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  1. Article ; Online: Evaluation for Fibrosis After Cure of Hepatitis C-Reply.

    Wilder, Julius / Choi, Steve S / Moylan, Cynthia A

    JAMA

    2019  Volume 321, Issue 15, Page(s) 1535

    MeSH term(s) Hepacivirus ; Hepatitis C ; Humans
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.0873
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  2. Article ; Online: Vibration-Controlled Transient Elastography for Diagnosing Cirrhosis and Staging Hepatic Fibrosis.

    Wilder, Julius / Choi, Steve S / Moylan, Cynthia A

    JAMA

    2018  Volume 320, Issue 19, Page(s) 2031–2032

    MeSH term(s) Aged ; Elasticity Imaging Techniques/methods ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnostic imaging ; Humans ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/virology ; Male ; Vibration
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2018.13073
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  3. Article ; Online: Econometrics Best Paper Award 2018

    In Choi / Steve Cook / Marc S. Paolella / Jeffrey S. Racine

    Econometrics, Vol 6, Iss 3, p

    2018  Volume 38

    Abstract: ... n/ ... ...

    Abstract n/a
    Keywords n/a ; Economics as a science ; HB71-74
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Reasons for Initiation and Regular Use of Heated Tobacco Products among Current and Former Smokers in South Korea: Findings from the 2020 ITC Korea Survey.

    Seo, Hong Gwan / Xu, Steve S / Li, Grace / Gravely, Shannon / Quah, Anne C K / Lee, Sungkyu / Lim, Sujin / Cho, Sung-Il / Kim, Yeol / Lee, Eon Sook / Choi, Yoon-Jung / Miller, Connor R / Goniewicz, Maciej L / O'Connor, Richard J / Fong, Geoffrey T

    International journal of environmental research and public health

    2023  Volume 20, Issue 6

    Abstract: ... Respondents were asked to report the reason(s) they used HTPs, with 25 possible reasons for HTP-cigarette ...

    Abstract South Korea is the world's second-largest heated tobacco product (HTP) market after Japan. HTP sales in South Korea have increased rapidly since May 2017, accounting for 10.6% of the total tobacco market in 2020. Despite this, little is known as to why HTP consumers who were current and former smokers started using HTPs and used them regularly. We analyzed cross-sectional data for 1815 adults (aged 19+) who participated in the 2020 International Tobacco Control (ITC) Korea Survey, of whom 1650 were HTP-cigarette consumers (those who reported smoking cigarettes and using HTPs ≥ weekly) and 165 were exclusive HTP consumers (using HTPs ≥ weekly) who were former or occasional smokers (smoking cigarette < weekly). Respondents were asked to report the reason(s) they used HTPs, with 25 possible reasons for HTP-cigarette consumers and 22 for exclusive HTP consumers. The most common reasons for initiating HTP use among all HTP consumers were out of curiosity (58.9%), family and friends use HTPs (45.5%), and they like the HTP technology (35.9%). The most common reasons for regularly using HTPs among all HTP consumers were that they were less smelly than cigarettes (71.3%), HTPs are less harmful to own health than cigarettes (48.6%), and stress reduction (47.4%). Overall, 35.4% of HTP-cigarette consumers reported using HTPs to quit smoking, 14.7% to reduce smoking but not to quit, and 49.7% for other reasons besides quitting or reducing smoking. In conclusion, several common reasons for initiating and regularly using HTPs were endorsed by all HTP consumers who were smoking, had quit smoking completely, or occasionally smoked. Notably, only about one-third of HTP-cigarette consumers said they were using HTPs to quit smoking, suggesting that most had no intention of using HTPs as an aid to quit smoking in South Korea.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Smokers ; Republic of Korea/epidemiology ; Smoking/epidemiology ; Tobacco Products ; Electronic Nicotine Delivery Systems ; Surveys and Questionnaires
    Language English
    Publishing date 2023-03-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20064963
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  5. Article ; Online: Risk for hepatocellular carcinoma in patients with alcoholic cirrhosis.

    Tillman, Hans L / Choi, Steve S

    Annals of internal medicine

    2012  Volume 157, Issue 9, Page(s) 677–8; author reply 678

    MeSH term(s) Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/epidemiology ; Female ; Humans ; Liver Cirrhosis, Alcoholic/complications ; Liver Cirrhosis, Alcoholic/epidemiology ; Liver Neoplasms/complications ; Liver Neoplasms/epidemiology ; Male
    Language English
    Publishing date 2012-11-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-157-9-201211060-00022
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  6. Article ; Online: Electrocatalytic Access to Azetidines via Intramolecular Allylic Hydroamination: Scrutinizing Key Oxidation Steps through Electrochemical Kinetic Analysis.

