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Article ; Online: Targeted Nanoparticles: the Smart Way for the Treatment of Colorectal Cancer.

Abdellatif, Ahmed A H / Alshubrumi, Abdulmajeed S / Younis, Mahmoud A

2024 Volume 25, Issue 1, Page(s) 23

Abstract: Colorectal cancer (CRC) is a widespread cancer that starts in the digestive tract. It is the third most common cause of cancer deaths around the world. The World Health Organization (WHO) estimates an expected death toll of over 1 million cases annually. ...

Abstract	Colorectal cancer (CRC) is a widespread cancer that starts in the digestive tract. It is the third most common cause of cancer deaths around the world. The World Health Organization (WHO) estimates an expected death toll of over 1 million cases annually. The limited therapeutic options as well as the drawbacks of the existing therapies necessitate the development of non-classic treatment approaches. Nanotechnology has led the evolution of valuable drug delivery systems thanks to their ability to control drug release and precisely target a wide variety of cancers. This has also been extended to the treatment of CRC. Herein, we shed light on the pertinent research that has been performed on the potential applications of nanoparticles in the treatment of CRC. The various types of nanoparticles in addition to their properties, applications, targeting approaches, merits, and demerits are discussed. Furthermore, innovative therapies for CRC, including gene therapies and immunotherapies, are also highlighted. Eventually, the research gaps, the clinical potential of such delivery systems, and a future outlook on their development are inspired.
MeSH term(s)	Humans ; Immunotherapy ; Drug Delivery Systems ; Drug Liberation ; Nanoparticles ; Colorectal Neoplasms/drug therapy
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-024-02734-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the anticancer activity of

Abdellatif, Ahmed A H / Alsharidah, Mansour

Drug development and industrial pharmacy

2023 Volume 49, Issue 9, Page(s) 572–579

Abstract: Background: Chemotherapeutic agents have numerous side effects. There is a major interest in using natural and safe plants as food or drink to prevent from cancer. : Objective: This study aimed to evaluate the potential anticancer effects of OMAE as ... ...

Abstract	Background: Chemotherapeutic agents have numerous side effects. There is a major interest in using natural and safe plants as food or drink to prevent from cancer. Objective: This study aimed to evaluate the potential anticancer effects of OMAE as a soft drink for daily use against a model cancer, prevention and treatment. Method: MCF-7 cells were chosen as model cancer cells. The MTT assay was used to assess the Results: OMAE has IC Conclusion: The results of the study were promising, suggesting that the reduced apoptotic rate of MCF-7 breast cancer cells in this work was correlated to the potential anticancer effect of OMAE which would be a suitable preventable drink against cancer. However, further studies are needed to fully understand the potential of OMAE as a cancer treatment.
MeSH term(s)	Humans ; Origanum/metabolism ; Apoptosis ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Protein p53/pharmacology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/pharmacology ; MCF-7 Cells ; Cell Proliferation
Chemical Substances	bcl-2-Associated X Protein ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2023.2257796
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Article ; Online: MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells.

Abdellatif, Ahmed A H / Bouazzaoui, Abdellatif / Tawfeek, Hesham M / Younis, Mahmoud A

Colloids and surfaces. B, Biointerfaces

2024 Volume 238, Page(s) 113930

Abstract: Breast cancer is a wide-spread threat to the women's health. The drawbacks of conventional treatments necessitate the development of alternative strategies, where gene therapy has regained hope in achieving an efficient eradication of aggressive tumors. ... ...

