LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 110

Search options

  1. Article ; Online: Patient-derived preclinical models to develop immunotherapies.

    Seoane, Joan

    Molecular oncology

    2023  Volume 17, Issue 7, Page(s) 1169–1172

    Abstract: Cancer immunotherapy has revolutionized the treatment of some malignancies. Yet, many tumors do not unfortunately respond to immune-based therapies. Deeper insights into the biology of the immune response to cancer are required to identify novel ... ...

    Abstract Cancer immunotherapy has revolutionized the treatment of some malignancies. Yet, many tumors do not unfortunately respond to immune-based therapies. Deeper insights into the biology of the immune response to cancer are required to identify novel therapeutic targets and advance immuno-oncology. To do so, we need to study cancer in patient-derived models that can faithfully recapitulate and capture the complexity and heterogeneity of the tumor immune ecosystem. Platforms facilitating the analysis of the human tumor immune microenvironment of individual patients are crucial. Patient-derived models are fundamental not only to better understand the biology of the cancer immune system but also to discern the mechanism of action of therapeutic compounds and perform preclinical studies toward improving the success of subsequent clinical testing. In this viewpoint, I present a brief review of patient-derived models for cancer immunotherapy.
    MeSH term(s) Humans ; Ecosystem ; Neoplasms/therapy ; Medical Oncology ; Immunotherapy ; Immune System ; Tumor Microenvironment
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.13470
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6637: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Targeting the Warburg Effect in Cancer: Where Do We Stand?

    Barba, Ignasi / Carrillo-Bosch, Laura / Seoane, Joan

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for ... ...

    Abstract The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy. Elevated lactate levels and acidic pH within the tumor microenvironment (TME) resulting from glycolytic profoundly impact various cellular populations, including macrophage reprogramming and impairment of T-cell functionality. Altogether, the Warburg effect has been shown to promote tumor progression and immunosuppression through multiple mechanisms. This review provides an overview of the current understanding of the Warburg effect in cancer and its implications. We summarize recent pharmacological strategies aimed at targeting glycolytic enzymes, highlighting the challenges encountered in achieving therapeutic efficacy. Additionally, we examine the utility of the Warburg effect as an early diagnostic tool. Finally, we discuss the multifaceted roles of lactate within the TME, emphasizing its potential as a therapeutic target to disrupt metabolic interactions between tumor and immune cells, thereby enhancing anti-tumor immunity.
    MeSH term(s) Humans ; Neoplasms/metabolism ; Glycolysis ; Oxygen/metabolism ; Mitochondria/metabolism ; Lactic Acid/metabolism ; Tumor Microenvironment
    Chemical Substances Oxygen (S88TT14065) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Cancer: Division hierarchy leads to cell heterogeneity.

    Seoane, Joan

    Nature

    2017  Volume 549, Issue 7671, Page(s) 164–166

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature23546
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Cerebrospinal fluid liquid biopsies for medulloblastoma.

    Seoane, Joan / Escudero, Laura

    Nature reviews. Clinical oncology

    2021  Volume 19, Issue 2, Page(s) 73–74

    MeSH term(s) Brain Neoplasms ; Cerebellar Neoplasms ; Humans ; Liquid Biopsy ; Medulloblastoma
    Language English
    Publishing date 2021-12-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-021-00590-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6029: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 103: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The Taming of the TAMs.

    Seoane, Joan

    Trends in cell biology

    2016  Volume 26, Issue 8, Page(s) 562–563

    Abstract: Tumor-associated macrophages and microglia (TAMs) are considered crucial elements in cancer progression. Recent work reveals the molecular mechanisms underlying acquired resistance to colony-stimulating factor-1 receptor (CSF-1R) inhibitors in ... ...

    Abstract Tumor-associated macrophages and microglia (TAMs) are considered crucial elements in cancer progression. Recent work reveals the molecular mechanisms underlying acquired resistance to colony-stimulating factor-1 receptor (CSF-1R) inhibitors in glioblastoma (GBM) and shows that targeting TAMs with CSF-1R inhibitors leads to an antitumor response in GBM followed by the acquisition of resistance to treatment through the induction of insulin-like growth factor 1 (IGF-1) expression in TAMs.
    MeSH term(s) Animals ; Glioblastoma/pathology ; Humans ; Macrophages/pathology ; Microglia/pathology ; Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptor, Macrophage Colony-Stimulating Factor (EC 2.7.10.1)
    Language English
    Publishing date 2016-07-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2016.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Gremlins sabotage the mechanisms of cancer stem cell differentiation.

    Seoane, Joan

    Cancer cell

    2014  Volume 25, Issue 6, Page(s) 716–717

    Abstract: BMP is highly expressed in glioblastoma and promotes differentiation of cancer stem cells (CSCs). Recently, Yan and colleagues found the explanation to this apparent paradox by showing that the antagonist of BMP, Gremlin1, is secreted by CSCs to protect ... ...

    Abstract BMP is highly expressed in glioblastoma and promotes differentiation of cancer stem cells (CSCs). Recently, Yan and colleagues found the explanation to this apparent paradox by showing that the antagonist of BMP, Gremlin1, is secreted by CSCs to protect them against the BMP-induced differentiation.
    MeSH term(s) Animals ; Glioma/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Intercellular Signaling Peptides and Proteins/secretion ; Neoplastic Stem Cells/metabolism
    Chemical Substances Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2014-06-16
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccr.2014.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer.

