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Article ; Online: Nano-Biogenic Heavy Metals Adsorptive Remediation for Enhanced Soil Health and Sustainable Agricultural Production.

Jha, Ayush / Barsola, Bindiya / Pathania, Diksha / Sonu / Raizada, Pankaj / Thakur, Pankaj / Singh, Pardeep / Rustagi, Sarvesh / Khosla, Ajit / Chaudhary, Vishal

Environmental research

2024 , Page(s) 118926

Abstract: Hazardous heavy metal (HM) pollution constitutes a pervasive global challenge, posing substantial risks to ecosystems and human health. The exigency for expeditious detection, meticulous monitoring, and efficacious remediation of HM within ecosystems is ... ...

Abstract	Hazardous heavy metal (HM) pollution constitutes a pervasive global challenge, posing substantial risks to ecosystems and human health. The exigency for expeditious detection, meticulous monitoring, and efficacious remediation of HM within ecosystems is indisputable. Soil contamination, stemming from a myriad of anthropogenic activities, emerges as a principal conduit for HM ingress into the food chain. Traditional soil remediation modalities for HM elimination, while effective are labor-intensive, susceptible to secondary contamination, and exhibit limited efficacy in regions characterized by low metal toxicity. In response to these exigencies, the eco-friendly paradigm of bioremediation has garnered prominence as a financially judicious and sustainable remedial strategy. This approach entails the utilization of hyperaccumulators, Genetically Modified Microorganisms (GMM), and advantageous microbes. The current review offers a comprehensive elucidation of cutting-edge phyto/microbe-based bioremediation techniques, with a specific emphasis on their amalgamation with nanotechnology. Accentuating their pivotal role in advancing sustainable agricultural practices, the review meticulously dissects the synergistic interplay between plants and microbes, underscoring their adeptness in HM remediation sans secondary contamination. Moreover, the review scrutinizes the challenges intrinsic to implementing bioremediation-nanotechnology interface techniques and propounds innovative resolutions. These discernments proffer auspicious trajectories for the future of agriculture. Through the environmentally conscientious marvels of phyto/microbe bioremediation, an optimistic outlook emerges for environmental preservation and the cultivation of a sustainable, salubrious planet via the conduit of cleaner agricultural production.
Language	English
Publishing date	2024-04-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118926
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Article ; Online: Environment-mediated mutagenetic interference on genetic stabilization and circadian rhythm in plants.

Nidhi / Kumar, Pradeep / Pathania, Diksha / Thakur, Sourbh / Sharma, Mamta

Cellular and molecular life sciences : CMLS

2022 Volume 79, Issue 7, Page(s) 358

Abstract: Many mortal organisms on this planet have developed the potential to merge all internal as well as external environmental cues to regulate various processes running inside organisms and in turn make them adaptive to the environment through the circadian ... ...

Abstract	Many mortal organisms on this planet have developed the potential to merge all internal as well as external environmental cues to regulate various processes running inside organisms and in turn make them adaptive to the environment through the circadian clock. This moving rotator controls processes like activation of hormonal, metabolic, or defense pathways, initiation of flowering at an accurate period, and developmental processes in plants to ensure their stability in the environment. All these processes that are under the control of this rotating wheel can be changed either by external environmental factors or by an unpredictable phenomenon called mutation that can be generated by either physical mutagens, chemical mutagens, or by internal genetic interruption during metabolic processes, which alters normal functionality of organisms like innate immune responses, entrainment of the clock, biomass reduction, chlorophyll formation, and hormonal signaling, despite its fewer positive roles in plants like changing plant type, loss of vernalization treatment to make them survivable in different latitudes, and defense responses during stress. In addition, with mutation, overexpression of gene components sometimes supresses mutation effect and promote normal circadian genes abundance in the cell, while sometimes it affects circadian functionality by generating arrhythmicity and shows that not only mutation but overexpression also effects normal functional activities of plant. Therefore, this review mainly summarizes the role of each circadian clock genes in regulating rhythmicity, and shows that how circadian outputs are controlled by mutations as well as overexpression phenomenon.
MeSH term(s)	Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Mutagens ; Mutation/genetics ; Plants/genetics
Chemical Substances	Mutagens
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04368-1
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Article: Environment-mediated mutagenetic interference on genetic stabilization and circadian rhythm in plants

