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  1. Article ; Online: How important is EMT for cancer metastasis?

    Celià-Terrassa, Toni / Kang, Yibin

    PLoS biology

    2024  Volume 22, Issue 2, Page(s) e3002487

    Abstract: Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress ... ...

    Abstract Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.
    MeSH term(s) Humans ; Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Embryonic Development ; Neoplasm Metastasis
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002487
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  2. Article: Phenotypic plasticity - Implications for tumours in bone.

    Han, Yujiao / Kang, Yibin

    Journal of bone oncology

    2024  Volume 45, Page(s) 100592

    Abstract: Metastasis is a major contributor to cancer patient mortality. Tumour cells often develop phenotypic plasticity to successfully metastasize to different target organs. Recent progress in the study of bone metastasis has provided novel insight into the ... ...

    Abstract Metastasis is a major contributor to cancer patient mortality. Tumour cells often develop phenotypic plasticity to successfully metastasize to different target organs. Recent progress in the study of bone metastasis has provided novel insight into the biological processes that drive the spread and growth of cancer cells in the bone. In this review, we provide a summary of how the bone marrow microenvironment promotes phenotypic plasticity of metastatic tumour cells and alters therapeutic responses. We highlight pivotal transformations in cellular status driven by plasticity, including mesenchymal-epithelial transition, acquisition of stem-like traits, and awakening from dormancy. Additionally, we describe the phenomenon of host-organ mimicry and metabolic rewiring that collectively serve as key attributes of disseminated tumour cells, enabling their successful colonization and growth within the bone marrow microenvironment.
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2212-1366
    ISSN 2212-1366
    DOI 10.1016/j.jbo.2024.100592
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  3. Article ; Online: Cold snap for cancer: cold-induced brown fat thermogenesis starves tumor growth.

    Chen, Ziqing / Kang, Yibin

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 10

    MeSH term(s) Humans ; Adipose Tissue, Brown ; Thermogenesis ; Neoplasms/genetics
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01284-5
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  4. Article ; Online: Cold snap for cancer

    Ziqing Chen / Yibin Kang

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    cold-induced brown fat thermogenesis starves tumor growth

    2023  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Microbial metabolite as icebreaker for immunotherapy.

    Tang, Yong / Kang, Yibin

    Cell metabolism

    2022  Volume 34, Issue 4, Page(s) 506–507

    Abstract: Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts ... ...

    Abstract Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8
    MeSH term(s) Humans ; Immunity, Cellular ; Immunotherapy ; Triple Negative Breast Neoplasms/metabolism
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.03.003
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    Zs.A 6169: Show issues Location:
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  6. Article ; Online: Cancer fitness genes: emerging therapeutic targets for metastasis.

    Shen, Minhong / Kang, Yibin

    Trends in cancer

    2022  Volume 9, Issue 1, Page(s) 69–82

    Abstract: Development of cancer therapeutics has traditionally focused on targeting driver oncogenes. Such an approach is limited by toxicity to normal tissues and treatment resistance. A class of 'cancer fitness genes' with crucial roles in metastasis have been ... ...

    Abstract Development of cancer therapeutics has traditionally focused on targeting driver oncogenes. Such an approach is limited by toxicity to normal tissues and treatment resistance. A class of 'cancer fitness genes' with crucial roles in metastasis have been identified. Elevated or altered activities of these genes do not directly cause cancer; instead, they relieve the stresses that tumor cells encounter and help them adapt to a changing microenvironment, thus facilitating tumor progression and metastasis. Importantly, as normal cells do not experience high levels of stress under physiological conditions, targeting cancer fitness genes is less likely to cause toxicity to noncancerous tissues. Here, we summarize the key features and function of cancer fitness genes and discuss their therapeutic potential.
    MeSH term(s) Humans ; Oncogenes ; Neoplasms/drug therapy ; Neoplasms/genetics ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.08.007
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  7. Article ; Online: Numerical computation of preimage domains for spiral slit regions and simulation of flow around bodies.