Abstract	Breast cancer is a wide-spread threat to the women's health. The drawbacks of conventional treatments necessitate the development of alternative strategies, where gene therapy has regained hope in achieving an efficient eradication of aggressive tumors. Monocarboxylate transporter 4 (MCT4) plays pivotal roles in the growth and survival of various tumors, which offers a promising target for treatment. In the present study, pH-responsive lipid nanoparticles (LNPs) based on the ionizable lipid,1,2-dioleoyl-3-dimethylammonium propane (DODAP), were designed for the delivery of siRNA targeting MCT4 gene to the breast cancer cells. Following multiple steps of characterization and optimization, the anticancer activities of the LNPs were assessed against an aggressive breast cancer cell line, 4T1, in comparison with a normal cell line, LX-2. The selection of the helper phospholipid to be incorporated into the LNPs had a dramatic impact on their gene delivery performance. The optimized LNPs enabled a powerful MCT4 silencing by ∼90 % at low siRNA concentrations, with a subsequent ∼80 % cytotoxicity to 4T1 cells. Meanwhile, the LNPs demonstrated a 5-fold higher affinity to the breast cancer cells versus the normal cells, in which they had a minimum effect. Moreover, the MCT4 knockdown by the treatment remodeled the cytokine profile in 4T1 cells, as evidenced by 90 % and ∼64 % reduction in the levels of TNF-α and IL-6; respectively. The findings of this study are promising for potential clinical applications. Furthermore, the simple and scalable delivery vector developed herein can serve as a breast cancer-targeting platform for the delivery of other RNA therapeutics.
Language	English
Publishing date	2024-04-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2024.113930
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Article ; Online: A plausible way for excretion of metal nanoparticles

Abdellatif, Ahmed A H

Drug development and industrial pharmacy

2020 Volume 46, Issue 5, Page(s) 744–750

Abstract: Even so, the metal nanoparticles (metal NPs) have attractive optical and biomedical applications, the translation of metal NPs into the clinical practice remains a challenge due to their severe accumulation in the body. Active targeting to renal ... ...

Abstract	Even so, the metal nanoparticles (metal NPs) have attractive optical and biomedical applications, the translation of metal NPs into the clinical practice remains a challenge due to their severe accumulation in the body. Active targeting to renal podocytes opens the door for enhancing kidney targeting and clearance. The goal of this study was to assess the excretion of larger particle size through kidney podocyte
MeSH term(s)	Analgesics/administration & dosage ; Analgesics/metabolism ; Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Delivery Systems/methods ; Drug Elimination Routes/drug effects ; Drug Elimination Routes/physiology ; Female ; Metal Nanoparticles ; Mice ; Mice, Inbred C57BL ; Podocytes/drug effects ; Podocytes/metabolism ; Protein Binding/drug effects ; Protein Binding/physiology ; Quantum Dots/administration & dosage ; Quantum Dots/metabolism ; Receptors, Somatostatin/metabolism ; Somatostatin/administration & dosage ; Somatostatin/analogs & derivatives ; Somatostatin/metabolism
Chemical Substances	Analgesics ; Receptors, Somatostatin ; Sstr2 protein, mouse ; vapreotide (2PK59M9GFF) ; Somatostatin (51110-01-1)
Language	English
Publishing date	2020-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2020.1752710
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Book ; Online: Generating Infinite-Size Textures using GANs with Patch-by-Patch Paradigm

Abdellatif, Alhasan / Elsheikh, Ahmed H.

2023

Abstract: In this paper, we introduce a novel approach for generating texture images of infinite sizes using Generative Adversarial Networks (GANs) based on a patch-by-patch paradigm. Existing texture synthesis techniques rely on generating large-scale textures ... ...

Abstract	In this paper, we introduce a novel approach for generating texture images of infinite sizes using Generative Adversarial Networks (GANs) based on a patch-by-patch paradigm. Existing texture synthesis techniques rely on generating large-scale textures using a single forward pass to the generative model; this approach limits the scalability and flexibility of the images produced. In contrast, the proposed approach trains a GAN model on a single texture image to generate relatively small-size patches that are locally correlated and can be seamlessly concatenated to form a larger image. The method relies on local padding in the generator to ensure consistency between the generated patches. It also utilizes spatial stochastic modulation to allow for local variations and improve patterns alignment in the large-scale image. The trained models learn the local texture structure and are able to generate images of arbitrary sizes, while also maintaining the coherence and diversity. Experimental results demonstrate constant GPU scalability with respect to the generated image size compared to existing approaches that exhibit a proportional growth in GPU memory.
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
Subject code	004
Publishing date	2023-09-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of somatostatin receptors using labeled PEGylated octreotide, as an active internalization.