Nidhi / Kumar, Pradeep / Pathania, Diksha / Thakur, Sourbh / Sharma, Mamta

Cellular and molecular life sciences. 2022 July, v. 79, no. 7

2022

Abstract	Many mortal organisms on this planet have developed the potential to merge all internal as well as external environmental cues to regulate various processes running inside organisms and in turn make them adaptive to the environment through the circadian clock. This moving rotator controls processes like activation of hormonal, metabolic, or defense pathways, initiation of flowering at an accurate period, and developmental processes in plants to ensure their stability in the environment. All these processes that are under the control of this rotating wheel can be changed either by external environmental factors or by an unpredictable phenomenon called mutation that can be generated by either physical mutagens, chemical mutagens, or by internal genetic interruption during metabolic processes, which alters normal functionality of organisms like innate immune responses, entrainment of the clock, biomass reduction, chlorophyll formation, and hormonal signaling, despite its fewer positive roles in plants like changing plant type, loss of vernalization treatment to make them survivable in different latitudes, and defense responses during stress. In addition, with mutation, overexpression of gene components sometimes supresses mutation effect and promote normal circadian genes abundance in the cell, while sometimes it affects circadian functionality by generating arrhythmicity and shows that not only mutation but overexpression also effects normal functional activities of plant. Therefore, this review mainly summarizes the role of each circadian clock genes in regulating rhythmicity, and shows that how circadian outputs are controlled by mutations as well as overexpression phenomenon.
Keywords	biomass ; chlorophyll ; circadian clocks ; circadian rhythm ; mutation ; vernalization
Language	English
Dates of publication	2022-07
Size	p. 358.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04368-1
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Article ; Online: Panorama of biogenic nano-fertilizers: A road to sustainable agriculture.

Jha, Ayush / Pathania, Diksha / Sonu / Damathia, Bhavna / Raizada, Pankaj / Rustagi, Sarvesh / Singh, Pardeep / Rani, Gokana Mohana / Chaudhary, Vishal

Environmental research

2023 Volume 235, Page(s) 116456

Abstract: The ever-increasing demand for food from the growing population has augmented the consumption of fertilizers in global agricultural practices. However, the excessive usage of chemical fertilizers with poor efficacy is drastically deteriorating ecosystem ... ...

Abstract	The ever-increasing demand for food from the growing population has augmented the consumption of fertilizers in global agricultural practices. However, the excessive usage of chemical fertilizers with poor efficacy is drastically deteriorating ecosystem health through the degradation of soil fertility by diminishing soil microflora, environment contamination, and human health by inducing chemical remnants to the food chain. These challenges have been addressed by the integration of nanotechnological and biotechnological approaches resulting in nano-enabled biogenic fertilizers (NBF), which have revolutionized agriculture sector and food production. This review critically details the state-of-the-art NBF production, types, and mechanism involved in cultivating crop productivity/quality with insights into genetic, physiological, morphological, microbiological, and physiochemical attributes. Besides, it explores the associated challenges and future routes to promote the adoption of NBF for intelligent and sustainable agriculture. Furthermore, diverse applications of nanotechnology in precision agriculture including plant biosensors and its impact on agribusiness and environmental management are discussed.
MeSH term(s)	Humans ; Ecosystem ; Fertilizers/analysis ; Agriculture/methods ; Soil ; Plants
Chemical Substances	Fertilizers ; Soil
Language	English
Publishing date	2023-06-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116456
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Article ; Online: Exploring phytochemical composition, photocatalytic, antibacterial, and antifungal efficacies of Au NPs supported by Cymbopogon flexuosus essential oil.

Pathania, Diksha / Sharma, Mamta / Thakur, Pankaj / Chaudhary, Vishal / Kaushik, Ajeet / Furukawa, Hidemitsu / Khosla, Ajit

Scientific reports

2022 Volume 12, Issue 1, Page(s) 14249

Abstract: Biofabrication of gold nanoparticles (AuNPs) using the aromatic essential oils is highlighted due to its simple, economical, low toxicity, and eco-friendly nature. Essential oil of Cymbopogon flexuosus (CF), an economically valuable medicinal plant, ... ...

