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  1. Article ; Online: A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging.

    Ke, Dan / Zhang, Han / Tian, Li-Ming / Han, Miao / Zhang, Chong / Tian, Dai-Zhi / Chen, Long / Zhan, Li-Rui / Zong, Shi-Qin / Zhang, Ping

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 10, Page(s) 4956–4964

    Abstract: ... and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.: Methods ... integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan ... showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group ...

    Abstract Objective: The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.
    Methods: The traditional Chinese medicine systems pharmacology database and analysis platform, and the traditional Chinese medicine integrated database, were used to screen the active ingredients and targets of Qibao Meiran Dan. The human gene database GeneCards and the gene database of the National Center for Biotechnology Information were jointly adopted to obtain skin aging-related target genes. The search tool for the retrieval of interacting genes/proteins (STRING) database was used for core analysis of protein-protein interaction.
    Results: In total, 72 effective active ingredients, 273 action targets, 234 skin aging target genes, and 64 intersecting core targets were identified. GO enrichment analysis provided 393 biological process entries, and the KEGG analysis was represented by the tumor necrosis factor (TNF) signaling pathway, where the core targets of TNF-α and matrix metalloproteinase-1 (MMP-1) were enriched. The experimental results showed that cell morphology was clearer and more refractive in the Qibao Meiran Dan group than in the model group.
    Conclusion: Qibao Meiran Dan may regulate oxidative stress injury and collagen metabolism by downregulating the expression of TNF-α and MMP-1, thus slowing skin aging.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Matrix Metalloproteinase 1/genetics ; Skin Aging ; Tumor Necrosis Factor-alpha ; Network Pharmacology
    Chemical Substances Drugs, Chinese Herbal ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14908
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  2. Article ; Online: Dan-shen Yin promotes bile acid metabolism and excretion to prevent atherosclerosis via activating FXR/BSEP signaling pathway.

    Sheng, Yingkun / Meng, Guibing / Zhang, Min / Chen, Xiaopeng / Chai, Xin / Yu, Haiyang / Han, Lifeng / Wang, Qilong / Wang, Yuefei / Jiang, Miaomiao

    Journal of ethnopharmacology

    2024  , Page(s) 118209

    Abstract: Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been ...

    Abstract Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been demonstrated to be effective in decreasing hyperlipidemia and preventing atherosclerosis (AS), but its mechanism remains unknown. We hypothesized that DSY activates farnesoid X receptor (FXR) to promote bile acid metabolism and excretion, thereby alleviating AS.
    Aim of the study: This study was designed to explore whether DSY reduces liver lipid accumulation and prevents AS by activating FXR and increasing cholesterol metabolism and bile acid excretion.
    Materials and methods: The comprehensive chemical characterization of DSY was analyzed by UHPLC-MS/MS. The AS models of ApoE
    Results: A total of 36 ingredients in DSY were identified by UPLC-MS/MS analysis. In vivo, high-dose DSY significantly inhibited aortic intimal thickening, improved arrangement disorder, tortuosity, and rupture of elastic fibers, decreased lipid levels, and reduced the number of fat vacuoles and lipid droplets in liver tissue in SD rats and ApoE
    Conclusion: This study demonstrated that DSY promotes bile acid metabolism and excretion to prevent AS by activating FXR. For the prevent of AS and drug discovery provided experimental basis.
    Language English
    Publishing date 2024-04-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118209
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  3. Article ; Online: Mechanism of Lingbao Huxin Dan in the treatment of bradyarrhythmia complicated with coronary heart disease: a network pharmacology analysis.

    Huagang, Han / Ziqiang, L I / Jingfeng, Ouyang / Tianquan, Wang / Lingyan, Dong / Junling, Cao

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2023  Volume 43, Issue 5, Page(s) 1001–1009

    Abstract: Objective: To investigate the mechanism of action of the Lingbao Huxin Dan in treating bradycardia ... of the Lingbao Huxin Dan were screened on the Traditional Chinese Medicine Systems Pharmacology Database and ... of the active ingredients of the Lingbao Huxin Dan.: Results: There were 121 active ingredients, 899 related targets, 39 ...

