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  1. Book ; Online ; E-Book: Resistant hypertension in chronic kidney disease

    Covic, Adrian / Kanbay, Mehmet / Lerma, Edgar V.

    2017  

    Author's details Adrian Covic, Mehmet Kanbay, Edgar V. Lerma editors
    Language English
    Size 1 Online-Ressource (xviii, 365 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019536270
    ISBN 978-3-319-56827-0 ; 9783319568256 ; 3-319-56827-2 ; 3319568256
    DOI 10.1007/978-3-319-56827-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Should we continue to use renin-angiotensin-aldosterone system blockers in patients with COVID-19?

    Copur, Sidar / Kanbay, Asiye / Kanbay, Mehmet

    Clinical kidney journal

    2022  Volume 15, Issue 5, Page(s) 852–854

    Abstract: Patients with chronic kidney disease, chronic heart failure and hypertension have an increased risk of coronavirus disease 2019 (COVID-19)-related death. Renin-angiotensin-aldosterone system (RAS) blockers are commonly prescribed to decrease morbidity ... ...

    Abstract Patients with chronic kidney disease, chronic heart failure and hypertension have an increased risk of coronavirus disease 2019 (COVID-19)-related death. Renin-angiotensin-aldosterone system (RAS) blockers are commonly prescribed to decrease morbidity and mortality in these conditions. Following the pre-clinical demonstration of COVID-19 viral entry into cells via angiotensin-converting enzyme-2, the use of RAS blockers was questioned in infected individuals. Theodorakopoulou
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intradialysis exercise in haemodialysis patients: effective but complex and costly.

    Zoccali, Carmine / Manfredini, Fabio / Kanbay, Mehmet / Mallamaci, Francesca

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 39, Issue 1, Page(s) 7–9

    MeSH term(s) Humans ; Renal Dialysis ; Kidney Failure, Chronic/therapy ; Exercise
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad178
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  4. Article: Visit-to-visit blood pressure variability and risk of dementia in chronic kidney disease patients: why are blood pressure changes so important in cognitive functions?

    Yavuz, Furkan / Kanbay, Mehmet

    Clinical kidney journal

    2022  Volume 15, Issue 8, Page(s) 1447–1449

    Abstract: Chronic kidney disease (CKD) is associated with cognitive functional impairment or dementia in addition to cardiovascular diseases. Aging of the population and the increasing prevalence of CKD in elderly patients are making dementia more prevalent. Blood ...

    Abstract Chronic kidney disease (CKD) is associated with cognitive functional impairment or dementia in addition to cardiovascular diseases. Aging of the population and the increasing prevalence of CKD in elderly patients are making dementia more prevalent. Blood pressure (BP) variability is an important risk factor for dementia. Although ample data link high BP variability with the risk of dementia in the general population, data on CKD patients are scarce. An observational cohort study conducted by Park
    Language English
    Publishing date 2022-01-29
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac028
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  5. Article ; Online: Mineralocorticoid receptor antagonists in kidney transplantation.

    Kanbay, Mehmet / Copur, Sidar / Mizrak, Berk / Mallamaci, Francesca / Zoccali, Carmine

    European journal of clinical investigation

    2024  , Page(s) e14206

    Abstract: Background: The fundamental role of the renin-angiotensin-aldosterone system in the pathophysiology of chronic kidney disease, congestive heart failure, hypertension and proteinuria is well established in pre-clinical and clinical studies. ... ...

