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  1. Article ; Online: Lipase-catalyzed synthesis of two new antioxidants: 4-O- and 3-O-palmitoyl chlorogenic acids.

    Lorentz, C / Dulac, A / Pencreac'h, G / Ergan, F / Richomme, P / Soultani-Vigneron, S

    Biotechnology letters

    2010  Volume 32, Issue 12, Page(s) 1955–1960

    Abstract: ... product acylated at the C-4 of the quinic moiety (4-O-palmitoyl chlorogenic acid) and a minor product ... acylated at the C-3 (3-O-palmitoyl chlorogenic acid). The bioconversions obtained in 7 days ranged from 14 ... The regioselectivity (4-O-palmitoyl/3-O-palmitoyl ratio) of the reaction was also affected by the molar ratio, and ...

    Abstract Chlorogenic acid (5-caffeoyl quinic acid (CQA)) extracted from Hydrangea macrophylla (44%, w/w) with 98% purity, was acylated with palmitic acid by Novozym 435 to yield mono-acylated CQA. Acylation of CQA was achieved in 2-methyl-2-butanol at 60°C, and yielded two mono-acylated products: a major product acylated at the C-4 of the quinic moiety (4-O-palmitoyl chlorogenic acid) and a minor product acylated at the C-3 (3-O-palmitoyl chlorogenic acid). The bioconversions obtained in 7 days ranged from 14 to 60% and were influenced by the molar ratio of palmitic acid/CQA, which ranged from 10 to 80. The regioselectivity (4-O-palmitoyl/3-O-palmitoyl ratio) of the reaction was also affected by the molar ratio, and ranged from 90 to 70%. The scavenging activities against 1,1-diphenyl-2-picryl-hydrazyl radicals demonstrated that these palmitoyl CQA derivatives are associated with antioxidant activity (70% vs CQA).
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/metabolism ; Biotransformation ; Chlorogenic Acid/analogs & derivatives ; Chlorogenic Acid/metabolism ; Hot Temperature ; Hydrangea/chemistry ; Lipase/metabolism ; Palmitic Acid/metabolism ; Pentanols/metabolism
    Chemical Substances Antioxidants ; Pentanols ; Palmitic Acid (2V16EO95H1) ; Chlorogenic Acid (318ADP12RI) ; tert-amyl alcohol (69C393R11Z) ; Novozyme 435 (EC 3.1.1.-) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2010-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-010-0386-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Lipase-catalyzed synthesis of two new antioxidants: 4-O- and 3-O-palmitoyl chlorogenic acids

    Lorentz, C / Dulac, A / Pencreac'h, G / Ergan, F / Richomme, P / Soultani-Vigneron, S

    Biotechnology letters. 2010 Dec., v. 32, no. 12

    2010  

    Abstract: ... product acylated at the C-4 of the quinic moiety (4-O-palmitoyl chlorogenic acid) and a minor product ... acylated at the C-3 (3-O-palmitoyl chlorogenic acid). The bioconversions obtained in 7 days ranged from 14 ... The regioselectivity (4-O-palmitoyl/3-O-palmitoyl ratio) of the reaction was also affected by the molar ratio, and ...

    Abstract Chlorogenic acid (5-caffeoyl quinic acid (CQA)) extracted from Hydrangea macrophylla (44%, w/w) with 98% purity, was acylated with palmitic acid by Novozym 435 to yield mono-acylated CQA. Acylation of CQA was achieved in 2-methyl-2-butanol at 60°C, and yielded two mono-acylated products: a major product acylated at the C-4 of the quinic moiety (4-O-palmitoyl chlorogenic acid) and a minor product acylated at the C-3 (3-O-palmitoyl chlorogenic acid). The bioconversions obtained in 7 days ranged from 14 to 60% and were influenced by the molar ratio of palmitic acid/CQA, which ranged from 10 to 80. The regioselectivity (4-O-palmitoyl/3-O-palmitoyl ratio) of the reaction was also affected by the molar ratio, and ranged from 90 to 70%. The scavenging activities against 1,1-diphenyl-2-picryl-hydrazyl radicals demonstrated that these palmitoyl CQA derivatives are associated with antioxidant activity (70% vs CQA).
    Keywords acylation ; chlorogenic acid ; palmitic acid
    Language English
    Dates of publication 2010-12
    Size p. 1955-1960.
    Publisher Springer Netherlands
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-010-0386-6
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  3. Article ; Online: Are Epileptic Spasms a Seizure Type for the Insular Region?

