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  1. Book ; Online ; E-Book: Neuroscience of social stress

    Miczek, Klaus A. / Sinha, Rajita

    (Current topics in behavioral neurosciences ; 54 ; Springer eBook Collection)

    2022  

    Author's details Klaus A. Miczek, Rajita Sinha editors
    Series title Current topics in behavioral neurosciences ; 54
    Springer eBook Collection
    Collection
    Keywords Psychobiology ; Human behavior ; Stress, Psychological ; Social Environment ; Neurosciences
    Language English
    Size 1 Online-Ressource (viii, 515 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021700751
    ISBN 978-3-031-04256-0 ; 9783031042553 ; 3-031-04256-5 ; 3031042557
    DOI 10.1007/978-3-031-04256-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Anger and Interpersonal Aggression

    Alia-Klein, Nelly / Falkner, Annegret L. / Gan, Gabriela / Miczek, Klaus A. / Takahashi, Aki / Maria Martins De Almeida, Rosa

    2020  

    Keywords Science: general issues ; Neurosciences ; anger ; aggression ; violence ; aggressive behaviors
    Size 1 electronic resource (278 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231228
    ISBN 9782889639045 ; 2889639045
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Psychopharmacology in its 60th year.

    Miczek, Klaus A / Robbins, Trevor W

    Psychopharmacology

    2019  Volume 236, Issue 12, Page(s) 3383–3384

    Language English
    Publishing date 2019-11-20
    Publishing country Germany
    Document type Editorial
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-019-05402-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Emerging threats in addiction: will novel psychoactive substances contribute to exacerbating the ongoing drug overdose epidemic?

    Hall, F Scott / Miczek, Klaus A

    Psychopharmacology

    2019  Volume 236, Issue 3, Page(s) 839–843

    Language English
    Publishing date 2019-05-22
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-019-05271-7
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  5. Article: Psychopharmacological management and treatment of patients. Preface.

    Miczek, Klaus / Meyer, Klaus A

    Current topics in behavioral neurosciences

    2014  Volume 17, Page(s) v – vi

    MeSH term(s) Aggression/drug effects ; Behavioral Symptoms/drug therapy ; Behavioral Symptoms/psychology ; Humans ; Psychopharmacology ; Psychotropic Drugs/therapeutic use
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2014
    Publishing country Germany
    Document type Introductory Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neurobiological Bases of Alcohol Consumption After Social Stress.

    Miczek, Klaus A / DiLeo, Alyssa / Newman, Emily L / Akdilek, Naz / Covington, Herbert E

    Current topics in behavioral neurosciences

    2021  Volume 54, Page(s) 245–281

    Abstract: The urge to seek and consume excessive alcohol is intensified by prior experiences with social stress, and this cascade can be modeled under systematically controlled laboratory conditions in rodents and non-human primates. Adaptive coping with ... ...

    Abstract The urge to seek and consume excessive alcohol is intensified by prior experiences with social stress, and this cascade can be modeled under systematically controlled laboratory conditions in rodents and non-human primates. Adaptive coping with intermittent episodes of social defeat stress often transitions to maladaptive responses to traumatic continuous stress, and alcohol consumption may become part of coping responses. At the circuit level, the neural pathways subserving stress coping intersect with those for alcohol consumption. Increasingly discrete regions and connections within the prefrontal cortex, the ventral and dorsal striatum, thalamic and hypothalamic nuclei, tegmental areas as well as brain stem structures begin to be identified as critical for reacting to and coping with social stress while seeking and consuming alcohol. Several candidate molecules that modulate signals within these neural connections have been targeted in order to reduce excessive drinking and relapse. In spite of some early clinical failures, neuropeptides such as CRF, opioids, or oxytocin continue to be examined for their role in attenuating stress-escalated drinking. Recent work has focused on neural sites of action for peptides and steroids, most likely in neuroinflammatory processes as a result of interactive effects of episodic social stress and excessive alcohol seeking and drinking.
    MeSH term(s) Alcohol Drinking/metabolism ; Animals ; Ethanol ; Prefrontal Cortex/metabolism ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Stress, Psychological/metabolism
    Chemical Substances Receptors, Corticotropin-Releasing Hormone ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-12-30
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2021_273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Capturing Individual Differences: Challenges in Animal Models of Posttraumatic Stress Disorder and Drug Abuse.

