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  1. Article ; Conference proceedings: Leberphänotyp bei Erwachsenen mit compound-heterozygotem Alpha1-Antitrypsin-Mangel (Genotyp Pi*SZ)

    Fromme, M / Schneider, CV / Hamesch, K / Ellis, P / Pereira, V / Pons, M / Genesca, J / Miravitlles, M / Nuñez, A / Reichert, M / Benini, F / Burbaum, B / Woditsch, V / Schaefer, B / Zoller, H / Hurst, JR / Lomas, DA / Verbeek, J / Nevens, F /
    Janciauskiene, S / Chorostowska-Wynimko, J / Lammert, F / Clark, V / Griffiths, WJ / Turner, A / McElvaney, NG / Trautwein, C / Strnad, P

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 01

    Event/congress 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Münster, 2021-01-29
    Language German
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0040-1721992
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
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  2. Article ; Conference proceedings: Populations-basierte Erfassung des Leberphänotyps bei Alpha1-Antitrypsinmangel

    Burbaum, B / Fromme, M / Schneider, C / Pereira, V / Hamesch, K / Pons, M / Reichert, MC / Benini, F / Ellis, P / Thorhauge, K / Mandorfer, M / Woditsch, V / Chorostowska-Wynimko, J / Nuñez, A / Schäfer, B / Zoller, H / Janciauskiene, S / Abreu, N / Jasmins, L /
    Gaspar, R / Gomes, C / Schneider, KM / Trauner, M / Krag, A / Gooptu, B / Thorburn, D / Marshall, A / Hurst, JR / Lomas, DA / Lammert, F / Gaisa, NT / Clark, V / Griffiths, WJ / Trautwein, C / Turner, AM / McElvaney, NG

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 01

    Event/congress 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Münster, 2021-01-29
    Language German
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0040-1722005
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.A 111/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

    Mackay, Hannah L / Stone, Helen R / Ellis, Katherine / Ronson, George E / Walker, Alexandra K / Starowicz, Katarzyna / Garvin, Alexander J / van Eijk, Patrick / Vaitsiankova, Alina / Vijayendran, Sobana / Beesley, James F / Petermann, Eva / Brown, Eric J / Densham, Ruth M / Reed, Simon H / Dobbs, Felix / Saponaro, Marco / Morris, Joanna R

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mammalian DNA replication employs several RecQ DNA helicases to orchestrate the faithful duplication of genetic information. Helicase function is often coupled to the activity of specific nucleases, but how helicase and nuclease activities are co- ... ...

    Abstract Mammalian DNA replication employs several RecQ DNA helicases to orchestrate the faithful duplication of genetic information. Helicase function is often coupled to the activity of specific nucleases, but how helicase and nuclease activities are co-directed is unclear. Here we identify the inactive ubiquitin-specific protease, USP50, as a ubiquitin-binding and chromatin-associated protein required for ongoing replication, fork restart, telomere maintenance and cellular survival during replicative stress. USP50 supports WRN:FEN1 at stalled replication forks, suppresses MUS81-dependent fork collapse and restricts double-strand DNA breaks at GC-rich sequences. Surprisingly we find that cells depleted for USP50 and recovering from a replication block exhibit increased DNA2 and RECQL4 foci and that the defects in ongoing replication, poor fork restart and increased fork collapse seen in these cells are mediated by DNA2, RECQL4 and RECQL5. These data define a novel ubiquitin-dependent pathway that promotes the balance of helicase: nuclease use at ongoing and stalled replication forks.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.10.574674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recurrence After Atrial Fibrillation Ablation and Investigational Biomarkers of Cardiac Remodeling.

    El-Harasis, Majd A / Quintana, Joseph A / Martinez-Parachini, J Roberto / Jackson, Gregory G / Varghese, Bibin T / Yoneda, Zachary T / Murphy, Brittany S / Crawford, Diane M / Tomasek, Kelsey / Su, Yan Ru / Wells, Quinn S / Roden, Dan M / Michaud, Gregory F / Saavedra, Pablo / Estrada, Juan Carlos / Richardson, Travis D / Kanagasundram, Arvindh N / Shen, Sharon T / Montgomery, Jay A /
    Ellis, Christopher R / Crossley, George H / Eberl, Magdalena / Gillet, Ludovic / Ziegler, Andre / Shoemaker, M Benjamin

    Journal of the American Heart Association

    2024  Volume 13, Issue 6, Page(s) e031029

    Abstract: Background: Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical ... ...