    Park, Steve H / Bae, Geunsu / Choi, Ahhyeon / Shin, Suyeon / Shin, Kwangmin / Choi, Chang Hyuck / Kim, Hyunwoo

    Journal of the American Chemical Society

    2023  Volume 145, Issue 28, Page(s) 15360–15369

    Abstract: Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry, and ligand design for transition metals. However, state-of-the-art methods cannot be applied to intramolecular hydroamination of allylic amine derivatives despite ... ...

    Abstract Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry, and ligand design for transition metals. However, state-of-the-art methods cannot be applied to intramolecular hydroamination of allylic amine derivatives despite their underlying potential as one of the most prevalent synthetic precursors to azetidines. Herein, we report an electrocatalytic method for intramolecular hydroamination of allylic sulfonamides to access azetidines for the first time. The merger of cobalt catalysis and electricity enables the regioselective generation of key carbocationic intermediates, which could directly undergo intramolecular C-N bond formation. The mechanistic investigations including electrochemical kinetic analysis suggest that either the catalyst regeneration by nucleophilic cyclization or the second electrochemical oxidation to access the carbocationic intermediate is involved in the rate-determining step (RDS) of our electrochemical protocol and highlight the ability of electrochemistry in providing ideal means to mediate catalyst oxidation.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03172
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  7. Article ; Online: Direct interhemispheric cortical communication via thalamic commissures: a new white matter pathway in the primate brain.

    Szczupak, Diego / Schaeffer, David J / Tian, Xiaoguang / Choi, Sang-Ho / Fang-Cheng / Iack, Pamela Meneses / Campos, Vinicius P / Mayo, J Patrick / Patsch, Janina / Mitter, Christian / Haboosheh, Amit / Kwon, Ha Seung / Vieira, Marcelo A C / Reich, Daniel S / Jacobson, Steve / Kasprian, Gregor / Tovar-Moll, Fernanda / Lent, Roberto / Silva, Afonso C

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Volume 34, Issue 1

    Abstract: Cortical neurons of eutherian mammals project to the contralateral hemisphere, crossing the midline primarily via the corpus callosum and the anterior, posterior, and hippocampal commissures. We recently reported and named the thalamic commissures (TCs) ... ...

    Abstract Cortical neurons of eutherian mammals project to the contralateral hemisphere, crossing the midline primarily via the corpus callosum and the anterior, posterior, and hippocampal commissures. We recently reported and named the thalamic commissures (TCs) as an additional interhemispheric axonal fiber pathway connecting the cortex to the contralateral thalamus in the rodent brain. Here, we demonstrate that TCs also exist in primates and characterize the connectivity of these pathways with high-resolution diffusion-weighted MRI, viral axonal tracing, and fMRI. We present evidence of TCs in both New World (Callithrix jacchus and Cebus apella) and Old World primates (Macaca mulatta). Further, like rodents, we show that the TCs in primates develop during the embryonic period, forming anatomical and functionally active connections of the cortex with the contralateral thalamus. We also searched for TCs in the human brain, showing their presence in humans with brain malformations, although we could not identify TCs in healthy subjects. These results pose the TCs as a vital fiber pathway in the primate brain, allowing for more robust interhemispheric connectivity and synchrony and serving as an alternative commissural route in developmental brain malformations.
    MeSH term(s) Animals ; Humans ; White Matter/diagnostic imaging ; Brain ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/physiology ; Thalamus/diagnostic imaging ; Macaca mulatta ; Mammals
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad394
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3235: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Current approaches to the diagnosis and management of amyloidosis.

    Taylor, Mark S / Sidiqi, Hasib / Hare, James / Kwok, Fiona / Choi, Bo / Lee, Darren / Baumwol, Jay / Carroll, Antonia S / Vucic, Steve / Neely, Pat / Korczyk, Dariusz / Thomas, Liza / Mollee, Peter / Stewart, Graeme J / Gibbs, Simon D J

    Internal medicine journal

    2022  Volume 52, Issue 12, Page(s) 2046–2067

    Abstract: Amyloidosis is a collection of diseases caused by the misfolding of proteins that aggregate into insoluble amyloid fibrils and deposit in tissues. While these fibrils may aggregate to form insignificant localised deposits, they can also accumulate in ... ...

