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Article ; Online: Performance of the preanalytical check module of the Stago STA R Max2 mechanical endpoint detection analyzer for assessing the impact of hemolysis, lipemia, and icterus on aPTT and PT.

Florin, L / Oyaert, M / Van Maerken, T / Devreese, K M J

International journal of laboratory hematology

2018 Volume 40, Issue 6, Page(s) e109–e112

MeSH term(s)	Blood Coagulation Tests/instrumentation ; Blood Coagulation Tests/standards ; Hemolysis ; Humans ; Hyperlipidemias ; Jaundice ; Partial Thromboplastin Time/instrumentation ; Prothrombin Time/instrumentation
Language	English
Publishing date	2018-06-13
Publishing country	England
Document type	Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.12871
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Zs.A 1499: Show issues

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Article ; Online: Nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae among cardiothoracic surgical patients: causes and consequences.

Noël, A / Vastrade, C / Dupont, S / de Barsy, M / Huang, T D / Van Maerken, T / Leroux-Roels, I / Delaere, B / Melly, L / Rondelet, B / Dransart, C / Dincq, A S / Michaux, I / Bogaerts, P / Glupczynski, Y

The Journal of hospital infection

2019 Volume 102, Issue 1, Page(s) 54–60

Abstract: Background: Enterobacteriaceae are recognized as leading pathogens of healthcare-associated infections.: Aim: To report the investigation of a nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae affecting ... ...

Abstract	Background: Enterobacteriaceae are recognized as leading pathogens of healthcare-associated infections. Aim: To report the investigation of a nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae affecting cardiothoracic surgery patients in a Belgian academic hospital. Methods: Cases were defined based on epidemiological and microbiological investigations, including molecular typing using repetitive element-based polymerase chain reaction and multi-locus sequence typing. Case-control studies followed by field evaluations allowed the identification of a possible reservoir, and the retrospective assessment of human and financial consequences. Findings: Over a three-month period, 42 patients were infected or colonized by CTX-M-15-producing E. cloacae strains that belonged to the same clonal lineage. Acquisition mainly occurred in the intensive care unit (N = 23) and in the cardiothoracic surgery ward (N = 16). All but one patient had, prior to acquisition, undergone a cardiothoracic surgical procedure, monitored by the same transoesophageal echocardiography (TOE) probe in the operating room. Despite negative microbiological culture results, the exclusion of the suspected probe resulted in rapid termination of the outbreak. Overall, the outbreak was associated with a high mortality rate among infected patients (40%) as well as significant costs (€266,550). Conclusion: The outbreak was indirectly shown to be associated with the contamination of a manually disinfected TOE probe used per-operatively during cardiothoracic surgery procedures, because withdrawal of the putative device led to rapid termination of the outbreak.
MeSH term(s)	Aged ; Aged, 80 and over ; Belgium/epidemiology ; Case-Control Studies ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Disease Outbreaks ; Echocardiography, Transesophageal/adverse effects ; Enterobacter cloacae/classification ; Enterobacter cloacae/enzymology ; Enterobacter cloacae/genetics ; Enterobacter cloacae/isolation & purification ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Female ; Genotyping Techniques ; Humans ; Male ; Middle Aged ; Multilocus Sequence Typing ; Retrospective Studies ; Thoracic Surgical Procedures/adverse effects ; beta-Lactamases/metabolism
Chemical Substances	beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2019-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2019.01.001
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Zs.A 1586: Show issues

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Article ; Online: Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation.

Van Goethem, Alan / Deleu, Jill / Yigit, Nurten / Everaert, Celine / Moreno-Smith, Myrthala / Vasudevan, Sanjeev A / Zeka, Fjoralba / Demuynck, Fleur / Barbieri, Eveline / Speleman, Frank / Mestdagh, Pieter / Shohet, Jason / Vandesompele, Jo / Van Maerken, Tom

NAR cancer

2023 Volume 5, Issue 1, Page(s) zcad002

Abstract: Accurate assessment of treatment response and residual disease is indispensable for the evaluation of cancer treatment efficacy. However, performing tissue biopsies for longitudinal follow-up poses a major challenge in the management of solid tumours ... ...

