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Article: Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.

Zhang, Yi-Bing / Bao, Yong-Rui / Wang, Shuai / Li, Tian-Jiao / Tai, He / Leng, Jia-Peng / Yang, Xin-Xin / Wang, Bo-Cai / Meng, Xian-Sheng

World journal of gastrointestinal oncology

2023 Volume 15, Issue 3, Page(s) 504–522

Abstract: ... with high mortality rates worldwide. The main ingredients in Mu Ji Fang Granules (MJF) are alkaloids ...

Abstract	Background: Hepatocellular carcinoma (HCC) is one of the most common digestive system cancers with high mortality rates worldwide. The main ingredients in Mu Ji Fang Granules (MJF) are alkaloids, flavonoids, and polysaccharides. MJF has been used in the clinical treatment of hepatitis, cirrhosis and HCC for more than 30 years. Few previous studies have focused on the mechanism of MJF on tumor immu-nology in the treatment of HCC. Aim: To explore the mechanism of action of MJF on tumor immunology in the treatment of HCC. Methods: The absorbable ingredients of MJF were identified using Molecule Network related to High Performance Liquid Chromatography-Electron Spray Ionization-Time of Flight- Mass Spectrometry, and hub potential anti-HCC targets were screened using network pharmacology and pathway enrichment analysis. Forty male mice were randomly divided into the Blank, Model, and MJF groups (1.8, 5.4, and 10.8 g/kg/d) following 7 d of oral administration. Average body weight gain, spleen and thymus indices were calculated, tumor tissues were stained with hematoxylin and eosin, and Interferon gamma (IFN-γ), Tumor necrosis factor α (TNF-α), Interleukin-2, aspartate aminotransferase, alanine aminotransferase, alpha-fetoprotein (AFP), Fas, and FasL were measured by Enzyme-linked Immunosorbent Assay. Relevant mRNA expression of Results: It was shown that MJF improved body weight gain and tumor inhibition rate in H22 tumor-bearing mice, protected immune organs and liver function, reduced the HCC indicator AFP, affected immunity and apoptosis, and up-regulated the TGF-β1/SMAD signaling pathway, by increasing the relative expression of TGF-β1, SMAD2, p-SMAD2 and SMAD4 and decreasing SMAD7, reducing immune factors TNF-α and IFN-γ, decreasing apoptosis cytokines Fas, FasL and Conclusion: MJF inhibits HCC by activating the TGF-β1/SMAD signaling pathway, and affecting immune and apoptotic cytokines, which may be due to MJF adjusting immune escape and apoptosis.
Language	English
Publishing date	2023-03-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v15.i3.504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice.

Chen, Wen-Jin / Zhuang, Yin / Peng, Wei / Cui, Wei / Zhang, Shu-Jun / Wang, Jian-Wei

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 80

Abstract: ... to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA ...

Abstract	Background: Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism for treating KOA has not been revealed. In our previous study, we confirmed that DHJST inhibited the activation of NLRP3 signaling in rats and humans. In the current study, we aimed to determine how DHJST inhibits NLRP3 to alleviate knee cartilage damage. Methods: Mice were injected with NLRP3 shRNA or Notch1-overexpressing adenovirus into the tail vein to construct systemic NLRP3 low-expressing or Notch1 high-expressing mice. Mice were injected with papain into the knee joint to replicate the KOA model. DHJST was used to treat KOA model mice with different backgrounds. The thickness of the right paw was measured to evaluate toe swelling. The pathohistological changes and the levels of IL-1β, MMP2, NLRP3, Notch1, collagen 2, collagen 4, HES1, HEY1, and Caspase3 were detected by HE staining, ELISA, immunohistochemical staining, western blotting, or real-time qPCR. Results: DHJST reduced tissue swelling and serum and knee cartilage IL-1β levels, inhibited cartilage MMP2 expression, increased collagen 2 and collagen 4 levels, decreased Notch1 and NLRP3 positive expression rates in cartilage, and decreased HES1 and HEY1 mRNA levels in KOA model mice. In addition, NLRP3 interference decreased cartilage MMP2 expression and increased collagen 2 and collagen 4 levels without affecting the expression levels of notch1, HES1 and HEY1 mRNA levels in the synovium of KOA mice. In KOA mice with NLRP interference, DHJST further reduced tissue swelling and knee cartilage damage in mice. Finally, Notch1-overexpressing mice not only showed more severe tissue swelling and knee cartilage degradation but also abolished the therapeutic effect of DHJST on KOA mice. Importantly, the inhibitory effects of DHJST on the mRNA expression of NLRP3, Caspase3 and IL-1β in the knee joint of KOA mice were completely limited after Notch1 overexpression. Conclusion: DHJST significantly reduced inflammation and cartilage degradation in KOA mice by inhibiting Ntoch1 signaling and its subsequent NLRP3 activation in the knee joint.
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00784-y
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Article: [PAHs Pollution Characteristics and Source Analysis of Typical Lake and Reservoir Sediments in Jin-Ji-Liao Area].