    Abstract Amyloidosis is a collection of diseases caused by the misfolding of proteins that aggregate into insoluble amyloid fibrils and deposit in tissues. While these fibrils may aggregate to form insignificant localised deposits, they can also accumulate in multiple organs to the extent that amyloidosis can be an immediately life-threatening disease, requiring urgent treatment. Recent advances in diagnostic techniques and therapies are dramatically changing the disease landscape and patient prognosis. Delays in diagnosis and treatment remain the greatest challenge, necessitating physician awareness of the common clinical presentations that suggest amyloidosis. The most common types are transthyretin (ATTR) amyloidosis followed by immunoglobulin light-chain (AL) amyloidosis. While systemic AL amyloidosis was previously considered a death sentence with no effective therapies, significant improvement in patient survival has occurred over the past 2 decades, driven by greater understanding of the disease process, risk-adapted adoption of myeloma therapies such as proteosome inhibitors (bortezomib) and monoclonal antibodies (daratumumab) and improved supportive care. ATTR amyloidosis is an underdiagnosed cause of heart failure. Technetium scintigraphy has made noninvasive diagnosis much easier, and ATTR is now recognised as the most common type of amyloidosis because of the increased identification of age-related ATTR. There are emerging ATTR treatments that slow disease progression, decrease patient hospitalisations and improve patient quality of life and survival. This review aims to update physicians on recent developments in amyloidosis diagnosis and management and to provide a diagnostic and treatment framework to improve the management of patients with all forms of amyloidosis.
    MeSH term(s) Humans ; Quality of Life ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Amyloidosis/complications ; Heart Failure/diagnosis ; Prognosis ; Bortezomib/therapeutic use ; Cardiomyopathies/diagnosis
    Chemical Substances Bortezomib (69G8BD63PP)
    Language English
    Publishing date 2022-12-07
    Publishing country Australia
    Document type Review ; Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15974
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  9. Article ; Online: Large-area synthesis of nanoscopic catalyst-decorated conductive MOF film using microfluidic-based solution shearing.

    Kim, Jin-Oh / Koo, Won-Tae / Kim, Hanul / Park, Chungseong / Lee, Taehoon / Hutomo, Calvin Andreas / Choi, Siyoung Q / Kim, Dong Soo / Kim, Il-Doo / Park, Steve

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4294

    Abstract: ... microfluidic channel-embedded solution-shearing (MiCS) for ultra-fast (≤5 mm/s) and large-area synthesis ...

    Abstract Conductive metal-organic framework (C-MOF) thin-films have a wide variety of potential applications in the field of electronics, sensors, and energy devices. The immobilization of various functional species within the pores of C-MOFs can further improve the performance and extend the potential applications of C-MOFs thin films. However, developing facile and scalable synthesis of high quality ultra-thin C-MOFs while simultaneously immobilizing functional species within the MOF pores remains challenging. Here, we develop microfluidic channel-embedded solution-shearing (MiCS) for ultra-fast (≤5 mm/s) and large-area synthesis of high quality nanocatalyst-embedded C-MOF thin films with thickness controllability down to tens of nanometers. The MiCS method synthesizes nanoscopic catalyst-embedded C-MOF particles within the microfluidic channels, and simultaneously grows catalyst-embedded C-MOF thin-film uniformly over a large area using solution shearing. The thin film displays high nitrogen dioxide (NO
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24571-1
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  10. Article: Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.

    Hong, Eun Pyo / Kim, Bong Jun / Cho, Steve S / Yang, Jin Seo / Choi, Hyuk Jai / Kang, Suk Hyung / Jeon, Jin Pyeong

    Journal of clinical medicine

    2019  Volume 8, Issue 2

    Abstract: Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA in a ... ...

    Abstract Genome-wide association studies found genetic variations with modulatory effects for intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to identify the susceptibility of single nucleotide polymorphisms (SNPs) to IA in a Korean population consisting of 250 patients, and 294 controls using the Asian-specific Axiom Precision Medicine Research Array. Twenty-nine SNPs reached a genome-wide significance threshold (5 × 10
    Language English
    Publishing date 2019-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm8020275
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