Abstract	Accurate assessment of treatment response and residual disease is indispensable for the evaluation of cancer treatment efficacy. However, performing tissue biopsies for longitudinal follow-up poses a major challenge in the management of solid tumours like neuroblastoma. In the present study, we evaluated whether circulating miRNAs are suitable to monitor neuroblastoma tumour burden and whether treatment-induced changes of miRNA abundance in the tumour are detectable in serum. We performed small RNA sequencing on longitudinally collected serum samples from mice carrying orthotopic neuroblastoma xenografts that were exposed to treatment with idasanutlin or temsirolimus. We identified 57 serum miRNAs to be differentially expressed upon xenograft tumour manifestation, out of which 21 were also found specifically expressed in the serum of human high-risk neuroblastoma patients. The murine serum levels of these 57 miRNAs correlated with tumour tissue expression and tumour volume, suggesting potential utility for monitoring tumour burden. In addition, we describe serum miRNAs that dynamically respond to p53 activation following treatment of engrafted mice with idasanutlin. We identified idasanutlin-induced serum miRNA expression changes upon one day and 11 days of treatment. By limiting to miRNAs with a tumour-related induction, we put forward hsa-miR-34a-5p as a potential pharmacodynamic biomarker of p53 activation in serum.
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ISSN	2632-8674
ISSN (online)	2632-8674
DOI	10.1093/narcan/zcad002
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Article: Hepatitis E seroprevalence in east and west Flanders, Belgium.

Van Hoecke, F / Van Maerken, T / De Boulle, M / Geerts, A / Vlierberghe, Van / Colle, I / Padalko, H E

Acta gastro-enterologica Belgica

2012 Volume 75, Issue 3, Page(s) 322–324

Abstract: Background and study aim: Hepatitis E virus (HEV) infection is increasingly recognized as a cause of hepatitis in developed countries. The goal of this study is to provide an estimate of the seroprevalence of HEV in Belgium, more precisely in East and ... ...

Abstract	Background and study aim: Hepatitis E virus (HEV) infection is increasingly recognized as a cause of hepatitis in developed countries. The goal of this study is to provide an estimate of the seroprevalence of HEV in Belgium, more precisely in East and West Flanders, since data for this country are currently lacking. Patients and methods: One hundred patients presenting at the gynecological (mainly fertility center) or orthopedic clinics of our hospital were randomly selected to be tested for anti-HEV IgG antibodies using a sensitive indirect ELISA and, in the case of a borderline result, a strip immunoassay. Results: The anti-HEV IgG seroprevalence was found to be 14%. Conclusions: The observed seroprevalence rate suggests that HEV infection is not an uncommon occurrence in Belgium. Comparisons with published seroprevalence data of other Western European countries should be made with caution due to differences in the analytical performance of anti-HEV IgG assays.
MeSH term(s)	Adolescent ; Adult ; Aged ; Belgium/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis E/epidemiology ; Humans ; Male ; Middle Aged ; Seroepidemiologic Studies ; Young Adult
Language	English
Publishing date	2012-09
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
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Article ; Online: Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis.

Van Maerken, T / Vandesompele, J / Rihani, A / De Paepe, A / Speleman, F

Cell death and differentiation

2009 Volume 16, Issue 12, Page(s) 1563–1572

Abstract: A primary failsafe program against unrestrained proliferation and oncogenesis is provided by the p53 tumor suppressor protein, inactivation of which is considered as a hallmark of cancer. Intriguingly, mutations of the TP53 gene are rarely encountered in ...

