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  1. Article ; Online: Function matters-From defective ion transport to dysbiosis and inflammatory bowel disease.

    Bleich, Markus

    Acta physiologica (Oxford, England)

    2020  Volume 230, Issue 2, Page(s) e13546

    MeSH term(s) Animals ; Antiporters ; Dysbiosis ; Hydrogen-Ion Concentration ; Inflammatory Bowel Diseases ; Ion Transport ; Mice ; Microbiota ; Microclimate ; Mucins ; Sulfate Transporters ; Tumor Necrosis Factor-alpha
    Chemical Substances Antiporters ; Mucins ; Slc26a3 protein, mouse ; Sulfate Transporters ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2020-08-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13546
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  2. Book ; Online ; Thesis: Longitudinale Analyse der visuellen Funktion bei Experimenteller Autoimmuner Uveitis (EAU) im Mausmodell

    Stöcker, Markus Verfasser] / [Roider, Johann [Akademischer Betreuer] / Bleich, Markus [Gutachter]

    2022  

    Author's details Markus Stöcker ; Gutachter: Markus Bleich ; Betreuer: Johann Baptist Roider
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  3. Book ; Online ; Thesis: Das FAM20A-Knockout-Mausmodell zeigt keine renalen Funktionseinschränkungen

    Heinekamp, Lara Verfasser] / [Bleich, Markus [Akademischer Betreuer] / Damme, Markus [Gutachter]

    2022  

    Author's details Lara Heinekamp ; Gutachter: Markus Damme ; Betreuer: Markus Bleich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  4. Book ; Thesis: Kaliumkanäle in der luminalen Zellmembran des distalen Nephrons

    Bleich, Markus

    Regulation und Eigenschaften

    1990  

    Author's details vorgelegt von Markus Bleich
    Size 102 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg, Univ., Diss., 1990
    HBZ-ID HT004028960
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  5. Book ; Online ; Thesis: Wasser- und Protonenausschluss in Formiat-Nitrit-Transportern

    Schmidt, Jana [Verfasser] / Beitz, Eric [Akademischer Betreuer] / Bleich, Markus [Gutachter]

    2022  

    Author's details Jana Dorothea Renate Schmidt ; Gutachter: Markus Bleich ; Betreuer: Eric Beitz
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  6. Book ; Online ; Thesis: Die Rolle von Claudin-4 in der parazellulären Chloridreorption im Sammelrohr der Niere

    Isermann, Julian Verfasser] / [Bleich, Markus [Akademischer Betreuer] / Krautwald, Stefan [Gutachter]

    2022  

    Author's details Julian Isermann ; Gutachter: Stefan Krautwald ; Betreuer: Markus Bleich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Contribution of bacterial and host factors to pathogen "blooming" in a gnotobiotic mouse model for

    Beutler, Markus / Eberl, Claudia / Garzetti, Debora / Herp, Simone / Münch, Philipp / Ring, Diana / Dolowschiak, Tamas / Brugiroux, Sandrine / Schiller, Patrick / Hussain, Saib / Basic, Marijana / Bleich, André / Stecher, Bärbel

    Infection and immunity

    2024  Volume 92, Issue 2, Page(s) e0031823

    Abstract: Inflammation has a pronounced impact on the intestinal ecosystem by driving an expansion of facultative anaerobic bacteria at the cost of obligate anaerobic microbiota. This pathogen "blooming" is also a hallmark of ... ...

    Abstract Inflammation has a pronounced impact on the intestinal ecosystem by driving an expansion of facultative anaerobic bacteria at the cost of obligate anaerobic microbiota. This pathogen "blooming" is also a hallmark of enteric
    MeSH term(s) Mice ; Animals ; Salmonella typhimurium ; Serogroup ; Enterocolitis ; Bacteria ; Inflammation ; Disease Models, Animal ; Microbiota ; Germ-Free Life ; Salmonella Infections, Animal/microbiology
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00318-23
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  8. Article ; Online: Physiology, pathophysiology, and clinical impact of claudins.

    Bleich, Markus / Günzel, Dorothee

    Pflugers Archiv : European journal of physiology

    2017  Volume 469, Issue 1, Page(s) 1–2

    MeSH term(s) Animals ; Claudins/chemistry ; Claudins/genetics ; Claudins/metabolism ; Epithelium/metabolism ; Epithelium/pathology ; Epithelium/physiology ; Humans ; Tight Junctions/metabolism ; Tight Junctions/pathology
    Chemical Substances Claudins
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-016-1918-2
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  9. Article ; Online: Membrane physiology--bridging the gap between medical disciplines.

    Bleich, Markus

    The New England journal of medicine

    2009  Volume 360, Issue 19, Page(s) 2012–2014

    MeSH term(s) Ataxia/genetics ; Epilepsy/genetics ; Hearing Loss, Sensorineural/genetics ; Humans ; Mutation, Missense ; Potassium/metabolism ; Potassium Channels, Inwardly Rectifying/genetics ; Renal Tubular Transport, Inborn Errors/genetics ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Syndrome
    Chemical Substances Kcnj10 (channel) ; Potassium Channels, Inwardly Rectifying ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2009-05-07
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe0901812
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  10. Article ; Online: Capacity for Cellular Osmoregulation Defines Critical Salinity of Marine Invertebrates at Low Salinity

    Imke Podbielski / Claas Hiebenthal / Mithra-Christin Hajati / Christian Bock / Markus Bleich / Frank Melzner

    Frontiers in Marine Science, Vol

    2022  Volume 9

    Abstract: Low-salinity stress can severely affect the fitness of marine organisms. As desalination has been predicted for many coastal areas with ongoing climate change, it is crucial to gain more insight in mechanisms that constrain salinity acclimation ability. ... ...

    Abstract Low-salinity stress can severely affect the fitness of marine organisms. As desalination has been predicted for many coastal areas with ongoing climate change, it is crucial to gain more insight in mechanisms that constrain salinity acclimation ability. Low-salinity induced depletion of the organic osmolyte pool has been suggested to set a critical boundary in osmoconforming marine invertebrates. Whether inorganic ions also play a persistent role during low-salinity acclimation processes is currently inconclusive. We investigated the salinity tolerance of six marine invertebrate species following a four-week acclimation period around their low-salinity tolerance threshold. To obtain complete osmolyte budgets, we quantified organic and inorganic osmolytes and determined fitness proxies. Our experiments corroborated the importance of the organic osmolyte pool during low-salinity acclimation. Methylamines constituted a large portion of the organic osmolyte pool in molluscs, whereas echinoderms exclusively utilized free amino acids. Inorganic osmolytes were involved in long-term cellular osmoregulation in most species, thus are not just modulated with acute salinity stress. The organic osmolyte pool was not depleted at low salinities, whilst fitness was severely impacted. Instead, organic and inorganic osmolytes often stabilized at low-salinity. These findings suggest that low-salinity acclimation capacity cannot be simply predicted from organic osmolyte pool size. Rather, multiple parameters (i.e. osmolyte pools, net growth, water content and survival) are necessary to establish critical salinity ranges. However, a quantitative knowledge of cellular osmolyte systems is key to understand the evolution of euryhalinity and to characterize targets of selection during rapid adaptation to ongoing desalination.
    Keywords salinity stress ; osmolytes ; cellular volume regulation ; invertebrates ; osmoconformer ; climate change ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 710
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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