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  1. Article ; Online: For decades against the mainstream - From erythropoietin and hypoxia as novel treatment strategies to deep phenotyping in neuropsychiatric disorders.

    Ehrenreich, Hannelore

    Psychiatry research

    2022  Volume 317, Page(s) 114854

    MeSH term(s) Humans ; Erythropoietin/therapeutic use ; Hypoxia
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2022-09-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2022.114854
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1541: Show issues Location:
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  2. Article: Autoantibodies against the

    Ehrenreich, Hannelore

    Frontiers in immunology

    2017  Volume 8, Page(s) 181

    Abstract: This viewpoint review provides an integrative picture of seemingly contradictory work published ... ...

    Abstract This viewpoint review provides an integrative picture of seemingly contradictory work published on
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.00181
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  3. Article ; Online: Autoantibodies against N-methyl-d-aspartate receptor 1 in health and disease.

    Ehrenreich, Hannelore

    Current opinion in neurology

    2018  Volume 31, Issue 3, Page(s) 306–312

    Abstract: Purpose of review: Humoral autoimmunity has gained highest interest in neurology and psychiatry. Despite numerous recent articles on this hot topic, however, the biological significance of natural autoantibodies (AB) and the normal autoimmune repertoire ...

    Abstract Purpose of review: Humoral autoimmunity has gained highest interest in neurology and psychiatry. Despite numerous recent articles on this hot topic, however, the biological significance of natural autoantibodies (AB) and the normal autoimmune repertoire of mammals remained quite obscure. AB may contribute to disorder-relevant phenotypes and are even believed to induce diseases themselves, but the circumstances under which AB become pathogenic are not fully understood. This review will focus on the highly frequent AB against the N-methyl-d-aspartate receptor 1 (NMDAR1-AB) as an illustrating example and provide a critical overview of current work (please note that the new nomenclature, GluN1, is disregarded here for consistency with the AB literature). In particular, it will demonstrate how little is known at this point and how many conclusions are drawn based on small numbers of individuals, fragmentary experimental approaches or missing controls.
    Recent findings: NMDAR1-AB were investigated by clinicians world-wide with numerous small studies and case reports appearing yearly. Many publications were on 'anti-NMDAR encephalitis' cases or tried to separate those from other NMDAR1-AB associated conditions. Original exclusivity claims (e.g. electroencephalogram, EEG or functional magnetic resonance imaging, fMRI findings) turned out not to be exclusive for 'anti-NMDAR encephalitis'. Systematic analyses of representative NMDAR1-AB positive sera of all immunoglobulin (Ig) classes showed comparable distribution of different epitopes, often polyspecific/polyclonal, across health and disease. Sophisticated imaging tools provided findings on synapse trafficking changes induced by NMDAR1-AB from psychotic subjects but still lack epitope data to support any claimed disorder link. Persistently high titers of NMDAR1-AB (IgG) in immunized mice with open blood-brain barrier (BBB)-induced psychosis-like symptoms but failed to induce inflammation in the brain. Knowledge on peripheral NMDAR, for example in the immune system, and on potential inducers of NMDAR1-AB is only slowly increasing.
    Summary: The present knowledge on the (patho) physiological role of NMDAR1-AB is very limited and still characterized by adamant rumors. Much more experimental work and more solid and informative clinical reports, including large numbers of subjects and adequate control groups, follow-up investigations and interdisciplinary approaches will be necessary to obtain a better understanding of the significance of humoral autoimmunity in general (in focus here: NMDAR1-AB) and its disease-relevance in particular.
    MeSH term(s) Animals ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology ; Autoantibodies ; Autoimmunity/physiology ; Blood-Brain Barrier/immunology ; Electroencephalography ; Humans ; Receptors, N-Methyl-D-Aspartate/immunology
    Chemical Substances Autoantibodies ; NMDA receptor A1 ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2018-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000546
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
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  4. Article ; Online: The impact of environment on abnormal behavior and mental disease: To alleviate the prevalence of mental disorders, we need to phenotype the environment for risk factors.

    Ehrenreich, Hannelore

    EMBO reports

    2017  Volume 18, Issue 5, Page(s) 661–665

    MeSH term(s) Female ; Humans ; Male ; Mental Disorders/metabolism ; Mental Disorders/physiopathology ; Phenotype ; Prevalence ; Risk Factors
    Language English
    Publishing date 2017-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.201744197
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5433: Show issues Location:
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    Zs.MG 41: Show issues

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  5. Article ; Online: Quo Vaditis Anti-Brain Autoantibodies: Causes, Consequences, or Epiphenomena?

