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Article ; Online: Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization.

Li, Fei / Liu, Tingting / Liu, Xia / Han, Cuiyan / Li, Lili / Zhang, Qi / Sui, Xiaoyu

International journal of biological macromolecules

2024 Volume 260, Issue Pt 2, Page(s) 129682

Abstract: Impaired macrophage polarization or the high levels of reactive oxygen species (ROS) produced by high glucose conditions and bacterial infection are the primary factors that make healing diabetic wounds difficult. Here, we prepared an OGLP-CMC/SA ... ...

Abstract	Impaired macrophage polarization or the high levels of reactive oxygen species (ROS) produced by high glucose conditions and bacterial infection are the primary factors that make healing diabetic wounds difficult. Here, we prepared an OGLP-CMC/SA hydrogel with a double network structure that was synthesized with oxidized Ganoderma lucidum polysaccharide (OGLP), sodium alginate (SA) and carboxymethyl chitosan (CMC) as the matrix. The results showed that the OGLP-CMC/SA hydrogel had good mechanical properties, tissue adhesion, oxidation resistance and biocompatibility. Moreover, the hydrogel could effectively improve the proliferation and migration of fibroblasts, also can enhance antibacterial properties. We found that the OGLP-CMC/SA hydrogel can promote the polarization of M1 macrophages towards the M2 and decrease intracellular ROS levels, effectively reduce the inflammatory response, and promote epidermal growth, the development of skin appendages and collagen deposition in wounds, which hasten diabetic wound healing. Therefore, using this versatile biologically active new hydrogel network constructed with OGLP provides a promising therapeutic strategy for chronic diabetic wound repair.
MeSH term(s)	Hydrogels ; Reishi ; Reactive Oxygen Species ; Polysaccharides/pharmacology ; Alginates/pharmacology ; Macrophages ; Wound Healing ; Diabetes Mellitus
Chemical Substances	Hydrogels ; Reactive Oxygen Species ; Polysaccharides ; Alginates
Language	English
Publishing date	2024-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129682
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Article ; Online: An integrated strategy for the discovery of quality marker of Dactylicapnos scandens based on phytochemical analysis, network pharmacology and activity screening.

Jiang, Hui / Hou, Tao / Cao, Cuiyan / Liu, Yanfang / Xu, Qing / Wang, Chaoran / Wang, Jixia / Xue, Xingya / Liang, Xinmiao

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115969

Abstract: Dactylicapnos scandens (D. scandens) is an ethnic medicine commonly used for the treatment of analgesia. In this study, an integrated strategy was proposed for the quality evaluation of D. scandens based on "phytochemistry-network pharmacology- ... ...

Abstract	Dactylicapnos scandens (D. scandens) is an ethnic medicine commonly used for the treatment of analgesia. In this study, an integrated strategy was proposed for the quality evaluation of D. scandens based on "phytochemistry-network pharmacology-effectiveness-specificity" to discover and determine the quality marker (Q-marker) related to analgesia. First, phytochemical analysis was conducted using UPLC-Q-TOF-MS/MS and a self-built compound library, and 19 components were identified in D. scandens extracts. Next, the "compounds-targets" network was constructed to predict the relevant targets and compounds related to analgesia. Then, the analgesic activity of related compounds was verified through dynamic mass redistribution (DMR) assays on D2 and Mu receptors, and 5 components showed D2 antagonistic activity with IC
MeSH term(s)	Tandem Mass Spectrometry ; Network Pharmacology ; Medicine, Chinese Traditional ; Drugs, Chinese Herbal/chemistry ; Phytochemicals/pharmacology
Chemical Substances	Drugs, Chinese Herbal ; Phytochemicals
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115969
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Article ; Online: Application of chromatography in purification and structural analysis of natural polysaccharides: A review.

