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  1. Article ; Online: Can we classify central serous chorioretinopathy better? Yes we can.

    Lotery, Andrew

    Eye (London, England)

    2021  Volume 36, Issue 3, Page(s) 487

    MeSH term(s) Central Serous Chorioretinopathy/diagnosis ; Choroid Diseases ; Fluorescein Angiography ; Humans
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01786-6
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  2. Article ; Online: Asymptomatic retinal dysfunction in a patient with alpha-methylacyl-CoA racemase deficiency.

    Kalogeropoulos, Dimitrios / Lagha, Lilia / Lotery, Andrew J

    Retinal cases & brief reports

    2024  

    Abstract: Purpose: To present a case of a young female patient with asymptomatic retinal dysfunction associated with alpha-methylacyl-CoA (AMACR) racemase deficiency.: Methods: Retrospective analysis of the medical notes of a single patient. Detailed slit-lamp ...

    Abstract Purpose: To present a case of a young female patient with asymptomatic retinal dysfunction associated with alpha-methylacyl-CoA (AMACR) racemase deficiency.
    Methods: Retrospective analysis of the medical notes of a single patient. Detailed slit-lamp examination was completed by Optos colour fundus photography and enhanced depth imaging optical coherence tomography (EDI-OCT). Genetic testing was conducted to establish the diagnosis, and the patient was also referred to the Department of Neurology for further assessment.
    Results: Dilated fundoscopy and ophthalmic imaging revealed bilateral retinal pigment epithelium abnormalities that could be associated with a genetic retinal disorder. Indeed, genetic testing showed that this lady was homozygous for AMACR (OMIM 604489; Gene ID 23600) variant NM 014324.6: c.154T>C; p.(Ser52Pro). She had no detectable neurological deficit.
    Conclusion: AMACR deficiency is a rare genetic condition that can potentially contribute to retinal dystrophy through various mechanisms. Additionally, it may lead to a wide spectrum of systemic signs and symptoms. Interestingly, in contrast to other reported studies, our patient was completely asymptomatic, with no evidence of systemic disorders.
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thinking Outside the Circle-The Potential Value of Ultra-Widefield Imaging.

    Yusuf, Imran H / Lotery, Andrew J

    JAMA ophthalmology

    2022  Volume 140, Issue 10, Page(s) 955–956

    MeSH term(s) Humans ; Fluorescein Angiography/methods ; Diagnostic Imaging
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2022.3166
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  4. Article ; Online: Central retinal artery occlusion after cardioversion of atrial fibrillation.

    Lagha, Lilia / Kalogeropoulos, Dimitrios / Goverdhan, Srinivas / Lotery, Andrew J

    Retinal cases & brief reports

    2024  

    Abstract: Central retinal artery occlusion (CRAO) is a vascular ophthalmic emergency. Often caused by a sudden interruption of blood flow to the eye, with profound and painless vision loss, resulting in irreversible cell damage. An impacted embolus at the ... ...

    Abstract Central retinal artery occlusion (CRAO) is a vascular ophthalmic emergency. Often caused by a sudden interruption of blood flow to the eye, with profound and painless vision loss, resulting in irreversible cell damage. An impacted embolus at the narrowest part of the central retinal artery is the most common cause. Cardioversion is a medical procedure used to restore a normal heart rhythm in individuals with atrial fibrillation (AF). In some cases, cardioversion can lead to thromboembolic complications. If an embolus reaches the central retinal artery, it can block the blood flow to the retina, resulting in CRAO and subsequent vision loss.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001559
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  5. Book ; Online: COVID19 and ophthalmology

    Lotery, Andrew

    a brief summary of the literature

    2020  

    Abstract: This literature review aims to address the available evidence on COVID19 related issues faced in ophthalmology practice. ...

    Abstract This literature review aims to address the available evidence on COVID19 related issues faced in ophthalmology practice.
    Keywords covid19
    Language English
    Publishing country uk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Multimodal Imaging of Vitelliform Lesions in Multiple Myeloma: A Case Report.

    Baltmr, Abeir / Lotery, Andrew

    Case reports in ophthalmology

    2022  Volume 13, Issue 2, Page(s) 523–528

    Abstract: We report the case of a patient with multiple myeloma who presented acutely with bilateral vitelliform-like macular lesions. This 85-year-old Caucasian lady was referred for treatment of presumed bilateral neovascular age-related macular degeneration ( ... ...

    Abstract We report the case of a patient with multiple myeloma who presented acutely with bilateral vitelliform-like macular lesions. This 85-year-old Caucasian lady was referred for treatment of presumed bilateral neovascular age-related macular degeneration (nAMD). Interestingly, this was a few months after starting on chemotherapy for multiple myeloma. We performed a clinical examination and multimodal imaging. This comprised colour fundus photography, fundus autofluorescence, near-infrared fundus photography, spectral-domain optical coherence tomography, and optical coherence tomography angiography. These tests excluded nAMD and demonstrated instead vitelliform-like macular lesions. Subfoveal vitelliform-like macular lesions, believed to be subretinal deposition of immunoglobulin, are one of the retinal signs of multiple myeloma. This can present acutely mimicking nAMD. These retinal lesions can be a presenting manifestation of the disease or may present later on during the course of the disease. Therefore, acute presentation of vitelliform macular lesions in an elderly patient should arouse suspicion. Serum protein electrophoresis is recommended to detect multiple myeloma at an early stage.
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000525466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of the ongoing worldwide shortage of verteporfin (Visudyne®) on the visual function of patients with chronic central serous chorioretinopathy.