    Abstract Background: The fundamental role of the renin-angiotensin-aldosterone system in the pathophysiology of chronic kidney disease, congestive heart failure, hypertension and proteinuria is well established in pre-clinical and clinical studies. Mineralocorticoid receptor antagonists are among the primary options for renin-angiotensin-aldosterone system blockage, along with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
    Methods: In this narrative review, we aim to evaluate the efficiency and safety of mineralocorticoid receptor antagonists in kidney transplant recipients, including the potential underlying pathophysiology.
    Results: The efficiency and safety of mineralocorticoid receptor antagonists in managing chronic kidney disease and proteinuria, either non-nephrotic or nephrotic range, have been demonstrated among nontransplanted patients, though studies investigating the role of mineralocorticoid receptor antagonists among kidney transplant recipients are scarce. Nevertheless, promising results have been reported in pre-clinical and clinical studies among kidney transplant recipients regarding the role of mineralocorticoid receptor antagonists in terms of ischaemia-reperfusion injury, proteinuria, or calcineurin inhibitor-mediated nephrotoxicity without considerable adverse events such as hypotension, hyperkalaemia or worsening renal functions.
    Conclusion: Even though initial results regarding the role of mineralocorticoid receptor antagonist therapy for kidney transplant recipients are promising, there is clear need for large-scale randomized clinical trials with long-term follow-up data.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14206
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  6. Article ; Online: A review on renal autologous cell transplantation: an investigational approach towards chronic kidney disease.

    Copur, Sidar / Yavuz, Furkan / Covic, Adrian / Kanbay, Mehmet

    International urology and nephrology

    2023  Volume 55, Issue 10, Page(s) 2539–2544

    Abstract: Chronic kidney disease is among the most common causes of mortality and morbidity in adult population with limited therapeutic approaches including various medications and kidney replacement therapies. Kidney transplantation is the gold standard ... ...

    Abstract Chronic kidney disease is among the most common causes of mortality and morbidity in adult population with limited therapeutic approaches including various medications and kidney replacement therapies. Kidney transplantation is the gold standard therapeutic alternative for the management of chronic kidney disease; nonetheless, important drawbacks include the lack of adequate living or deceased donors, high rates of pre- and post-operative complications including surgical complications, infectious complications and medication-induced adverse effects. With the latest preclinical and in vitro studies demonstrating the potentiality of kidney cells obtained from diseased kidneys to convert into fully functional kidney cells lead to a novel therapeutic alternative referred as autologous selected renal cell transplantation. Even though the clinical studies investigating the efficiency and adverse effects of autologous selected renal cell transplantation are limited, it is no doubt promising. The need for future large-scale studies on chronic kidney disease patients from a diversity of etiologies is clear for the better establishment of the therapeutic potential of autologous selected renal cell transplantation. In this narrative review, our aim is to evaluate the role of renal autologous stem cell therapy in the management of chronic kidney disease.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation/adverse effects ; Kidney ; Renal Insufficiency, Chronic ; Tissue Donors ; Transplantation, Autologous ; Cell Transplantation
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03574-5
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    Zs.A 733: Show issues Location:
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  7. Article ; Online: Endocrinological disorders in acute kidney injury: an often overlooked field of clinical research.

    Copur, Sidar / Demiray, Atalay / Basile, Carlo / Kanbay, Mehmet

    Journal of nephrology

    2023  Volume 36, Issue 3, Page(s) 885–893

    Abstract: Acute kidney injury (AKI) is a common comorbidity, affecting approximately one in five hospitalized adults. The kidney is the site for the production, metabolism or excretion of most hormones, including the production of erythropoietin (EPO), the active ... ...

