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Article ; Online: Complication rates in very low and extremely low birth weight infants following laparotomy: a prospective study.

Li, Linda T / Hebballi, Nutan B / Nguyen, Thian / Morice, Christina / Lally, Kevin P

2023 Volume 39, Issue 1, Page(s) 237

Abstract: Introduction: Surgical site occurrences (SSO), including surgical site infection, dehiscence, and incisional hernia, are complications following laparotomy. SSO rates in premature neonates are poorly understood. We hypothesize that SSO rates are higher ... ...

Abstract	Introduction: Surgical site occurrences (SSO), including surgical site infection, dehiscence, and incisional hernia, are complications following laparotomy. SSO rates in premature neonates are poorly understood. We hypothesize that SSO rates are higher among extremely low birth weight (ELBW) infants compared to very low birth weight (VLBW) infants and strive to determine the optimal abdominal closure method for these infants. Methods: We conducted a prospective observational study of infants < 1.5 kg (kg) undergoing laparotomy at two institutions from 1/1/2020 to 5/1/2022. Patients were grouped by weight and closure; SSO rates were computed and the association tested using Fisher's exact test. Results: We identified 59 patients and 104 total operations. At initial surgery, 37 patients weighed < 1 kg (ELBW); 22 patients weighed 1-1.5 kg (VLBW). Complication rate for ELBW was 6(16%) vs. 2(9%) in VLBW, but not significant (p = 0.45). More complications followed a single-layer compared to a two-layer closure (18 vs. 2), but not significant (p = 0.30). Conclusions: SSO rates are higher for ELBW infants undergoing laparotomy, and fewer complications follow two-layer closure. However, these findings did not reach statistical significance. Further studies are needed to identify modifiable factors to reduce postoperative complications in these infants.
MeSH term(s)	Infant, Newborn ; Infant ; Female ; Humans ; Infant, Extremely Low Birth Weight ; Prospective Studies ; Laparotomy/adverse effects ; Infant, Very Low Birth Weight ; Pregnancy Complications ; Enterocolitis, Necrotizing/epidemiology ; Enterocolitis, Necrotizing/surgery ; Birth Weight
Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-023-05520-z
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Zs.A 2138: Show issues

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Article: Nonliver Comorbidities in Patients With Chronic Hepatitis B.

Wei, Mike T / Henry, Linda / Nguyen, Mindie H

Clinical liver disease

2019 Volume 14, Issue 3, Page(s) 126–130

Language	English
Publishing date	2019-10-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1002/cld.829
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Article ; Online: A case of ice-pack dermatosis in a patient with chronic back pain and review of the literature.

Sabeti, Sara / Birmingham, Suzanne W / Urso, Brittany / Nguyen, Michael O / Doan, Linda T / Rojek, Nathan W

International journal of dermatology

2022 Volume 62, Issue 6, Page(s) e367–e369

MeSH term(s)	Humans ; Ice ; Back Pain/diagnosis ; Back Pain/etiology ; Back Pain/therapy ; Cryotherapy ; Skin Diseases
Chemical Substances	Ice
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Review ; Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16258
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Ui VI Zs.189: Show issues

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Article ; Online: miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology.

Walsh, Alexander D / Nguyen, Linda T / Binder, Michele D

ASN neuro

2021 Volume 13, Page(s) 1759091420981182

Abstract: Microglia are the resident immune cells of the central nervous system and important regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that enables microglia to respond to environmental and pathological stimuli. ... ...

