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Article ; Online: Analysis of the U.S. Military Trauma System in Accordance With Doctrinal Levels of Warfare.

Baker, Jay B / Keenan, Sean / Duquette-Frame, Teresa A / Kotwal, Russ / Harvey, Andrew S / Cap, Andrew P / Shackelford, Stacy A / Gurney, Jennifer M

Military medicine

2023

Abstract: ... Conclusion: The deployed U.S. military trauma system requires a robust PI capability to optimize combat ...

Abstract	Introduction: In recent conflicts, the Joint Theater Trauma System (JTTS) led the systematic approach to improve battlefield trauma care, substantially contributing to the unprecedented survival of combat casualties. The Joint Trauma System (JTS) was codified in 2016 to preserve the lessons learned and functions of the JTTS, including the Department of Defense Trauma Registry. Concurrently, Combatant Commands (CCMD) were directed to establish CCMD Trauma Systems (CTS) "modeled after the JTTS" and to maintain a baseline of core functions intended to rapidly scale as needed. The complex nature of both CCMDs and the military trauma system has challenged the full implementation of the CTS. Analyzing the historical experiences of the JTTS, JTS, and CTS within a military doctrinal framework might enable the further success of the military trauma system. Methods: The strategic, operational, and tactical levels of warfare, in accordance with Joint Publication 1-0, Doctrine of the Armed Forces of the United States, and Joint Publication 3-0, Joint Operations, established the analytic framework for this study. The literature regarding the JTTS, CTS, and JTS was reviewed for relevant information concerning organizational structure and functions of trauma system performance improvement (PI) capabilities. A comprehensive analysis was performed using a thematic approach to evaluating descriptive data contained within the collected data set. Deployed trauma system PI tasks, functions, and responsibilities were identified, defined, and correlated according to the respective levels of warfare. Results: The comprehensive analysis revealed both discrete and overlapping tasks, functions, and responsibilities of the trauma system PI capabilities at each of the three levels of warfare. Strategic-level actions were categorized according to 12 distinct themes: reduce mortality; strategic reporting; centralized trauma registry; strategic communications; centralized organization; direct support to CCMDs; Department of Defense policy and doctrine; strategic-level PI; clinical practice guidelines; training and readiness standards; force structure, standardization, and interoperability; and research and development. Operational-level actions were categorized according to seven distinct themes: theater trauma system policies and requirements; theater trauma system leadership; stakeholder coordination; theater communication; theater standards for readiness and skill sustainment; trauma system planning; and medical logistics support. Tactical-level actions were categorized according to seven distinct themes: trauma system personnel; PI; documentation enforcement and patient care data collection; tactical planning recommendations for employing medical assets; research support; communication and reporting; and training and skills sustainment. Conclusion: The deployed U.S. military trauma system requires a robust PI capability to optimize combat casualty care. Policy updates, a joint military trauma system doctrine, and force design updates are necessary for deployed military trauma system PI capabilities to function optimally across all levels of warfare.
Language	English
Publishing date	2023-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad053
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Article ; Online: Lifestyle tools for men’s health and disease prevention

Leigh A. Frame

Journal of Men's Health, Vol 18, Iss 12, Pp 1-

well-being through nutrition, physical activity, stress management, and connection

2022 Volume 2

Keywords	lifestyle ; disease prevention ; nutrition ; physical activity ; stress management ; connection ; men's health ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MRE Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sleep Environments of Children in an Urban U.S. Setting Exposed to Interpersonal Violence.

Spilsbury, James C / Frame, Jennifer / Magtanong, Ruth / Rork, Kristine

Behavioral sleep medicine

2016 Volume 14, Issue 6, Page(s) 585–601

Abstract: This study investigated how violence influences children's sleep environments. Sixty-five children ages 8-16 years and a parent or guardian were recruited from agencies serving families experiencing violence. At baseline (5 weeks post-violent event), 6 ... ...

