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Article ; Online: Illuminating liver fibrosis with vitamin D.

Firrincieli, D / Braescu, T / Housset, C / Chignard, N

Clinics and research in hepatology and gastroenterology

2014 Volume 38, Issue 1, Page(s) 5–8

Abstract: ... have been documented. Recently, the vitamin D-VDR axis has been shown to modulate HSC activity ...

Abstract	Hepatic fibrosis results from the accumulation of extracellular matrix-producing myofibroblasts in the liver. The mechanisms leading to the activation of hepatic stellate cells (HSCs) into myofibroblasts have been well described. By contrast, few molecular pathways leading to myofibroblast deactivation have been documented. Recently, the vitamin D-VDR axis has been shown to modulate HSC activity through a complex mechanism involving epigenetic modifications induced by the SMAD pathway.
MeSH term(s)	Animals ; Gene Regulatory Networks ; Liver/metabolism ; Liver/pathology ; Male ; Receptors, Calcitriol/metabolism ; Signal Transduction
Chemical Substances	Receptors, Calcitriol
Language	English
Publishing date	2014-02
Publishing country	France
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2013.10.004
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Article ; Online: Vitamin D and the vitamin D receptor in liver pathophysiology.

Zúñiga, Silvia / Firrincieli, Delphine / Housset, Chantal / Chignard, Nicolas

Clinics and research in hepatology and gastroenterology

2011 Volume 35, Issue 4, Page(s) 295–302

Abstract: Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis ... The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis ... on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms ...

Abstract	Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms of homeostatic control. We will also address the associations between the vitamin D-VDR axis and pathological liver entities, such as non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis and liver cancer. The link between liver diseases and the vitamin D-VDR axis will be discussed in light of evidences arising from in vitro and in vivo studies. Finally, we will consider the therapeutic potential of the vitamin D-VDR axis in liver diseases.
MeSH term(s)	Animals ; Homeostasis ; Humans ; Liver/metabolism ; Liver/physiopathology ; Liver Diseases/metabolism ; Liver Diseases/physiopathology ; Receptors, Calcitriol/physiology ; Vitamin D/metabolism ; Vitamin D/physiology
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2011-04
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2011.02.003
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Article ; Online: Curtobacterium salicis sp. nov., isolated from willow tree stems in Washington state.

Freeman, John / Firrincieli, Andrea / Baker, Douglas / Doty, Sharon

Antonie van Leeuwenhoek

2024 Volume 117, Issue 1, Page(s) 62

Abstract: Curtobacterium sp. strain WW7 is a Gram-positive, non-motile, orange rod-shaped bacterium isolated from branches of wild willow (Salix sitchensis) trees. The ... ...

Abstract	Curtobacterium sp. strain WW7 is a Gram-positive, non-motile, orange rod-shaped bacterium isolated from branches of wild willow (Salix sitchensis) trees. The WW7
MeSH term(s)	Trees ; Salix/genetics ; Sequence Analysis, DNA ; Washington ; Actinomycetales ; Fatty Acids/chemistry ; Succinates ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Phospholipids/chemistry
Chemical Substances	Fatty Acids ; Succinates ; RNA, Ribosomal, 16S ; DNA, Bacterial ; Phospholipids
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	214861-4
ISSN	1572-9699 ; 0003-6072
ISSN (online)	1572-9699
ISSN	0003-6072
DOI	10.1007/s10482-024-01956-y
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Article ; Online: Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice.

Firrincieli, Delphine / Zúñiga, Silvia / Rey, Colette / Wendum, Dominique / Lasnier, Elisabeth / Rainteau, Dominique / Braescu, Thomas / Falguières, Thomas / Boissan, Mathieu / Cadoret, Axelle / Housset, Chantal / Chignard, Nicolas

Hepatology (Baltimore, Md.)

2013 Volume 58, Issue 4, Page(s) 1401–1412

Abstract: ... acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary ...