    Escudero, Laura / Martínez-Ricarte, Francisco / Seoane, Joan

    Cancers

    2021  Volume 13, Issue 9

    Abstract: The correct characterisation of central nervous system (CNS) malignancies is crucial for accurate diagnosis and prognosis and also the identification of actionable genomic alterations that can guide the therapeutic strategy. Surgical biopsies are ... ...

    Abstract The correct characterisation of central nervous system (CNS) malignancies is crucial for accurate diagnosis and prognosis and also the identification of actionable genomic alterations that can guide the therapeutic strategy. Surgical biopsies are performed to characterise the tumour; however, these procedures are invasive and are not always feasible for all patients. Moreover, they only provide a static snapshot and can miss tumour heterogeneity. Currently, monitoring of CNS cancer is performed by conventional imaging techniques and, in some cases, cytology analysis of the cerebrospinal fluid (CSF); however, these techniques have limited sensitivity. To overcome these limitations, a liquid biopsy of the CSF can be used to obtain information about the tumour in a less invasive manner. The CSF is a source of cell-free circulating tumour DNA (ctDNA), and the analysis of this biomarker can characterise and monitor brain cancer. Recent studies have shown that ctDNA is more abundant in the CSF than plasma for CNS malignancies and that it can be sequenced to reveal tumour heterogeneity and provide diagnostic and prognostic information. Furthermore, analysis of longitudinal samples can aid patient monitoring by detecting residual disease or even tracking tumour evolution at relapse and, therefore, tailoring the therapeutic strategy. In this review, we provide an overview of the potential clinical applications of the analysis of CSF ctDNA and the challenges that need to be overcome in order to translate research findings into a tool for clinical practice.
    Language English
    Publishing date 2021-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13091989
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Cerebrospinal fluid circulating tumour DNA as a liquid biopsy for central nervous system malignancies.

    Escudero, Laura / Martínez-Ricarte, Francisco / Seoane, Joan

    Current opinion in neurology

    2020  Volume 33, Issue 6, Page(s) 736–741

    Abstract: Purpose of review: The molecular characterization of central nervous system (CNS) malignancies is crucial for obtaining the correct diagnosis and prognosis, and to guide the optimal therapeutic approach. However, obtaining surgical specimens can be ... ...

    Abstract Purpose of review: The molecular characterization of central nervous system (CNS) malignancies is crucial for obtaining the correct diagnosis and prognosis, and to guide the optimal therapeutic approach. However, obtaining surgical specimens can be challenging because of the anatomical location of the tumour and may limit the correct characterization of these malignancies. Recently, it has been shown that the cerebrospinal fluid (CSF) circulating tumour DNA (ctDNA) can be used as a liquid biopsy to characterize and monitor CNS malignancies and here we review its implications and advances.
    Recent findings: In the last 5 years, several groups including ours have shown that ctDNA is highly present in the CSF, in larger amounts than in plasma, and that ctDNA can be sequenced to provide information about the diagnosis and prognosis of brain malignancies. Furthermore, the analysis of CSF ctDNA has allowed the selection of optimal therapeutic approaches monitoring response to treatment and tracking tumour evolution, providing crucial information about the molecular changes during tumour progression.
    Summary: Here, we review the recent discoveries and data relative to CSF ctDNA and discuss how CSF ctDNA can be used as a liquid biopsy to facilitate and complement the clinical management of patients with CNS malignancies.
    MeSH term(s) Biomarkers, Tumor/cerebrospinal fluid ; Central Nervous System Neoplasms/cerebrospinal fluid ; Central Nervous System Neoplasms/diagnosis ; Circulating Tumor DNA/cerebrospinal fluid ; Humans ; Liquid Biopsy ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Circulating Tumor DNA
    Language English
    Publishing date 2020-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000869
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: TGFbeta and cancer initiating cells.

    Seoane, Joan

    Cell cycle (Georgetown, Tex.)

    2011  Volume 8, Issue 23, Page(s) 3787–3788

    MeSH term(s) Bone Morphogenetic Proteins/metabolism ; Cell Differentiation ; Humans ; Interleukin-6/metabolism ; Leukemia Inhibitory Factor/metabolism ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/metabolism ; Signal Transduction ; Transforming Growth Factor beta/physiology
    Chemical Substances Bone Morphogenetic Proteins ; Interleukin-6 ; Leukemia Inhibitory Factor ; Transforming Growth Factor beta
    Language English
    Publishing date 2011-03-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.8.23.10054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: NO Signals from the Cancer Stem Cell Niche.

    Seoane, Joan

    Cell stem cell

    2010  Volume 6, Issue 2, Page(s) 97–98

    Abstract: Characterization of signaling pathways that control cancer stem cells may lead to more effective treatments against cancer. In this issue of Cell Stem Cell, a study by Charles et al. (2010) identifies the NO and Notch pathways as important regulators of ... ...

    Abstract Characterization of signaling pathways that control cancer stem cells may lead to more effective treatments against cancer. In this issue of Cell Stem Cell, a study by Charles et al. (2010) identifies the NO and Notch pathways as important regulators of the perivascular niche of cancer stem cells in glioma.
    Language English
    Publishing date 2010-02-05
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2010.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 75: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top