Abstract	This study investigated how violence influences children's sleep environments. Sixty-five children ages 8-16 years and a parent or guardian were recruited from agencies serving families experiencing violence. At baseline (5 weeks post-violent event), 6 months, and 12 months postbaseline, study staff collected sleep-behavior information and conducted systematic, qualitative assessments of sleep environments. Child sleep problems were generally frequent and persistent. However, 9 children reported improved sleep after the violent event, mainly because perpetrators were no longer present. Sleeping environments were dynamic via changes in location and modifications to improve safety and sleep. Incongruence between children's and parents' perceptions of environmental characteristics influencing sleep was common. Families' motivation to improve children's sleep represents a foundation to build upon when working with families victimized by violence.
MeSH term(s)	Adolescent ; Child ; Environment ; Female ; Humans ; Interpersonal Relations ; Male ; Parents/psychology ; Sleep ; United States ; Violence/psychology
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2099743-7
ISSN	1540-2010 ; 1540-2002
ISSN (online)	1540-2010
ISSN	1540-2002
DOI	10.1080/15402002.2015.1048449
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Article: Cotton yield response to soil applied potassium across the U. S. Cotton Belt

Lewis, Katie / Morgan, Gaylon / Frame, William Hunter / Fromme, Daniel / Dodds, Darrin M. / Edmisten, Keith L. / Robertson, Bill / Boman, Randy / Cutts, Trey / Delaney, Dennis P. / Burke, Joseph Alan / Nichols, Robert L.

Agronomy journal. 2021 July, v. 113, no. 4

2021

Abstract: Across the U.S. Cotton Belt, potassium (K) deficiency symptoms in cotton (Gossypium hirsutum L ...

Abstract	Across the U.S. Cotton Belt, potassium (K) deficiency symptoms in cotton (Gossypium hirsutum L.) have become more common over the past decade. In 2015–2017, an experiment was conducted in Alabama, Arkansas, Louisiana, Mississippi, North Carolina, Oklahoma, South Carolina, two regions in Texas, and Virginia for a total of 23 site‐years. The objectives were (a) to quantify soil K levels at‐depth in representative soils where cotton is commonly grown in major cotton production regions with observed K deficiencies; and (b) to evaluate the effects of application method and K rates on cotton lint yield, loan value, and return on fertilizer investment. Granular and liquid potassium chloride were broadcast or injected, respectively, 2–4 wk prior to planting at 0, 45, 90, 135, and 180 kg K₂O ha⁻¹. Locations other than Texas and Oklahoma generally had soil K levels <less than 150 mg kg⁻¹, the Mehlich III critical K level, and thus, a yield response to applied K fertilizer was expected. However, among the 23 site‐years, a treatment effect was determined at 5 site‐years. Two of those, Williamson County, Texas, and Virginia endured severe moisture stress and resulted in low yields (<526 kg lint ha⁻¹). A positive lint yield response to knife‐injected 0–0–15 was determined in 2015 at the Lubbock County, Texas, location—a location with high yield (>1,653 kg lint ha⁻¹). Inconsistent yield responses among locations indicate that K dynamics in the soil–cotton plant system are not well understood and deserve continued investigation.
Keywords	Gossypium hirsutum ; agronomy ; lint cotton ; lint yield ; liquids ; loans ; potassium ; potassium chloride ; potassium fertilizers ; soil ; Alabama ; Arkansas ; Louisiana ; Mississippi ; North Carolina ; Oklahoma ; South Carolina ; Texas ; Virginia
Language	English
Dates of publication	2021-07
Size	p. 3600-3614.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	410332-4
ISSN	1435-0645 ; 0002-1962
ISSN (online)	1435-0645
ISSN	0002-1962
DOI	10.1002/agj2.20719
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Book ; Online: The Federal Home Loan Bank System and U.S. housing finance

Frame, W. Scott

(Working paper series / Federal Reserve Bank of Atlanta ; 2016-2)

2016

Abstract: This paper examines the role of the Federal Home Loan Bank (FHLB) System in the U.S ...

