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  1. Article ; Online: Gluten and non-coeliac gluten sensitivity: the nocebo effect and future avenues.

    Mennini, Maurizio / Ferrari, Federica / Parisi, Pasquale / Di Nardo, Giovanni

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 4, Page(s) 292–293

    MeSH term(s) Humans ; Glutens/adverse effects ; Nocebo Effect ; Celiac Disease/diagnosis ; Diet, Gluten-Free
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2024-02-27
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00444-2
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  2. Article ; Online: Videofluoroscopy-guided botulinum toxin for pharyngoesophageal spasm: a promising advance in laryngectomy rehabilitation.

    Maniaci, Antonino / Lavalle, Salvatore / Mayo-Yanez, Miguel / Parisi, Federica Maria / Cocuzza, Salvatore

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08554-8
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  3. Article ; Online: Biochemical and genetic tools to predict the progression to Cystic Fibrosis in CRMS/CFSPID subjects: A systematic review.

    Terlizzi, Vito / Manti, Sara / D'Amico, Federica / Parisi, Giuseppe F / Chiappini, Elena / Padoan, Rita

    Paediatric respiratory reviews

    2024  

    Abstract: Objectives: Aim of this study was to identify risk factors for a progression to cystic fibrosis (CF) in individuals detected as CF Screening Positive, Inconclusive Diagnosis (CFSPID).: Methods: This is a systematic review through literature databases ...

    Abstract Objectives: Aim of this study was to identify risk factors for a progression to cystic fibrosis (CF) in individuals detected as CF Screening Positive, Inconclusive Diagnosis (CFSPID).
    Methods: This is a systematic review through literature databases (2015-2023). Blood immunoreactive trypsinogen (b-IRT) values, CFTR genotype, sweat chloride (SC) values, isolation of Pseudomonas aeruginosa (Pa) from respiratory samples, Lung Clearance Index (LCI) values in CFSPIDs who converted to CF (CFSPID > CF) and age at CF transition were assessed.
    Results: Percentage of CFSPID > CF varies from 5.3 % to 44 %. Presence of one CF-causing CFTR variant in trans with a variant with variable clinical consequences (VVCC), an initial SC ≥ 40 mmol/L, an increase of SC > 2.5 mmol/L/year and recurrent isolation of pseudomonas aeruginosa (Pa) from airway samples could allow identification of subjects at risk of progression to CF.
    Conclusions: CFSPIDs with CF causing variant/VVCC genotype and first SC in the higher borderline range may require more frequent and prolonged clinical follow-up.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2024.01.001
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    Zs.A 5919: Show issues Location:
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  4. Article: Outcomes of postnatal systemic corticosteroids administration in ventilated preterm newborns: a systematic review of randomized controlled trials.

    Boscarino, Giovanni / Cardilli, Viviana / Conti, Maria Giulia / Liguori, Federica / Repole, Paola / Parisi, Pasquale / Terrin, Gianluca

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1344337

    Abstract: Introduction: Prolonged mechanical ventilation, commonly used to assist preterm newborns, increases the risk of developing bronchopulmonary dysplasia (BPD). In recent decades, studies have demonstrated that systemic corticosteroids play a significant ... ...

    Abstract Introduction: Prolonged mechanical ventilation, commonly used to assist preterm newborns, increases the risk of developing bronchopulmonary dysplasia (BPD). In recent decades, studies have demonstrated that systemic corticosteroids play a significant role in the prevention and management of BPD. In this systematic review of randomized controlled trials (RCTs), we evaluated the association between the administration of systemic corticosteroids in preterm infants and its long-term outcomes, such as neurodevelopment, growth, extubation rate, and related adverse effects.
    Methods: We conducted an electronic search in Medline, Scopus, and PubMed using the following terms: "premature infants" and "corticosteroids." We considered all RCTs published up to June 2023 as eligible. We included all studies involving preterm newborns treated with systemic corticosteroids and excluded studies on inhaled corticosteroids.
    Results: A total of 39 RCTs were evaluated. The influence of steroids administered systemically during the neonatal period on long-term neurological outcomes remains unknown, with no influence observed for long-term growth. The postnatal administration of systemic corticosteroids has been found to reduce the timing of extubation and improve respiratory outcomes. Dexamethasone appears to be more effective than hydrocortisone, despite causing a higher rate of systemic hypertension and hyperglycemia. However, in the majority of RCTs analyzed, there were no differences in the adverse effects related to postnatal corticosteroid administration.
    Conclusion: Dexamethasone administered during the neonatal period appears to be more effective than hydrocortisone in terms of respiratory outcomes; however, caution should be taken when administering dexamethasone. Data derived from current evidence, including meta-analyses, are inconclusive on the long-term effects of the administration of systemic steroids in preterm infants or the possibility of neurodevelopmental consequences.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1344337
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  5. Article ; Online: Associations between immune biomarkers and symptoms of anxiety, depression, and insomnia in paediatric inflammatory bowel disease: A preliminary longitudinal analysis.

