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Article ; Online: Colorectal cancer in young adults.

Kim, Bradford J / Hanna, Mark H

2023 Volume 127, Issue 8, Page(s) 1247–1251

Abstract: The incidence of colorectal cancer in young adults (CRCYAs) is increasing globally, and it is now ... the third leading cause of cancer death among young adults under 50 years old. The rising incidence is ...

Abstract	The incidence of colorectal cancer in young adults (CRCYAs) is increasing globally, and it is now the third leading cause of cancer death among young adults under 50 years old. The rising incidence is attributed to various emerging risk factors such as genetics, lifestyle factors, and microbiome profiles. Delayed diagnosis and more advanced disease presentation contribute to worse outcomes. A multidisciplinary approach to care is crucial to ensure comprehensive and personalized treatment plans for CRCYA.
MeSH term(s)	Humans ; Young Adult ; Middle Aged ; Risk Factors ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27320
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Article: Genetic Characteristics of Patients with Young-Onset Myelodysplastic Neoplasms.

Kim, Hyun-Young / Yoo, Keon Hee / Jung, Chul Won / Kim, Hee-Jin / Kim, Sun-Hee

Journal of clinical medicine

2023 Volume 12, Issue 24

Abstract: ... and somatic genetic alterations. The incidence of MDS increases with age but rarely occurs at a young ... age. We investigated the germline and somatic genetic alterations of Korean patients with young-onset ...

Abstract	Myelodysplastic neoplasm (MDS) is a heterogeneous group of myeloid neoplasms affected by germline and somatic genetic alterations. The incidence of MDS increases with age but rarely occurs at a young age. We investigated the germline and somatic genetic alterations of Korean patients with young-onset MDS (<40 years). Among the thirty-one patients, five (16.1%) had causative germline variants predisposing them to myeloid neoplasms (three with
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12247651
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Article ; Online: Development of innate and adaptive immunity to RSV in young children.

Parsons, Emily L / Kim, Jisung S / Malloy, Allison M W

Cellular immunology

2024 Volume 399-400, Page(s) 104824

Abstract: ... repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and ... in the design of therapeutics and vaccines for young infants. However, advancements in structural biology have ... in infants and young children as well as highlight areas where more research is needed. ...

Abstract	Infection of the respiratory tract with respiratory syncytial virus (RSV) is common and occurs repeatedly throughout life with most severe disease occurring at the extremes of age: in young infants and the elderly. Effective anti-viral therapeutics are not available and therefore prevention has been the primary strategy for reducing the disease burden. Our current understanding of respiratory mucosal cell biology and the immune response within the respiratory tract is inadequate to prevent infection caused by a pathogen like RSV that does not disseminate outside of this environment. Gaps in our understanding of the activation of innate and adaptive immunity in response to RSV and the role of age upon infection also limit improvements in the design of therapeutics and vaccines for young infants. However, advancements in structural biology have improved our ability to characterize antibodies against viral proteins and in 2023 the first vaccines for those over 60 years and pregnant women became available, potentially reducing the burden of disease. This review will examine our current understanding of the critical facets of anti-RSV immune responses in infants and young children as well as highlight areas where more research is needed.
Language	English
Publishing date	2024-03-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2024.104824
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Article ; Online: Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults.

Lee, Min-Kyung / Han, Kyungdo / Kim, Bongsung / Kim, Jong-Dai / Jung Kim, Moon / Kim, Byungpyo / Heo, Jung / Ahn, Jiyeon / Sohn, Seo-Young / Lee, Jae-Hyuk

Diabetes research and clinical practice

2024 Volume 208, Page(s) 111109

Abstract: ... with an increased risk of developing type 2 diabetes in young adults.: Methods: The study included 1,840,251 ... of 0.: Conclusions: In this large-scale prospective cohort study of young adults, cumulative ...