    Abstract Background: Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model.
    Methods and results: Blood samples collected before de novo catheter ablation were analyzed. Levels of bone morphogenetic protein-10, angiopoietin-2, fibroblast growth factor-23, insulin-like growth factor-binding protein-7, myosin-binding protein C3, growth differentiation factor-15, interleukin-6, N-terminal pro-brain natriuretic peptide, and high-sensitivity troponin T were measured. Recurrence was defined as ≥30 seconds of an atrial arrhythmia 3 to 12 months postablation. Multivariable logistic regression was performed using biomarker levels along with clinical covariates: APPLE score (Age >65 years, Persistent AF, imPaired eGFR [<60 ml/min/1.73m
    Conclusions: Higher angiopoietin-2 and interleukin-6 levels were associated with recurrence after atrial fibrillation ablation in multivariable modeling. However, the addition of biomarkers to a clinical prediction model did not significantly improve recurrence prediction.
    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Angiopoietin-2 ; Interleukin-6 ; Models, Statistical ; Stroke Volume ; Ventricular Remodeling ; Risk Factors ; Prognosis ; Recurrence ; Ventricular Function, Left ; Biomarkers ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Treatment Outcome ; Atrial Remodeling
    Chemical Substances Angiopoietin-2 ; Interleukin-6 ; Biomarkers
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016-2017.

    Santiago, Gilberto A / Kalinich, Chaney C / Cruz-López, Fabiola / González, Glenda L / Flores, Betzabel / Hentoff, Aaron / Charriez, Keyla N / Fauver, Joseph R / Adams, Laura E / Sharp, Tyler M / Black, Allison / Bedford, Trevor / Ellis, Esther / Ellis, Brett / Waterman, Steve H / Paz-Bailey, Gabriela / Grubaugh, Nathan D / Muñoz-Jordán, Jorge L

    Emerging infectious diseases

    2021  Volume 27, Issue 11, Page(s) 2971–2973

    Abstract: We reconstructed the 2016-2017 Zika virus epidemic in Puerto Rico by using complete genomes to uncover the epidemic's origin, spread, and evolutionary dynamics. Our study revealed that the epidemic was propelled by multiple introductions that spread ... ...

    Abstract We reconstructed the 2016-2017 Zika virus epidemic in Puerto Rico by using complete genomes to uncover the epidemic's origin, spread, and evolutionary dynamics. Our study revealed that the epidemic was propelled by multiple introductions that spread across the island, intricate evolutionary patterns, and ≈10 months of cryptic transmission.
    MeSH term(s) Epidemics ; Evolution, Molecular ; Humans ; Puerto Rico/epidemiology ; Zika Virus/genetics ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2711.211575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 27. Barracudinas (Paralepididae)

    Kloppmann, Matthias H. F. / Ellis, Jim R.

    2015  

    Language English
    Publisher Wageningen Academic Publishers
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: 26. Barbeled dragonfish (Stomiidae)

    Kloppmann, Matthias H. F. / Ellis, Jim R.

    2015  

    Language English
    Publisher Wageningen Academic Publishers
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: 25. Hatchetfish and Pearlsides (Sternoptychidae)

    Kloppmann, Matthias H. F. / Ellis, Jim R.

    2015  

    Language English
    Publisher Wageningen Academic Publishers
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: 28. Lanternfish (Myctophidae)

    Kloppmann, Matthias H. F. / Ellis, Jim R.

    2015  

    Language English
    Publisher Wageningen Academic Publishers
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: 1. Hagfish (Myxinidae)

    Kloppmann, Matthias H. F. / Ellis, Jim R.

    2015  

    Language English
    Publisher Wageningen Academic Publishers
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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