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  1. Article ; Online: Logical Inconsistencies with Expected Utility Theory May Align Better With Patient Preferences-A Response to Paulden et al.

    Basu, Anirban

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2023.12.016
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    Zs.A 5904: Show issues Location:
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  2. Article ; Online: Use of race in clinical algorithms.

    Basu, Anirban

    Science advances

    2023  Volume 9, Issue 21, Page(s) eadd2704

    Abstract: To answer whether patients' race belongs in clinical prediction algorithms, two types of prediction models are considered: (i) diagnostic, which describes a patient's clinical characteristics, and (ii) prognostic, which forecasts a clinical risk or ... ...

    Abstract To answer whether patients' race belongs in clinical prediction algorithms, two types of prediction models are considered: (i) diagnostic, which describes a patient's clinical characteristics, and (ii) prognostic, which forecasts a clinical risk or treatment effect that a patient is likely to experience in the future. The ex ante equality of opportunity framework is used, where specific health outcomes, which are prediction targets, evolve dynamically due to the effects of legacy levels of outcomes, circumstances, and current individual efforts. In practical settings, this study shows that failure to include race corrections will propagate systemic inequities and discrimination in any diagnostic model and specific prognostic models that inform decisions by invoking an ex ante compensation principle. In contrast, including race in prognostic models that inform resource allocations following an ex ante reward principle can compromise the equality of opportunities for patients from different races. Simulation results demonstrate these arguments.
    MeSH term(s) Humans ; Computer Simulation ; Reward
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add2704
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  3. Book ; Online ; E-Book: Inflammation: the Common Link in Brain Pathologies

    Jana, Nihar / Basu, Anirban / Tandon, Prakash Narain

    2016  

    Author's details Nihar Jana, Anirban Basu, Prakash Narain Tandon editors
    Keywords Medicine ; Immunology ; Neurochemistry ; Neurology ; Neurobiology
    Subject code 612.8042
    Language English
    Size 1 Online-Ressource (X, 345 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019442009
    ISBN 978-981-10-1711-7 ; 9789811017100 ; 981-10-1711-5 ; 9811017107
    DOI 10.1007/978-981-10-1711-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: COVID-19 Infection Fatality Rates: The Author Replies.

    Basu, Anirban

    Health affairs (Project Hope)

    2020  Volume 39, Issue 8, Page(s) 1462–1463

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.2020.01182
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  5. Article ; Online: A welfare-theoretic model consistent with the practice of cost-effectiveness analysis and its implications.

    Basu, Anirban

    Journal of health economics

    2020  Volume 70, Page(s) 102287

    Abstract: I look at three debates in the health economics literature in the context of cost-effectiveness analysis (CEA): 1) inclusion of future costs, 2) discounting, and 3) consistency with a welfare-economic perspective. These debates thus far have been studied ...

    Abstract I look at three debates in the health economics literature in the context of cost-effectiveness analysis (CEA): 1) inclusion of future costs, 2) discounting, and 3) consistency with a welfare-economic perspective. These debates thus far have been studied in isolation leading to confusion and lingering questions. I look at these three debates holistically and present a welfare theoretic model that is consistent with the practice of CEA and can help inform all of these three debates. It shows rationales for the recommendations of the Second Panel and clarifies some nuanced implications for the practice of CEA when taking a societal perspective in the context of distributional CEA and multi-sectorial budgets.
    Language English
    Publishing date 2020-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 625797-5
    ISSN 1879-1646 ; 0167-6296
    ISSN (online) 1879-1646
    ISSN 0167-6296
    DOI 10.1016/j.jhealeco.2020.102287
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  6. Article ; Online: Estimating The Infection Fatality Rate Among Symptomatic COVID-19 Cases In The United States.

    Basu, Anirban

    Health affairs (Project Hope)

    2020  Volume 39, Issue 7, Page(s) 1229–1236

    Abstract: Knowing the infection fatality rate (IFR) of novel coronavirus (SARS-CoV-2) infections is essential for the fight against the coronavirus disease (COVID-19) pandemic. Using data through April 20, 2020, I fit a statistical model to COVID-19 case fatality ... ...

    Abstract Knowing the infection fatality rate (IFR) of novel coronavirus (SARS-CoV-2) infections is essential for the fight against the coronavirus disease (COVID-19) pandemic. Using data through April 20, 2020, I fit a statistical model to COVID-19 case fatality rates over time at the US county level to estimate the COVID-19 IFR among symptomatic cases (IFR-S) as time goes to infinity. The IFR-S in the US was estimated to be 1.3 percent. County-specific rates varied from 0.5 percent to 3.6 percent. The overall IFR for COVID-19 should be lower when I account for cases where patients are asymptomatic and recover without symptoms. When used with other estimating approaches, my model and estimates can help disease and policy modelers obtain more accurate predictions for the epidemiology of the disease and the impact of various policy levers to contain the pandemic. The model could also be used with future pandemics to get an early sense of the magnitude of symptomatic infection at the population level before other direct estimates are available. Substantial variation across patient demographics likely exists and should be the focus of future studies.
    MeSH term(s) COVID-19 ; Cause of Death ; Coronavirus Infections/epidemiology ; Databases, Factual ; Female ; Humans ; Incidence ; Male ; Models, Statistical ; Mortality ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Predictive Value of Tests ; Severity of Illness Index ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.2020.00455
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    Zs.A 2118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Associating Health-Related Quality-of-Life Score with Time Uses to Inform Productivity Measures in Cost-Effectiveness Analysis.