Abstract	Aim: This study aimed to examine whether cumulative exposure to hypertriglyceridemia is associated with an increased risk of developing type 2 diabetes in young adults. Methods: The study included 1,840,251 participants aged 20-39 years who had undergonefourconsecutiveannualhealth checkups and had no history of type 2 diabetes. Participants werecategorized into five groups (exposure score 0-4) based on the frequencies of hypertriglyceridemia diagnosis over a four-year period. The primary outcome was newly diagnosed type 2 diabetes. Exploratory analyses were performed for the different subgroups. Results: During a follow-up period of 6.53 years, 40,286 participants developed type 2 diabetes. The cumulative incidence of type 2 diabetes significantly increased with higher exposure scores for hypertriglyceridemia (log-rank test, P < 0.001). The multivariable-adjusted hazard ratios for incident diabetes were 1.674 (95 % CI, 1.619, 1.732), 2.192 (95 % CI, 2.117, 2.269), 2.637 (95 % CI, 2.548, 2.73), and 3.715 (95 % CI, 3.6, 3.834) for participants with scores of 1-4, respectively, compared with those with an exposure score of 0. Conclusions: In this large-scale prospective cohort study of young adults, cumulative exposure to hypertriglyceridemia was significantly associated with an increased risk of type 2 diabetes, independent of lifestyle-related factors.
MeSH term(s)	Humans ; Young Adult ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Prospective Studies ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/epidemiology ; Incidence ; Life Style ; Risk Factors
Language	English
Publishing date	2024-01-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2024.111109
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Article ; Online: Keeping oocytes young.

Baumann, Kim

Nature reviews. Molecular cell biology

2021 Volume 22, Issue 9, Page(s) 586

MeSH term(s)	Oocytes
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2031313-5
ISSN	1471-0080 ; 1471-0072
ISSN (online)	1471-0080
ISSN	1471-0072
DOI	10.1038/s41580-021-00410-5
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Zs.A 5446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Different glaucoma progression rates by age groups in young myopic glaucoma patients.

Lee, Eun Jung / Lee, Dongyoung / Kim, Min-Ji / Kim, Kyunga / Han, Jong Chul / Kee, Changwon

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2589

Abstract: ... evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG ...

Abstract	We aimed to investigate the age-related glaucoma progression rates in myopic normal tension glaucoma (NTG). In this long-term retrospective cohort (7.2 ± 3.5 years), we grouped patients based on their age at initial presentation: group A (age < 30 years, 60 eyes), group B (30 ≤ age < 40, 66 eyes), and group C (40 ≤ age < 50 years, 63 eyes). We used a linear mixed-effects model to estimate retinal nerve fiber layer (RNFL) defect width enlargement rates. Group A showed a significantly faster rate of RNFL defect progression (3.01 ± 1.74°/year) than those of groups B and C (2.05 ± 1.55°/year and 2.06 ± 1.29°/year, P = 0.004 and 0.002). The difference was more marked when calculated for the first 10 years of follow-up in group A, B, and C (3.95 ± 2.70°/year, 2.39 ± 1.64°/year, and 1.98 ± 1.31°/year), and between the periods of age < 30 years, 30 ≤ age < 40 years, and 40 ≤ age < 50 years within group A. This is the first evidence of rapid glaucoma progression in the young adulthood and stabilization in older age in myopic NTG. Clinicians should consider the potentially aggressive course of glaucoma, especially in younger patients with myopic NTG, in contrast to the general slow progression in adulthood.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Optic Disk ; Retrospective Studies ; Visual Fields ; Intraocular Pressure ; Nerve Fibers ; Disease Progression ; Glaucoma ; Low Tension Glaucoma ; Myopia ; Tomography, Optical Coherence
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53133-w
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Article ; Online: [The Experience of Gynecologic Cancer in Young Women: A Qualitative Study].

Kim, Sung-Jin / Shin, Hyunjeong

Journal of Korean Academy of Nursing

2023 Volume 53, Issue 1, Page(s) 115–128

Abstract: ... to the development of a substantive theory of the experience of gynecologic cancer in young women, which has been ... to help young women with gynecologic cancer adapt to their disease. ...

