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  1. Article: Development of a symbiotic culture of bacteria and yeast (SCOBY) farm to manufacture artificial skin for front of neck airway access simulation.

    Young, Jeremy S / Palepu, Raja R / Macdonald, Melita / Mcalpine, James R / Broadbent, James R

    Anaesthesia and intensive care

    2024  , Page(s) 310057X231213109

    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
    DOI 10.1177/0310057X231213109
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1017: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Bulk Depolymerization of Methacrylate Polymers via Pendent Group Activation.

    Hughes, Rhys W / Lott, Megan E / Zastrow, Isabella S / Young, James B / Maity, Tanmoy / Sumerlin, Brent S

    Journal of the American Chemical Society

    2024  Volume 146, Issue 9, Page(s) 6217–6224

    Abstract: In this study, we present an efficient approach for the depolymerization of poly(methyl methacrylate) (PMMA) copolymers synthesized via conventional radical polymerization. By incorporating low mol % phthalimide ester-containing monomers during the ... ...

    Abstract In this study, we present an efficient approach for the depolymerization of poly(methyl methacrylate) (PMMA) copolymers synthesized via conventional radical polymerization. By incorporating low mol % phthalimide ester-containing monomers during the polymerization process, colorless and transparent polymers closely resembling unfunctionalized PMMA are obtained, which can achieve >95% reversion to methyl methacrylate (MMA). Notably, our catalyst-free bulk depolymerization method exhibits exceptional efficiency, even for high-molecular-weight polymers, including ultrahigh-molecular-weight (10
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  3. Article ; Online: Biomaterials in non-integer dimensions.

    Young, Iris D / Fraser, James S

    Nature chemistry

    2019  Volume 11, Issue 7, Page(s) 599–600

    MeSH term(s) Biocompatible Materials ; Fractals
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2019-06-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-019-0286-x
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  4. Article ; Online: Selective Electrochemical Modification and Degradation of Polymers.

    Hughes, Rhys W / Marquez, Joshua D / Young, James B / Garrison, John B / Zastrow, Isabella S / Evans, Austin M / Sumerlin, Brent S

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202403026

    Abstract: We demonstrate that electrochemical-induced decarboxylation enables reliable post-polymerization modification and degradation of polymers. Polymers containing N-(acryloxy)phthalimides were subjected to electrochemical decarboxylation under mild ... ...

    Abstract We demonstrate that electrochemical-induced decarboxylation enables reliable post-polymerization modification and degradation of polymers. Polymers containing N-(acryloxy)phthalimides were subjected to electrochemical decarboxylation under mild conditions, which led to the formation of transient alkyl radicals. By installing these redox-active units, we systematically modified the pendent groups and chain ends of polyacrylates. This approach enabled the production of poly(ethylene-co-methyl acrylate) and poly(propylene-co-methyl acrylate) copolymers, which are difficult to synthesize by direct polymerization. Spectroscopic and chromatographic techniques reveal these transformations are near-quantitative on several polymer systems. Electrochemical decarboxylation also enables the degradation of all-methacrylate poly(N-(methacryloxy)phthalimide-co-methyl methacrylate) copolymers with a degradation efficiency of >95 %. Chain cleavage is achieved through the decarboxylation of the N-hydroxyphthalimide ester and subsequent β-scission of the backbone radical. Electrochemistry is thus shown to be a powerful tool in selective polymer transformations and controlled macromolecular degradation.
    Language English
    Publishing date 2024-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202403026
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  5. Article: Dynamic three-dimensional printing: The future of bronchoscopic simulation training?

    Fu, Rao / Hone, Nicole G / Broadbent, James R / Guy, Bernard J / Young, Jeremy S

    Anaesthesia and intensive care

    2023  Volume 51, Issue 4, Page(s) 274–280

    Abstract: High-fidelity models are required for technical mastery of bronchoscopic procedures in the fields of anaesthesia, intensive care, surgery and respiratory medicine. Our group has created a three-dimensional (3D) airway model prototype to emulate ... ...

    Abstract High-fidelity models are required for technical mastery of bronchoscopic procedures in the fields of anaesthesia, intensive care, surgery and respiratory medicine. Our group has created a three-dimensional (3D) airway model prototype to emulate physiological and pathological movement. Developed from the concepts of our previously described 3D printed paediatric trachea for airway management training, this model produces movements created by injection of air or saline through a side Luer Lock port. The anaesthesia and intensive care applications of the model could include bronchoscopic navigation through narrow pathologies and simulated bleeding tumours. It also has the potential to be used to practice placement of a double-lumen tube and broncho-alveolar lavage among other procedures. For surgical training, the model has high tissue realism and allows for rigid bronchoscopy. The novel and high-fidelity 3D printed airway model with dynamic pathologies represents capability to provide both generic and patient-specific advancement for all modes of anatomical representation. The prototype illustrates the potential of combining the fields of industrial design with clinical anaesthesia.
    MeSH term(s) Child ; Humans ; Models, Anatomic ; Printing, Three-Dimensional ; Bronchoscopy ; Anesthesia ; Simulation Training/methods
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
    DOI 10.1177/0310057X231154015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1017: Show issues Location:
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  6. Article ; Online: Retained Vaginal Remnant and Urethrocutaneous Fistula in Transgender Man After Phalloplasty.