    Ballesio, Andrea / Santamaria, Tiziana / Furio, Silvia / Parisi, Pasquale / Polese, Daniela / Micheli, Federica / Baccini, Flavia / Di Nardo, Giovanni / Lombardo, Caterina

    Physiology & behavior

    2024  Volume 278, Page(s) 114510

    Abstract: Innate immunity may influence the onset of affective symptoms and alter sleep patterns in chronic inflammatory conditions. Here, we tested the prospective associations between baseline serum C-reactive protein (CRP), albumin, and CRP/albumin ratio (CAR, ... ...

    Abstract Innate immunity may influence the onset of affective symptoms and alter sleep patterns in chronic inflammatory conditions. Here, we tested the prospective associations between baseline serum C-reactive protein (CRP), albumin, and CRP/albumin ratio (CAR, i.e., an emerging biomarker of disease activity), and self-reported symptoms of anxiety, depression, and insomnia at 1-year follow up in paediatric inflammatory bowel disease (n = 17). After controlling for baseline values, CAR (ρ = 0.591, p = 0.026) predicted anxiety symptoms, while albumin predicted both anxiety (ρ = -0.687, p = 0.007) and insomnia symptoms (ρ = -0.648, p = 0.012). Current findings preliminarily suggest that inflammation may influence anxiety and sleep disturbance in paediatric IBD.
    MeSH term(s) Humans ; Child ; Sleep Initiation and Maintenance Disorders/complications ; Depression/complications ; Depression/psychology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Biomarkers ; Anxiety/complications ; Anxiety/psychology ; C-Reactive Protein/metabolism ; Albumins
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4) ; Albumins
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2024.114510
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    Zs.A 747: Show issues Location:
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  6. Article ; Online: Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

    Doni, Davide / Cavallari, Eva / Noguera, Martin Ezequiel / Gentili, Hernan Gustavo / Cavion, Federica / Parisi, Gustavo / Fornasari, Maria Silvina / Sartori, Geppo / Santos, Javier / Bellanda, Massimo / Carbonera, Donatella / Costantini, Paola / Bortolus, Marco

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Nqo15 is a subunit of respiratory complex I of the ... ...

    Abstract Nqo15 is a subunit of respiratory complex I of the bacterium
    MeSH term(s) Humans ; Frataxin ; Electron Transport Complex I/metabolism ; Thermus thermophilus/metabolism ; Molecular Dynamics Simulation ; Iron/metabolism ; Iron-Binding Proteins/metabolism ; Friedreich Ataxia/metabolism
    Chemical Substances Frataxin ; Electron Transport Complex I (EC 7.1.1.2) ; Iron (E1UOL152H7) ; Iron-Binding Proteins
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031912
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  7. Article ; Online: Peptide Stereochemistry Effects from p

    Adorinni, Simone / Gentile, Serena / Bellotto, Ottavia / Kralj, Slavko / Parisi, Evelina / Cringoli, Maria C / Deganutti, Caterina / Malloci, Giuliano / Piccirilli, Federica / Pengo, Paolo / Vaccari, Lisa / Geremia, Silvano / Vargiu, Attilio V / De Zorzi, Rita / Marchesan, Silvia

    ACS nano

    2024  Volume 18, Issue 4, Page(s) 3011–3022

    Abstract: The divergent supramolecular behavior of a series of tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic, and computational techniques. Only two epimers were able to effectively self-organize into amphipathic ... ...

    Abstract The divergent supramolecular behavior of a series of tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic, and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading to supramolecular hydrogels or crystals, respectively. Despite the similarity between the two peptides' turn conformations, stereoconfiguration led to different abilities to engage in intramolecular hydrogen bonding. Self-assembly further shifted the p
    MeSH term(s) Hydrogels/chemistry ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Peptides/chemistry
    Chemical Substances Hydrogels ; Gold (7440-57-5) ; Peptides
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c08004
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  8. Article: Response of Sabella spallanzanii to multiple stressors. The combined effect of infection and copper sulphate.