Author's details	W. Scott Frame
Series title	Working paper series / Federal Reserve Bank of Atlanta ; 2016-2
Abstract	This paper examines the role of the Federal Home Loan Bank (FHLB) System in the U.S. housing finance system. This cooperatively owned government-sponsored enterprise has changed markedly over the past 25 years as a result of membership liberalization and the demise of thrift institutions. Today, despite its name, size, and principal activities, the FHLB System actually provides little targeted support to the housing sector. Instead, recent research highlights the role of the FHLB System as a provider of subsidized general liquidity to its members, including the very largest commercial banking organizations. This role was especially pronounced during the onset of the recent financial crisis and gave rise to the perception of the FHLB System as having become the "lender of next-to-last-resort."
Keywords	residential mortgages ; government-sponsored enterprises ; liquidity
Language	English
Size	1 Online-Ressource (22 Seiten), Illustrationen
Publisher	Federal Reserve Bank of Atlanta
Publishing place	Atlanta, Ga
Document type	Book ; Online
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Book ; Online: Foreign investment, regulatory arbitrage, and the risk of U.S. banking organizations

Frame, W. Scott / Mihov, Atanas / Sanz, Leandro

(Working paper series / Federal Reserve Bank of Atlanta ; 2017, 2 (March 2017))

2016

Abstract: ... supervision for the international subsidiary locations and risk of U.S. bank holding companies (BHCs). We find ... that U.S. BHCs are more likely to operate subsidiaries in countries with weaker regulation and ... in these location choices and risk outcomes. Overall, our study suggests that U.S. banking organizations engage ...

Author's details	W. Scott Frame, Atanas Mihov, and Leandro Sanz
Series title	Working paper series / Federal Reserve Bank of Atlanta ; 2017, 2 (March 2017)
Abstract	This study investigates the implications of cross-country differences in banking regulation and supervision for the international subsidiary locations and risk of U.S. bank holding companies (BHCs). We find that U.S. BHCs are more likely to operate subsidiaries in countries with weaker regulation and supervision and that such location decisions are associated with elevated BHC risk and higher contribution to systemic risk. The quality of BHCs' internal controls and risk management play an important role in these location choices and risk outcomes. Overall, our study suggests that U.S. banking organizations engage in cross-country regulatory arbitrage with potentially adverse consequences.
Keywords	regulation ; supervision ; bank holding companies ; cross-border operations ; subsidiary locations ; risk ; systemic risk
Language	English
Size	1 Online-Ressource (circa 60 Seiten), Illustrationen
Publisher	Federal Reserve Bank of Atlanta
Publishing place	Atlanta, Ga
Document type	Book ; Online
Database	ECONomics Information System

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Article: Cotton Varietal Responses to Tillage Type in the Upper Southeastern U.S. Coastal Plain

Longest, Robert / Frame, William / Abaye, Ozzie / Hodges, Steven

Agronomy journal. 2018 May, v. 110, no. 3

2018

Abstract: Current understanding of the effects of tillage systems on cotton growth and development of contemporary varieties is limited for producers of the Upper Southeast Coastal Plain of the United States. Tillage studies were conducted in Suffolk, VA, from ... ...

Abstract	Current understanding of the effects of tillage systems on cotton growth and development of contemporary varieties is limited for producers of the Upper Southeast Coastal Plain of the United States. Tillage studies were conducted in Suffolk, VA, from 2013 to 2016 evaluating conventional, minimal, no-tillage, and strip-tillage systems on early season growth, soil compaction, and lint yield of four contemporary varieties using a split-plot design. Soil compaction was greatest in the no-till system with yearly depths to a root restrictive layer ranging from 8–26 cm. No-till resulted in shorter plant heights compared to other tillage methods in 2 out of 4 yr. Relative yield for no-till was 0.78, an 8% reduction compared to the other tillage systems. Deltapine 1321 B2RF was consistently taller than other varieties in all years; with significant varietal differences being present during all sampling intervals each year except 2013. Fibermax 1944 GLB2 was shorter than other varieties. In-season plant development was affected more by variety than tillage. Lint yield differed among varieties in 2013, 2014, and 2016. Deltapine 1321 B2RF produced the highest lint yields of 1746 kg ha−1, 1467 kg ha−1, and 693 kg ha−1 in 2013, 2014, and 2015, respectively. Differences in lint quality parameters were influenced more by variety than tillage system. In the short term there was no significant growth or yield penalty associated with no-till cotton production as compared to other tillage systems. Variety selection and environment were the most important factors contributing to cotton yield during this four year study.
Keywords	coastal plains ; experimental design ; growth and development ; lint cotton ; lint yield ; no-tillage ; plant development ; soil compaction ; strip tillage ; Virginia
Language	English
Dates of publication	2018-05
Size	p. 1157-1164.
Publishing place	The American Society of Agronomy, Inc.
Document type	Article
Note	epub
ZDB-ID	410332-4
ISSN	1435-0645 ; 0002-1962
ISSN (online)	1435-0645
ISSN	0002-1962
DOI	10.2134/agronj2017.06.0335
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.