    Kharytonov, Volodymyr / Dulac, Olivier

    Neuropediatrics

    2020  Volume 51, Issue 4, Page(s) 295–297

    Abstract: Two patients with insular and striatal postnatal scar had epileptic spasms (ES) that were asymmetrical and the only seizure type, whereas none of the usual ictal symptoms of insular seizures occurred. Ictal electroencephalography (EEG) showed the high- ... ...

    Abstract Two patients with insular and striatal postnatal scar had epileptic spasms (ES) that were asymmetrical and the only seizure type, whereas none of the usual ictal symptoms of insular seizures occurred. Ictal electroencephalography (EEG) showed the high-amplitude slow-wave characteristic of ES. Vigabatrin remained efficient for over 4 years for one patient and right into the third decade for the other one. Such ES are distinct from infantile and late onset spasms. Furthermore, these observations suggest that in ES insular epilepsy triggers paroxysmal activation of the striatum, and that vigabatrin inhibits the striatal startle motor program, thus interrupting the corticostriatal loop.
    MeSH term(s) Adult ; Anticonvulsants/administration & dosage ; Cerebral Cortex/physiopathology ; Child ; Corpus Striatum/physiopathology ; Electroencephalography ; Epilepsy/drug therapy ; Epilepsy/physiopathology ; Female ; Humans ; Male ; Vigabatrin/administration & dosage ; Young Adult
    Chemical Substances Anticonvulsants ; Vigabatrin (GR120KRT6K)
    Language English
    Publishing date 2020-03-28
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0040-1702226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Epileptic syndromes in infancy and childhood: recent advances.

    Dulac, O

    Epilepsia

    2012  Volume 36 Suppl 1, Page(s) S51–7

    Abstract: Epileptic syndromes are more reliable than etiology in determining prognosis and optimal treatment in infants and children. Benign neonatal and infantile convulsions are either idiopathic or dominantly inherited, the latter being genetically nonallelic. ... ...

    Abstract Epileptic syndromes are more reliable than etiology in determining prognosis and optimal treatment in infants and children. Benign neonatal and infantile convulsions are either idiopathic or dominantly inherited, the latter being genetically nonallelic. Forms of idiopathic generalized epilepsy (IGE) include absence epilepsy, benign myoclonic epilepsy of infancy, and epilepsy with generalized myoclonic atonic seizures. Forms of idiopathic partial epilepsy include benign partial epilepsy with centrotemporal spikes (BECT), benign partial epilepsy with occipital paroxysms, idiopathic partial epilepsy with affective seizures, and benign partial epilepsies with extreme somatosensory evoked potentials (SEPS). These idiopathic epilepsies appear to result from a multifactorial genetic predisposition. The diagnosis is based on strict clinical and EEG criteria. In epileptogenic encephalopathies, cognitive disorders are the main feature and are linked to so-called interictal abnormalities. Some epileptic syndromes, particularly myoclonic epilepsies, remain unclassifiable because of poor understanding of nosology or heterogeneous outcome.
    MeSH term(s) Brain Waves/physiology ; Child ; Child, Preschool ; Electroencephalography ; Epilepsy/classification ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Humans ; Infant
    Language English
    Publishing date 2012-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/j.1528-1157.1995.tb01653.x
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    Zs.MO 475: Show issues

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  5. Article: Ketogenic diet for super-refractory status epilepticus (SRSE) with NORSE and FIRES: Single tertiary center experience and literature data.