Abstract	Microglia are the resident immune cells of the central nervous system and important regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that enables microglia to respond to environmental and pathological stimuli. Importantly, different microglial phenotypes can be both beneficial and detrimental to central nervous system health. Chronically activated inflammatory microglia are a hallmark of neurodegeneration, including the autoimmune disease multiple sclerosis (MS). By contrast, microglial phagocytosis of myelin debris is essential for resolving inflammation and promoting remyelination. As such, microglia are being explored as a potential therapeutic target for MS. MicroRNAs (miRNAs) are short non-coding ribonucleic acids that regulate gene expression and act as master regulators of cellular phenotype and function. Dysregulation of certain miRNAs can aberrantly activate and promote specific polarisation states in microglia to modulate their activity in inflammation and neurodegeneration. In addition, miRNA dysregulation is implicated in MS pathogenesis, with circulating biomarkers and lesion specific miRNAs identified as regulators of inflammation and myelination. However, the role of miRNAs in microglia that specifically contribute to MS progression are still largely unknown. miRNAs are being explored as therapeutic agents, providing an opportunity to modulate microglial function in neurodegenerative diseases such as MS. This review will focus firstly on elucidating the complex role of microglia in MS pathogenesis. Secondly, we explore the essential roles of miRNAs in microglial function. Finally, we focus on miRNAs that are implicated in microglial processes that contribute directly to MS pathology, prioritising targets that could inform novel therapeutic approaches to MS.
MeSH term(s)	Humans ; Inflammation ; MicroRNAs/genetics ; Microglia ; Multiple Sclerosis/genetics ; Remyelination
Chemical Substances	MicroRNAs
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2485467-0
ISSN	1759-0914 ; 1759-0914
ISSN (online)	1759-0914
ISSN	1759-0914
DOI	10.1177/1759091420981182
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Article ; Online: CD8

Nature communications

2024 Volume 15, Issue 1, Page(s) 3387

Abstract: Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. ... ...

Abstract	Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; Humans ; Epitopes, T-Lymphocyte/immunology ; Influenza B virus/immunology ; Influenza, Human/immunology ; Influenza, Human/virology ; Adult ; Middle Aged ; Aged ; Cross Reactions/immunology ; Young Adult ; Female ; Male ; Immunologic Memory/immunology ; Adolescent ; HLA-B Antigens/immunology ; Child ; Child, Preschool
Chemical Substances	Epitopes, T-Lymphocyte ; HLA-B Antigens
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47576-y
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Article ; Online: Attitudes on Artificial Intelligence use in Pediatric Care From Parents of Hospitalized Children.

Haley, Lauren C / Boyd, Alexandra K / Hebballi, Nutan B / Reynolds, Eric W / Smith, Keely G / Scully, Peter T / Nguyen, Thao L / Bernstam, Elmer V / Li, Linda T

The Journal of surgical research

2023 Volume 295, Page(s) 158–167

Abstract: Introduction: Artificial intelligence (AI) may benefit pediatric healthcare, but it also raises ethical and pragmatic questions. Parental support is important for the advancement of AI in pediatric medicine. However, there is little literature ... ...

Abstract	Introduction: Artificial intelligence (AI) may benefit pediatric healthcare, but it also raises ethical and pragmatic questions. Parental support is important for the advancement of AI in pediatric medicine. However, there is little literature describing parental attitudes toward AI in pediatric healthcare, and existing studies do not represent parents of hospitalized children well. Methods: We administered the Attitudes toward Artificial Intelligence in Pediatric Healthcare, a validated survey, to parents of hospitalized children in a single tertiary children's hospital. Surveys were administered by trained study personnel (11/2/2021-5/1/2022). Demographic data were collected. An Attitudes toward Artificial Intelligence in Pediatric Healthcare score, assessing openness toward AI-assisted medicine, was calculated for seven areas of concern. Subgroup analyses were conducted using Mann-Whitney U tests to assess the effect of race, gender, education, insurance, length of stay, and intensive care unit (ICU) admission on AI use. Results: We approached 90 parents and conducted 76 surveys for a response rate of 84%. Overall, parents were open to the use of AI in pediatric medicine. Social justice, convenience, privacy, and shared decision-making were important concerns. Parents of children admitted to an ICU expressed the most significantly different attitudes compared to parents of children not admitted to an ICU. Conclusions: Parents were overall supportive of AI-assisted healthcare decision-making. In particular, parents of children admitted to ICU have significantly different attitudes, and further study is needed to characterize these differences. Parents value transparency and disclosure pathways should be developed to support this expectation.
MeSH term(s)	Humans ; Child ; Artificial Intelligence ; Child, Hospitalized ; Attitude ; Intensive Care Units ; Parents
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.10.027
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Zs.A 178: Show issues

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Article ; Online: Precision Nutrition Model Predicts Glucose Control of Overweight Females Following the Consumption of Potatoes High in Resistant Starch.