    Abstract Objective: To investigate the mechanism of action of the Lingbao Huxin Dan in treating bradycardia arrhythmia with coronary heart disease (BA-CHD) by network pharmacology.
    Methods: The active ingredients of the Lingbao Huxin Dan were screened on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Bioinformatics tools designed for the analysis of molecular mechanisms of Chinese medicine platform; target prediction was conducted with the SwissTargetPrediction database, and Cytoscape 3.8 was used to construct a drug ingredient-target network. The Genecards, Online Mendelian Inheritance in Man, and DrugBank databases were searched for disease targets. Venn plots were used to display the common targets of BA-CHD and active ingredients. The STRING platform was used to construct a protein-protein interaction network. The Metascape data platform was used for Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to construct a signaling pathway network of the active ingredients of the Lingbao Huxin Dan.
    Results: There were 121 active ingredients, 899 related targets, 39 targets important in BA-CHD and 14 targets which intersected between the active ingredients and BA-CHD. There were 27 core therapeutic ingredients, 153 biological processes, 18 cell ingredients and 20 molecular functions obtained by GO enrichment analysis. The KEGG pathway analysis yielded 19 signaling pathways.
    Conclusion: RBA-CHD may treat BA-CHD by regulating adrenergic receptor beta-1, alpha 1-α adrenergic receptor, calcium voltage-gated channel subunit alpha1 C, alpha-1β-adrenergic receptor, nitric oxide synthase 2, beta-2 adrenergic receptor, voltage-dependent calcium channel subunit alpha-2/delta-1, an- giotensin-converting enzyme, Raf-1 proto-oncogene serine/threonine-protein kinase, and other targets, potentially by affecting adrenergic receptor binding and calcium channel opening, to regulate the activity of cardiomyocytes.
    MeSH term(s) Humans ; Bradycardia/drug therapy ; Network Pharmacology ; Coronary Disease/complications ; Coronary Disease/drug therapy ; Coronary Disease/genetics ; Receptors, Adrenergic
    Chemical Substances huxin ; Receptors, Adrenergic
    Language English
    Publishing date 2023-09-08
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.20230802.001
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  4. Article ; Online: Effect of an herbal medicine, Chunghyul-dan, on prevention of recurrence in patients with ischemic stroke: A retrospective cohort study.

    Lee, Han-Gyul / Kwon, Seungwon / Cho, Seung-Yeon / Park, Seong-Uk / Jung, Woo-Sang / Moon, Sang-Kwan / Park, Jung-Mi / Ko, Chang-Nam / Jang, Hyeung-Jin / Cho, Ki-Ho

    Medicine

    2023  Volume 102, Issue 45, Page(s) e35840

    Abstract: Research indicates that Chunghyul-dan (CHD), a herbal medicine, has an inhibitory effect on stroke ...

    Abstract Research indicates that Chunghyul-dan (CHD), a herbal medicine, has an inhibitory effect on stroke recurrence in small vessel disease. Recent studies have suggested that CHD might also act on large arteries. This study aimed to verify the preventive effect of CHD on strokes of all the Trial of Org 10172 in Acute Stroke Treatment (TOAST) causative classifications. We retrospectively analyzed 2 years of medical records of patients with ischemic stroke treated with CHD, 600 mg once daily, in combination with antiplatelet or anticoagulant agents. The prevalence of stroke recurrence in 2 years was analyzed. Stroke recurrence was defined as new neurological symptoms with corresponding brain imaging results. Nine of the 202 patients (4.46%) had recurrent ischemic stroke. Four occurred within 180 days, 3 between 180 and 365 days, and 2 between 365 and 730 days. All had only 1 recurrence. The recurrence rates were 1.12%, 5%, and 5.48% for small vessel occlusion, cardioembolism, and large vessel atherosclerosis, respectively. There were no adverse effects. These results suggest that CHD could inhibit ischemic stroke recurrence of all TOAST causative categories. A randomized controlled trial is needed to confirm this hypothesis.
    MeSH term(s) Humans ; Ischemic Stroke/complications ; Retrospective Studies ; Stroke/drug therapy ; Stroke/etiology ; Stroke/prevention & control ; Atherosclerosis/complications ; Plant Extracts ; Brain Ischemia/drug therapy ; Brain Ischemia/prevention & control ; Brain Ischemia/complications ; Recurrence ; Risk Factors
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000035840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Action mechanism of Professor Xu Fusong's Shuilu Erxian Dan in the treatment of premature ejaculation: An exploration based on network pharmacology and molecular docking technology].

