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  1. Article ; Online: Medicine and the Law.

    Ramoolla, B / Van der Haar, G / Luke, A / King, R / Jacob, N / Luke, B

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2023  Volume 113, Issue 5, Page(s) 19–24

    Abstract: The South African (SA) medical internship training programme model was recently revised to extend training into the primary care platform. In this article, we reflect on the experiences of training under the new model from an intern perspective. We use ... ...

    Abstract The South African (SA) medical internship training programme model was recently revised to extend training into the primary care platform. In this article, we reflect on the experiences of training under the new model from an intern perspective. We use these reflections to make recommendations to the Health Professions Council of SA on how to further improve the training model by implementing systems that guide and empower the intern doctor practising at a primary level of care.
    MeSH term(s) Humans ; South Africa ; Internship and Residency ; Health Occupations ; Students, Medical ; Attitude of Health Personnel
    Language English
    Publishing date 2023-05-05
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0038-2469 ; 0256-9574
    ISSN (online) 2078-5135
    ISSN 0038-2469 ; 0256-9574
    DOI 10.7196/SAMJ.2023.v113i5.16784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improved CNS Control With the Addition of Chemotherapy to Osimertinib-A Devil's Bargain?

    Yu, Yao / Miao, Emily / Pike, Luke R G

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  , Page(s) JCO2302699

    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Letter
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.02699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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  3. Article ; Online: Medicine and the Law

    B Ramoolla / G van der Haar / A Luke / R King / N Jacob / B Luke

    South African Medical Journal, Vol 113, Iss

    2023  Volume 5

    Abstract: The South African (SA) medical internship training programme model was recently revised to extend training into the primary care platform. In this article, we reflect on the experiences of training under the new model from an intern perspective. We use ... ...

    Abstract The South African (SA) medical internship training programme model was recently revised to extend training into the primary care platform. In this article, we reflect on the experiences of training under the new model from an intern perspective. We use these reflections to make recommendations to the Health Professions Council of SA on how to further improve the training model by implementing systems that guide and empower the intern doctor practising at a primary level of care.
    Keywords internship training ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher South African Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Artificial-intelligence-driven measurements of brain metastases' response to SRS compare favorably with current manual standards of assessment.

    Prezelski, Kayla / Hsu, Dylan G / Del Balzo, Luke / Heller, Erica / Ma, Jennifer / Pike, Luke R G / Ballangrud, Åse / Aristophanous, Michalis

    Neuro-oncology advances

    2024  Volume 6, Issue 1, Page(s) vdae015

    Abstract: Background: Evaluation of treatment response for brain metastases (BMs) following stereotactic radiosurgery (SRS) becomes complex as the number of treated BMs increases. This study uses artificial intelligence (AI) to track BMs after SRS and validates ... ...

    Abstract Background: Evaluation of treatment response for brain metastases (BMs) following stereotactic radiosurgery (SRS) becomes complex as the number of treated BMs increases. This study uses artificial intelligence (AI) to track BMs after SRS and validates its output compared with manual measurements.
    Methods: Patients with BMs who received at least one course of SRS and followed up with MRI scans were retrospectively identified. A tool for automated detection, segmentation, and tracking of intracranial metastases on longitudinal imaging, MEtastasis Tracking with Repeated Observations (METRO), was applied to the dataset. The longest three-dimensional (3D) diameter identified with METRO was compared with manual measurements of maximum axial BM diameter, and their correlation was analyzed. Change in size of the measured BM identified with METRO after SRS treatment was used to classify BMs as responding, or not responding, to treatment, and its accuracy was determined relative to manual measurements.
    Results: From 71 patients, 176 BMs were identified and measured with METRO and manual methods. Based on a one-to-one correlation analysis, the correlation coefficient was
    Conclusions: Using AI to automatically measure and track BM volumes following SRS treatment, this study showed a strong correlation between AI-driven measurements and the current clinically used method: manual axial diameter measurements.
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdae015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: DNA-RNA Hybrids at Telomeres in Budding Yeast.

    Wagner, Carolin B / Luke, Brian

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2528, Page(s) 145–157

    Abstract: ... noncoding RNA. Due to the G-rich nature of the coding strand, TERRA has a tendency to form DNA-RNA hybrids ... and potentially R-loops, which in turn, promote repair at short telomeres. Here, we report two methods ... antibody, and R-ChIP, which takes advantage of a catalytic dead form of RNase H1 (Rnh1-cd). We use ...