    Nabbout, Rima / Matricardi, Sara / De Liso, Paola / Dulac, Olivier / Oualha, Mehdi

    Frontiers in neurology

    2023  Volume 14, Page(s) 1134827

    Abstract: Background and purpose: Ketogenic diet (KD) is an emerging treatment option for super-refractory status epilepticus (SRSE). We evaluated the effectiveness of KD in patients presenting SRSE including NORSE (and its subcategory FIRES).: Methods: A ... ...

    Abstract Background and purpose: Ketogenic diet (KD) is an emerging treatment option for super-refractory status epilepticus (SRSE). We evaluated the effectiveness of KD in patients presenting SRSE including NORSE (and its subcategory FIRES).
    Methods: A retrospective review of the medical records was performed at the Necker Enfants Malades Hospital. All children with SRSE in whom KD was started during the last 10 years were included. A systematic search was carried out for all study designs, including at least one patient of any age with SRSE in whom KD was started. The primary outcome was the responder rate and Kaplan-Meier survival curves were generated for the time-to-KD response. As secondary outcomes, Cox proportional hazard models were created to assess the impact of NORSE-related factors on KD efficacy.
    Results: Sixteen children received KD for treatment of SRSE, and three had NORSE presentation (one infectious etiology, two FIRES). In medical literature, 1,613 records were initially identified, and 75 were selected for review. We selected 276 patients receiving KD during SRSE. The most common etiology of SRSE was acute symptomatic (21.3%), among these patients, 67.7% presented with NORSE of immune and infectious etiologies. Other etiologies were remote symptomatic (6.8%), progressive symptomatic (6.1%), and SE in defined electroclinical syndromes (14.8%), including two patients with genetic etiology and NORSE presentation. The etiology was unknown in 50.7% of the patients presenting with cryptogenic NORSE, of which 102 presented with FIRES. Overall, most patients with NORSE benefit from KD (
    Conclusions: The search for underlying etiology should help to a better-targeted therapy. KD can have good efficacy in NORSE; however, the time to achieve SE resolution seems to be longer in cryptogenic cases. These findings highlight the therapeutic role of KD in NORSE, even though this favorable response needs to be better confirmed in prospective controlled studies.
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1134827
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  6. Article: Epileptic encephalopathy with suppression-bursts and nonketotic hyperglycinemia.

    Dulac, Olivier

    Handbook of clinical neurology

    2013  Volume 113, Page(s) 1785–1797

    Abstract: Bursts of paroxysmal activity alternating with lack of activity define the suppression-burst (SB) pattern that may be acute, in hypoxic-ischemic encephalopathy and barbiturate intoxication, or chronic in the course of early epileptic and neonatal ... ...

    Abstract Bursts of paroxysmal activity alternating with lack of activity define the suppression-burst (SB) pattern that may be acute, in hypoxic-ischemic encephalopathy and barbiturate intoxication, or chronic in the course of early epileptic and neonatal myoclonic (NME) encephalopathies. Malformations, namely Aicardi syndrome and hemimegalencephaly, gene mutations - of ARX and MUNC18 -, and inborn errors of metabolism, namely glycine encephalopathy, are the main causes, with spasms indicating more likely a malformation whereas myoclonus indicates metabolic disorders. Although glycine encephalopathy has a very severe outcome in its classical expression, it may be transient in the neonatal period, for reasons yet not identified. Although glycine encephalopathy is the main identified cause of NME, the disorder may not cause SB, especially in cases with later onset. The biochemical bases, due to changes in one of the four proteins that compose the enzyme, are well understood, but there is no phenotype-genotype correlation. Prenatal diagnosis is based on villous biopsy. The mechanism of SB partly depends on glutamate - or glycine, the co-neurotransmitter for NMDA transmission - overflow, mainly in the immature brain but also in cases due to barbiturate intoxication. Energy supply defect may also be involved in some inborn errors of metabolism.
    MeSH term(s) Brain/physiopathology ; Electroencephalography ; Epilepsy/complications ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Humans ; Hyperglycinemia, Nonketotic/complications ; Hyperglycinemia, Nonketotic/diagnosis ; Hyperglycinemia, Nonketotic/physiopathology ; Infant ; Infant, Newborn ; Opsoclonus-Myoclonus Syndrome/complications ; Opsoclonus-Myoclonus Syndrome/diagnosis ; Opsoclonus-Myoclonus Syndrome/physiopathology
    Language English
    Publishing date 2013
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-59565-2.00048-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: STXBP1 germline mutation and focal cortical dysplasia.