    Zhang, Xing / Han, Zi-Yang / Nie, Pan / Wang, Heng / Chen, Jian-Huai / Chen, Yun

    Zhonghua nan ke xue = National journal of andrology

    2023  Volume 28, Issue 2, Page(s) 149–156

    Abstract: Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment ... constituents of Euryale and golden cherry, the core components of Shuilu Erxian Dan. Oral bioavailability and ... the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation, which has paved ...

    Abstract Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation based on network pharmacology.
    Methods: The TCMSP database was searched for the main chemical constituents of Euryale and golden cherry, the core components of Shuilu Erxian Dan. Oral bioavailability and medicinal properties were set as the parameters for screening active components, premature ejaculation-related disease targets retrieved from the DisGeNET, GeneCards, OMIM and TTD databases, the common targets of drug pairs and diseases identified with the Wayne diagram, and a drug-active ingredient-target-disease network map constructed with the software Cytoscape. A PPI network map designed through the STRING platform, the website Metascape used for GO and KEGG analyses of the common targets, and the protein receptors and small molecular ligands of the core genes employed for molecular docking and PyMOL visualization.
    Results: A total of 7 chemical constituents and 171 predictive targets, 1 918 premature ejaculation targets and 113 common targets were identified. GO analysis showed significant enrichment of BP in response to toxic substances and inorganic substances, CC in membrane raft and plasma membrane protein complex, and MF in transcription factor binding and kinase binding. KEGG analysis manifested markedly enriched TNF signaling pathway, JAK-STAT signaling pathway and Cocaine addiction. The results of molecular docking exhibited a good binding energy between the core gene and the component.
    Conclusion: Network pharmacology has revealed the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation, which has paved the theoretical ground for verification of the effectiveness of Shuilu Erxian Dan in the treatment of premature ejaculation via animals and cells.
    MeSH term(s) Animals ; Male ; Humans ; Network Pharmacology ; Molecular Docking Simulation ; Premature Ejaculation/drug therapy ; Signal Transduction ; Drugs, Chinese Herbal/pharmacology
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6577: Show issues Location:
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  6. Article: Babao Dan decreases hepatocarcinogenesis by inhibiting hepatic progenitor cells malignant transformation via down-regulating toll-like receptor 4.

    Liang, Lei / Zhang, Lu-Yao / Liu, Wen-Ting / Zong, Chen / Gao, Lu / Li, Rong / Zhao, Qiu-Dong / Zhao, Na-Ping / Wei, Li-Xin / Zhang, Li / Han, Zhi-Peng

    Frontiers in oncology

    2023  Volume 13, Page(s) 1073859

    Abstract: Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used ...

    Abstract Background: Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of BBD on the incidence of diethylnitrosamine (DEN)-initiated hepatocellular carcinoma formation in rats and explored its possible mechanism.
    Methods: To verify this hypothesis, BBD was administrated to rats at a dose of 0.5g/kg body weight per two days from the 9th to 12th week in HCC-induced by DEN. Liver injury biomarkers and hepatic inflammatory parameters were evaluated by histopathology as well as serum and hepatic content analysis. We applied immunohistochemical analysis to investigate the expression of CK-19 and SOX-9 in liver tissues. The expression of TLR4 was determined by immunohistochemical, RT-PCR, and western blot analysis. Furthermore, we also detected the efficacy of BBD against primary HPCs neoplastic transformation induced by LPS.
    Results: We observed that DEN could induce hepatocarcinogenesis, and BBD could obviously decrease the incidence. The biochemical and histopathological examination results confirmed that BBD could protect against liver injury and decrease inflammatory infiltration. Immunohistochemistry staining results showed that BBD could effectively inhibit the ductal reaction and the expression of TLR4. The results showed that BBD-serumcould obviously inhibit primary HPCs neoplastic transformation induced by regulating the TLR4/Ras/ERK signaling pathway.
    Conclusion: In summary, our results indicate that BBD has potential applications in the prevention and treatment of HCC, which may be related to its effect on hepatic progenitor cells malignant transformation via inhibiting the TLR4/Ras/ERK signaling pathway.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1073859
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  7. Article: Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy.