Wu, Peng / Lu, Yi-Ren / Li, Hui / Zheng, Tian-Jiaozi / Cheng, Yun-Xuan / Jiao, Li-Xin

Huan jing ke xue= Huanjing kexue

2021 Volume 42, Issue 4, Page(s) 1791–1800

Abstract: ... Reservoir, Hengshui Lake, and Dahuofang Reservoir) in the Jin-Ji-Liao area were collected and investigated ...

Abstract	In this research, 29 surface sediments samples of three typical lake reservoirs (in Yuqiao Reservoir, Hengshui Lake, and Dahuofang Reservoir) in the Jin-Ji-Liao area were collected and investigated, and the contents of 16 polycyclic aromatic hydrocarbons were detected using GC-MS. The results show that the Sigma PAHs (ng·g
Language	Chinese
Publishing date	2021-03-20
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202008046
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Article ; Online: Du Huo Ji Sheng Tang inhibits Notch1 signaling and subsequent NLRP3 activation to alleviate cartilage degradation in KOA mice

Wen-jin Chen / Yin Zhuang / Wei Peng / Wei Cui / Shu-jun Zhang / Jian-wei Wang

Chinese Medicine, Vol 18, Iss 1, Pp 1-

2023 Volume 15

Abstract: ... to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA ...

Abstract	Abstract Background Knee osteoarthritis (KOA) has a complex pathological mechanism and is difficult to cure. The traditional medicine Du Huo Ji Sheng Tang (DHJST) has been used for the treatment of KOA for more than one thousand years, but its mechanism for treating KOA has not been revealed. In our previous study, we confirmed that DHJST inhibited the activation of NLRP3 signaling in rats and humans. In the current study, we aimed to determine how DHJST inhibits NLRP3 to alleviate knee cartilage damage. Methods Mice were injected with NLRP3 shRNA or Notch1-overexpressing adenovirus into the tail vein to construct systemic NLRP3 low-expressing or Notch1 high-expressing mice. Mice were injected with papain into the knee joint to replicate the KOA model. DHJST was used to treat KOA model mice with different backgrounds. The thickness of the right paw was measured to evaluate toe swelling. The pathohistological changes and the levels of IL-1β, MMP2, NLRP3, Notch1, collagen 2, collagen 4, HES1, HEY1, and Caspase3 were detected by HE staining, ELISA, immunohistochemical staining, western blotting, or real-time qPCR. Results DHJST reduced tissue swelling and serum and knee cartilage IL-1β levels, inhibited cartilage MMP2 expression, increased collagen 2 and collagen 4 levels, decreased Notch1 and NLRP3 positive expression rates in cartilage, and decreased HES1 and HEY1 mRNA levels in KOA model mice. In addition, NLRP3 interference decreased cartilage MMP2 expression and increased collagen 2 and collagen 4 levels without affecting the expression levels of notch1, HES1 and HEY1 mRNA levels in the synovium of KOA mice. In KOA mice with NLRP interference, DHJST further reduced tissue swelling and knee cartilage damage in mice. Finally, Notch1-overexpressing mice not only showed more severe tissue swelling and knee cartilage degradation but also abolished the therapeutic effect of DHJST on KOA mice. Importantly, the inhibitory effects of DHJST on the mRNA expression of NLRP3, Caspase3 and IL-1β in the knee joint of KOA ...
Keywords	Osteoarthritis ; DHJST ; NLRP3 ; Notch1 ; Mice ; Inflammation ; Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Detection of wind corridors based on “Climatopes”: a study in central Ji’nan