    Sharkov, Artem / Dulac, Olivier / Gataullina, Svetlana

    Epileptic disorders : international epilepsy journal with videotape

    2021  Volume 23, Issue 1, Page(s) 143–147

    Abstract: A child with a de novo STXBP1 heterozygous missense mutation, believed to be a pathogenic variant, presented with clustering focal seizures affecting both hemispheres. These had begun at the age of 10 months with a phenotype similar to that of PCDH19 ... ...

    Abstract A child with a de novo STXBP1 heterozygous missense mutation, believed to be a pathogenic variant, presented with clustering focal seizures affecting both hemispheres. These had begun at the age of 10 months with a phenotype similar to that of PCDH19 encephalopathy. MRI suggested a similarity to focal cortical dysplasia, though further research is needed. There was no evidence of either suppression-bursts or infantile spasms. This new case adds to the few other cases of patients with STXBP1 mutation in whom imaging features of focal cortical dysplasia on MRI have been reported, implying a possible role of STXBP1 mutation in neuronal migration disorders. If such a mutation with focal seizures is suspected, the possibility of focal cortical dysplasia should be investigated. [Published with video sequences].
    MeSH term(s) Child, Preschool ; Electroencephalography ; Epilepsies, Partial/diagnosis ; Epilepsies, Partial/genetics ; Germ-Line Mutation ; Humans ; Magnetic Resonance Imaging ; Malformations of Cortical Development/diagnosis ; Malformations of Cortical Development/genetics ; Munc18 Proteins/genetics ; Mutation, Missense
    Chemical Substances Munc18 Proteins ; STXBP1 protein, human
    Language English
    Publishing date 2021-02-25
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1684/epd.2021.1245
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    Zs.MO 252: Show issues
    Zs.MN 11: Show issues

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  8. Article ; Online: Mitigating fugitive methane emissions from closed landfills: A pilot-scale field study.

    Nelson, Brienne / Zytner, Richard G / Dulac, Yohan / Cabral, Alexandre R

    The Science of the total environment

    2022  Volume 851, Issue Pt 2, Page(s) 158351

    Abstract: ... moisture and sufficient supply of O ...

    Abstract Emissions from Canadian landfills account for 20 % of national greenhouse gas emissions, a portion of which occur as fugitive emissions. Depending on management factors, significant quantities of landfill gas are emitted during the operational phase and over several decades following landfill closure. Successful landfill reclamation developments depend on low-maintenance solutions to manage fugitive emissions. Designing passive methane oxidation biosystems (PMOBs) to complement landfill covers has become a promising complementary strategy. Achieving year-round methane oxidation in cold climates, requires specific conditions for survival of methanotrophic bacteria (responsible for methane oxidation), including optimal temperature, moisture and sufficient supply of O
    MeSH term(s) Methane/analysis ; Refuse Disposal/methods ; Air Pollutants/analysis ; Greenhouse Gases ; Environmental Monitoring/methods ; Waste Disposal Facilities ; Oxidation-Reduction ; Ontario
    Chemical Substances Methane (OP0UW79H66) ; Air Pollutants ; Greenhouse Gases
    Language English
    Publishing date 2022-08-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.158351
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  9. Article: Indications de la chirurgie dans les épilepsies de l'enfant: quand et comment opérer ?

