in symptoms were found in both, home and institutionalized treatment. In the long-term, home treatment seems to be slightly superior and involves fewer hospital days. However, a best-practice model cannot be derived from the data available.
    Conclusion: Home treatment can be considered as an alternative to inpatient treatment, but requires coordination with other mental health care elements and further evaluation.
    MeSH term(s) Adolescent ; Adolescent Psychiatry ; Child ; Day Care, Medical ; Germany ; Hospitalization ; Humans ; Mental Health
    Language German
    Publishing date 2021-08-20
    Publishing country Germany
    Document type Journal Article ; Systematic Review
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-1517-6171
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  10. Article ; Online: Cortical interneuron development is affected in 4H leukodystrophy.

    Dooves, Stephanie / Kok, Liza M L / Holmes, Dwayne B / Breeuwsma, Nicole / Breur, Marjolein / Bugiani, Marianna / Wolf, Nicole I / Heine, Vivi M

    Brain : a journal of neurology

    2023  Volume 146, Issue 7, Page(s) 2846–2860

    Abstract: 4H leukodystrophy is a rare genetic disorder classically characterized by hypomyelination, hypodontia and hypogonadotropic hypogonadism. With the discovery that 4H is caused by mutations that affect RNA polymerase III, mainly involved in the ... ...

    Abstract 4H leukodystrophy is a rare genetic disorder classically characterized by hypomyelination, hypodontia and hypogonadotropic hypogonadism. With the discovery that 4H is caused by mutations that affect RNA polymerase III, mainly involved in the transcription of small non-coding RNAs, patients with atypical presentations with mainly a neuronal phenotype were also identified. Pathomechanisms of 4H brain abnormalities are still unknown and research is hampered by a lack of preclinical models. We aimed to identify cells and pathways that are affected by 4H mutations using induced pluripotent stem cell models. RNA sequencing analysis on induced pluripotent stem cell-derived cerebellar cells revealed several differentially expressed genes between 4H patients and control samples, including reduced ARX expression. As ARX is involved in early brain and interneuron development, we studied and confirmed interneuron changes in primary tissue of 4H patients. Subsequently, we studied interneuron changes in more depth and analysed induced pluripotent stem cell-derived cortical neuron cultures for changes in neuronal morphology, synaptic balance, network activity and myelination. We showed a decreased percentage of GABAergic synapses in 4H, which correlated to increased neuronal network activity. Treatment of cultures with GABA antagonists led to a significant increase in neuronal network activity in control cells but not in 4H cells, also pointing to lack of inhibitory activity in 4H. Myelination and oligodendrocyte maturation in cultures with 4H neurons was normal, and treatment with sonic hedgehog agonist SAG did not improve 4H related neuronal phenotypes. Quantitative PCR analysis revealed increased expression of parvalbumin interneuron marker ERBB4, suggesting that the development rather than generation of interneurons may be affected in 4H. Together, these results indicate that interneurons are involved, possibly parvalbumin interneurons, in disease mechanisms of 4H leukodystrophy.
    MeSH term(s) Hedgehog Proteins/genetics ; Parvalbumins/genetics ; Parvalbumins/metabolism ; Interneurons/metabolism ; Mutation
    Chemical Substances Hedgehog Proteins ; Parvalbumins
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad017
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