Abstract	Biofabrication of gold nanoparticles (AuNPs) using the aromatic essential oils is highlighted due to its simple, economical, low toxicity, and eco-friendly nature. Essential oil of Cymbopogon flexuosus (CF), an economically valuable medicinal plant, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. For the first time, this research accounts for the biosynthesis, physicochemical, photocatalytic, antifungal, antibacterial properties of biogenic AuNPs, fabricated using CF essential oil collected from different altitudes (S1-Palampur, S2-Haryana, S3-Dehradun). The altitudinal disparity in the phytochemical composition of essential oils is highlighted. The average crystallite size ranged from 10 to 32 nm and was influenced by CF samples used in the synthesis. The spectroscopic outcomes revealed the involvement of bioactive reagents from CF essential oil in the fabrication and stabilization of AuNPs. The fabricated AuNPs exhibited excellent antimicrobial activities against all tested strains (Staphyloccucs aureus, Escherichia coli, Fusarium oxysporum), showing their efficacy as an antimicrobial agent to treat infectious diseases. Moreover, AuNPs exhibited excellent photocatalytic efficacy of around 91.8% for the degradation of methylene blue under exposure of direct sunlight for 3 h without the assistance of an external reducing agent. The outcomes highlight a potential economic and environmentally friendly strategy to fabricate biogenic AuNPs for diversified industrial applications where antimicrobial and photocatalytic efficacies are the key requirements.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Antifungal Agents ; Cymbopogon/chemistry ; Escherichia coli ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Microbial Sensitivity Tests ; Oils, Volatile/chemistry ; Phytochemicals
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Antifungal Agents ; Oils, Volatile ; Phytochemicals ; Gold (7440-57-5)
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-15899-9
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Article ; Online: Agro-waste to sustainable energy: A green strategy of converting agricultural waste to nano-enabled energy applications.

Sonu / Rani, Gokana Mohana / Pathania, Diksha / Abhimanyu / Umapathi, Reddicherla / Rustagi, Sarvesh / Huh, Yun Suk / Gupta, Vijai Kumar / Kaushik, Ajeet / Chaudhary, Vishal

The Science of the total environment

2023 Volume 875, Page(s) 162667

Abstract: The rising demands of the growing population have raised two significant global challenges viz. energy crisis and solid-waste management, ultimately leading to environmental deterioration. Agricultural waste (agro-waste) contributes to a large amount of ... ...

Abstract	The rising demands of the growing population have raised two significant global challenges viz. energy crisis and solid-waste management, ultimately leading to environmental deterioration. Agricultural waste (agro-waste) contributes to a large amount of globally produced solid waste, contaminating the environment, and raising human-health issues on improper management. It is essential for a circular economy to meet sustainable development goals and to design strategies to convert agro-waste into energy using nanotechnology-based processing strategies, by addressing the two significant challenges. This review illustrates the nano-strategic aspects of state-of-the-art agro-waste applications for energy harvesting and storage. It details the fundamentals related to converting agro-waste into energy resources in the form of green nanomaterials, biofuels, biogas, thermal energy, solar energy, triboelectricity, green hydrogen, and energy storage modules in supercapacitors and batteries. Besides, it highlights the challenges associated with agro-waste-to-green energy modules with their possible alternate solutions and advanced prospects. This comprehensive review will serve as a fundamental structure to guide future research on smart agro-waste management and nanotechnological innovations dedicated to its utilization for green energy applications without harming the environment. The nanomaterials assisted generation and storage of energy from agro-waste is touted to be the near-future of smart solid-waste management strategy for green and circular economy.
Language	English
Publishing date	2023-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162667
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Article ; Online: Exploring phytochemical composition, photocatalytic, antibacterial, and antifungal efficacies of Au NPs supported by Cymbopogon flexuosus essential oil

Diksha Pathania / Mamta Sharma / Pankaj Thakur / Vishal Chaudhary / Ajeet Kaushik / Hidemitsu Furukawa / Ajit Khosla

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Biofabrication of gold nanoparticles (AuNPs) using the aromatic essential oils is highlighted due to its simple, economical, low toxicity, and eco-friendly nature. Essential oil of Cymbopogon flexuosus (CF), an economically valuable medicinal ... ...

Abstract	Abstract Biofabrication of gold nanoparticles (AuNPs) using the aromatic essential oils is highlighted due to its simple, economical, low toxicity, and eco-friendly nature. Essential oil of Cymbopogon flexuosus (CF), an economically valuable medicinal plant, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. For the first time, this research accounts for the biosynthesis, physicochemical, photocatalytic, antifungal, antibacterial properties of biogenic AuNPs, fabricated using CF essential oil collected from different altitudes (S1-Palampur, S2-Haryana, S3-Dehradun). The altitudinal disparity in the phytochemical composition of essential oils is highlighted. The average crystallite size ranged from 10 to 32 nm and was influenced by CF samples used in the synthesis. The spectroscopic outcomes revealed the involvement of bioactive reagents from CF essential oil in the fabrication and stabilization of AuNPs. The fabricated AuNPs exhibited excellent antimicrobial activities against all tested strains (Staphyloccucs aureus, Escherichia coli, Fusarium oxysporum), showing their efficacy as an antimicrobial agent to treat infectious diseases. Moreover, AuNPs exhibited excellent photocatalytic efficacy of around 91.8% for the degradation of methylene blue under exposure of direct sunlight for 3 h without the assistance of an external reducing agent. The outcomes highlight a potential economic and environmentally friendly strategy to fabricate biogenic AuNPs for diversified industrial applications where antimicrobial and photocatalytic efficacies are the key requirements.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Panorama of biogenic nano-fertilizers: A road to sustainable agriculture