    La Corte, Claudia / Dara, Mariano / Bertini, Federica / Parrinello, Daniela / Piazzese, Daniela / Parisi, Maria Giovanna

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2022  Volume 263, Page(s) 109475

    Abstract: The aim of this work is to study the immune responses of the polychaete Sabella spallanzanii after exposure to copper sulphate, an immunomodulating agent in marine organisms, and the multiple stresses caused by Escherichia coli infection, to validate the ...

    Abstract The aim of this work is to study the immune responses of the polychaete Sabella spallanzanii after exposure to copper sulphate, an immunomodulating agent in marine organisms, and the multiple stresses caused by Escherichia coli infection, to validate the species as a model organism in marine-coastal biomonitoring programmes. Polychaetes were housed in laboratory and divided into five experimental groups: 1. Control (no microinjected), 2. filtered seawater + TBS injection (control of point 3), 3. filtered seawater + E. coli injection (control of point 4), 4. CuSO
    MeSH term(s) Animals ; Copper Sulfate/toxicity ; Escherichia coli ; Polychaeta ; Seawater ; Oxidative Stress
    Chemical Substances Copper Sulfate (LRX7AJ16DT)
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2022.109475
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    Zs.A 44/C: Show issues Location:
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  9. Article: Current Evidence and Future Perspectives about the Role of PARP Inhibitors in the Treatment of Thoracic Cancers.

    Parisi, Alessandro / Rossi, Francesca / De Filippis, Chiara / Paoloni, Francesco / Felicetti, Cristiano / Mammarella, Alex / Pecci, Federica / Lupi, Alessio / Berardi, Rossana

    OncoTargets and therapy

    2023  Volume 16, Page(s) 585–613

    Abstract: In recent years, poly (ADP-ribose) polymerase (PARP) inhibition has become a promising therapeutic option for several tumors, especially for those harboring a BRCA 1-2 mutation or a deficit in the homologous recombination repair (HRR) pathway. ... ...

    Abstract In recent years, poly (ADP-ribose) polymerase (PARP) inhibition has become a promising therapeutic option for several tumors, especially for those harboring a BRCA 1-2 mutation or a deficit in the homologous recombination repair (HRR) pathway. Nevertheless, to date, PARP inhibitors are still not largely used for thoracic malignancies neither as a single agent nor in combination with other treatments. Recently, a deeper understanding of HRR mechanisms, alongside the development of new targeted and immunotherapy agents, particularly against HRR-deficient tumors, traced the path to new treatment strategies for many tumor types including lung cancer and malignant pleural mesothelioma. The aim of this review is to sum up the current knowledge about cancer-DNA damage response pathways inhibition and to update the status of recent clinical trials investigating the use of PARP inhibitors, either as monotherapy or in combination with other agents for the treatment of thoracic malignancies. We will also briefly discuss available evidence on Poly(ADP-Ribose) Glycohydrolase (PARG) inhibitors, a novel promising therapeutic option in oncology.
    Language English
    Publishing date 2023-07-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S272563
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  10. Article: Recurrent Extreme Bilateral Gigantomastia Caused by Pseudoangiomatous Stromal Hyperplasia (PASH) Syndrome: A Case Report.

    Parisi, Paola / Vinci, Federica / Di Meglio, Filippo / Marruzzo, Giovanni / De Luca, Alessandro / Ascione, Andrea / Vittori, Luigi / Ribuffo, Diego

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 1, Page(s) e4571

    Abstract: Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a rare and benign medical condition in which the breast tissue is affected by an abnormal myofibroblastic proliferation, which mimics a low-grade sarcoma angiomatous proliferation. PASH ... ...

    Abstract Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a rare and benign medical condition in which the breast tissue is affected by an abnormal myofibroblastic proliferation, which mimics a low-grade sarcoma angiomatous proliferation. PASH usually presents itself either as a palpable mass or as an incidental diagnosis during breast specimens' histological examination. A few cases have been reported in the literature of a diffuse form of breast PASH syndrome in which the clinical presentation is a bilateral form of gigantomastia without palpable masses. In such cases, the optimal surgical management is still debated due to a significant risk of relapse after breast reduction. Mastectomy seems to be the endpoint of this condition in relapsing cases. Recent studies report a good outcome with a Tamoxifen regimen when surgery cannot be performed, supporting a hormonal component for the etiology of the condition. This study reports on an extremely rare case of bilateral, rapid, and severe PASH in a young patient, presenting as a truly disabling gigantomastia that forced the patient to use a wheelchair due to the excessive breast weights (25 kg the right breast and 21 kg the left). We describe her complicated medical history, her diagnosis, and our course of treatment.
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004571
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    Zs.A 7091: Show issues Location:
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