    Abstract It has recently been demonstrated that budding yeast telomeres are transcribed into TERRA, a long noncoding RNA. Due to the G-rich nature of the coding strand, TERRA has a tendency to form DNA-RNA hybrids and potentially R-loops, which in turn, promote repair at short telomeres. Here, we report two methods to detect DNA-RNA hybrids at yeast telomeres, namely, DRIP, which employs the S9.6 hybrid-recognizing antibody, and R-ChIP, which takes advantage of a catalytic dead form of RNase H1 (Rnh1-cd). We use cross-linked material for both protocols as we have found that this does not negatively affect recovered material, and furthermore allows the precipitation of other proteins from the identical cross-linked material. Although both methods are successful in terms of detecting DNA-RNA hybrids at telomeres, the R-ChIP method yields an approximately ten-fold increased enrichment.
    MeSH term(s) DNA/genetics ; RNA/genetics ; RNA/metabolism ; Ribonuclease H/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomycetales/genetics ; Saccharomycetales/metabolism ; Telomere/genetics ; Telomere/metabolism
    Chemical Substances RNA (63231-63-0) ; DNA (9007-49-2) ; Ribonuclease H (EC 3.1.26.4)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2477-7_10
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  6. Article: Addressing Genetic Tumor Heterogeneity, Post-Therapy Metastatic Spread, Cancer Repopulation, and Development of Acquired Tumor Cell Resistance.

    Harrer, Dennis Christoph / Lüke, Florian / Pukrop, Tobias / Ghibelli, Lina / Reichle, Albrecht / Heudobler, Daniel

    Cancers

    2023  Volume 16, Issue 1

    Abstract: ... patients with r/r malignancies, e.g., non-small cell lung cancer, Hodgkin's lymphoma ... to treat patients, who are refractory to or relapsing (r/r) after conventional chemotherapy, which is ...

    Abstract The concept of post-therapy metastatic spread, cancer repopulation and acquired tumor cell resistance (M-CRAC) rationalizes tumor progression because of tumor cell heterogeneity arising from post-therapy genetic damage and subsequent tissue repair mechanisms. Therapeutic strategies designed to specifically address M-CRAC involve tissue editing approaches, such as low-dose metronomic chemotherapy and the use of transcriptional modulators with or without targeted therapies. Notably, tumor tissue editing holds the potential to treat patients, who are refractory to or relapsing (r/r) after conventional chemotherapy, which is usually based on administering a maximum tolerable dose of a cytostatic drugs. Clinical trials enrolling patients with r/r malignancies, e.g., non-small cell lung cancer, Hodgkin's lymphoma, Langerhans cell histiocytosis and acute myelocytic leukemia, indicate that tissue editing approaches could yield tangible clinical benefit. In contrast to conventional chemotherapy or state-of-the-art precision medicine, tissue editing employs a multi-pronged approach targeting important drivers of M-CRAC across various tumor entities, thereby, simultaneously engaging tumor cell differentiation, immunomodulation, and inflammation control. In this review, we highlight the M-CRAC concept as a major factor in resistance to conventional cancer therapies and discusses tissue editing as a potential treatment.
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010180
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  7. Article ; Online: Effect of water management on microbial diversity and composition in an Italian rice field system.

    Hester, Eric R / Vaksmaa, Annika / Valè, Giampiero / Monaco, Stefano / Jetten, Mike S M / Lüke, Claudia

    FEMS microbiology ecology

    2022  Volume 98, Issue 3

    Abstract: Traditional rice cultivation consumes up to 2500 L of water per kg yield and new strategies such as the 'Alternate Wetting and Drying' (AWD) might be promising water-saving alternatives. However, they might have large impacts on the soil microbiology. In ...

    Abstract Traditional rice cultivation consumes up to 2500 L of water per kg yield and new strategies such as the 'Alternate Wetting and Drying' (AWD) might be promising water-saving alternatives. However, they might have large impacts on the soil microbiology. In this study, we compared the bacterial and archaeal communities in experimental field plots, cultivated under continuously flooding (CF) and AWD management, by high-throughput sequencing of the 16S rRNA gene. We analysed alpha and beta diversity in bulk soil and on plant roots, in plots cultivated with two different rice cultivars. The strongest difference was found between soil and root communities. Beside others, the anaerobic methanotroph Methanoperedens was abundant in soil, however, we detected a considerable number of ANME-2a-2b on plant roots. Furthermore, root communities were significantly affected by the water management: Differential abundance analysis revealed the enrichment of aerobic and potentially plant-growth-promoting bacteria under AWD treatment, such as Sphingomonadaceae and Rhizobiaceae (both Alphaproteobacteria), and Bacteroidetes families. Microorganisms with an overall anaerobic lifestyle, such as various Delta- and Epsilonproteobacteria, and Firmicutes were depleted. Our study indicates that the bulk soil communities seem overall well adapted and more resistant to changes in the water treatment, whereas the root microbiota seems more vulnerable.
    MeSH term(s) Humans ; Oryza ; RNA, Ribosomal, 16S/genetics ; Rhizobiaceae ; Soil/chemistry ; Soil Microbiology ; Water Supply
    Chemical Substances RNA, Ribosomal, 16S ; Soil
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283722-5
    ISSN 1574-6941 ; 0168-6496
    ISSN (online) 1574-6941
    ISSN 0168-6496
    DOI 10.1093/femsec/fiac018
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    Zs.A 2967: Show issues Location:
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  8. Article ; Online: Ensemble species distribution modeling of Culex tarsalis (Diptera: Culicidae) in the continental United States.