    Holly, Elizabeth N / Miczek, Klaus A

    Biological psychiatry

    2015  Volume 78, Issue 12, Page(s) 816–818

    MeSH term(s) Animals ; Humans ; Individuality ; Models, Animal ; Risk Factors ; Stress Disorders, Post-Traumatic ; Substance-Related Disorders
    Language English
    Publishing date 2015-12-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2015.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Hypoactive Thalamic Crh+ Cells in a Female Mouse Model of Alcohol Drinking After Social Trauma.

    Newman, Emily L / Covington, Herbert E / Leonard, Michael Z / Burk, Kelly / Miczek, Klaus A

    Biological psychiatry

    2021  Volume 90, Issue 8, Page(s) 563–574

    Abstract: Background: Comorbid stress-induced mood and alcohol use disorders are increasingly prevalent among female patients. Stress exposure can disrupt salience processing and goal-directed decision making, contributing to persistent maladaptive behavioral ... ...

    Abstract Background: Comorbid stress-induced mood and alcohol use disorders are increasingly prevalent among female patients. Stress exposure can disrupt salience processing and goal-directed decision making, contributing to persistent maladaptive behavioral patterns; these and other stress-sensitive cognitive and behavioral processes rely on dynamic and coordinated signaling by midline and intralaminar thalamic nuclei. Considering the role of social trauma in the trajectory of these debilitating psychopathologies, identifying vulnerable thalamic cells may provide guidance for targeting persistent stress-induced symptoms.
    Methods: A novel behavioral protocol traced the progression from social trauma to the development of social defensiveness and chronically escalated alcohol consumption in female mice. Recent cell activation-measured as cFos-was quantified in thalamic cells after safe social interactions, revealing stress-sensitive corticotropin-releasing hormone-expressing (Crh+) anterior central medial thalamic (aCMT) cells. These cells were optogenetically stimulated during stress-induced social defensiveness and abstinence-escalated binge drinking.
    Results: Crh+ aCMT neurons exhibited substantial activation after social interactions in stress-naïve but not in stressed female mice. Photoactivating Crh+ aCMT cells dampened stress-induced social deficits, whereas inhibiting these cells increased social defensiveness in stress-naïve mice. Optogenetically activating Crh+ aCMT cells diminished abstinence-escalated binge alcohol drinking in female mice, regardless of stress history.
    Conclusions: This work uncovers a role for Crh+ aCMT neurons in maladaptive stress-induced social interactions and in binge drinking after forced abstinence in female mice. This molecularly defined thalamic cell population may serve as a critical stress-sensitive hub for social deficits caused by exposure to social trauma and for patterns of excessive alcohol drinking in female populations.
    MeSH term(s) Alcohol Drinking ; Alcoholism ; Animals ; Corticotropin-Releasing Hormone ; Ethanol ; Female ; Humans ; Mice ; Receptors, Corticotropin-Releasing Hormone ; Stress, Psychological
    Chemical Substances Receptors, Corticotropin-Releasing Hormone ; Ethanol (3K9958V90M) ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2021.05.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking.

    Miczek, Klaus A / Akdilek, Naz / Ferreira, Vania M M / Kenneally, Elizabeth / Leonard, Michael Z / Covington, Herbert E

    Psychopharmacology

    2022  Volume 239, Issue 10, Page(s) 3287–3296

    Abstract: Rationale: The attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate voluntary alcohol drinking under some conditions, aversive social experience (i.e., social stress) can ... ...