Zheng, Yi / Yan, Jingyu / Cao, Cuiyan / Liu, Yanfang / Yu, Dongping / Liang, Xinmiao

Journal of separation science

2023 Volume 46, Issue 18, Page(s) e2300368

Abstract: Polysaccharides are widely distributed in natural sources from monocytic microorganisms to higher animals, and are found in a variety of biological activities in recent decades. Natural polysaccharides have the characteristics of large molecular weight, ... ...

Abstract	Polysaccharides are widely distributed in natural sources from monocytic microorganisms to higher animals, and are found in a variety of biological activities in recent decades. Natural polysaccharides have the characteristics of large molecular weight, diverse composition, and complex structure, so their purification and structural analysis are difficult issues in research. Chromatography as a powerful separation technique, plays an irreplaceable role in the separation and structural analysis of natural polysaccharides, especially in the purification of polysaccharides, the separation of hydrolysates, and the analysis of monosaccharide composition. The separation mechanisms and application of different chromatographic methods in the studies of polysaccharides were summarized in this review. Moreover, the advantages and drawbacks of various chromatography methods were discussed as well.
MeSH term(s)	Animals ; Chromatography ; Molecular Weight ; Monosaccharides ; Polysaccharides
Chemical Substances	Monosaccharides ; Polysaccharides
Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202300368
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Article ; Online: Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity.

Yao, Cong / Hao, Shuichu / Zhang, Chun / Liu, Li / Jia, Yumeng / Meng, Peilin / Wu, Cuiyan / Guo, Xiong

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 , Page(s) 114630

Abstract: In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. ... ...

Abstract	In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone structure, we employed biomechanical analysis, micro-computed tomography (micro-CT), and transmission electron microscopy.Our findings unveiled a significant revelation: the mice exhibited a dose-dependent decrease in body weight upon exposure to individual mycotoxins, while the combined use of these toxins manifested an atypical antagonistic effect. Furthermore, we observed variations in the levels of calcium, phosphorus, and vitamin D, as well as adjustments in the activities of osteoblasts and osteoclasts, all intricately linked to the dosage and ratio of the toxins. Alterations in biomechanical properties were also noted to correlate with the dosage and combination of toxins. Analyses via micro-CT and transmission electron microscopy further corroborated the substantial impact of toxin dosage and combinations on both cortical and trabecular bone structures.In summation, our research unequivocally demonstrates the dose- and ratio-dependent detrimental effects of DON and T-2 mycotoxins on the growth and structural integrity of murine femurs. These insights accentuate the importance of a profound understanding of the potential risks these toxins pose to bone health, offering pivotal guidance for future toxicological research and public health preventative strategies.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114630
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Article ; Online: Consuming intracellular glucose and regulating the levels of O

Gui, Jialing / Chen, Haoyu / Liu, Jing / Liu, Yani / Wu, Cuiyan / Zhu, Xiaohua / Wei, Mingjie / Liu, Meiling / Zhang, Youyu / Yao, Shouzhuo

Journal of colloid and interface science

2023 Volume 651, Page(s) 191–199

Abstract: Imbalances in the intracellular environment caused by high levels of glucose, ... ...

Abstract	Imbalances in the intracellular environment caused by high levels of glucose, H
MeSH term(s)	Humans ; Glucose ; Hydrogen Peroxide ; Glucose Oxidase/chemistry ; Neoplasms/therapy ; Silicon Dioxide/chemistry ; Catalysis ; Cell Line, Tumor
Chemical Substances	Glucose (IY9XDZ35W2) ; Hydrogen Peroxide (BBX060AN9V) ; Glucose Oxidase (EC 1.1.3.4) ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.07.190
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Article ; Online: Critical influence of vegetation response to rising CO

Liu, Cuiyan / Feng, Shuyun / Zhang, Qiang / Hu, Jiaxin / Ma, Ning / Ci, Hui / Kong, Dongdong / Gu, Xihui

The Science of the total environment

2023 Volume 906, Page(s) 167717

Abstract: Satellite observations show widespread greening over the global land, which potentially contributes to runoff (R) changes. However, there are discrepancies in the impacts of vegetation greening on R under elevated atmospheric ... ...