Nolte Fong, Joy V / Miketinas, Derek / Moore, Linda W / Nguyen, Duc T / Graviss, Edward A / Ajami, Nadim / Patterson, Mindy A

Nutrients

2022 Volume 14, Issue 2

Abstract: Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed ...

Abstract	Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed to provide personalized dietary recommendations to reduce chronic disease development. Therefore, a precision nutrition model predicting the postprandial glucose response (PPGR) in overweight women following the consumption of potatoes was formulated. Thirty overweight women participated in this randomized crossover trial. Participants consumed 250 g of hot (9.2 g RS) or cold (13.7 g RS) potatoes on two separate occasions. Baseline characteristics included demographics, 10-day dietary records, body composition, and the relative abundance (RA) and α-diversity of gut microbiota. Elastic net regression using 5-fold cross-validation predicted PPGR after potato intake. Most participants (70%) had a favorable PPGR to the cold potato. The model explained 32.2% of the variance in PPGR with the equation: 547.65 × (0 [if cold, high-RS potato], ×1, if hot, low-RS potato]) + (BMI [kg/m
MeSH term(s)	Adult ; Area Under Curve ; Blood Glucose/metabolism ; Body Mass Index ; Cross-Over Studies ; Diet ; Faecalibacterium ; Female ; Gastrointestinal Microbiome ; Glycemic Index ; Humans ; Models, Biological ; Nutritional Status ; Obesity/blood ; Obesity/microbiology ; Overweight/blood ; Overweight/microbiology ; Postprandial Period ; Resistant Starch/pharmacology ; Solanum tuberosum/chemistry ; Vegetables/chemistry ; Young Adult
Chemical Substances	Blood Glucose ; Resistant Starch
Language	English
Publishing date	2022-01-09
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Observational Study ; Validation Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14020268
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Article ; Online: Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS.

Nguyen, Linda T / Aprico, Andrea / Nwoke, Eze / Walsh, Alexander D / Blades, Farrah / Avneri, Raphael / Martin, Elodie / Zalc, Bernard / Kilpatrick, Trevor J / Binder, Michele D

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 253

Abstract: Background: Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have been demonstrated to play an ... ...

Abstract	Background: Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have been demonstrated to play an important role in the development of oligodendrocytes, the myelin producing cells in the CNS, as well as in myelination. Mertk is a receptor expressed on microglia that mediates immunoregulatory functions, including myelin efferocytosis. Findings: Here we demonstrate an unexpected role for Mertk-expressing microglia in both oligodendrogenesis and myelination. The selective depletion of Mertk from microglia resulted in reduced oligodendrocyte production in early development and the generation of pathological myelin. During demyelination, mice deficient in microglial Mertk had thinner myelin and showed signs of impaired OPC differentiation. We established that Mertk signalling inhibition impairs oligodendrocyte repopulation in Xenopus tadpoles following demyelination. Conclusion: These data highlight the importance of microglia in myelination and are the first to identify Mertk as a regulator of oligodendrogenesis and myelin ultrastructure.
MeSH term(s)	Mice ; Animals ; Myelin Sheath/pathology ; Microglia ; c-Mer Tyrosine Kinase/genetics ; Oligodendroglia/pathology ; Cell Differentiation/physiology ; Demyelinating Diseases/pathology
Chemical Substances	c-Mer Tyrosine Kinase (EC 2.7.10.1) ; Mertk protein, mouse (EC 2.7.10.1)
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02921-8
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Article ; Online: Modern Outcomes After Liver Retransplantation: A Single-center Experience.