Liu, Yonghong / Cheng, Pengfei / Chen, Peng / Zhang, Shuo

Theoretical and applied climatology. 2020 Nov., v. 142, no. 3-4

2020

Abstract: ... of wind corridors in the urban centre of Ji’nan. The results reveal that the intensity of urban heat ... islands in Ji’nan is closely related to a lack of natural cold sources, the specific layout of different ...

Abstract	Wind corridor blueprints are an essential reference for climate planning that takes into account zones of fresh cold air, air channels as well as heat island alleviation zones. This article addresses the matter of how to plan urban wind corridors more efficiently by proposing a “ventilation potential coefficient” (VPC) as well as providing an index for natural cold sources. The study additionally proposes a surface urban heat island (SUHI) index as a means of evaluating the severity of the heat island effect. Based on these three indexes, a new method of categorizing urban climatic zones, called “Climatopes”, is developed. Using the above methods, data from 2016 meteorological observation stations and Landsat8 satellites, as well as urban planning materials and basic geographical information on a scale of 1:2000 are used to create an Urban Climate Analysis Map (UCAnMap) and formulate a plan for the construction of wind corridors in the urban centre of Ji’nan. The results reveal that the intensity of urban heat islands in Ji’nan is closely related to a lack of natural cold sources, the specific layout of different types of land use as well as poor planning of urban “function zones”. Moreover, there is a significant correlation between the VPC and other factors such as surface roughness length, building height, the density of building frontal area and floor area ratios. The potential wind corridors could also be determined based on the VPC. Based on an UCAnMap composed of 11 Climatopes and background wind environments, this article ascertains that it would be possible to construct a network of 3 Level One corridors (each over 500 m wide) and 11 Level Two corridors (each over 80-m wide). Additionally, regulatory measures and protective legislation are proposed for the corridors, as well as for the city’s overall development.
Keywords	air ; climatology ; cold ; heat island ; land use ; laws and regulations ; roughness length ; spatial data ; surface roughness ; wind
Language	English
Dates of publication	2020-11
Size	p. 869-884.
Publishing place	Springer Vienna
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1463177-5
ISSN	1434-4483 ; 0177-798X
ISSN (online)	1434-4483
ISSN	0177-798X
DOI	10.1007/s00704-020-03323-z
Database	NAL-Catalogue (AGRICOLA)

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Book: Chu Ai ji ji

Peng, Haoxiang

Exodus

2007

Author's details	[Regie: Peng Haoxiang]
Language	Chinese
Size	2 VCDs, 95 Min.
Publishing place	Hongkong
Document type	Book
Note	Audiosprache: Chinesisch, Kantonesisch ; Untertitel: Chinesisch (Langzeichen), Englisch
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: The characteristics of abnormal wintertime pollution events in the Jing-Jin-Ji region and its relationships with meteorological factors.

Zhu, Wenhui / Xu, Xiangde / Zheng, Jun / Yan, Peng / Wang, Yinjun / Cai, Wenyue

The Science of the total environment

2018 Volume 626, Page(s) 887–898

Abstract: ... events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016 ... dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years ...

Abstract	Despite the implementation of strict air pollution control measures in recent years, severe haze events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016. In this work, seasonal differences in correlations between air pollution and geographic terrain, atmospheric dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years were investigated and a comprehensive model of atmospheric factors affecting winter air pollution formation was proposed. We found that the distribution of PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/statistics & numerical data ; Beijing ; Environmental Monitoring ; Meteorological Concepts ; Particulate Matter/analysis ; Seasons
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2018-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2018.01.083
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
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Book: Zhong yi fang ji da ci dian