    Young, James / Purohit, Rajveer S

    Urology

    2019  Volume 136, Page(s) e5–e6

    Abstract: As gender-affirming genital surgery for transgender men becomes more common, general urologists may be confronted with unfamiliar anatomy and complications. We describe the use of voiding cystourethrogram and retrograde urethrogram in a transgender man ... ...

    Abstract As gender-affirming genital surgery for transgender men becomes more common, general urologists may be confronted with unfamiliar anatomy and complications. We describe the use of voiding cystourethrogram and retrograde urethrogram in a transgender man in demonstrating the anatomy of the urethra, urethrocutaneous fistula, and a vaginal remnant after phalloplasty.
    MeSH term(s) Cutaneous Fistula/diagnostic imaging ; Cystography ; Female ; Humans ; Male ; Middle Aged ; Penis/surgery ; Postoperative Complications/diagnostic imaging ; Sex Reassignment Surgery/methods ; Urethral Diseases/diagnostic imaging ; Urinary Fistula/diagnostic imaging ; Vagina/diagnostic imaging
    Language English
    Publishing date 2019-11-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2019.10.016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  7. Article ; Online: Understanding the Stability of Etched or Platinized p-GaInP Photocathodes for Solar-Driven H

    Yu, Weilai / Young, James L / Deutsch, Todd G / Lewis, Nathan S

    ACS applied materials & interfaces

    2021  Volume 13, Issue 48, Page(s) 57350–57361

    Abstract: The long-term stability in acidic or alkaline aqueous electrolytes of p- ... ...

    Abstract The long-term stability in acidic or alkaline aqueous electrolytes of p-Ga
    Language English
    Publishing date 2021-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c18243
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  8. Article ; Online: The network model of delirium.

    Young, James W S

    Medical hypotheses

    2017  Volume 104, Page(s) 80–85

    Abstract: The coordinated function of brain networks underlies consciousness, attention and reality testing, all of which are impaired in delirium. The default-mode network, salience network, frontoparietal control network and dorsal attention network are brain ... ...

    Abstract The coordinated function of brain networks underlies consciousness, attention and reality testing, all of which are impaired in delirium. The default-mode network, salience network, frontoparietal control network and dorsal attention network are brain networks with integral roles in the maintenance and modulation of the aforementioned functions. Multiple lines of evidence point to their dysfunction in delirium. The convergence of neurotransmitter changes, neuroendocrine and inflammatory stressors on brain networks disrupts bottom-up and top-down attentional control. Neuroimaging and neuroanatomy correlates are potentially consistent with this hypothesis. Overall, this model appears to have significant utility in connecting the seemingly disparate precipitants of delirium while accounting for the clinical manifestations of the syndrome.
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2017.05.027
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.

    Cuyckens, Filip / Hvenegaard, Mette G / Cassidy, Kenneth C / Spracklin, Douglas K / James, Alexander D / Pedersen, Mette L / Scarfe, Graeme / Wagner, David S / Georgi, Katrin / Schulz, Simone I / Schieferstein, Hanno / Bjornsdottir, Inga / Romeo, Andrea A / Da Violante, Georges / Blech, Stefan / Moliner, Patricia / Young, Graeme C

    Drug metabolism and disposition: the biological fate of chemicals

    2024  Volume 52, Issue 3, Page(s) 153–158

    Abstract: The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism, and excretion studies for small-molecule drugs since it allows facile and accurate quantification of parent drug, metabolites, and ...

    Abstract The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism, and excretion studies for small-molecule drugs since it allows facile and accurate quantification of parent drug, metabolites, and total drug-related material independent of the compound structure. The choice of the position of the radiolabel, typically
    MeSH term(s) Humans ; Pharmaceutical Preparations/metabolism ; Metabolic Clearance Rate ; Biotransformation
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.123.001429
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    Zs.A 1014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

    Jackson, Hannah K / Long, Heather M / Yam-Puc, Juan Carlos / Palmulli, Roberta / Haigh, Tracey A / Gerber, Pehuén Pereyra / Lee, Jin S / Matheson, Nicholas J / Young, Lesley / Trowsdale, John / Lo, Mathew / Taylor, Graham S / Thaventhiran, James E / Edgar, James R

    Journal of extracellular vesicles

    2024  Volume 13, Issue 2, Page(s) e12412

    Abstract: The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emergence ... ...

    Abstract The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emergence of SARS-CoV-2 breakthrough infections highlights the need for additional vaccine modalities to provide stronger, long-lived protective immunity. Here we report the design and preclinical testing of small extracellular vesicles (sEVs) as a multi-subunit vaccine. Cell lines were engineered to produce sEVs containing either the SARS-CoV-2 Spike receptor-binding domain, or an antigenic region from SARS-CoV-2 Nucleocapsid, or both in combination, and we tested their ability to evoke immune responses in vitro and in vivo. B cells incubated with bioengineered sEVs were potent activators of antigen-specific T cell clones. Mice immunised with sEVs containing both sRBD and Nucleocapsid antigens generated sRBD-specific IgGs, nucleocapsid-specific IgGs, which neutralised SARS-CoV-2 infection. sEV-based vaccines allow multiple antigens to be delivered simultaneously resulting in potent, broad immunity, and provide a quick, cheap, and reliable method to test vaccine candidates.
    MeSH term(s) Animals ; Humans ; Mice ; SARS-CoV-2 ; Pandemics ; COVID-19 ; Extracellular Vesicles ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12412
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