    Tsika, Chrysanthi / Mohamed, Moin D / Lotery, Andrew J

    Acta ophthalmologica

    2023  Volume 102, Issue 1, Page(s) e137–e138

    MeSH term(s) Humans ; Verteporfin/therapeutic use ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Photosensitizing Agents/therapeutic use ; Photochemotherapy ; Longitudinal Studies ; Fluorescein Angiography ; Tomography, Optical Coherence ; Porphyrins/therapeutic use ; Chronic Disease ; Treatment Outcome
    Chemical Substances Verteporfin (0X9PA28K43) ; Photosensitizing Agents ; Porphyrins
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Letter
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15714
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  8. Article ; Online: Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment.

    Khan, Adnan H / Chowers, Itay / Lotery, Andrew J

    Cells

    2023  Volume 12, Issue 13

    Abstract: Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD). Limited phase 3 clinical trial data showing a benefit of complement inhibition in AMD raises the ... ...

    Abstract Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD). Limited phase 3 clinical trial data showing a benefit of complement inhibition in AMD raises the prospect of more complex mediators at play. Substantial evidence supports the role of para-inflammation in maintaining homeostasis in the retina and choroid. With increasing age, a decline in immune system regulation, known as immunosenescence, has been shown to alter the equilibrium maintained by para-inflammation. The altered equilibrium results in chronic, sterile inflammation with aging, termed 'inflammaging', including in the retina and choroid. The chronic inflammatory state in AMD is complex, with contributions from cells of the innate and adaptive branches of the immune system, sometimes with overlapping features, and the interaction of their secretory products with retinal cells such as microglia and retinal pigment epithelium (RPE), extracellular matrix and choroidal vascular endothelial cells. In this review, the chronic inflammatory state in AMD will be explored by immune cell type, with a discussion of factors that will need to be overcome in the development of curative therapies.
    MeSH term(s) Humans ; Immunosenescence ; Endothelial Cells/metabolism ; Retina/metabolism ; Macular Degeneration/metabolism ; Inflammation/pathology
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12131708
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  9. Book: Idiopathic vitreomacular traction and macular hole

    Steel, David H. W. / Lotery, Andrew J.

    a comprehensive review of pathophysiology, diagnosis, and treatment

    (Eye ; 27, Suppl. 1)

    2013  

    Author's details [DHW Steel and AJ Lotery]
    Series title Eye ; 27, Suppl. 1
    Collection
    Language English
    Size S21 S. : Ill.
    Publisher Nature Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018100252
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs B 3010 -27,Suppl.1- verfügbar in Königswinter Königswinter

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  10. Article ; Online: Punctate inner choroidopathy: A review of the current diagnostic and therapeutic approaches.

    Kalogeropoulos, Dimitrios / Rahman, Najiha / Afshar, Farid / Hall, Nigel / Lotery, Andrew John

    Progress in retinal and eye research

    2024  Volume 99, Page(s) 101235

    Abstract: Punctate inner choroidopathy (PIC) is an uncommon idiopathic inflammatory condition characterized by multifocal chorioretinopathy that primarily affects young adults, with a predilection for myopic females. Clinically, it manifests as small, yellowish- ... ...

    Abstract Punctate inner choroidopathy (PIC) is an uncommon idiopathic inflammatory condition characterized by multifocal chorioretinopathy that primarily affects young adults, with a predilection for myopic females. Clinically, it manifests as small, yellowish-white lesions in the inner choroid and outer retina, often associated with inflammatory changes. Accurate diagnosis remains a challenge due to its resemblance to other posterior uveitic entities, necessitating an astute clinical eye and advanced imaging techniques for differentiation. Multimodal imaging plays a crucial role by offering valuable insights, as it enables the visualization of various abnormalities related to uveitis. The pathogenesis of PIC is still a subject of debate, with a complex interplay of genetic, immunological, and environmental factors proposed. Managing PIC presents multiple challenges for clinicians. Firstly, variable disease severity within and among patients requires diverse treatments, from observation to aggressive immunosuppression and/or anti-VEGF therapy. Secondly, treatment must distinguish between primary causes of vision loss. New or worsening PIC lesions suggest active inflammation, while new neovascular membranes may indicate secondary neovascular processes. Thirdly, deciding on maintenance therapy is complex, balancing PIC prognosis variability against immunosuppression risks. Some patients have long periods of inactivity and remission, while others face sudden, vision-threatening episodes during quiescent phases. Through a systematic review of the literature, this paper sheds light on the current understanding of PIC, its challenges, and the prospects for future research. By synthesizing existing knowledge, it aims to aid clinicians in accurate diagnosis and guide treatment decisions for improved visual outcomes in individuals affected by PIC.
    MeSH term(s) Female ; Young Adult ; Humans ; Fluorescein Angiography/methods ; Visual Acuity ; White Dot Syndromes/diagnosis ; White Dot Syndromes/pathology ; Choroid/blood supply ; Choroid Diseases/diagnosis ; Choroid Diseases/therapy ; Choroid Diseases/pathology ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182683-6
    ISSN 1873-1635 ; 1350-9462
    ISSN (online) 1873-1635
    ISSN 1350-9462
    DOI 10.1016/j.preteyeres.2023.101235
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