    Yu, Yang / Tian, Zhi-Qiang / Liang, Lei / Yang, Xue / Sheng, Dan-Dan / Zeng, Jian-Xing / Li, Xiao-Yong / Shi, Rong-Yu / Han, Zhi-Peng / Wei, Li-Xin

    Cell & bioscience

    2019  Volume 9, Page(s) 80

    Abstract: Background: Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and ...

    Abstract Background: Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on ethanol-induced liver injury and explore potential mechanisms.
    Methods: Mice pretreated with BBD (0.125, 0.25 and 0.5 g/kg BW) were administrated by ethanol gavage (5 g/kg BW). Liver injury biomarkers and hepatic redox parameters were evaluated by histopathology as well as serum and hepatic content analysis. AML-12 cell was also utilized to determine the efficacy of BBD against ethanol-induced hepatotoxicity.
    Results: Drunkenness experiment showed that the latency was significantly increased and the drunken sleep time was decreased in mice pretreated with BBD. We then found that BBD could reduce hepatic lipid peroxidation and steatosis induced by ethanol exposure. BBD could also suppress ethanol-induced depletion of hepatic antioxidant enzyme. Besides that, BBD treatment lessened the induction of hepatic cytochrome P450 2E1, a major contributor to ethanol-mediated oxidative stress, and up-regulated the expression of nuclear factor erythroid 2-related factor 2 and its two transcriptional targets hemeoxygenase-1 and glutamate-cysteine ligase catalytic subunit. Furthermore, autophagy induced by BBD contributed to hepatoprotection activity.
    Conclusions: Our results suggest that BBD can markedly dispel acute ethanol-induced hepatotoxicity through multiple pathways including attenuation of ethanol-mediated oxidative stress, enhancement of the oxidative defense systems and activation of autophagy.
    Language English
    Publishing date 2019-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-019-0343-6
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  8. Article ; Online: Compensatory roles of Protein Related to DAN and Cerberus (PRDC) decrease in pulmonary arterial hypertension.

    He, Ting / Zhang, Junzhi / Qiao, Ting / Zhang, Zhongjun / Han, Hui / Yang, Chao / Chen, Yong / Ruan, Yiwen / Meng, Liukun

    International journal of biological sciences

    2022  Volume 18, Issue 6, Page(s) 2372–2391

    Abstract: Bone morphogenetic protein (BMP) signaling is commonly suppressed in patients with pulmonary arterial hypertension (PAH), but the compensatory mechanism of BMP signaling suppression is incompletely elucidated. This study aimed to investigate the role of ... ...

    Abstract Bone morphogenetic protein (BMP) signaling is commonly suppressed in patients with pulmonary arterial hypertension (PAH), but the compensatory mechanism of BMP signaling suppression is incompletely elucidated. This study aimed to investigate the role of PRDC, an antagonist of BMPs, in PAH and the underlying mechanism. Human lungs were collected and rat PAH was induced (monocrotaline, 60 mg/kg). BMP cascade and PRDC were detected in lungs and distal pulmonary artery smooth muscle cells (dPASMCs).
    MeSH term(s) Animals ; Bone Morphogenetic Proteins/metabolism ; Cell Proliferation ; Cytokines/metabolism ; Humans ; Myocytes, Smooth Muscle/metabolism ; Pulmonary Arterial Hypertension/drug therapy ; Pulmonary Artery ; Rats
    Chemical Substances Bone Morphogenetic Proteins ; Cytokines
    Language English
    Publishing date 2022-03-06
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.70247
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  9. Article ; Online: Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy

    Yang Yu / Zhi-qiang Tian / Lei Liang / Xue Yang / Dan-dan Sheng / Jian-xing Zeng / Xiao-yong Li / Rong-yu Shi / Zhi-peng Han / Li-xin Wei

    Cell & Bioscience, Vol 9, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Abstract Background Babao Dan (BBD), a traditional Chinese medicine, has been used ...