Abstract	A primary failsafe program against unrestrained proliferation and oncogenesis is provided by the p53 tumor suppressor protein, inactivation of which is considered as a hallmark of cancer. Intriguingly, mutations of the TP53 gene are rarely encountered in neuroblastoma tumors, suggesting that alternative p53-inactivating lesions account for escape from p53 control in this childhood malignancy. Several recent studies have shed light on the mechanisms by which neuroblastoma cells circumvent the p53-driven antitumor barrier. We review here these mechanisms for evasion of p53-mediated growth control and conclude that deregulation of the p14(ARF)-MDM2-p53 axis seems to be the principal mode of p53 inactivation in neuroblastoma, opening new perspectives for targeted therapeutic intervention.
MeSH term(s)	Animals ; Gene Expression Regulation, Neoplastic ; Humans ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Neuroblastoma/therapy ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Signal Transduction ; Tumor Suppressor Protein p14ARF/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Tumor Suppressor Protein p14ARF ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2009-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/cdd.2009.138
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Copy number variation analysis and methylome profiling of a GNAQ-mutant primary meningeal melanocytic tumor and its liver metastasis.

Küsters-Vandevelde, Heidi V N / Kruse, Vibeke / Van Maerken, Tom / Boterberg, Tom / Pfundt, Rolph / Creytens, David / Van den Broecke, Caroline / Machielsen, Trudi C / Koelsche, Christian / von Deimling, Andreas / Küsters, Benno / Groenen, Patricia J T A / Wesseling, Pieter / Blokx, Willeke A M

Experimental and molecular pathology

2016 Volume 102, Issue 1, Page(s) 25–31

Abstract: Primary meningeal melanocytic tumors have genetic similarities with uveal melanomas, including GNAQ or GNA11 mutations. While BAP1 mutations and loss of chromosome 3 have adverse prognostic meaning in uveal melanoma, genetic alterations associated with ... ...

Abstract	Primary meningeal melanocytic tumors have genetic similarities with uveal melanomas, including GNAQ or GNA11 mutations. While BAP1 mutations and loss of chromosome 3 have adverse prognostic meaning in uveal melanoma, genetic alterations associated with metastasis have not been investigated in primary meningeal melanocytic tumors. We describe a 43-year-old female with a GNAQ-mutated, BAP1-wt melanocytic tumor originating in the parietal brain region and liver metastases 4years after initial diagnosis. After repeated surgery and chemotherapy she was treated with the immunomodulatory agent ipilimumab. Tissue from the primary and recurrent intracranial tumor (histologically originally diagnosed as intermediate-grade melanocytoma resp. melanoma) and from the liver metastasis was investigated for genome-wide copy number variations and DNA methylation profile. Complete loss of 10p and 19p, partial loss of 16p and a small deletion on 10q were only present in the liver metastasis and not in the intracranial tumors. The DNA methylation profiles of the intracranial tumors and the liver metastasis resembled those of meningeal melanocytomas. In conclusion, in this report we show that a distant metastasis of a meningeal melanocytic tumor has a similar methylation profile as the primary tumor and suggest that particular copy number variations may be associated with metastatic behavior.
MeSH term(s)	Adult ; Chromosome Deletion ; Combined Modality Therapy ; DNA Copy Number Variations ; DNA Methylation ; Fatal Outcome ; Female ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Melanocytes/metabolism ; Melanocytes/pathology ; Melanoma/genetics ; Melanoma/pathology ; Melanoma/therapy ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/pathology ; Meningeal Neoplasms/therapy ; Mutation ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics
Chemical Substances	BAP1 protein, human ; GNAQ protein, human ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1)
Language	English
Publishing date	2016-12-11
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2016.12.006
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Zs.A 183: Show issues

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Article ; Online: MicroRNA Expression Analysis Using Small RNA Sequencing Discovery and RT-qPCR-Based Validation.

Van Goethem, Alan / Mestdagh, Pieter / Van Maerken, Tom / Vandesompele, Jo

Methods in molecular biology (Clifton, N.J.)