Abstract	Purpose: This study aimed to understand the experiences of women under 40 years of age with gynecologic cancer. Methods: Semi-structured individual in-depth interviews were conducted with 14 Korean female patients aged 21~39 years with gynecologic cancer. The data were analyzed using Corbin and Strauss' grounded theory approach, including open coding, context analysis, and integrating categories. Results: Grounded theory analysis revealed nine categories and a core category of 'the journey to find my life after losing the life as a typical woman.' The categories that emerged as the conditions are 'Unwelcomed guest, cancer,' 'Completely devastated life as an ordinary woman,' 'Uncertain future,' 'Losing my physical characteristics as a woman,' and 'Life tied with treatments.' The actions/interactions were'Decrease of interpersonal relationships,' 'A lonely battle to overcome alone,' and 'The power to overcome hardships.' The consequence was 'Live my own life.' Conclusion: This study contributes to the development of a substantive theory of the experience of gynecologic cancer in young women, which has been on the rise in recent years. The study's results are expected to be used as a basis for providing nursing care to help young women with gynecologic cancer adapt to their disease.
MeSH term(s)	Humans ; Female ; Adult ; Genital Neoplasms, Female ; Qualitative Research ; Interpersonal Relations ; Grounded Theory
Language	Korean
Publishing date	2023-03-10
Publishing country	Korea (South)
Document type	English Abstract ; Journal Article
ZDB-ID	2619665-7
ISSN	2093-758X ; 2093-758X
ISSN (online)	2093-758X
ISSN	2093-758X
DOI	10.4040/jkan.22119
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Article: Features of d-vitamin status in young children in the Kazakh population.

Zhumalina, Akmaral / Kim, Irina / Tusupkaliev, Balash / Zharlykasinova, Mairamkul / Zhekeyeva, Botagoz

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

2024 Volume 52, Issue 2, Page(s) 161–170

Abstract: ... in young children in the ethnic group of Kazakh nationality with the factor of highlighting the necessary ... for the study of the highlighted problem are the diagnosis of young children in the parameter of clinical and ... implementing preventive measures in pregnant women and young children, including a balanced diet enriched ...

Abstract	Objective: Aim: The purpose of the article is to form the parameters of vitamin D status in young children in the ethnic group of Kazakh nationality with the factor of highlighting the necessary recommendations for the prevention of hypovitaminosis D. Patients and methods: Materials and Methods: Methods for the study of the highlighted problem are the diagnosis of young children in the parameter of clinical and anamnestic research, which includes the collection of anamnestic data of children of Kazakh nationality within the framework of the identified data based on a questionnaire of parents, an evaluation component in the child's health factor at the level of his initial state, and laboratory analysis to determine 25(OH)D to identify the content of vitamin D using the method of electrochemiluminescent immunoassay. Results: Results: Analysis of vitamin D levels revealed significant differences among age groups. In the 0-28-day group, average vitamin D was 13.35 ng/ml, with 92.8% deficient. In the 1-6-month group, it was 21.47 ng/ml, with 84% deficient. In the over 6-month group, it was 33.58 ng/ml, with 40% sufficient. Formula-fed children had the lowest levels (average 15.21 ng/ml), while breastfed children had insufficiency (average 23.91 ng/ml). Children with vitamin D supplementation averaged 25.9 ng/ml, compared to 19.01 ng/ml without supplementation. Conclusion: Conclusions: The results point to a widespread deficiency of vitamin D and offer practical recommendations for its prevention, such as creating a unified system of timely diagnosis, implementing preventive measures in pregnant women and young children, including a balanced diet enriched with vitamin D, staying outdoors in the bright hours of the day.
MeSH term(s)	Child ; Humans ; Female ; Pregnancy ; Child, Preschool ; Vitamins/therapeutic use ; Vitamin D/therapeutic use ; Vitamin D Deficiency ; Breast Feeding ; Surveys and Questionnaires
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-03-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1388406-2
ISSN	1426-9686
ISSN	1426-9686
DOI	10.36740/Merkur202402104
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Article: Characteristics of Hirayama Disease in Young South Korean Soldiers: A Retrospective Study.

Yun, Jae-Hyun / Jung, Chul / Kim, Eun Jin / Park, Jaechan / Yeom, Jiwoon / Jung, Ji Su / Kim, Kyoung-Eun

Journal of clinical neurology (Seoul, Korea)

2024

Abstract: ... features in electrodiagnostic and imaging investigations of young South Korean males diagnosed ... of HD in the young South Korean male population. ...