    Rhodes, Charlotte G / Chaves, Luis F / Bergmann, Luke R / Hamer, Gabriel L

    Journal of medical entomology

    2023  Volume 60, Issue 4, Page(s) 664–679

    Abstract: West Nile virus (WNV) is the primary mosquito-borne disease in the United States and has had case reports every year since its introduction in 1999. As such, it is critical that we characterize the distribution of WNV vectors. Estimates of Culex tarsalis ...

    Abstract West Nile virus (WNV) is the primary mosquito-borne disease in the United States and has had case reports every year since its introduction in 1999. As such, it is critical that we characterize the distribution of WNV vectors. Estimates of Culex tarsalis Coquillett species distribution, a major WNV vector, are scarce. We used ensemble distribution modeling to estimate habitat suitability for this species across the contiguous United States by consolidating presence data from four publicly available mosquito trapping data servers. The central plains region and much of the western US were estimated to have high habitat suitability. We identified multiple metrics of temperature and precipitation to be important in predicting the occurrence of Cx. tarsalis in a given geographic area. Furthermore, we observed habitat suitability for Cx. tarsalis to be significantly higher in areas with a high incidence of West Nile neuroinvasive disease compared to areas with low WN disease incidence, suggesting that Cx. tarsalis is present in regions with a high incidence of disease.
    MeSH term(s) United States ; Animals ; Culex ; West Nile Fever ; Culicidae ; Mosquito Vectors ; West Nile virus
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 410635-0
    ISSN 1938-2928 ; 0022-2585
    ISSN (online) 1938-2928
    ISSN 0022-2585
    DOI 10.1093/jme/tjad027
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  9. Article ; Online: Methylene Blue in a High-Performance Hydrogen-Organic Rechargeable Fuel Cell.

    Cannon, Christopher G / Klusener, Peter A A / Petit, Luke F / Wong, Toby / Wang, Anqi / Song, Qilei / Brandon, Nigel P / Kucernak, Anthony R J

    ACS applied energy materials

    2024  Volume 7, Issue 6, Page(s) 2080–2087

    Abstract: A hydrogen-organic hybrid flow battery (FB) has been developed using methylene blue (MB) in an aqueous acid electrolyte with a theoretical positive electrolyte energy storage capacity of 65.4 A h ... ...

    Abstract A hydrogen-organic hybrid flow battery (FB) has been developed using methylene blue (MB) in an aqueous acid electrolyte with a theoretical positive electrolyte energy storage capacity of 65.4 A h L
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2574-0962
    ISSN (online) 2574-0962
    DOI 10.1021/acsaem.3c02515
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  10. Article ; Online: Emergent Phenol Injection of Bilateral Stellate Ganglion for Management of Refractory Malignant Ventricular Arrhythmias.

    Luke, Whitney R / Daoud, Emile G / Latif, Omar S

    The American journal of case reports

    2020  Volume 21, Page(s) e921465

    Abstract: BACKGROUND Management of incessant electrical storm is poorly defined. These 2 case studies demonstrate a simplified percutaneous approach to achieve stellate ganglion ablation (SGA) and to promptly control malignant ventricular arrhythmias. CASE REPORT ... ...

    Abstract BACKGROUND Management of incessant electrical storm is poorly defined. These 2 case studies demonstrate a simplified percutaneous approach to achieve stellate ganglion ablation (SGA) and to promptly control malignant ventricular arrhythmias. CASE REPORT This report describes 2 patients with deteriorating hemodynamics, progressive ventricular arrhythmias, and worsening heart failure, managed with emergent percutaneous fluoroscopically-guided bilateral SGA to achieve bilateral cardiac sympathetic denervation. While supine and intubated, the left and then right stellate ganglion were identified guided by anatomic landmarks. Using a 22-guage, 3.5-inch spinal needle, contrast dye was injected with appropriate outline of the stellate ganglion at the uncinate process of the C6 vertebra. Bupivacaine 0.5% was injected, followed by phenol 6%. Successful SGA was confirmed by intentional Horner's syndrome with bilateral eye lag. The procedures were completed in about 30 min without complications and there was a dramatic reduction in ventricular arrhythmias. CONCLUSIONS Emergent percutaneous bilateral SGA can be accomplished with a brief procedure resulting in management of electrical storm.
    MeSH term(s) Ablation Techniques ; Bupivacaine/administration & dosage ; Fluoroscopy ; Humans ; Injections ; Male ; Middle Aged ; Phenol/administration & dosage ; Stellate Ganglion/surgery ; Sympathectomy, Chemical ; Tachycardia, Ventricular/therapy
    Chemical Substances Phenol (339NCG44TV) ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.921465
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