Connor, Ashton A / Saharia, Ashish / Mobley, Constance M / Hobeika, Mark J / Victor, David W / Kodali, Sudha / Brombosz, Elizabeth W / Graviss, Edward A / Nguyen, Duc T / Moore, Linda W / Gaber, A Osama / Ghobrial, R Mark

Transplantation

2023 Volume 107, Issue 7, Page(s) 1513–1523

Abstract: Background: The need for liver retransplantation (reLT) has increased proportionally with greater numbers of liver transplants (LTs) performed, use of marginal donors, degree of recipient preoperative liver dysfunction, and longer survival after LT. ... ...

Abstract	Background: The need for liver retransplantation (reLT) has increased proportionally with greater numbers of liver transplants (LTs) performed, use of marginal donors, degree of recipient preoperative liver dysfunction, and longer survival after LT. However, outcomes following reLT have been historically regarded as poor. Methods: To evaluate reLT in modern recipients, we retrospectively examined our single-center experience. Analysis included 1268 patients undergoing single LT and 68 patients undergoing reLT from January 2008 to December 2021. Results: Pre-LT mechanical ventilation, body mass index at LT, donor-recipient ABO incompatibility, early acute rejection, and length of hospitalization were associated with increased risk of needing reLT following index transplant. Overall and graft survival outcomes in the reLT cohort were equivalent to those after single LT. Mortality after reLT was associated with Kidney Donor Profile Index, national organ sharing at reLT, and LT donor death by anoxia and blood urea nitrogen levels. Survival after reLT was independent of the interval between initial LT and reLT, intraoperative packed red blood cell use, cold ischemia time, and preoperative mechanical ventilation, all previously linked to worse outcomes. Conclusions: These data suggest that reLT is currently a safer option for patients with liver graft failure, with comparable outcomes to primary LT.
MeSH term(s)	Humans ; Reoperation/adverse effects ; Retrospective Studies ; Risk Factors ; Liver Transplantation/adverse effects ; Liver Diseases ; Graft Survival
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004500
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Introduction of triggers for palliative care consultation improves utilization and satisfaction within a level four NICU.

Nguyen, Linda T / Cooperberg, David B / Spear, Michael L

Journal of perinatology : official journal of the California Perinatal Association

2018 Volume 38, Issue 5, Page(s) 574–579

Abstract: Objective: We sought to explore the beliefs regarding palliative care team utilization, as well as increase consultation and awareness of the palliative care team's role in the NICU.: Study design: The study design in this Level 4 NICU included ... ...

Abstract	Objective: We sought to explore the beliefs regarding palliative care team utilization, as well as increase consultation and awareness of the palliative care team's role in the NICU. Study design: The study design in this Level 4 NICU included observational time series with multiple planned sequential interventions. Medical chart review was conducted to determine eligibility, and statistical process control charts were used to show performance over time. Results: Prior to implementation of the triggers, 26% received consultation, which increased to 46% after implementation. There was an increase in level of understanding, knowledge of team's role, and improved utilization. The time until initial consultation decreased from ~1.5 months to 1 week. Conclusions: We observed a 20% increase in consultations. Key interventions included continual education, reminders, and clear postage of the trigger list. Written guidelines increase awareness of a palliative care team's role within a NICU, and provider satisfaction.
MeSH term(s)	Hospitals, Pediatric ; Humans ; Intensive Care Units, Neonatal/organization & administration ; Intensive Care Units, Neonatal/standards ; Palliative Care/standards ; Palliative Care/statistics & numerical data ; Patient Care Team/organization & administration ; Personal Satisfaction ; Referral and Consultation/statistics & numerical data
Language	English
Publishing date	2018-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-018-0067-1
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