Abdellatif, Ahmed A H

Drug development and industrial pharmacy

2019 Volume 45, Issue 10, Page(s) 1707–1715

Abstract: Numerous normal and tumors cells are well-known to express the somatostatin receptors (SSTRs) on their surface which makes the receptor be useful for tumor scintigraphy. Thus, the identification of SSTRs is beneficial, especially ... ...

Abstract	Numerous normal and tumors cells are well-known to express the somatostatin receptors (SSTRs) on their surface which makes the receptor be useful for tumor scintigraphy. Thus, the identification of SSTRs is beneficial, especially SSTR
MeSH term(s)	Caco-2 Cells ; Cell Line, Tumor ; HCT116 Cells ; Humans ; MCF-7 Cells ; Octreotide/metabolism ; Pancreatic Neoplasms/metabolism ; Polyethylene Glycols/metabolism ; Radionuclide Imaging/methods ; Receptors, Somatostatin/metabolism ; Somatostatin/metabolism
Chemical Substances	Receptors, Somatostatin ; Polyethylene Glycols (3WJQ0SDW1A) ; Somatostatin (51110-01-1) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2019-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2019.1656735
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Article ; Online: Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation.

Osman, Shaaban K / Yassin, Taher M / Abdelzaher, Arafat / Ahmed, Fatma / Mohammed, Ahmed M / Abdellatif, Ahmed A H / Saleh, Khalid I / Mahdi, Wael A / Alshehri, Sultan / Hamd, Mohamed A El / Sarhan, Hatem

AAPS PharmSciTech

2024 Volume 25, Issue 1, Page(s) 18

Abstract: ... that the increase in dose is accompanied by higher activity and a longer duration of action which extended to 12 h ...

Abstract	Due to tenoxicam (TX)'s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe GIT disturbances. Topical administration of TX can help in bypassing the GIT adverse effects. Therefore, in the present work, we constructed different pluronic/lecithin organogels (PLOs) for topical delivery of TX. PLO was constructed simply via direct mixing of an aqueous pluronic solution with lecithin solution. The prepared PLO formulations were characterized for their physicochemical properties including pH, drug content, visual inspection, viscosity, and spreadability. Also, the in vitro release and kinetic studies were carried out to investigate the mechanism of drug release. Moreover, the in vivo studies were carried out by investigating the anti-inflammatory and analgesic activities using albino male rats. The results showed that the modified PLOs have good physicochemical properties. The viscosity of the modified gels is a direct proportionality with both lecithin and pluronic concentrations. Also, subsequently, the drug release rate is directly proportional to gel viscosity. Moreover, the in vivo studies showed that the modified PLOs (F19) showed a significant ( < 0.05%) paw edema inhibition and pain analgesia compared with other investigated groups. Also, the results indicated that the increase in dose is accompanied by higher activity and a longer duration of action which extended to 12 h. Hence, the modified PLOs are promising safe candidates or vehicles for effective TX loading with sustained delivery behavior.
MeSH term(s)	Animals ; Rats ; Kinetics ; Lecithins ; Poloxamer ; Inflammation ; Pain ; Piroxicam/analogs & derivatives
Chemical Substances	tenoxicam (Z1R9N0A399) ; Lecithins ; Poloxamer (106392-12-5) ; Piroxicam (13T4O6VMAM)
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-024-02742-9
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Article ; Online: Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles.