    Dulac, O

    Neuro-Chirurgie

    2008  Volume 54, Issue 3, Page(s) 340–341

    Title translation Indications for surgery in childhood epilepsies: when and how should children be operated?.
    MeSH term(s) Anticonvulsants/therapeutic use ; Brain Neoplasms/complications ; Child ; Drug Resistance ; Electroencephalography ; Epilepsy/classification ; Epilepsy/diagnosis ; Epilepsy/surgery ; Humans ; Neurosurgical Procedures
    Chemical Substances Anticonvulsants
    Language French
    Publishing date 2008-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 207146-0
    ISSN 1773-0619 ; 0028-3770 ; 0150-9586
    ISSN (online) 1773-0619
    ISSN 0028-3770 ; 0150-9586
    DOI 10.1016/j.neuchi.2008.02.049
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  10. Article ; Online: Neonatal SCN2A encephalopathy: A peculiar recognizable electroclinical sequence.

    Melikishvili, Gia / Dulac, Olivier / Gataullina, Svetlana

    Epilepsy & behavior : E&B

    2020  Volume 111, Page(s) 107187

    Abstract: Introduction: Sodium voltage-gated channel alpha subunit 2 (SCN2A) gene encodes the Nav1.2 subunit of voltage-gated sodium channel in pyramidal neurons. SCN2A gain-of-function mutations are identified more and more often with gene panels and whole exome ...

    Abstract Introduction: Sodium voltage-gated channel alpha subunit 2 (SCN2A) gene encodes the Nav1.2 subunit of voltage-gated sodium channel in pyramidal neurons. SCN2A gain-of-function mutations are identified more and more often with gene panels and whole exome sequencing. Phenotype ranges from benign neonatal or infantile seizures to severe epileptic encephalopathy. Although large series of patients targeting genetic background point out two main phenotypes with SCN2A encephalopathy, Ohtahara syndrome and malignant migrating partial seizures in infancy (EMPSI), we noticed that in fact, a peculiar clinical and electroencephalogram (EEG) sequence distinct from these syndromes should suggest the diagnosis early.
    Patients and methods: We report three new cases with de novo SCN2A mutations - 166237617C>A p.(Asp1487Glu), c.407T>G p.(Met136Arg), and c.4633A>G p.(Met1545Val) - diagnosed by direct sequencing or genes panel, their follow-up ranging from 4 to 5 years.
    Results: For all three patients, seizures started at two days of life and consisted of apnea and cyanosis with partial clonic or tonic, alternating on both sides with, up to 100/day, evolving to generalized tonic-clonic seizures (GTCS) and epileptic spasms by three months. First EEG showed a discontinuous pattern, evolving to multifocal spikes, by 3 (two patients) and 6 months (one). Seizure frequency decreased progressively by the middle or end of the first year of life. Only less frequent GTCS persisted during the second year of life for two patients. Improvement was observed in two patients with sodium channel blocker (phenytoin) used at age of 1 month for one patient and at 2 years for another one. All patients remained with severe psychomotor delay.
    Discussion: All three infants share a condition different from Ohtahara syndrome in which tonic spasms predominate and suppression-burst pattern is obvious, and from EMPSI, in which partial migrating discharges involve successively the various parts of the brain including occipital regions with oculoclonic seizures, but there is neither discontinuous pattern nor therapeutic response to sodium channel blockers.
    Conclusion: Neonatal SCN2A encephalopathy has a recognizable phenotype starting soon after birth with alternating partial motor seizures evolving to infantile spasms and a discontinuous EEG pattern. Seizures improve spontaneously in the first year of life. This electroclinical sequence should indicate the search of SCN2A mutation and suggest the administration of sodium channel blockers.
    MeSH term(s) Brain/drug effects ; Brain/physiopathology ; Child ; Child, Preschool ; Electroencephalography/drug effects ; Electroencephalography/methods ; Female ; Humans ; Infant, Newborn ; Male ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; Phenytoin/therapeutic use ; Sodium Channel Blockers/therapeutic use ; Spasms, Infantile/drug therapy ; Spasms, Infantile/genetics ; Spasms, Infantile/physiopathology
    Chemical Substances NAV1.2 Voltage-Gated Sodium Channel ; SCN2A protein, human ; Sodium Channel Blockers ; Phenytoin (6158TKW0C5)
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2020.107187
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