Abstract	Background and purpose: The purpose of this study was to describe the clinical presentation and features in electrodiagnostic and imaging investigations of young South Korean males diagnosed with Hirayama disease (HD). Methods: We reviewed the electronic medical records of South Korean enlisted soldiers who were diagnosed with HD and discharged from military service during 2011-2021. We investigated the clinical characteristics and results of electrodiagnostic and magnetic resonance imaging (MRI) investigations. We analyzed laterality and identified the involved muscles using needle electromyography (EMG). Loss of lordosis, localized cervical cord atrophy, loss of attachment between the posterior dura and subjacent lamina, asymmetric flattening of the cord, crescent-shaped mass in the posterior epidural space, and noncompressive intramedullary T2-weighted high signal intensity were investigated using neutral- or flexion-position MRI. Results: Forty-two male patients aged 20.2±0.8 years (mean±standard deviation) were identified. All patients complained of hand weakness, and 10 complained of hand tremor (23.8%). Four patients (9.5%) had symptoms in both upper limbs, and five (11.9%) had sensory disturbances. Needle EMG revealed that muscles in the C7-T1 myotome were commonly involved, and C5-C6 involvement of the deltoid (10.5%) and biceps brachii (12.5%) was also observed. In cervical MRI, localized cord atrophy (90.0%) was the most characteristic finding, and cord atrophy was most severe at the C5-C6 level (58.3%). Conclusions: This is the first description of a large number of patients with HD in South Korea. The clinical presentation and features found in electrodiagnostic and imaging investigations will improve the understanding of HD in the young South Korean male population.
Language	English
Publishing date	2024-02-05
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2500489-X
ISSN	2005-5013 ; 1738-6586
ISSN (online)	2005-5013
ISSN	1738-6586
DOI	10.3988/jcn.2023.0244
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Article ; Online: Chalazion-mimicked eyelid angiosarcoma in a young Asian with good prognosis: a case report.

Hwang, Gyudeok / Kim, Jong Ok / Paik, Ji-Sun / Yang, Suk-Woo / Cho, Won-Kyung

BMC ophthalmology

2024 Volume 24, Issue 1, Page(s) 1

Abstract: ... Caucasian males and is prone to misdiagnosis. We present a case report in a young Asian male patient ... of chalazion-mimicked eyelid angiosarcoma in a young Asian male aged under 50 years. This case shows that even ... if a benign eyelid disease is suspected in a young patient, an incisional biopsy must be performed to confirm ...

Abstract	Background: Angiosarcoma is an extremely rare malignant tumor. So far, only about 42 cases of angiosarcoma involving the eyelids have been reported. Eyelid angiosarcoma occurs more frequently in elderly Caucasian males and is prone to misdiagnosis. We present a case report in a young Asian male patient with eyelid angiosarcoma that was misdiagnosed as a chalazion. Case presentation: A 46-year-old South Korean male with no underlying disease had a right lower lid mass. The lesion was initially misdiagnosed as a chalazion at a local clinic, but a diagnosis of eyelid angiosarcoma was made after the first biopsy trial. PET-CT was performed to ensure that there was no metastasis in the whole body. Surgical excision with enough surgical margin was used alone for treatment and reconstruction was performed with a tarsoconjunctival advancement flap (modified Hughes procedure), which helped ensure good cosmesis. No recurrence was observed 4 years and 5 months after the surgery. Conclusions: The current study presents the first case of chalazion-mimicked eyelid angiosarcoma in a young Asian male aged under 50 years. This case shows that even if a benign eyelid disease is suspected in a young patient, an incisional biopsy must be performed to confirm whether the lesion is malignant. Since the prognosis is good for the case of eyelid angiosarcoma, if there is no clear evidence of distal metastasis, surgical resection should be performed with an enough safety margin.
MeSH term(s)	Aged ; Male ; Humans ; Middle Aged ; Chalazion/diagnosis ; Eyelid Neoplasms/diagnosis ; Eyelid Neoplasms/surgery ; Eyelid Neoplasms/pathology ; Hemangiosarcoma/diagnosis ; Hemangiosarcoma/surgery ; Hemangiosarcoma/pathology ; Positron Emission Tomography Computed Tomography ; Eyelids/surgery ; Eyelids/pathology
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-03262-z
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