2017 Volume 1654, Page(s) 197–208

Abstract: miRNAs are small noncoding RNA molecules that function as regulators of gene expression. Deregulated miRNA expression has been reported in various diseases including cancer. Due to their small size and high degree of homology, accurate quantification of ... ...

Abstract	miRNAs are small noncoding RNA molecules that function as regulators of gene expression. Deregulated miRNA expression has been reported in various diseases including cancer. Due to their small size and high degree of homology, accurate quantification of miRNA expression is technically challenging. In this chapter, we present two different technologies for miRNA quantification: small RNA sequencing and RT-qPCR.
MeSH term(s)	Gene Expression Profiling/methods ; Humans ; MicroRNAs/genetics ; RNA, Small Untranslated/genetics ; Real-Time Polymerase Chain Reaction/methods ; Sequence Analysis, RNA/methods
Chemical Substances	MicroRNAs ; RNA, Small Untranslated
Language	English
Publishing date	2017-10-06
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-7231-9_13
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Article ; Online: BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer.

Francies, F Z / Wainstein, T / De Leeneer, K / Cairns, A / Murdoch, M / Nietz, S / Cubasch, H / Poppe, B / Van Maerken, T / Crombez, B / Coene, I / Kerr, R / Slabbert, J P / Vral, A / Krause, A / Baeyens, A / Claes, K B M

BMC cancer

2015 Volume 15, Page(s) 912

Abstract: Background: Current knowledge of the aetiology of hereditary breast cancer in the four main South African population groups (black, coloured, Indian and white) is limited. Risk assessments in the black, coloured and Indian population groups are ... ...

Abstract	Background: Current knowledge of the aetiology of hereditary breast cancer in the four main South African population groups (black, coloured, Indian and white) is limited. Risk assessments in the black, coloured and Indian population groups are challenging because of restricted information regarding the underlying genetic contributions to inherited breast cancer in these populations. We focused this study on premenopausal patients (diagnosed with breast cancer before the age of 50; n = 78) and triple negative breast cancer (TNBC) patients (n = 30) from the four South African ethnic groups. The aim of this study was to determine the frequency and spectrum of germline mutations in BRCA1, BRCA2 and PALB2 and to evaluate the presence of the CHEK2 c.1100delC allele in these patients. Methods: In total, 108 South African breast cancer patients underwent mutation screening using a Next-Generation Sequencing (NGS) approach in combination with Multiplex Ligation-dependent Probe Amplification (MLPA) to detect large rearrangements in BRCA1 and BRCA2. Results: In 13 (12 %) patients a deleterious mutation in BRCA1/2 was detected, three of which were novel mutations in black patients. None of the study participants was found to have an unequivocal pathogenic mutation in PALB2. Two (white) patients tested positive for the CHEK2 c.1100delC mutation, however, one of these also carried a deleterious BRCA2 mutation. Additionally, six variants of unknown clinical significance were identified (4 in BRCA2, 2 in PALB2), all in black patients. Within the group of TNBC patients, a higher mutation frequency was obtained (23.3 %; 7/30) than in the group of patients diagnosed before the age of 50 (7.7 %; 6/78). Conclusion: This study highlights the importance of evaluating germline mutations in major breast cancer genes in all of the South African population groups. This NGS study shows that mutation analysis is warranted in South African patients with triple negative and/or in premenopausal breast cancer.
MeSH term(s)	Adult ; Aged ; Alleles ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Checkpoint Kinase 2/genetics ; Ethnic Groups/genetics ; Fanconi Anemia Complementation Group N Protein ; Female ; Genetic Predisposition to Disease ; Germ-Line Mutation ; High-Throughput Nucleotide Sequencing ; Humans ; Middle Aged ; Nuclear Proteins/genetics ; Premenopause ; Sequence Deletion/genetics ; South Africa ; Triple Negative Breast Neoplasms/diagnosis ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; Tumor Suppressor Proteins/genetics
Chemical Substances	BRCA1 Protein ; BRCA2 Protein ; BRCA2 protein, human ; Fanconi Anemia Complementation Group N Protein ; Nuclear Proteins ; PALB2 protein, human ; Tumor Suppressor Proteins ; Checkpoint Kinase 2 (EC 2.7.1.11) ; CHEK2 protein, human (EC 2.7.11.1)
Language	English
Publishing date	2015-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-015-1913-6
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Article ; Online: Analytical and pre-analytical performance characteristics of a novel cartridge-type blood gas analyzer for point-of-care and laboratory testing.