Abstract	Unlabelled: Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs. The aim of our study was thus to investigate the role of VDR in the maintenance of bile duct integrity in mice challenged with biliary-type liver injury. Vdr(-/-) mice subjected to bile duct ligation (BDL) displayed increased liver damage compared to wildtype BDL mice. Adaptation to cholestasis, ascertained by expression of genes involved in bile acid metabolism and tissue repair, was limited in Vdr(-/-) BDL mice. Furthermore, evaluation of Vdr(-/-) BDL mouse liver tissue sections indicated altered E-cadherin staining associated with increased bile duct rupture. Total liver protein analysis revealed that a truncated form of E-cadherin was present in higher amounts in Vdr(-/-) mice subjected to BDL compared to wildtype BDL mice. Truncated E-cadherin was also associated with loss of cell adhesion in biliary epithelial cells silenced for VDR. In these cells, E-cadherin cleavage occurred together with calpain 1 activation and was prevented by the silencing of calpain 1. Furthermore, VDR deficiency led to the activation of the epidermal growth factor receptor (EGFR) pathway, while EGFR activation by EGF induced both calpain 1 activation and E-cadherin cleavage in these cells. Finally, truncation of E-cadherin was blunted when EGFR signaling was inhibited in VDR-silenced cells. Conclusion: Biliary-type liver injury is exacerbated in Vdr(-/-) mice by limited adaptive response and increased bile duct rupture. These results indicate that loss of VDR restricts the adaptation to cholestasis and diminishes bile duct integrity in the setting of biliary-type liver injury.
MeSH term(s)	Amino Acid Sequence ; Animals ; Bile Ducts/physiopathology ; Biliary Tract/pathology ; Cadherins/analysis ; Cadherins/physiology ; Calpain/physiology ; Cholestasis/pathology ; Cholestasis/physiopathology ; Disease Models, Animal ; Epithelial Cells/pathology ; ErbB Receptors/physiology ; Intercellular Junctions/pathology ; Ligation ; Liver/pathology ; Liver/physiopathology ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Receptors, Calcitriol/deficiency ; Receptors, Calcitriol/physiology
Chemical Substances	Cadherins ; Receptors, Calcitriol ; ErbB Receptors (EC 2.7.10.1) ; Calpain (EC 3.4.22.-) ; Capn1 protein, mouse (EC 3.4.22.52)
Language	English
Publishing date	2013-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.26453
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Article ; Online: Unravelling the role of the group 6 soluble di-iron monooxygenase (SDIMO) SmoABCD in alkane metabolism and chlorinated alkane degradation.

Ferrari, Eleonora / Di Benedetto, Giulio / Firrincieli, Andrea / Presentato, Alessandro / Frascari, Dario / Cappelletti, Martina

Microbial biotechnology

2024 Volume 17, Issue 5, Page(s) e14453

Abstract: Soluble di-iron monooxygenases (SDIMOs) are multi-component enzymes catalysing the oxidation of various substrates. These enzymes are characterized by high sequence and functional diversity that is still not well understood despite their key role in ... ...