    Abstract Acute kidney injury (AKI) is a common comorbidity, affecting approximately one in five hospitalized adults. The kidney is the site for the production, metabolism or excretion of most hormones, including the production of erythropoietin (EPO), the active form of vitamin D, renin, thrombopoietin, and the excretion of insulin, catecholamines, gastrin and many other hormones. Therefore, it is reasonable to say that AKI can have a considerable impact on the endocrine system. Although the effects of AKI on various parameters, including cardiovascular parameters, serum electrolytes and acid-base disorders, neuro-humoral mechanisms and neurological outcomes have been extensively studied, the endocrinological consequences of AKI are understudied. Thyroid dysfunction, mainly euthyroid sick syndrome, hypo/hyperglycemia, bone mineral disorders, changes in EPO and atrial natriuretic peptide (ANP) levels are commonly found in AKI. EPO, thyroxine and ANP administration have been evaluated as potential tools to prevent or treat AKI with varying success, while the effects of AKI on some key hormones, including cortisol and insulin, have never been studied. Aim of this narrative review is to illustrate what is known and what is not known about the endocrinological outcomes of AKI. Few clinical trials are ongoing: however, there is a clear need for large-scale randomized controlled trials investigating the endocrinological consequences of AKI.
    MeSH term(s) Adult ; Humans ; Hormones/therapeutic use ; Epoetin Alfa/therapeutic use ; Acute Kidney Injury/prevention & control ; Catecholamines/therapeutic use ; Insulins/therapeutic use
    Chemical Substances Hormones ; Epoetin Alfa (64FS3BFH5W) ; Catecholamines ; Insulins
    Language English
    Publishing date 2023-01-18
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01554-z
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    Zs.A 3369: Show issues Location:
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  8. Article ; Online: Thyroid hormone Beta receptor agonists for treatment of kidney disease: A promising agent?

    Copur, Sidar / Yavuz, Furkan / Kanbay, Mehmet

    European journal of clinical investigation

    2023  Volume 53, Issue 5, Page(s) e13939

    Abstract: Background: Chronic kidney disease is a common disorder affecting a significant portion of the adult population with high mortality and morbidity. Obesity and hyperlipidemia are prevalent in chronic kidney disease, and they may trigger fat accumulation ... ...

    Abstract Background: Chronic kidney disease is a common disorder affecting a significant portion of the adult population with high mortality and morbidity. Obesity and hyperlipidemia are prevalent in chronic kidney disease, and they may trigger fat accumulation in renal parenchyma and eventually fatty kidney. Chronic kidney disease and fatty kidney are also strongly associated with nonalcoholic fatty liver disease. Because they both lead to detrimental effects on organ function, they both need to be treated effectively to improve the outcome.
    Aim: In this narrative review, we have hypothesized that thyroid hormone beta receptor agonists, a novel drug group, may potentially be beneficial in the management of chronic kidney disease due to its promising outcomes among patients with nonalcoholic fatty liver disease, a condition sharing multiple common underlying pathophysiological mechanisms.
    Results and conclusion: Thyroid hormone beta receptors are abundantly expressed in liver and kidney tissues, while both nonalcoholic fatty liver disease and chronic kidney disease share various similar pathophysiological mechanisms and triggers. Therefore, thyroid hormone beta receptor agonists may become a promising tool in the management of patients with chronic kidney disease.
    MeSH term(s) Adult ; Humans ; Kidney ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/complications ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Thyroid Hormones
    Chemical Substances Thyroid Hormones
    Language English
    Publishing date 2023-01-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13939
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  9. Article ; Online: Novel Biomarkers of Kidney Injury

    Sidar Çopur / Nuri Barış Hasbal / Mehmet Kanbay

    Turkish Journal of Nephrology, Vol 32, Iss 3, Pp 181-

    Possibility Toward Preventive Strategies

    2023  Volume 187

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The assessment of hypertension in kidney transplant patients: time to change our approach?

    Demiray, Atalay / Kanbay, Mehmet

    Clinical kidney journal

    2021  Volume 15, Issue 1, Page(s) 1–4

    Abstract: Kidney transplantation (KT) is an increasingly utilized treatment for end-stage kidney disease. Hypertension either as a cause of kidney disease or as a complication of chronic kidney disease is the most frequently encountered comorbidity of KT patients. ...

    Abstract Kidney transplantation (KT) is an increasingly utilized treatment for end-stage kidney disease. Hypertension either as a cause of kidney disease or as a complication of chronic kidney disease is the most frequently encountered comorbidity of KT patients. Hence, the management of hypertension in KT patients is crucial to prolong patient and graft survival. Ambulatory blood pressure monitoring (ABPM) appeared as a promising technique that has superiority over office and home blood pressure (BP) monitoring to correctly diagnose and manage hypertension. A recent meta-analysis by Pisano
    Language English
    Publishing date 2021-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab151
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