Oyaert, Matthijs / Van Maerken, Tom / Bridts, Silke / Van Loon, Silvi / Laverge, Heleen / Stove, Veronique

Clinical biochemistry

2018 Volume 53, Page(s) 116–126

Abstract: Background: Point-of-care blood gas test results may benefit therapeutic decision making by their immediate impact on patient care. We evaluated the (pre-)analytical performance of a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (Werfen), ...

Abstract	Background: Point-of-care blood gas test results may benefit therapeutic decision making by their immediate impact on patient care. We evaluated the (pre-)analytical performance of a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (Werfen), for the determination of pH, partial carbon dioxide pressure (pCO Methods: Total imprecision was estimated according to the CLSI EP5-A2 protocol. The estimated total error was calculated based on the mean of the range claimed by the manufacturer. Based on the CLSI EP9-A2 evaluation protocol, a method comparison with the Siemens RapidPoint 500 and Abbott i-STAT CG8+ was performed. Obtained data were compared against preset quality specifications. Interference of potential pre-analytical confounders on co-oximetry and electrolyte concentrations were studied. Results: The analytical performance was acceptable for all parameters tested. Method comparison demonstrated good agreement to the RapidPoint 500 and i-STAT CG8+, except for some parameters (RapidPoint 500: pCO Conclusion: Identification of sample errors from pre-analytical sources, such as interferences and automatic corrective actions, along with the analytical performance, ease of use and low maintenance time of the instrument, makes the evaluated instrument a suitable blood gas analyzer for both POCT and laboratory use.
MeSH term(s)	Blood Gas Analysis/instrumentation ; Blood Gas Analysis/methods ; Female ; Humans ; Male ; Point-of-Care Systems
Language	English
Publishing date	2018-03
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2018.01.007
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Zs.A 624: Show issues

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Article ; Online: Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma.

Rihani, Ali / Van Maerken, Tom / De Wilde, Bram / Zeka, Fjoralba / Laureys, Geneviève / Norga, Koen / Tonini, Gian Paolo / Coco, Simona / Versteeg, Rogier / Noguera, Rosa / Schulte, Johannes H / Eggert, Angelika / Stallings, Raymond L / Speleman, Frank / Vandesompele, Jo

Pediatric blood & cancer

2014 Volume 61, Issue 10, Page(s) 1867–1870

Abstract: While a polymorphism located within the promoter region of the MDM2 proto-oncogene, SNP309 (T > G ...

Abstract	While a polymorphism located within the promoter region of the MDM2 proto-oncogene, SNP309 (T > G), has previously been associated with increased risk and aggressiveness of neuroblastoma and other tumor entities, a protective effect has also been reported in certain other cancers. In this study, we evaluated the association of MDM2 SNP309 with outcome in 496 patients with neuroblastoma and its effect on MDM2 expression. No significant difference in overall or event-free survival was observed among patients with neuroblastoma with or without MDM2 SNP309. The presence of SNP309 does not affect MDM2 expression in neuroblastoma.
MeSH term(s)	Disease-Free Survival ; Genetic Predisposition to Disease ; Genotype ; Humans ; Kaplan-Meier Estimate ; Neuroblastoma/genetics ; Neuroblastoma/mortality ; Polymorphism, Single Nucleotide ; Prognosis ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins c-mdm2/genetics
Chemical Substances	MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.24927
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