Abstract	Soluble di-iron monooxygenases (SDIMOs) are multi-component enzymes catalysing the oxidation of various substrates. These enzymes are characterized by high sequence and functional diversity that is still not well understood despite their key role in biotechnological processes including contaminant biodegradation. In this study, we analysed a mutant of Rhodoccocus aetherivorans BCP1 (BCP1-2.10) characterized by a transposon insertion in the gene smoA encoding the alpha subunit of the plasmid-located SDIMO SmoABCD. The mutant BCP1-2.10 showed a reduced capacity to grow on propane, lost the ability to grow on butane, pentane and n-hexane and was heavily impaired in the capacity to degrade chloroform and trichloroethane. The expression of the additional SDIMO prmABCD in BCP1-2.10 probably allowed the mutant to partially grow on propane and to degrade it, to some extent, together with the other short-chain n-alkanes. The complementation of the mutant, conducted by introducing smoABCD in the genome as a single copy under a constitutive promoter or within a plasmid under a thiostreptone-inducible promoter, allowed the recovery of the alkanotrophic phenotype as well as the capacity to degrade chlorinated n-alkanes. The heterologous expression of smoABCD allowed a non-alkanotrophic Rhodococcus strain to grow on pentane and n-hexane when the gene cluster was introduced together with the downstream genes encoding alcohol and aldehyde dehydrogenases and a GroEL chaperon. BCP1 smoA gene was shown to belong to the group 6 SDIMOs, which is a rare group of monooxygenases mostly present in Mycobacterium genus and in a few Rhodococcus strains. SmoABCD originally evolved in Mycobacterium and was then acquired by Rhodococcus through horizontal gene transfer events. This work extends the knowledge of the biotechnologically relevant SDIMOs by providing functional and evolutionary insights into a group 6 SDIMO in Rhodococcus and demonstrating its key role in the metabolism of short-chain alkanes and degradation of chlorinated n-alkanes.
MeSH term(s)	Alkanes/metabolism ; Mixed Function Oxygenases/metabolism ; Mixed Function Oxygenases/genetics ; Genetic Complementation Test ; Mutagenesis, Insertional ; Biotransformation ; DNA Transposable Elements ; Hydrocarbons, Chlorinated/metabolism
Chemical Substances	Alkanes ; Mixed Function Oxygenases (EC 1.-) ; DNA Transposable Elements ; Hydrocarbons, Chlorinated
Language	English
Publishing date	2024-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2406063-X
ISSN	1751-7915 ; 1751-7915
ISSN (online)	1751-7915
ISSN	1751-7915
DOI	10.1111/1751-7915.14453
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Article ; Online: The actinomycete Kitasatospora sp. SeTe27, subjected to adaptive laboratory evolution (ALE) in the presence of selenite, varies its cellular morphology, redox stability, and tolerance to the toxic oxyanion.

Firrincieli, Andrea / Tornatore, Enrico / Piacenza, Elena / Cappelletti, Martina / Saiano, Filippo / Pavia, Francesco Carfì / Alduina, Rosa / Zannoni, Davide / Presentato, Alessandro

Chemosphere

2024 Volume 354, Page(s) 141712

Abstract: The effects of oxyanions selenite ( ... ...

Abstract	The effects of oxyanions selenite (SeO
MeSH term(s)	Selenious Acid/toxicity ; Sodium Selenite/metabolism ; Sodium Selenite/toxicity ; Actinobacteria/genetics ; Actinobacteria/metabolism ; Bacteria/metabolism ; Selenium/metabolism ; Oxidation-Reduction
Chemical Substances	Selenious Acid (F6A27P4Q4R) ; Sodium Selenite (HIW548RQ3W) ; Selenium (H6241UJ22B)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141712
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Article ; Online: Insights into the Synergistic Antibacterial Activity of Silver Nitrate with Potassium Tellurite against

Pormohammad, Ali / Firrincieli, Andrea / Salazar-Alemán, Daniel A / Mohammadi, Mehdi / Hansen, Dave / Cappelletti, Martina / Zannoni, Davide / Zarei, Mohammad / Turner, Raymond J

Microbiology spectrum

2023 Volume 11, Issue 4, Page(s) e0062823

Abstract: The constant, ever-increasing antibiotic resistance crisis leads to the announcement of "urgent, novel antibiotics needed" by the World Health Organization. Our previous works showed a promising synergistic antibacterial activity of silver nitrate with ... ...