    Wu, Kang / Lu, Yibin

    Mathematical biosciences and engineering : MBE

    2022  Volume 20, Issue 1, Page(s) 720–736

    Abstract: In this paper, we propose the iterative numerical methods to calculate the conformal preimage domains for the specified logarithmic spiral slit regions and develop the applications of conformal mappings in the simulations of the flow around bodies. ... ...

    Abstract In this paper, we propose the iterative numerical methods to calculate the conformal preimage domains for the specified logarithmic spiral slit regions and develop the applications of conformal mappings in the simulations of the flow around bodies. Firstly, we postulate that the boundaries of the preimage domains mapped onto logarithmic spiral slits are ellipses. The lengths of the long axes of ellipses and the coordinates of the centers are calculated using our iterative methods. Secondly, each type of the presented iterative method calculates numerical conformal mappings via solving the boundary integral equation with the generalized Neumann kernel. Finally, numerical examples show the convergence and availability of our iterative methods and display the simulations of the flow around the bodies as an application.
    MeSH term(s) Computer Simulation
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023033
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  8. Article ; Online: Mechanisms of Organ-Specific Metastasis of Breast Cancer.

    Nolan, Emma / Kang, Yibin / Malanchi, Ilaria

    Cold Spring Harbor perspectives in medicine

    2023  Volume 13, Issue 11

    Abstract: Cancer metastasis, or the development of secondary tumors in distant tissues, accounts for the vast majority of fatalities in patients with breast cancer. Breast cancer cells show a striking proclivity to metastasize to distinct organs, specifically the ... ...

    Abstract Cancer metastasis, or the development of secondary tumors in distant tissues, accounts for the vast majority of fatalities in patients with breast cancer. Breast cancer cells show a striking proclivity to metastasize to distinct organs, specifically the lung, liver, bone, and brain, where they face unique environmental pressures and a wide variety of tissue-resident cells that together create a strong barrier for tumor survival and growth. As a consequence, successful metastatic colonization is critically dependent on reciprocal cross talk between cancer cells and host cells within the target organ, a relationship that shapes the formation of a tumor-supportive microenvironment. Here, we discuss the mechanisms governing organ-specific metastasis in breast cancer, focusing on the intricate interactions between metastatic cells and specific niche cells within a secondary organ, and the remarkable adaptations of both compartments that cooperatively support cancer growth. More broadly, we aim to provide a framework for the microenvironmental prerequisites within each distinct metastatic site for successful breast cancer metastatic seeding and outgrowth.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Brain/pathology ; Liver/pathology ; Bone and Bones/pathology ; Neoplasm Metastasis/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a041326
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  9. Article ; Online: Evolving barcodes shed light into evolving metastases.

    Kang, Yibin / Kuperwasser, Charlotte

    Developmental cell

    2021  Volume 56, Issue 8, Page(s) 1077–1079

    Abstract: Selective pressure and signals from the tissue microenvironment drive metastasis and determine the survival of metastatic tumor cells at distant organs. Zhang et al. and Bado et al. apply CRISPR-mediated evolving barcode technology to elucidate the role ... ...

    Abstract Selective pressure and signals from the tissue microenvironment drive metastasis and determine the survival of metastatic tumor cells at distant organs. Zhang et al. and Bado et al. apply CRISPR-mediated evolving barcode technology to elucidate the role of the bone microenvironment in the evolution of breast cancer metastasis.
    MeSH term(s) Bone and Bones ; Breast Neoplasms ; Female ; Humans ; Tumor Microenvironment
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.03.029
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    Zs.A 5742: Show issues Location:
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  10. Article ; Online: Lineage tracing reveals metastatic dynamics.

    Lee, Eunmi / Kang, Yibin

    Cancer cell

    2021  Volume 39, Issue 8, Page(s) 1050–1052

    Abstract: Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. developed the macsGESTALT lineage recording system to ... ...

    Abstract Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. developed the macsGESTALT lineage recording system to reveal that hybrid EMT states and S100 expression are associated with elevated metastatic abilities in a pancreatic cancer model.
    MeSH term(s) Cell Lineage/genetics ; Humans ; Pancreatic Neoplasms/genetics ; Sequence Analysis, RNA ; Whole Exome Sequencing
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.06.005
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