    Jiao, Boshen / Basu, Anirban

    PharmacoEconomics

    2023  Volume 41, Issue 9, Page(s) 1065–1077

    Abstract: Background: The Second Panel on Cost Effectiveness in Health and Medicine recommended that cost-effectiveness analyses (CEA) explicitly incorporate the valuation of productive time from a societal perspective. We developed a new approach to capture ... ...

    Abstract Background: The Second Panel on Cost Effectiveness in Health and Medicine recommended that cost-effectiveness analyses (CEA) explicitly incorporate the valuation of productive time from a societal perspective. We developed a new approach to capture productivity impacts in CEA without direct evidence on these impacts by associating varying levels of health-related quality-of-life (HrQoL) score with different time uses in the United States.
    Methods: We conceptualized a framework that estimates the association between HrQoL score with productivity through time uses. We used the American Time-Use Survey (ATUS) from year 2012-2013, when data on a Well-Being Module (WBM) was additionally collected alongside ATUS. The WBM measured the quality of life (QoL) score using a visual analog scale. To operationalize our conceptual framework, we employed an econometric approach that addressed three technical issues in the observed data: (i) distinction between overall QoL and HrQoL, (ii) correlation across different categories of time use and the share structure of time-use data, and (iii) reverse causality between time uses and HrQoL score in a cross-sectional setting. Furthermore, we developed a metamodel-based algorithm to summarize the numerous estimates from the primary econometric model efficiently. Finally, we illustrated the use of our algorithm to calculate productivity and time spent seeking care costs in an empirical CEA of a prostate cancer treatment.
    Results: We provide the estimates of the metamodel algorithm. Incorporating these estimates into the empirical CEA reduced the incremental cost-effectiveness ratio by 27%.
    Conclusion: Our estimates can facilitate the inclusion of productivity and time spent seeking care in CEA as recommended by the Second Panel.
    MeSH term(s) Male ; Humans ; United States ; Quality of Life ; Cost-Effectiveness Analysis ; Cross-Sectional Studies ; Quality-Adjusted Life Years ; Cost-Benefit Analysis
    Language English
    Publishing date 2023-03-06
    Publishing country New Zealand
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-023-01246-x
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  8. Article ; Online: Interaction of food colorant indigo carmine with human and bovine serum albumins: A multispectroscopic, calorimetric, and theoretical investigation.

    Jana, Gouranga / Sing, Shukdeb / Das, Arindam / Basu, Anirban

    International journal of biological macromolecules

    2024  Volume 259, Issue Pt 1, Page(s) 129143

    Abstract: In this work we have studied the interaction of the food dye Indigo-Carmine (IndC) with the most studied model transport proteins i.e. human and bovine serum albumin (HSA & BSA). A multispectroscopic approach was used to analyze the details of the ... ...

    Abstract In this work we have studied the interaction of the food dye Indigo-Carmine (IndC) with the most studied model transport proteins i.e. human and bovine serum albumin (HSA & BSA). A multispectroscopic approach was used to analyze the details of the binding process. The intrinsic fluorescence of both the albumins was significantly quenched by IndC and the quenching was both static and dynamic in nature with the former being dominant. The HSA-lndC and BSA-IndC distance after complexation was determined by Förster resonance energy transfer (FRET) method which suggested efficient energy transfer from the albumins to IndC. Thermodynamics of serum protein-IndC complexation was estimated by isothermal titration calorimetry (ITC) which revealed that the binding was enthalpy driven. Circular dichroism (CD) and FTIR spectroscopy revealed that the binding of IndC induced secondary structural changes in both the serum proteins. Synchronous and 3D fluorescence spectroscopy revealed that the binding interaction caused microenvironmental changes of protein fluorophores. Molecular docking analysis suggested that hydrogen bonding and hydrophobic interactions are the major forces involved in the complexation process.
    MeSH term(s) Humans ; Indigo Carmine ; Molecular Docking Simulation ; Serum Albumin, Bovine/chemistry ; Food Coloring Agents ; Spectrometry, Fluorescence/methods ; Fluorescence Resonance Energy Transfer ; Circular Dichroism ; Thermodynamics ; Calorimetry ; Protein Binding ; Binding Sites
    Chemical Substances Indigo Carmine (D3741U8K7L) ; Serum Albumin, Bovine (27432CM55Q) ; Food Coloring Agents
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.129143
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  9. Article ; Online: Insights into the interaction and inhibitory action of palmatine on lysozyme fibrillogenesis: Spectroscopic and computational studies.