Abstract	The constant, ever-increasing antibiotic resistance crisis leads to the announcement of "urgent, novel antibiotics needed" by the World Health Organization. Our previous works showed a promising synergistic antibacterial activity of silver nitrate with potassium tellurite out of thousands of other metal/metalloid-based antibacterial combinations. The silver-tellurite combined treatment not only is more effective than common antibiotics but also prevents bacterial recovery, decreases the risk of future resistance chance, and decreases the effective concentrations. We demonstrate that the silver-tellurite combination is effective against clinical isolates. Further, this study was conducted to address knowledge gaps in the available data on the antibacterial mechanism of both silver and tellurite, as well as to give insight into how the mixture provides synergism as a combination. Here, we defined the differentially expressed gene profile of Pseudomonas aeruginosa under silver, tellurite, and silver-tellurite combination stress using an RNA sequencing approach to examine the global transcriptional changes in the challenged cultures grown in simulated wound fluid. The study was complemented with metabolomics and biochemistry assays. Both metal ions mainly affected four cellular processes, including sulfur homeostasis, reactive oxygen species response, energy pathways, and the bacterial cell membrane (for silver). Using a Caenorhabditis elegans animal model we showed silver-tellurite has reduced toxicity over individual metal/metalloid salts and provides increased antioxidant properties to the host. This work demonstrates that the addition of tellurite would improve the efficacy of silver in biomedical applications.
MeSH term(s)	Animals ; Silver Nitrate/pharmacology ; Silver Nitrate/metabolism ; Pseudomonas aeruginosa/metabolism ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/metabolism ; Metalloids/metabolism ; Microbial Sensitivity Tests
Chemical Substances	tellurous acid (IVA6SGP6QM) ; Silver Nitrate (95IT3W8JZE) ; potassium tellurate(IV) (71M41949N8) ; Anti-Bacterial Agents ; Anti-Infective Agents ; Metalloids
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00628-23
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Article ; Online: Molecular characterization of microbial communities in a peat-rich aquifer system contaminated with chlorinated aliphatic compounds.

Ghezzi, Daniele / Filippini, Maria / Cappelletti, Martina / Firrincieli, Andrea / Zannoni, Davide / Gargini, Alessandro / Fedi, Stefano

Environmental science and pollution research international

2021 Volume 28, Issue 18, Page(s) 23017–23035

Abstract: In an aquifer-aquitard system in the subsoil of the city of Ferrara (Emilia-Romagna region, northern Italy) highly contaminated with chlorinated aliphatic toxic organics such as trichloroethylene (TCE) and tetrachloroethylene (PCE), a strong microbial- ... ...

Abstract	In an aquifer-aquitard system in the subsoil of the city of Ferrara (Emilia-Romagna region, northern Italy) highly contaminated with chlorinated aliphatic toxic organics such as trichloroethylene (TCE) and tetrachloroethylene (PCE), a strong microbial-dependent dechlorination activity takes place during migration of contaminants through shallow organic-rich layers with peat intercalations. The in situ microbial degradation of chlorinated ethenes, formerly inferred by the utilization of contaminant concentration profiles and Compound-Specific Isotope Analysis (CSIA), was here assessed using Illumina sequencing of V4 hypervariable region of 16S rRNA gene and by clone library analysis of dehalogenase metabolic genes. Taxon-specific investigation of the microbial communities catalyzing the chlorination process revealed the presence of not only dehalogenating genera such as Dehalococcoides and Dehalobacter but also of numerous other groups of non-dehalogenating bacteria and archaea thriving on diverse metabolisms such as hydrolysis and fermentation of complex organic matter, acidogenesis, acetogenesis, and methanogenesis, which can indirectly support the reductive dechlorination process. Besides, the diversity of genes encoding some reductive dehalogenases was also analyzed. Geochemical and 16S rRNA and RDH gene analyses, as a whole, provided insights into the microbial community complexity and the distribution of potential dechlorinators. Based on the data obtained, a possible network of metabolic interactions has been hypothesized to obtain an effective reductive dechlorination process.
MeSH term(s)	Biodegradation, Environmental ; Groundwater ; Italy ; Microbiota ; RNA, Ribosomal, 16S/genetics ; Soil ; Trichloroethylene ; Water Pollutants, Chemical/analysis
Chemical Substances	RNA, Ribosomal, 16S ; Soil ; Water Pollutants, Chemical ; Trichloroethylene (290YE8AR51)
Language	English
Publishing date	2021-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-12236-3
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Article: Insights into the microbial life in silica-rich subterranean environments: microbial communities and ecological interactions in an orthoquartzite cave (Imawarì Yeuta, Auyan Tepui, Venezuela).