Judson, Richard S / Martin, Matthew T / Egeghy, Peter / Gangwal, Sumit / Reif, David M / Kothiya, Parth / Wolf, Maritja / Cathey, Tommy / Transue, Thomas / Smith, Doris / Vail, James / Frame, Alicia / Mosher, Shad / Hubal, Elaine A Cohen / Richard, Ann M

International journal of molecular sciences

2012 Volume 13, Issue 2, Page(s) 1805–1831

Abstract: ... from large collections of data and data sets in computable formats. The U.S. Environmental Protection Agency ...

Abstract	Computational toxicology combines data from high-throughput test methods, chemical structure analyses and other biological domains (e.g., genes, proteins, cells, tissues) with the goals of predicting and understanding the underlying mechanistic causes of chemical toxicity and for predicting toxicity of new chemicals and products. A key feature of such approaches is their reliance on knowledge extracted from large collections of data and data sets in computable formats. The U.S. Environmental Protection Agency (EPA) has developed a large data resource called ACToR (Aggregated Computational Toxicology Resource) to support these data-intensive efforts. ACToR comprises four main repositories: core ACToR (chemical identifiers and structures, and summary data on hazard, exposure, use, and other domains), ToxRefDB (Toxicity Reference Database, a compilation of detailed in vivo toxicity data from guideline studies), ExpoCastDB (detailed human exposure data from observational studies of selected chemicals), and ToxCastDB (data from high-throughput screening programs, including links to underlying biological information related to genes and pathways). The EPA DSSTox (Distributed Structure-Searchable Toxicity) program provides expert-reviewed chemical structures and associated information for these and other high-interest public inventories. Overall, the ACToR system contains information on about 400,000 chemicals from 1100 different sources. The entire system is built using open source tools and is freely available to download. This review describes the organization of the data repository and provides selected examples of use cases.
MeSH term(s)	Algorithms ; Computational Biology/methods ; Databases, Factual/standards ; Databases, Factual/supply & distribution ; Ecotoxicology/methods ; Ecotoxicology/organization & administration ; Environmental Pollutants/toxicity ; Humans ; Software ; United States ; United States Environmental Protection Agency/organization & administration
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2012-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms13021805
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Article ; Online: Murine monoclonal anti-s and other anti-glycophorin B antibodies resulting from immunizations with a GPB.s peptide.

Halverson, Gregory R / Tossas, Edith / Velliquette, Randall W / Lobo, Cheryl / Reid, Marion E / Frame, Tom / Castilho, Lilian / Lee, Agnes H / Storry, Jill R / Grodecka, Magdalena / Waśniowska, Kazimiera / Duk, Maria / Lisowska, Elwira

Transfusion

2009 Volume 49, Issue 3, Page(s) 485–494

Abstract: Background: The blood group antigens S and s are defined by amino acids Met or Thr at position 29 ... respectively, on glycophorin B (GPB). Commercial anti-s reagents are expensive to produce ... because of the scarcity of human anti-s serum. Our aim was to develop hybridoma cell lines that secrete reagent-grade anti ...