Abstract	Satellite observations show widespread greening over the global land, which potentially contributes to runoff (R) changes. However, there are discrepancies in the impacts of vegetation greening on R under elevated atmospheric CO
MeSH term(s)	Carbon Dioxide/analysis ; Climate Change ; Climate Models
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167717
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Article ; Online: Identification and Verification of Hub Mitochondrial Dysfunction Genes in Osteoarthritis Based on Bioinformatics Analysis.

Niu, Hui / Deng, Xingxing / Zhang, Qian / Zhao, Yijun / Wen, Jinfeng / Li, Wenyu / Liu, Huan / Guo, Xiong / Wu, Cuiyan

Journal of immunology research

2024 Volume 2024, Page(s) 6822664

Abstract: Objective: Age-related mitochondrial dysfunction and associated oxidative stress may contribute to the development of osteoarthritis. The aim of this study was to identify hub genes associated with mitochondrial dysfunction in osteoarthritis (OA) ... ...

Abstract	Objective: Age-related mitochondrial dysfunction and associated oxidative stress may contribute to the development of osteoarthritis. The aim of this study was to identify hub genes associated with mitochondrial dysfunction in osteoarthritis (OA) patients, helping predict the risk of OA, and revealing the mechanism of OA progression. Methods: OA expression data and mitochondrial dysfunction genes were downloaded from GEO (GSE55235, GSE82107, and GSE114007) and GeneCard databases. The differentially expressed mitochondrial dysfunction genes (DEMDFGs) between OA and control samples were screened. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes pathways were analyzed for DEMDFGs. The hub genes were determined by WGCNA and LASSO regression analysis. ROC curves manifested the diagnostic efficacy of each hub gene. A nomogram model was constructed and validated to predict OA risk. The expression of hub genes in OA and normal chondrocytes was verified by external datasets, qRT-PCR and western blotting. Results: A total of 31 DEMDFGs were identified, with 15 genes upregulated and 16 genes downregulated. GO functional enrichment analysis revealed that DEMDFGs were enriched in biological processes related to energy metabolism and cellular respiration. By employing weighted gene coexpression network analysis, we identified four distinct coexpression modules, among which the blue module exhibited the strongest correlation with OA. The intersection between DEMDFGs and this module yielded eight candidate genes. After LASSO analysis of the data, four hub genes (ACADL, CYBA, SLC19A2, and UCP2) were identified as potential biomarkers for OA. The expression levels of these four genes were externally validated in the GSE114007 dataset. And the biologically differential expression of these four genes has been verified in OA and normal chondrocytes. Moreover, the four hub genes had good sensitivity and specificity by ROC curve analysis, and the risk model constructed with these four genes showed promising performance. In conclusion, our study may provide novel mitochondrial dysfunction hub genes with potential clinical applications for understanding the pathology, diagnosis, and treatment of OA.
MeSH term(s)	Humans ; Blotting, Western ; Chondrocytes ; Computational Biology ; Osteoarthritis/diagnosis ; Osteoarthritis/genetics ; Mitochondrial Diseases ; Membrane Transport Proteins
Chemical Substances	SLC19A2 protein, human ; Membrane Transport Proteins
Language	English
Publishing date	2024-01-23
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2024/6822664
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Article ; Online: Crosstalk between Extracellular Matrix Stiffness and ROS Drives Endometrial Repair via the HIF-1α/YAP Axis during Menstruation.

Zhang, Tao / Wang, Yan / Wang, Yingnan / Liu, Cuiyan / Han, Chunyang

Cells

2022 Volume 11, Issue 19

Abstract: Although the menstrual cycle driven by sex steroid hormones is an uncomplicated physiological process, it is important for female health, fertility and regenerative biology. However, our understanding of this unique type of tissue homeostasis remains ... ...