    Abstract Rationale: The attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate voluntary alcohol drinking under some conditions, aversive social experience (i.e., social stress) can similarly intensify alcohol consumption.
    Objective: We sought to determine how exposure to different types of chronic social stress (i.e., intermittent episodes of social defeat or continuous social stress) influences alcohol consumption and the reinforcing effects of alcohol in mice with a history of drinking.
    Methods: Separate cohorts of male C57BL/6J mice were exposed to either 10 days of continuous or intermittent social defeat stress. In experiment 1, mice were assigned to 20% w/v alcohol consumption in a two-bottle choice protocol both prior to and after exposure to social defeat stress. In a second experiment, mice engaged in an operant response sequence to gain access to alcohol wherein completion of a fixed interval (FI; 5 min) schedule was reinforced with continuous access to alcohol (fixed ratio; FR1) for up to 1.8 g/kg. Alcohol-reinforced responding and subsequent alcohol consumption were assessed daily for 4 weeks prior to the 10-day social stress exposure and for 6-week post-stress. Machine learning was implemented to standardize the analysis of defeat behaviors exhibited by the intruder mouse during confrontation with an attacking resident.
    Results: In mice with a prior history of alcohol drinking, intermittent episodes of social defeat stress produced a significant increase in 20% EtOH consumption in preference over concurrently available water. This increased intake persisted for at least 6 weeks after the final social stress experience. Intermittently stressed mice also accelerated their anticipatory responding during the fixed interval component of the operant response chain that was reinforced by alcohol. Neither unstressed controls nor mice exposed to continuous social stress exhibited significant increases in alcohol consumption and alcohol reinforcement.
    Discussion: Episodic social defeat stress promotes the seeking and consumption of alcohol, extending earlier work to alcohol-experienced mice. We hypothesize that intermittent access to alcohol and intermittent episodes of social stress are additive and share common sensitizing neural mechanisms that engender excessive alcohol consumption.
    MeSH term(s) Alcohol Drinking ; Animals ; Ethanol ; Male ; Mice ; Mice, Inbred C57BL ; Stress, Psychological ; Water
    Chemical Substances Water (059QF0KO0R) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-022-06211-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Alcohol, psychomotor-stimulants and behaviour: methodological considerations in preclinical models of early-life stress.

    McDonnell-Dowling, Kate / Miczek, Klaus A

    Psychopharmacology

    2018  Volume 235, Issue 4, Page(s) 909–933

    Abstract: Background: In order to assess the risk associated with early-life stress, there has been an increase in the amount of preclinical studies investigating early-life stress. There are many challenges associated with investigating early-life stress in ... ...

    Abstract Background: In order to assess the risk associated with early-life stress, there has been an increase in the amount of preclinical studies investigating early-life stress. There are many challenges associated with investigating early-life stress in animal models and ensuring that such models are appropriate and clinically relevant.
    Objectives: The purpose of this review is to highlight the methodological considerations in the design of preclinical studies investigating the effects of early-life stress on alcohol and psychomotor-stimulant intake and behaviour.
    Methods: The protocols employed for exploring early-life stress were investigated and summarised. Experimental variables include animals, stress models, and endpoints employed.
    Results: The findings in this paper suggest that there is little consistency among these studies and so the interpretation of these results may not be as clinically relevant as previously thought.
    Conclusion: The standardisation of these simple stress procedures means that results will be more comparable between studies and that results generated will give us a more robust understanding of what can and may be happening in the human and veterinary clinic.
    MeSH term(s) Animals ; Central Nervous System Stimulants/toxicity ; Disease Models, Animal ; Drug Evaluation, Preclinical/methods ; Ethanol/toxicity ; Female ; Humans ; Stress, Psychological/chemically induced ; Stress, Psychological/psychology
    Chemical Substances Central Nervous System Stimulants ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2018-03-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-018-4852-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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