    Ehrenreich, Hannelore / Gastaldi, Vinicius Daguano / Wilke, Justus B H

    Biological psychiatry

    2022  Volume 92, Issue 4, Page(s) 254–255

    MeSH term(s) Autoantibodies ; Brain ; Causality
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.06.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
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  6. Article ; Online: [No title information]

    Ehrenreich, Hannelore

    Drug research

    2017  Volume 67, Issue S 01, Page(s) S14–S15

    Title translation „Hirn-Doping“: Erythropoietin zur Verbesserung kognitiver Leistung bei Mensch und Maus.
    MeSH term(s) Animals ; Cognition/drug effects ; Erythropoietin/pharmacology ; Erythropoietin/physiology ; Hippocampus/drug effects ; Hippocampus/pathology ; Humans ; Long-Term Potentiation/drug effects ; Mental Disorders/drug therapy ; Mental Disorders/pathology ; Mice
    Chemical Substances Erythropoietin (11096-26-7)
    Language German
    Publishing date 2017-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/s-0043-116529
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    Uf I Zs.151: Show issues Location:
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  7. Article ; Online: A bloody brake on myelin repair.

    Nave, Klaus-Armin / Ehrenreich, Hannelore

    Nature

    2020  Volume 553, Issue 7686, Page(s) 31–32

    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-017-08232-2
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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  8. Article: Autism as a disease of the synapse: search for mechanistic insight.

    Ehrenreich, Hannelore

    SpringerPlus

    2015  Volume 4, Issue Suppl 1, Page(s) L22

    Language English
    Publishing date 2015-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/2193-1801-4-S1-L22
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  9. Book ; Online ; Thesis: Modeling anti-NMDAR encephalitis

    Wilke, Justus [Verfasser] / Ehrenreich, Hannelore [Akademischer Betreuer] / Ehrenreich, Hannelore [Gutachter] / Wienands, Jürgen [Gutachter]

    2022  

    Author's details Justus Wilke ; Gutachter: Hannelore Ehrenreich, Jürgen Wienands ; Betreuer: Hannelore Ehrenreich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Unraveling Mechanisms of Cryptogenic Stroke at the Genetic Level: A Systematic Literature Review.

    Ernst, Johanna / Ehrenreich, Hannelore / Weissenborn, Karin / Grosse, Gerrit M

    Journal of the American Heart Association

    2023  Volume 12, Issue 15, Page(s) e029843

    Abstract: Background A substantial proportion of ischemic strokes remain cryptogenic, which has important implications for secondary prevention. Identifying genetic variants related to mechanisms of stroke causes may provide a chance to clarify the actual causes ... ...

    Abstract Background A substantial proportion of ischemic strokes remain cryptogenic, which has important implications for secondary prevention. Identifying genetic variants related to mechanisms of stroke causes may provide a chance to clarify the actual causes of cryptogenic strokes. Methods and Results In a 2-step process, 2 investigators independently and systematically screened studies that reported genetic variants in regard to stroke causes that were published between January 1991 and April 2021. Studies on monogenetic disorders, investigation of vascular risk factors as the primary end point, reviews, meta-analyses, and studies not written in English were excluded. We extracted information on study types, ancestries, corresponding single nucleotide polymorphisms, and sample and effect sizes. There were 937 studies screened, and 233 were eligible. We identified 35 single nucleotide polymorphisms and allele variants that were associated with an overlap between cryptogenic strokes and another defined cause. Conclusions Associations of single variants with an overlap between cryptogenic stroke and another defined cause were limited to a few polymorphisms. A limitation of all studies is a low granularity of clinical data, which is of major importance in a complex disease such as stroke. Deep phenotyping is in supposed contradiction with large sample sizes but needed for genome-wide analyses. Future studies should attempt to address this restriction to advance the promising approach of elucidating the cause of stroke at the genetic level. Especially in a highly heterogenous disease such as ischemic stroke, genetics are promising to establish a personalized approach in diagnostics and treatment in the sense of precision medicine.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Stroke/diagnosis ; Stroke/genetics ; Ischemic Stroke/complications ; Risk Factors ; Causality
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.029843
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