Peng, Huairen

2015

Author's details	zhu bian Peng Huairen, Wang Xudong, Wu Chengyan, Sun Shifa ; zhu bian dan wei Nanjing Zhong yi yao da xue
MeSH term(s)	Materia Medica ; Medicine, Chinese Traditional
Language	Chinese
Size	2 volumes
Edition	Di 2 ban.
Document type	Book
ISBN	9787117207621 ; 9787117210645 ; 7117207620 ; 7117210648
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Aerosol–cloud interaction in the atmospheric chemistry model GRAPES_Meso5.1/CUACE and its impacts on mesoscale numerical weather prediction under haze pollution conditions in Jing–Jin–Ji in China

W. Zhang / H. Wang / X. Zhang / L. Huang / Y. Peng / Z. Liu / H. Che

Atmospheric Chemistry and Physics, Vol 22, Pp 15207-

2022 Volume 15221

Abstract: ... aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI ...

Abstract	The representation of aerosol–cloud interaction (ACI) and its impacts in the current climate or weather model remains a challenge, especially for severely polluted regions with high aerosol concentration, which is even more important and worthy of study. Here, ACI is first implemented in the atmospheric chemistry model GRAPES_Meso5.1/CUACE by allowing for real-time aerosol activation in the Thompson cloud microphysics scheme. Two experiments are conducted focusing on a haze pollution case with coexisting high aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI on the mesoscale numerical weather prediction (NWP). Study results show that ACI increases cloud droplet number concentration, water mixing ratio, liquid water path (CLWP), and optical thickness (COT), as a result improving the underestimated CLWP and COT (reducing the mean bias by 21 % and 37 %, respectively) over a certain subarea by the model without ACI. A cooling in temperature in the daytime below 950 hPa occurs due to ACI, which can reduce the mean bias of 2 m temperature in the daytime by up to 14 % ( ∼ 0.6 ∘ C) in the subarea with the greatest change in CLWP and COT. The 24 h cumulative precipitation in this subarea corresponding to moderate-rainfall events increases, which can reduce the mean bias by 18 %, depending on the enhanced melting of the snow by more cloud droplets. In other areas or periods with a slight change in CLWP and COT, the impact of ACI on NWP is not significant, suggesting the inhomogeneity of ACI. This study demonstrates the critical role of ACI in the current NWP model over the severely polluted region and the complexity of the ACI effect.
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	551
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Aerosol–cloud interaction in the atmospheric chemistry model GRAPES_Meso5.1/CUACE and its impacts on mesoscale numerical weather prediction under haze pollution conditions in Jing–Jin–Ji in China

Zhang, Wenjie / Wang, Hong / Zhang, Xiaoye / Huang, Liping / Peng, Yue / Liu, Zhaodong / Zhang, Xiao / Che, Huizheng

eISSN: 1680-7324

2022

Abstract: ... aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI ...

Abstract	The representation of aerosol–cloud interaction (ACI) and its impacts in the current climate or weather model remains a challenge, especially for severely polluted regions with high aerosol concentration, which is even more important and worthy of study. Here, ACI is first implemented in the atmospheric chemistry model GRAPES_Meso5.1/CUACE by allowing for real-time aerosol activation in the Thompson cloud microphysics scheme. Two experiments are conducted focusing on a haze pollution case with coexisting high aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI on the mesoscale numerical weather prediction (NWP). Study results show that ACI increases cloud droplet number concentration, water mixing ratio, liquid water path (CLWP), and optical thickness (COT), as a result improving the underestimated CLWP and COT (reducing the mean bias by 21 % and 37 %, respectively) over a certain subarea by the model without ACI. A cooling in temperature in the daytime below 950 hPa occurs due to ACI, which can reduce the mean bias of 2 m temperature in the daytime by up to 14 % ( ∼ 0.6 ∘ C) in the subarea with the greatest change in CLWP and COT. The 24 h cumulative precipitation in this subarea corresponding to moderate-rainfall events increases, which can reduce the mean bias by 18 %, depending on the enhanced melting of the snow by more cloud droplets. In other areas or periods with a slight change in CLWP and COT, the impact of ACI on NWP is not significant, suggesting the inhomogeneity of ACI. This study demonstrates the critical role of ACI in the current NWP model over the severely polluted region and the complexity of the ACI effect.
Subject code	551
Language	English
Publishing date	2022-11-30
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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