Abstract	Background: The blood group antigens S and s are defined by amino acids Met or Thr at position 29, respectively, on glycophorin B (GPB). Commercial anti-s reagents are expensive to produce because of the scarcity of human anti-s serum. Our aim was to develop hybridoma cell lines that secrete reagent-grade anti-s monoclonal antibodies (MoAbs) to supplement the supply of human anti-s reagents. Study design and methods: Mice were immunized with the GPB(s) peptide sequence TKSTISSQTNGETGQLVHRF. Hybridomas were produced by fusing mouse splenocytes with mouse myeloma cells (X63.Ag8.653). Screening for antibody production was done on microtiter plates by hemagglutination. Characterization of the MoAbs was done by hemagglutination, immunoblotting, and epitope mapping. Results: Eight immunoglobulin G MoAbs were identified. Five antibodies are specific by hemagglutination for s and two MoAbs, when diluted, are anti-S-like, but additional analyses shows a broad range of reactivity for GPB. Typing red blood cells (RBCs) for s from 35 donors was concordant with molecular analyses as were tests on RBCs with a positive direct antiglobulin test (DAT) from 15 patients. The anti-s MoAbs are most reactive with peptides containing the (31)QLVHRF(36) motif, with (29)Thr. By Pepscan analyses, the anti-S-like MoAbs reacted within the same regions as did anti-s, but independently of (29)Met. One antibody was defined serologically as anti-U; however, its epitope was identified as (21)ISSQT(25), a sequence common for both GPA and GPB. Conclusion: In addition to their value as typing reagents, these MoAbs can be used to phenotype RBCs with a positive DAT without pre-test chemical modification.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/classification ; Antibodies, Monoclonal/immunology ; Glycophorin/chemistry ; Glycophorin/immunology ; Hemagglutinins/analysis ; Immunization ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Peptide Fragments/chemistry ; Peptide Fragments/immunology
Chemical Substances	Antibodies, Monoclonal ; Glycophorin ; Hemagglutinins ; Peptide Fragments
Language	English
Publishing date	2009-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/j.1537-2995.2008.02004.x
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Article ; Online: Among 10 sociodemographic and lifestyle variables, smoking is strongly associated with biomarkers of acrylamide exposure in a representative sample of the U.S. Population.

Vesper, Hubert W / Sternberg, Maya R / Frame, Tunde / Pfeiffer, Christine M

The Journal of nutrition

2013 Volume 143, Issue 6, Page(s) 995S–1000S

Abstract: ... of acrylamide exposure and metabolism in a nationally representative sample of the U.S. population in the NHANES ... variables with these biomarkers in U.S. adults (aged ≥ 20 y). We used bivariate and multiple regression ...

Abstract	Hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) have been measured as biomarkers of acrylamide exposure and metabolism in a nationally representative sample of the U.S. population in the NHANES 2003-2004. We assessed the association of sociodemographic (age, sex, race-ethnicity, education, and income) and lifestyle (smoking, alcohol consumption, BMI, physical activity, and dietary supplement use) variables with these biomarkers in U.S. adults (aged ≥ 20 y). We used bivariate and multiple regression models and assessed the magnitude of an estimated change in biomarker concentration with change in a covariable for 2 biomarkers of acrylamide exposure. Smoking was strongly and significantly correlated with HbAA and HbGA concentrations (rs = 0.51 and 0.42, respectively), with biomarker concentrations being 126 and 101% higher in smokers compared with nonsmokers after adjusting for sociodemographic and lifestyle covariates. Age was moderately and significantly correlated with both biomarkers (rs = -0.21 and -0.22, respectively). BMI (rs = -0.11) and alcohol consumption (rs = 0.13) were weakly yet significantly correlated with HbAA concentrations only. The estimated percentage change in biomarker concentration was ≤ 20% for all variables other than smoking after adjusting for sociodemographic and lifestyle covariates. Using multiple regression models, the sociodemographic variables explained 9 and 7% whereas the sociodemographic and lifestyle variables together explained 46 and 25% of the variability in HbAA and HbGA, respectively, showing the importance of considering and adequately controlling for these variables in future studies. Our findings will be useful in the design and analysis of future studies that assess and evaluate exposure to acrylamide and its metabolism to glycidamide.
MeSH term(s)	Acrylamide/blood ; Acrylamide/metabolism ; Adult ; Age Factors ; Alcohol Drinking/blood ; Biomarkers/blood ; Environmental Exposure ; Epoxy Compounds/blood ; Epoxy Compounds/metabolism ; Female ; Hemoglobins/metabolism ; Humans ; Life Style ; Liver/metabolism ; Male ; Middle Aged ; Nutrition Surveys ; Regression Analysis ; Sex Factors ; Smoking/blood ; Socioeconomic Factors ; United States
Chemical Substances	Biomarkers ; Epoxy Compounds ; Hemoglobins ; Acrylamide (20R035KLCI) ; glycidamide (6G5ELX5XYN)
Language	English
Publishing date	2013-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.3945/jn.112.173013
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