    Abstract Abstract Background Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on ethanol-induced liver injury and explore potential mechanisms. Methods Mice pretreated with BBD (0.125, 0.25 and 0.5 g/kg BW) were administrated by ethanol gavage (5 g/kg BW). Liver injury biomarkers and hepatic redox parameters were evaluated by histopathology as well as serum and hepatic content analysis. AML-12 cell was also utilized to determine the efficacy of BBD against ethanol-induced hepatotoxicity. Results Drunkenness experiment showed that the latency was significantly increased and the drunken sleep time was decreased in mice pretreated with BBD. We then found that BBD could reduce hepatic lipid peroxidation and steatosis induced by ethanol exposure. BBD could also suppress ethanol-induced depletion of hepatic antioxidant enzyme. Besides that, BBD treatment lessened the induction of hepatic cytochrome P450 2E1, a major contributor to ethanol-mediated oxidative stress, and up-regulated the expression of nuclear factor erythroid 2-related factor 2 and its two transcriptional targets hemeoxygenase-1 and glutamate-cysteine ligase catalytic subunit. Furthermore, autophagy induced by BBD contributed to hepatoprotection activity. Conclusions Our results suggest that BBD can markedly dispel acute ethanol-induced hepatotoxicity through multiple pathways including attenuation of ethanol-mediated oxidative stress, enhancement of the oxidative defense systems and activation of autophagy.
    Keywords Ethanol ; Liver injury ; Babao Dan ; Oxidative stress ; Autophagy ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 610
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A randomized, placebo-controlled, double-blind trial to evaluate efficacy and safety of Shen-Yuan-Dan capsules, a traditional Chinese medicine, for treatment of peri-procedure myocardial injury following percutaneous coronary intervention.

    Li, Xiang / Zhang, Ying / Liu, Hong-Xu / Shang, Ju-Ju / Zhou, Qi / Li, Ai-Yong / Lai, Xiao-Lei / Xing, Wen-Long / Jia, Si-Han

    Complementary therapies in medicine

    2022  Volume 69, Page(s) 102841

    Abstract: ... research have shown that Shen-Yuan-Dan (SYD) capsules, a traditional Chinese medicine, can potentially ...

    Abstract Background: Peri-procedural myocardial injury (PMI) is a common complication of percutaneous coronary intervention (PCI), which cannot be entirely avoided using available treatments. The findings of earlier research have shown that Shen-Yuan-Dan (SYD) capsules, a traditional Chinese medicine, can potentially alleviating PMI. This study aimed to confirm further this hypothesis in a rigorous, well-designed randomized controlled study.
    Methods: Our clinical trial was randomized, double-blinded, and placebo-controlled. A total of 181 patients with unstable angina (UA) undergoing elective PCI were randomized to pretreatment with SYD or a placebo under the basis of conventional treatment; 87 patients were pretreated with SYD (4 capsules, 3 times a day, with a further 4 capsules 2 h before PCI) 3 days before the procedure, and 94 patients were given a placebo. No patients received reloading statins before PCI, and SYD or placebo was maintained for 1 month after PCI. The primary endpoint was the incidence of PMI. The secondary endpoint was calculating the incidence rate of all 30-day major adverse cardiovascular events (all-cause mortality, non-fatal myocardial infarction, unplanned revascularization). The safety outcomes, including abnormalities in electrocardiogram and serum biochemical examinations caused by drug use, were also tested.
    Results: The levels of creatine kinase-myocardial band (CK-MB) in both the SYD and placebo groups were increased at 4 h and 24 h after PCI compared with before the procedure (P < 0.05). The incidence rate of PMI in the SYD group (10.3 %) was lower than that in the placebo group (34 %) (absolute difference, 23.7 % [95 % CI, 11.7-34.8 %], P < 0.01). After taking SYD, the relative risk reduction (RRR) and absolute risk reduction (ARR) were 69.7 % and 24.3 %, respectively; further, number needed to treat (NNT) was 4.2. The 30-day major adverse cardiovascular event (MACE) rate was not statistically different between the SYD and placebo groups (6.9 % vs. 9.6 %, P = 0.352). There were no abnormal situations during the trial.
    Conclusion: These findings showed that pretreatment with SYD could safely reduce the incidence rate of PMI in patients with UA undergoing elective PCI. Further study on the effects of SYD and how it can improve adverse cardiovascular events outcomes is needed.
    MeSH term(s) Double-Blind Method ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Medicine, Chinese Traditional ; Myocardial Infarction/drug therapy ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Treatment Outcome
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-05-25
    Publishing country Scotland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1155895-7
    ISSN 1873-6963 ; 0965-2299
    ISSN (online) 1873-6963
    ISSN 0965-2299
    DOI 10.1016/j.ctim.2022.102841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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