Abstract	Although the menstrual cycle driven by sex steroid hormones is an uncomplicated physiological process, it is important for female health, fertility and regenerative biology. However, our understanding of this unique type of tissue homeostasis remains unclear. Here, we examined the biological effects of mechanical force by evaluating the changing trend of extracellular matrix (ECM) stiffness, and the results suggested that ECM stiffness was reduced and that breaking of mechanotransduction delayed endometrium repair in a mouse model of simulated menses. We constructed an ECM stiffness interference model in vitro to explain the mechanical force conduction mechanism during endometrial regeneration. We discovered that ECM stiffness increased the expression and nuclear transfer of YAP, which improved the creation of a microenvironment, in a manner that induced proliferation and angiogenesis for endometrial repair by activating YAP. In addition, we observed that physiological endometrial hypoxia occurs during the menstrual cycle and that the expression of HIF-1α was increased. Mechanistically, in addition to the classical F-actin/YAP pathway, we also found that the ROS/HIF-1α/YAP axis was involved in the transmission of mechanical signals. This study provides novel insights into the essential menstrual cycle and presents an effective, nonhormonal treatment for menstrual disorders.
MeSH term(s)	Actins/metabolism ; Animals ; Endometrium/metabolism ; Extracellular Matrix/metabolism ; Female ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mechanotransduction, Cellular ; Menstruation ; Mice ; Reactive Oxygen Species/metabolism ; YAP-Signaling Proteins/metabolism
Chemical Substances	Actins ; Hif1a protein, mouse ; Hypoxia-Inducible Factor 1, alpha Subunit ; Reactive Oxygen Species ; YAP-Signaling Proteins ; Yap1 protein, mouse
Language	English
Publishing date	2022-10-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11193162
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Article ; Online: Attribution of NDVI Dynamics over the Globe from 1982 to 2015

Cuiyan Liu / Jianyu Liu / Qiang Zhang / Hui Ci / Xihui Gu / Aminjon Gulakhmadov

Remote Sensing, Vol 14, Iss 2706, p

2022 Volume 2706

Abstract: Satellite remote sensing has witnessed a global widespread vegetation greening since the 1980s. However, reliable observation-based quantitative knowledge on global greening remains obscure due to uncertainties in model simulations and the contribution ... ...

Abstract	Satellite remote sensing has witnessed a global widespread vegetation greening since the 1980s. However, reliable observation-based quantitative knowledge on global greening remains obscure due to uncertainties in model simulations and the contribution of natural variability is largely unknown. Here, we revisit the attribution of global vegetation changes using the Time Series Segment and Residual Trend (TSS-RESTREND) method. Results showed global vegetation significantly greening over 40.6% of the vegetated grids, whereas vegetation significantly browning over 11.6% of the vegetated grids. The attribution results based on the TSS-RESTREND method show that CO 2 fertilization (CO 2 ) plays an influential role in vegetation changes over 61.4% of the global vegetated areas, followed by land use (LU, 23.5%), climate change (CC, 7.3%), and climate variability (CV, 1.5%). The vegetation greening can be largely attributed to CO 2 fertilization while the vegetation browning is mainly caused by LU. Meanwhile, we also identify positive impacts of LU and CC on vegetation change in arid regions but negative impacts in humid regions. Our findings indicate spatial heterogeneity in causes behind global vegetation changes, providing more detailed references for global vegetation modeling.
Keywords	vegetation dynamics ; global greening ; observation-based attribution ; ecological modeling ; land use ; Science ; Q
Subject code	910
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors.

Liu, Ming / Li, Jihui / Liu, Wenqi / Yang, Ying / Zhang, Manman / Ye, Yuxin / Zhu, Wenning / Zhou, Cuiyan / Zhai, Hongbin / Xu, Zhengshuang / Zhang, Guoliang / Huang, Hao

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 41, Page(s) e202309657

Abstract: The main protease ( ... ...

Abstract	The main protease (M
Language	English
Publishing date	2023-09-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202309657
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