Abdellatif, Ahmed A H / Ahmed, Fatma / Mohammed, Ahmed M / Alsharidah, Mansour / Al-Subaiyel, Amal / Samman, Waad A / Alhaddad, Aisha A / Al-Mijalli, Samiah Hamad / Amin, Mohammed A / Barakat, Hassan / Osman, Shaaban K

International journal of nanomedicine

2023 Volume 18, Page(s) 3247–3281

Abstract: The real problem in pharmaceutical preparation is drugs' poor aqueous solubility, low permeability through biological membranes, and short biological ... ...

Abstract	The real problem in pharmaceutical preparation is drugs' poor aqueous solubility, low permeability through biological membranes, and short biological t
MeSH term(s)	Pharmaceutical Preparations ; Cyclodextrins/chemistry ; Gold ; Metal Nanoparticles ; Drug Delivery Systems ; Drug Carriers/chemistry
Chemical Substances	Pharmaceutical Preparations ; Cyclodextrins ; Gold (7440-57-5) ; Drug Carriers
Language	English
Publishing date	2023-06-14
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S405964
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Article ; Online: Development of oral formulation of

Aldosari, Basmah N / Abdellatif, Ahmed A H / Almurshedi, Alanood Sunhat / Alfagih, Iman Mohammed / AlQuadeib, Bushra Tawfeeq / Abbas, Asmaa Youssef A / Hassan, Yasser A / Abdelfattah, Ahmed / Tawfeek, Hesham M

Drug development and industrial pharmacy

2024 Volume 50, Issue 2, Page(s) 112–123

Abstract: Background: Lepidium sativum: Aim: The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin ... ...

Abstract	Background: Lepidium sativum Aim: The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin rats' model in comparison with positive control metformin. Methods: Micrometrics of GC grounded seeds with different excipients were investigated. Then, GC tablets were prepared via direct compression technique. GC tablets were characterized for their uniformity of dosage unit, friability, hardness, disintegration time, and Results: Prosolv Conclusion: GC tablets could be a promising alternative formulation to control the high blood glucose level in diabetic rats rather than chemically derivatized drugs.
MeSH term(s)	Rats ; Animals ; Hypoglycemic Agents/pharmacology ; Blood Glucose ; Lepidium ; Diabetes Mellitus, Experimental/drug therapy ; Metformin ; Tablets/chemistry
Chemical Substances	Hypoglycemic Agents ; Blood Glucose ; Metformin (9100L32L2N) ; Tablets
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	751874-2
ISSN	1520-5762 ; 0363-9045
ISSN (online)	1520-5762
ISSN	0363-9045
DOI	10.1080/03639045.2023.2300649
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Article: Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer.

Abdellatif, Ahmed A H / Mohammed, Ahmed M / Saleem, Imran / Alsharidah, Mansour / Al Rugaie, Osamah / Ahmed, Fatma / Osman, Shaaban K

Pharmaceutics

2022 Volume 14, Issue 3

Abstract: The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery of anticancer drugs helps to increase the drug concentration at the site of action and overcome such a problem. In the ... ...

Abstract	The treatment of breast cancer requires long chemotherapy management, which is accompanied by severe side effects. Localized delivery of anticancer drugs helps to increase the drug concentration at the site of action and overcome such a problem. In the present study, chitosan hydrogel was prepared for local delivery of 5-Fluorouracil. The in vitro release behavior was investigated and the anticancer activity was evaluated against MCF-7 cells using MTT assay. The in vivo studies were investigated via intra-tumoral injection of a 5-FU loaded hydrogel into breast cancer of female rats. The results indicated that the modified hydrogel has excellent physicochemical properties with a sustained in vitro release profile matching a zero-order kinetic for one month. In addition, the hydrogel showed superior inhibition of cell viability compared with the untreated control group. Moreover, the in vivo studies resulted in antitumor activity with minor side effects. The tumor volume and level of tumor markers in blood were inhibited significantly by applying the hydrogel compared with the untreated control group. In conclusion, the designed injectable hydrogels are potential drug delivery systems for the treatment of breast cancer with a controlled drug release profile, which could be suitable for decreasing the side effects of chemotherapy agents.
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14030661
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