Jha, Ayush / Pathania, Diksha / Sonu / Damathia, Bhavna / Raizada, Pankaj / Rustagi, Sarvesh / Singh, Pardeep / Rani, Gokana Mohana / Chaudhary, Vishal

Environmental Research. 2023 Oct., v. 235 p.116456-

2023

Abstract	The ever-increasing demand for food from the growing population has augmented the consumption of fertilizers in global agricultural practices. However, the excessive usage of chemical fertilizers with poor efficacy is drastically deteriorating ecosystem health through the degradation of soil fertility by diminishing soil microflora, environment contamination, and human health by inducing chemical remnants to the food chain. These challenges have been addressed by the integration of nanotechnological and biotechnological approaches resulting in nano-enabled biogenic fertilizers (NBF), which have revolutionized agriculture sector and food production. This review critically details the state-of-the-art NBF production, types, and mechanism involved in cultivating crop productivity/quality with insights into genetic, physiological, morphological, microbiological, and physiochemical attributes. Besides, it explores the associated challenges and future routes to promote the adoption of NBF for intelligent and sustainable agriculture. Furthermore, diverse applications of nanotechnology in precision agriculture including plant biosensors and its impact on agribusiness and environmental management are discussed.
Keywords	agribusiness ; agricultural industry ; biosensors ; environmental health ; environmental management ; food chain ; food production ; human health ; nanotechnology ; precision agriculture ; research ; soil fertility ; soil microorganisms ; sustainable agriculture ; Nano-fertilizers ; Smart agriculture ; Sustainability ; Environmental toxicology ; Biogenic nanomaterials
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116456
Database	NAL-Catalogue (AGRICOLA)

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Article: Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors.

Bhardwaj, Nivedita / Choudhary, Diksha / Pathania, Akashdeep / Baranwal, Somesh / Kumar, Pradeep

Turkish journal of chemistry

2020 Volume 44, Issue 6, Page(s) 1623–1641

Abstract: Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion ...

Abstract	Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs). Eleven compounds were synthesized and characterized by 1H and 13C NMR and mass spectrophotometry. The synthesized compounds were also docked on an HIV reverse transcriptase binding site (PDB: 4I2P); most of these compounds showed good binding interactions with the active domain of the receptor. Most of the compounds displayed a docking score higher than those of standard drugs. Among the synthesized quinoline derivatives, compound
Language	English
Publishing date	2020-12-16
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046471-X
ISSN	1303-6130 ; 1300-0527
ISSN (online)	1303-6130
ISSN	1300-0527
DOI	10.3906/kim-2004-14
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Essential oil-mediated biocompatible magnesium nanoparticles with enhanced antibacterial, antifungal, and photocatalytic efficacies.

Pathania, Diksha / Kumar, Sunil / Thakur, Pankaj / Chaudhary, Vishal / Kaushik, Ajeet / Varma, Rajender S / Furukawa, Hidemitsu / Sharma, Mamta / Khosla, Ajit

Scientific reports

2022 Volume 12, Issue 1, Page(s) 11431

Abstract: Emergent application of antimicrobial strategies as symptomatic treatment in coronavirus disease (COVID-19) and linkage of severe acute respiratory syndrome coronavirus2 with microbial infections, has created colossal demand for antimicrobials. For the ... ...

Abstract	Emergent application of antimicrobial strategies as symptomatic treatment in coronavirus disease (COVID-19) and linkage of severe acute respiratory syndrome coronavirus2 with microbial infections, has created colossal demand for antimicrobials. For the first time, this communication explore the physicochemical, antifungal, antibacterial, and photocatalytic properties of biogenic magnesium nanoparticles (MgNPs), synthesized using essential oil of Cymbopogon flexuosus's as an efficient multifunctional reducing and stabilizing/capping reagent. It is observed that MgNPs (ranging in size: 8-16 nm) of varying phytochemical compositions (MgS1, MgS2, MgS3) exhibited various useful physicochemical, antimicrobial, and photocatalytic properties. FTIR outcomes highlight the functional biomolecules-assisted reduction of Mg from Mg
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Antifungal Agents/pharmacology ; COVID-19/drug therapy ; Escherichia coli ; Humans ; Magnesium ; Nanoparticles ; Oils, Volatile/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Oils, Volatile ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-14984-3
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