Ghezzi, Daniele / Foschi, Lisa / Firrincieli, Andrea / Hong, Pei-Ying / Vergara, Freddy / De Waele, Jo / Sauro, Francesco / Cappelletti, Martina

Frontiers in microbiology

2022 Volume 13, Page(s) 930302

Abstract: Microbial communities inhabiting caves in quartz-rich rocks are still underexplored, despite their possible role in the silica cycle. The world's longest orthoquartzite cave, Imawarì Yeuta, represents a perfect arena for the investigation of the ... ...

Abstract	Microbial communities inhabiting caves in quartz-rich rocks are still underexplored, despite their possible role in the silica cycle. The world's longest orthoquartzite cave, Imawarì Yeuta, represents a perfect arena for the investigation of the interactions between microorganisms and silica in non-thermal environments due to the presence of extraordinary amounts of amorphous silica speleothems of different kinds. In this work, the microbial diversity of Imawarì Yeuta was dissected by analyzing nineteen samples collected from different locations representative of different silica amorphization phases and types of samples. Specifically, we investigated the major ecological patterns in cave biodiversity, specific taxa enrichment, and the main ecological clusters through co-occurrence network analysis. Water content greatly contributed to the microbial communities' composition and structures in the cave leading to the sample clustering into three groups DRY, WET, and WATER. Each of these groups was enriched in members of
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.930302
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Article ; Online: Biotechnology of Rhodococcus for the production of valuable compounds.

Cappelletti, Martina / Presentato, Alessandro / Piacenza, Elena / Firrincieli, Andrea / Turner, Raymond J / Zannoni, Davide

Applied microbiology and biotechnology

2020 Volume 104, Issue 20, Page(s) 8567–8594

Abstract: Bacteria belonging to Rhodococcus genus represent ideal candidates for microbial biotechnology applications because of their metabolic versatility, ability to degrade a wide range of organic compounds, and resistance to various stress conditions, such as ...

Abstract	Bacteria belonging to Rhodococcus genus represent ideal candidates for microbial biotechnology applications because of their metabolic versatility, ability to degrade a wide range of organic compounds, and resistance to various stress conditions, such as metal toxicity, desiccation, and high concentration of organic solvents. Rhodococcus spp. strains have also peculiar biosynthetic activities that contribute to their strong persistence in harsh and contaminated environments and provide them a competitive advantage over other microorganisms. This review is focused on the metabolic features of Rhodococcus genus and their potential use in biotechnology strategies for the production of compounds with environmental, industrial, and medical relevance such as biosurfactants, bioflocculants, carotenoids, triacylglycerols, polyhydroxyalkanoate, siderophores, antimicrobials, and metal-based nanostructures. These biosynthetic capacities can also be exploited to obtain high value-added products from low-cost substrates (industrial wastes and contaminants), offering the possibility to efficiently recover valuable resources and providing possible waste disposal solutions. Rhodococcus spp. strains have also recently been pointed out as a source of novel bioactive molecules highlighting the need to extend the knowledge on biosynthetic capacities of members of this genus and their potential utilization in the framework of bioeconomy. KEY POINTS: • Rhodococcus possesses promising biosynthetic and bioconversion capacities. • Rhodococcus bioconversion capacities can provide waste disposal solutions. • Rhodococcus bioproducts have environmental, industrial, and medical relevance. Graphical abstract.
MeSH term(s)	Biotechnology ; Industrial Waste ; Refuse Disposal ; Rhodococcus ; Triglycerides
Chemical Substances	Industrial Waste ; Triglycerides
Language	English
Publishing date	2020-09-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-020-10861-z
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