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  1. Article ; Online: For a dementia diagnosis, clinical acumen must precede biomarkers.

    Knopman, David S

    The Lancet. Neurology

    2024  Volume 23, Issue 3, Page(s) 225–226

    MeSH term(s) Humans ; Dementia/diagnosis ; Diagnosis, Differential ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(24)00021-8
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  2. Article ; Online: Lecanemab reduces brain amyloid-β and delays cognitive worsening.

    Knopman, David S

    Cell reports. Medicine

    2023  Volume 4, Issue 3, Page(s) 100982

    Abstract: Lecanemab cleared amyloid-β in two-thirds and reduced the rate of cognitive and functional worsening in people with mild cognitive impairment and mild dementia due to Alzheimer disease in an 18-month double-blinded randomized placebo-controlled trial ... ...

    Abstract Lecanemab cleared amyloid-β in two-thirds and reduced the rate of cognitive and functional worsening in people with mild cognitive impairment and mild dementia due to Alzheimer disease in an 18-month double-blinded randomized placebo-controlled trial reported by van Dyck et al.
    MeSH term(s) Humans ; Alzheimer Disease ; Amyloid beta-Peptides/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Cognition ; Randomized Controlled Trials as Topic
    Chemical Substances Amyloid beta-Peptides ; lecanemab (12PYH0FTU9)
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.100982
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  3. Article ; Online: Can CSF Biomarkers Decode Contributions of Combined Aβ Plaque, Tau Tangle, and α-Synuclein Pathology?

    Knopman, David S

    Neurology

    2022  Volume 99, Issue 20, Page(s) 877–878

    MeSH term(s) Humans ; alpha-Synuclein ; Biomarkers ; Parkinson Disease ; Synucleinopathies ; tau Proteins ; Amyloid beta-Peptides ; Peptide Fragments ; Alzheimer Disease
    Chemical Substances alpha-Synuclein ; Biomarkers ; tau Proteins ; Amyloid beta-Peptides ; Peptide Fragments
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201287
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  4. Article ; Online: Young-Onset Dementia-New Insights for an Underappreciated Problem.

    Knopman, David S

    JAMA neurology

    2021  Volume 78, Issue 9, Page(s) 1055–1056

    MeSH term(s) Age of Onset ; Dementia/epidemiology ; Humans
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2021.1760
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  5. Article ; Online: Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudoatrophy?

    Barkhof, Frederik / Knopman, David S

    Neurology

    2023  Volume 100, Issue 20, Page(s) 941–942

    MeSH term(s) Humans ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy ; Brain/diagnostic imaging ; Brain/metabolism ; Head
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207268
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  6. Article ; Online: Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?

    Knopman, David S / Hershey, Linda

    Neurology

    2023  Volume 101, Issue 14, Page(s) 610–620

    Abstract: The amyloid cascade model of the pathogenesis of Alzheimer disease (AD) is well supported in observational studies. Its therapeutic corollary asserts that removal of amyloid-β peptide ("amyloid") would provide clinical benefits. After 2 decades of ... ...

    Abstract The amyloid cascade model of the pathogenesis of Alzheimer disease (AD) is well supported in observational studies. Its therapeutic corollary asserts that removal of amyloid-β peptide ("amyloid") would provide clinical benefits. After 2 decades of pursuing the strategy of amyloid removal without success, clinical trials of the antiamyloid monoclonal antibody (AAMA) donanemab and a phase 3 clinical trial of lecanemab have reported clinical benefits linked to amyloid removal. Lecanemab (trade name, Leqembi) is the first with published phase 3 trial results. When administered through IV every 2 weeks to patients with elevated brain amyloid and mild cognitive impairment or mild dementia, lecanemab delayed cognitive and functional worsening by approximately 5 months in an 18-month double-blind, placebo-controlled trial. The trial was well conducted, and the results favoring lecanemab were internally consistent. The demonstration that lecanemab treatment delayed clinical progression in persons with mild symptoms due to AD is a major conceptual achievement, but a better appreciation of the magnitude and durability of benefits for individual patients will require extended observations from clinical practice settings. Amyloid-related imaging abnormalities (ARIA) that were largely asymptomatic occurred in approximately 20%, slightly more than half of which were attributable to treatment and the rest to underlying AD-related amyloid angiopathy. Persons who were homozygous for the
    MeSH term(s) Humans ; Alzheimer Disease/pathology ; Cerebral Amyloid Angiopathy/pathology ; Amyloid beta-Peptides ; Antibodies, Monoclonal/therapeutic use ; Patient Care
    Chemical Substances lecanemab (12PYH0FTU9) ; Amyloid beta-Peptides ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207438
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  7. Article ; Online: The Enigma of Decreasing Dementia Incidence.

    Knopman, David S

    JAMA network open

    2020  Volume 3, Issue 7, Page(s) e2011199

    MeSH term(s) Adult ; Dementia/epidemiology ; Dementia/prevention & control ; Female ; Humans ; Incidence ; Parturition ; Pregnancy ; Socioeconomic Factors
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2020.11199
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  8. Article ; Online: Hypertension and Racial Differences in Dementia Reveal a Strategy for Risk Reduction in All Races.

    Knopman, David S / Taler, Sandra J

    American journal of hypertension

    2022  Volume 35, Issue 8, Page(s) 691–693

    MeSH term(s) Alzheimer Disease ; Humans ; Hypertension/diagnosis ; Race Factors ; Racial Groups ; Risk Reduction Behavior
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpac073
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  9. Article ; Online: Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease.

    Nguyen, Hai V / Mital, Shweta / Knopman, David S / Alexander, G Caleb

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209218

    Abstract: Background and objectives: Little is known regarding the cost-effectiveness of lecanemab (Leqembi), a monoclonal antibody approved by the US Food and Drug Administration in January 2023 for the treatment of mild cognitive impairment (MCI) or mild ... ...

    Abstract Background and objectives: Little is known regarding the cost-effectiveness of lecanemab (Leqembi), a monoclonal antibody approved by the US Food and Drug Administration in January 2023 for the treatment of mild cognitive impairment (MCI) or mild dementia due to Alzheimer disease (AD). This study aims to quantify the cost-effectiveness of lecanemab and how it varies based on the accuracy of AD testing and individuals'
    Methods: Seven alternative test-treat-target strategies defined by combinations of testing approaches (PET, CSF, or plasma assay), treatment choices (standard of care [SoC] alone or lecanemab in addition to SoC), and targeting strategies (targeting
    Results: Among the 7 test-treat-target strategies, SoC alone was the optimal strategy from a cost-effectiveness perspective. Neither targeted lecanemab treatment nor treatment unrestricted by
    Discussion: Neither targeted lecanemab treatment nor treatment unrestricted by
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Alzheimer Disease/drug therapy ; Cost-Benefit Analysis ; Apolipoprotein E4/genetics ; Dementia/diagnosis ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/diagnosis ; Antibodies, Monoclonal, Humanized
    Chemical Substances lecanemab (12PYH0FTU9) ; Apolipoprotein E4 ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209218
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  10. Article ; Online: Lowering of Amyloid-Beta by β-Secretase Inhibitors - Some Informative Failures.

    Knopman, David S

    The New England journal of medicine

    2019  Volume 380, Issue 15, Page(s) 1476–1478

    MeSH term(s) Alzheimer Disease ; Amyloid Precursor Protein Secretases ; Cyclic S-Oxides ; Humans ; Thiadiazines
    Chemical Substances Cyclic S-Oxides ; Thiadiazines ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; verubecestat (J1I0P6WT7T)
    Language English
    Publishing date 2019-04-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1903193
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