    Das, Arindam / Jana, Gouranga / Sing, Shukdeb / Basu, Anirban

    International journal of biological macromolecules

    2024  Volume 268, Issue Pt 1, Page(s) 131703

    Abstract: Interaction under amyloidogenic condition between naturally occurring protoberberine alkaloid palmatine and hen egg white lysozyme was executed by adopting spectrofluorometric and theoretical molecular docking and dynamic simulation analysis. In ... ...

    Abstract Interaction under amyloidogenic condition between naturally occurring protoberberine alkaloid palmatine and hen egg white lysozyme was executed by adopting spectrofluorometric and theoretical molecular docking and dynamic simulation analysis. In spetrofluorometric method, different types of experiments were performed to explore the overall mode and mechanism of interaction. Intrinsic fluorescence quenching of lysozyme (Trp residues) by palmatine showed effective binding interaction and also yielded different binding parameters like binding constant, quenching constant and number of binding sites. Synchronous fluorescence quenching and 3D fluorescence map revealed that palmatine was able to change the microenvironment of the interacting site. Fluorescence life time measurements strongly suggested that this interaction was basically static in nature. Molecular docking result matched with fluorimetric experimental data. Efficient drug like interaction of palmatine with lysozyme at low pH and high salt concentration prompted us to analyze its antifibrillation potential. Different assays and microscopic techniques were employed for detailed analysis of lysozyme amyloidosis.Thioflavin T(ThT) assay, Congo Red (CR) assay, 8-anilino-1-naphthalenesulfonic acid (ANS) assay, Nile Red (NR) assay, anisotropy and intrinsic fluorescence measurements confirmed that palmatine successfully retarded and reduced lysozyme fibrillation. Dynamic light scattering (DLS) and atomic force microscopy (AFM) further reiterated the excellent antiamyloidogenic potency of palmatine.
    Language English
    Publishing date 2024-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131703
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  10. Article ; Online: Regulation of Onecut2 by miR-9-5p in Japanese encephalitis virus infected neural stem/progenitor cells.

    Sharma, Shivangi / Majumdar, Atreye / Basu, Anirban

    Microbiology spectrum

    2024  Volume 12, Issue 3, Page(s) e0323823

    Abstract: Japanese encephalitis virus (JEV) is one of the major neurotropic viral infections that is known to dysregulate the homeostasis of neural stem/progenitor cells (NSPCs) and depletes the stem cell pool. NSPCs are multipotent stem cell population of the ... ...

    Abstract Japanese encephalitis virus (JEV) is one of the major neurotropic viral infections that is known to dysregulate the homeostasis of neural stem/progenitor cells (NSPCs) and depletes the stem cell pool. NSPCs are multipotent stem cell population of the central nervous system (CNS) which are known to play an important role in the repair of the CNS during insults/injury caused by several factors such as ischemia, neurological disorders, CNS infections, and so on. Viruses have evolved to utilize host factors for their own benefit and during JEV infection, host factors, including the non-coding RNAs such as miRNAs, are reported to be affected, thereby cellular processes regulated by the miRNAs exhibit perturbed functionality. Previous studies from our laboratory have demonstrated the role of JEV infection in dysregulating the function of neural stem cells (NSCs) by altering the cell fate and depleting the stem cell pool leading to a decline in stem cell function in CNS repair mechanism post-infection. JEV-induced alteration in miRNA expression in the NSCs is one of the major interest to us. In prior studies, we have observed an altered expression pattern of certain miRNAs following JEV infection. In this study, we have validated the role of JEV infection in NSCs in altering the expression of miR-9-5p, which is a known regulator of neurogenesis in NSCs. Furthermore, we have validated the interaction of this miRNA with its target, Onecut2 (OC2), in primary NSCs utilizing miRNA mimic and inhibitor transfection experiments. Our findings indicate a possible role of JEV mediated dysregulated interaction between miR-9-5p and its putative target OC2 in NSPCs.
    Importance: MicroRNAs have emerged as key disease pathogenic markers and potential therapeutic targets. In this study, we solidify this concept by studying a key miRNA, miR-9-5p, in Japanese encephalitis virus infection of neural stem/progenitor cells. miRNA target Onecut2 has a possible role in stem cell pool biology. Here, we show a possible mechanistic axis worth investing in neurotropic viral biology.
    MeSH term(s) Humans ; Encephalitis Virus, Japanese/genetics ; Encephalitis Virus, Japanese/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Encephalitis, Japanese/genetics ; Encephalitis, Japanese/pathology ; Cell Differentiation
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03238-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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